7QTT: Splicing factor 3B subunit 3

Name: PDB 7QTT: Structural organization of a late activated human spliceosome (Baqr, core region)
Published: 2023-05-10
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: splicing

Structural organization of a late activated human spliceosome (Baqr, core region). Determined by electron microscopy at 3.1 Å resolution. Released 10 May 2023.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: Homo sapiens, unidentified adenovirus
Chains: 37
Atoms: 73,537
Mol. weight: 2495.69 kDa
Ligands: ZN, IHP, GTP, MG
Released: 10 May 2023

Explore 7QTT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7QTT contains 401 α-helices and 399 β-strands across 33 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 96 helices, 52 β-strands

Element	Residues	Length	Sheet
α-helix	63-71	9
α-helix	74-76	3
α-helix	85-90	6
α-helix	95-103	9
α-helix	106-108	3
β-strand	115-121	7	88
β-strand	127-129	3	88
β-strand	134-135	2	89
α-helix	137-157	21
α-helix	163-165	3
α-helix	174-177	4
α-helix	178-181	4
α-helix	201-203	3
β-strand	220	1	90
β-strand	227-229	3	90
α-helix	232-241	10
α-helix	252-254	3
α-helix	260-269	10
α-helix	295-297	3
α-helix	310-315	6
α-helix	327-331	5
α-helix	333-336	4
α-helix	340-342	3
α-helix	357-358	2
α-helix	379-381	3
α-helix	398-405	8
α-helix	409-411	3
β-strand	415-417	3	90
β-strand	419-420	2	89
α-helix	428-432	5
α-helix	434-436	3
α-helix	441-459	19
α-helix	472-477	6
β-strand	482-488	7	88
α-helix	489-510	22
β-strand	516-517	2	91
β-strand	525-526	2	91
α-helix	532-537	6
α-helix	542-565	24
α-helix	571-583	13
α-helix	585-588	4
α-helix	591-593	3
α-helix	598-616	19
α-helix	631-661	31
α-helix	669-671	3
α-helix	678-694	17
α-helix	706-721	16
α-helix	733-763	31
α-helix	769-797	29
α-helix	804-819	16
α-helix	822-825	4
α-helix	835-847	13
α-helix	858-872	15
α-helix	874-887	14
β-strand	894-900	7	72
β-strand	905-910	6	72
α-helix	913-932	20
β-strand	940-941	2	92
α-helix	948-960	13
β-strand	973-979	7	92
α-helix	985-987	3
α-helix	990-997	8
α-helix	1003-1013	11
β-strand	1016-1019	4	72
β-strand	1022-1025	4	72
α-helix	1037-1053	17
α-helix	1055-1062	8
α-helix	1077-1080	4
β-strand	1085-1091	7	92
β-strand	1094-1101	8	92
α-helix	1103-1116	14
α-helix	1144-1160	17
β-strand	1174-1178	5	92
β-strand	1185-1189	5	93
β-strand	1192-1198	7	93
β-strand	1213-1217	5	93
β-strand	1224-1232	9	93
α-helix	1234-1250	17
α-helix	1251-1253	3
α-helix	1256-1274	19
α-helix	1275-1278	4
α-helix	1282-1302	21
α-helix	1314-1317	4
α-helix	1320-1322	3
α-helix	1327-1329	3
α-helix	1334	1
β-strand	1335-1337	3	94
β-strand	1352-1354	3	94
α-helix	1365-1367	3
α-helix	1369-1371	3
α-helix	1375-1399	25
β-strand	1403	1	83
α-helix	1405-1408	4
α-helix	1419-1423	5
β-strand	1424	1	84
α-helix	1427-1430	4
α-helix	1437-1443	7
α-helix	1450-1451	2
α-helix	1468-1477	10
α-helix	1480-1485	6
α-helix	1491-1493	3
β-strand	1501-1502	2	32
α-helix	1528-1537	10
α-helix	1539-1542	4
β-strand	1552-1554	3	85
α-helix	1555	1
β-strand	1561-1563	3	85
α-helix	1567-1576	10
α-helix	1581-1599	19
α-helix	1602-1604	3
β-strand	1606-1611	6	95
α-helix	1616-1618	3
β-strand	1629-1633	5	95
β-strand	1637-1639	3	96
β-strand	1643-1644	2	95
β-strand	1655-1657	3	96
β-strand	1660-1667	8	95
α-helix	1677-1688	12
β-strand	1700-1706	7	95
β-strand	1711-1716	6	95
α-helix	1722-1736	15
α-helix	1738-1751	14
β-strand	1754-1755	2	32
α-helix	1767-1770	4
β-strand	1777	1	97
β-strand	1779-1781	3	98
β-strand	1789-1790	2	99
β-strand	1800-1801	2	99
α-helix	1803-1805	3
β-strand	1806-1811	6	98
β-strand	1816-1821	6	98
α-helix	1836-1851	16
β-strand	1860	1	97
β-strand	1861-1863	3	100
α-helix	1870-1874	5
β-strand	1884-1886	3	100
β-strand	1889	1	101
α-helix	1893-1895	3
α-helix	1900-1907	8
β-strand	1915-1918	4	98
α-helix	1929-1945	17
α-helix	1947-1954	8
α-helix	1958-1960	3
β-strand	1966	1	98
α-helix	1969-1970	2
α-helix	1973-1995	23
α-helix	2004-2012	9
β-strand	2014	1	101

