7QOO: Human inner kinetochore CCAN complex
Structure of the human inner kinetochore CCAN complex. Determined by electron microscopy at 4.6 Å resolution. Released 8 Jun 2022.
- Method
- Electron microscopy
- Resolution
- 4.6 Å
- Organism
- Homo sapiens
- Chains
- 15
- Atoms
- 24,085
- Mol. weight
- 544.72 kDa
- Released
- 8 Jun 2022
Explore 7QOO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7QOO contains 133 α-helices and 63 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain C: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 305 | 1 | 1 |
Chain H: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 39-65 | 27 | |
| α-helix | 75-117 | 43 | |
| α-helix | 123-188 | 66 | |
| α-helix | 195-223 | 29 | |
| α-helix | 231-239 | 9 | |
Chain I: 35 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 60-73 | 14 | |
| α-helix | 77-78 | 2 | |
| α-helix | 87-99 | 13 | |
| β-strand | 104 | 1 | 2 |
| α-helix | 106-116 | 11 | |
| α-helix | 123-131 | 9 | |
| β-strand | 135 | 1 | 2 |
| α-helix | 142-151 | 10 | |
| α-helix | 158-170 | 13 | |
| α-helix | 182-184 | 3 | |
| α-helix | 185-189 | 5 | |
| α-helix | 198-206 | 9 | |
| α-helix | 216-229 | 14 | |
| α-helix | 233-245 | 13 | |
| α-helix | 247-249 | 3 | |
| α-helix | 268-273 | 6 | |
| α-helix | 341-343 | 3 | |
| α-helix | 348-352 | 5 | |
| α-helix | 373-376 | 4 | |
| α-helix | 383-398 | 16 | |
| α-helix | 408-428 | 21 | |
| α-helix | 433-442 | 10 | |
| α-helix | 452-455 | 4 | |
| α-helix | 467-470 | 4 | |
| α-helix | 471-475 | 5 | |
| α-helix | 476-482 | 7 | |
| α-helix | 487-510 | 24 | |
| α-helix | 523-528 | 6 | |
| α-helix | 530-551 | 22 | |
| α-helix | 555-562 | 8 | |
| α-helix | 564-568 | 5 | |
| α-helix | 588-592 | 5 | |
| α-helix | 597-623 | 27 | |
| α-helix | 635-649 | 15 | |
| α-helix | 689-699 | 11 | |
| α-helix | 714-725 | 12 | |
| α-helix | 729-735 | 7 | |
Chain K: 10 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-30 | 13 | |
| α-helix | 32-42 | 11 | |
| α-helix | 57-69 | 13 | |
| α-helix | 73-76 | 4 | |
| α-helix | 89-147 | 59 | |
| α-helix | 155-187 | 33 | |
| α-helix | 190-192 | 3 | |
| α-helix | 207-209 | 3 | |
| α-helix | 212-225 | 14 | |
| β-strand | 232-233 | 2 | 3 |
| α-helix | 240-248 | 9 | |
| β-strand | 252-254 | 3 | 3 |
| β-strand | 261-264 | 4 | 3 |
Chain L: 11 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-38 | 11 | |
| β-strand | 47-48 | 2 | 4 |
| α-helix | 49-51 | 3 | |
| α-helix | 61-67 | 7 | |
| β-strand | 72-77 | 6 | 1 |
| β-strand | 80 | 1 | 5 |
| α-helix | 88-105 | 18 | |
| β-strand | 117-123 | 7 | 1 |
| α-helix | 134-136 | 3 | |
| β-strand | 137-143 | 7 | 1 |
| α-helix | 154-155 | 2 | |
| β-strand | 156-163 | 8 | 1 |
| β-strand | 179 | 1 | 5 |
| β-strand | 183-187 | 5 | 1 |
| α-helix | 190-203 | 14 | |
| β-strand | 208-210 | 3 | 1 |
| α-helix | 217-225 | 9 | |
| β-strand | 237-242 | 6 | 1 |
| β-strand | 251-256 | 6 | 1 |
| α-helix | 258-268 | 11 | |
| β-strand | 274-275 | 2 | 4 |
| α-helix | 277-295 | 19 | |
| β-strand | 297 | 1 | 6 |
| β-strand | 303-308 | 6 | 1 |
| β-strand | 312-315 | 4 | 1 |
| β-strand | 319-322 | 4 | 1 |
| α-helix | 328-343 | 16 | |
Chain M: 7 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15-21 | 7 | 7 |
| α-helix | 27-34 | 8 | |
| β-strand | 43-49 | 7 | 7 |
| α-helix | 54-55 | 2 | |
| β-strand | 66-71 | 6 | 7 |
| α-helix | 76-84 | 9 | |
| α-helix | 90-93 | 4 | |
| β-strand | 97-102 | 6 | 7 |
| α-helix | 114-122 | 9 | |
| β-strand | 128-131 | 4 | 7 |
| α-helix | 136-153 | 18 | |
| α-helix | 162-168 | 7 | |
Chain N: 17 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-14 | 12 | |
| α-helix | 21-28 | 8 | |
| α-helix | 33-36 | 4 | |
| α-helix | 45-58 | 14 | |
| α-helix | 63-76 | 14 | |
| β-strand | 83-89 | 7 | 8 |
| α-helix | 90-91 | 2 | |
| α-helix | 101-107 | 7 | |
| α-helix | 110-113 | 4 | |
| β-strand | 119-122 | 4 | 8 |
| β-strand | 125 | 1 | 8 |
| β-strand | 131-137 | 7 | 8 |
| β-strand | 150-154 | 5 | 8 |
| β-strand | 160-164 | 5 | 8 |
| α-helix | 165-166 | 2 | |
| α-helix | 169-171 | 3 | |
| α-helix | 172-182 | 11 | |
| β-strand | 187-195 | 9 | 8 |
| α-helix | 198-204 | 7 | |
| β-strand | 239 | 1 | 7 |
| α-helix | 242-245 | 4 | |
| α-helix | 250-255 | 6 | |
| β-strand | 266-271 | 6 | 1 |
| β-strand | 293-298 | 6 | 1 |
| α-helix | 306-308 | 3 | |
| α-helix | 309-312 | 4 | |
| β-strand | 315 | 1 | 6 |
| α-helix | 326-329 | 4 | |
| β-strand | 334-336 | 3 | 1 |
Chain O: 6 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 92-110 | 19 | |
| β-strand | 113-117 | 5 | 9 |
| β-strand | 122-126 | 5 | 9 |
| β-strand | 129 | 1 | 10 |
| β-strand | 133 | 1 | 11 |
| β-strand | 134 | 1 | 10 |
| β-strand | 138-142 | 5 | 9 |
| β-strand | 150-153 | 4 | 9 |
| α-helix | 162-165 | 4 | |
| α-helix | 168-171 | 4 | |
| α-helix | 174-197 | 24 | |
| β-strand | 205 | 1 | 12 |
| β-strand | 217-224 | 8 | 12 |
| β-strand | 231-238 | 8 | 12 |
| β-strand | 249-254 | 6 | 12 |
| α-helix | 263-273 | 11 | |
| α-helix | 280-287 | 8 | |
7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Centromere protein C | C | protein | 544 | Homo sapiens | Q03188 (AlphaFold model) |
| Centromere protein H | H | protein | 247 | Homo sapiens | Q9H3R5 (AlphaFold model) |
| Centromere protein I | I | protein | 756 | Homo sapiens | Q92674 (AlphaFold model) |
| Centromere protein K | K | protein | 269 | Homo sapiens | Q9BS16 (AlphaFold model) |
| Centromere protein L | L | protein | 344 | Homo sapiens | Q8N0S6 |
| Centromere protein M | M | protein | 180 | Homo sapiens | Q9NSP4 |
| Centromere protein N | N | protein | 339 | Homo sapiens | Q96H22 |
| Centromere protein O | O | protein | 300 | Homo sapiens | Q9BU64 |
| Centromere protein P | P | protein | 288 | Homo sapiens | Q6IPU0 |
| Centromere protein U | U | protein | 418 | Homo sapiens | Q71F23 |
| Centromere protein Q | Q | protein | 268 | Homo sapiens | Q7L2Z9 |
| Centromere protein R | R | protein | 177 | Homo sapiens | Q13352 |
3 more molecules are not listed.
Sequence of entity 1 (C), FASTA
>7QOO_1 Centromere protein C (chains C)
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP
NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI
LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK
RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS
GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE
DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN
DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK
QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP
VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV
YSNS
Sequence of entity 2 (H), FASTA
>7QOO_2 Centromere protein H (chains H)
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM
Sequence of entity 3 (I), FASTA
>7QOO_3 Centromere protein I (chains I)
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQ
AEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGK
FGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQ
INLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLS
LYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPL
KRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELP
SQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDT
IIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQ
LFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYV
GWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSIL
NQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKG
IYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYL
DYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY
Sequence of entity 4 (K), FASTA
>7QOO_4 Centromere protein K (chains K)
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ
Sequence of entity 5 (L), FASTA
>7QOO_5 Centromere protein L (chains L)
MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVD
PQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVI
FSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTC
LPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFL
WSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLS
ATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
Sequence of entity 6 (M), FASTA
>7QOO_6 Centromere protein M (chains M)
MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
Sequence of entity 7 (N), FASTA
>7QOO_7 Centromere protein N (chains N)
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKR
ASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVT
VSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALT
IASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHE
NIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAEREEPLRCLIKFSSP
HLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDK
Sequence of entity 8 (O), FASTA
>7QOO_8 Centromere protein O (chains O)
MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRD
ELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSR
GVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSL
CEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYK
DLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS
Sequence of entity 9 (P), FASTA
>7QOO_9 Centromere protein P (chains P)
MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQL
GHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEF
QILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYR
KRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLT
KVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN
Sequence of entity 10 (U), FASTA
>7QOO_10 Centromere protein U (chains U)
MAPRGRRRPRPHRSEGARRSKNTLERTHSMKDKAGQKCKPIDVFDFPDNSDVSSIGRLGE
NEKDEETYETFDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIES
VKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAES
VTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCP
EGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLT
NLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSN
LKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQG
Sequence of entity 11 (Q), FASTA
>7QOO_11 Centromere protein Q (chains Q)
MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKNHLKDLSSEGQTKHTNL
KHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQ
CETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLK
NKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLK
DLDILHNSSQMKSMSTFIEEAYKKLDAS
Sequence of entity 12 (R), FASTA
>7QOO_12 Centromere protein R (chains R)
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
Primary citation
Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization. Pesenti, M.E., Raisch, T., Conti, D. et al. Mol Cell (2022) 82:2113. DOI 10.1016/j.molcel.2022.04.027 · PubMed
Other PDB entries of the same protein (UniProt Q03188 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7R5R 2.44 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 7PII 2.68 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
- 5LSJ 3.25 Å, Crystal structure of the human kinetochore MIS12-cenp-C delta-HEAD2 complex
- 7XHO 3.29 Å, Structure of human inner kinetochore CCAN complex
- 6MUP 3.5 Å, CENP-A nucleosome bound by two copies of CENP-C(CD) and two copies CENP-N(NT)
- 6SE6 3.5 Å, Class2 : CENP-A nucleosome in complex with CENP-C central region
- 5LSK 3.5 Å, Crystal structure of the human kinetochore MIS12-cenp-C complex
- 9TAW 3.54 Å, Structure of the human inner kinetochore CCAN bound to DNA
- 6MUO 3.6 Å, CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT)
- 6SEF 3.7 Å, Class2C : CENP-A nucleosome in complex with CENP-C central region
- 7XHN 3.71 Å, Structure of human inner kinetochore CCAN-DNA complex
Browse structure collections
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