Chain A: 15 helices, 104 β-strands

Element	Residues	Length	Sheet
β-strand	3-9	7	1
β-strand	16-20	5	2
β-strand	29-33	5	2
β-strand	37-41	5	2
β-strand	52-57	6	2
β-strand	62-69	8	3
β-strand	76-82	7	3
β-strand	86-93	8	3
β-strand	98-106	9	3
β-strand	120-123	4	4
β-strand	129-133	5	4
β-strand	136	1	5
β-strand	139-143	5	4
α-helix	144	1
β-strand	145-146	2	6
β-strand	152-153	2	6
α-helix	156-157	2
β-strand	158-159	2	4
β-strand	165-173	9	5
β-strand	181-188	8	5
α-helix	190-194	5
α-helix	199-203	5
β-strand	207-214	8	5
β-strand	219-227	9	5
β-strand	234-237	4	7
β-strand	241	1	8
β-strand	244	1	8
β-strand	247-252	6	7
β-strand	255-260	6	7
β-strand	269	1	7
α-helix	270-271	2
β-strand	274	1	9
β-strand	290-294	5	10
β-strand	299-304	6	10
β-strand	309-314	6	10
β-strand	316	1	11
β-strand	324	1	11
β-strand	327-332	6	10
β-strand	336-342	7	12
β-strand	346-351	6	12
β-strand	356-360	5	12
β-strand	372-373	2	10
β-strand	387	1	9
β-strand	396-401	6	12
β-strand	407-413	7	13
β-strand	422-429	8	13
β-strand	432-439	8	13
β-strand	458-461	4	14
β-strand	474-477	4	14
β-strand	482-485	4	14
β-strand	507-509	3	15
β-strand	516-520	5	15
β-strand	523-527	5	15
β-strand	533-536	4	15
α-helix	537-538	2
α-helix	543-544	2
β-strand	546-548	3	16
β-strand	553-557	5	16
β-strand	563-568	6	16
β-strand	574-576	3	16
β-strand	581	1	16
β-strand	587-592	6	17
β-strand	605-609	5	17
β-strand	613-617	5	17
β-strand	627-632	6	17
β-strand	637-644	8	18
β-strand	663-669	7	18
β-strand	674-678	5	18
β-strand	687-689	3	18
β-strand	703-706	4	19
β-strand	709-714	6	19
β-strand	720-724	5	19
β-strand	729-733	5	19
β-strand	741-745	5	20
β-strand	753-758	6	20
β-strand	761-765	5	20
β-strand	775-780	6	13
β-strand	785-790	6	21
β-strand	797-804	8	21
α-helix	809-822	14
α-helix	834-844	11
β-strand	862-869	8	21
β-strand	876-881	6	21
β-strand	886-890	5	22
β-strand	905-911	7	22
β-strand	914	1	23
β-strand	919	1	23
β-strand	922-928	7	22
β-strand	931	1	24
β-strand	936	1	24
β-strand	939-945	7	22
β-strand	951-954	4	25
β-strand	959-963	5	25
β-strand	966-970	5	25
β-strand	971	1	26
β-strand	978	1	26
β-strand	982-983	2	25
β-strand	992-995	4	27
β-strand	1000-1003	4	27
β-strand	1007	1	28
β-strand	1010-1015	6	27
β-strand	1020-1025	6	27
β-strand	1026	1	29
β-strand	1030	1	28
β-strand	1043-1047	5	30
β-strand	1052-1057	6	30
α-helix	1058-1059	2
β-strand	1070	1	29
β-strand	1072-1078	7	30
β-strand	1083-1087	5	1
β-strand	1099-1103	5	1
β-strand	1108-1113	6	1
α-helix	1117-1133	17
α-helix	1142-1145	4
β-strand	1153	1	30
β-strand	1155-1157	3	1
α-helix	1158-1165	8
α-helix	1169-1178	10
α-helix	1183-1196	14

Chain b: 40 helices, 38 β-strands

Element	Residues	Length	Sheet
α-helix	69-73	5
β-strand	78-81	4	65
α-helix	92	1
α-helix	95-97	3
α-helix	116-122	7
β-strand	129-136	8	102
α-helix	142-153	12
α-helix	172-177	6
β-strand	184-191	8	102
β-strand	197-204	8	102
α-helix	209-211	3
α-helix	212-221	10
β-strand	224-230	7	102
α-helix	237-248	12
β-strand	252-258	7	102
α-helix	261	1
α-helix	262-266	5
α-helix	271-292	22
β-strand	307-311	5	102
β-strand	316-318	3	102
α-helix	320-330	11
α-helix	336-343	8
β-strand	348-350	3	103
β-strand	355-357	3	103
α-helix	368-369	2
α-helix	370-374	5
α-helix	375-386	12
α-helix	392-398	7
α-helix	412-424	13
α-helix	429-437	9
α-helix	441-452	12
β-strand	453	1	104
α-helix	460-466	7
β-strand	475-483	9	105
β-strand	490-498	9	105
β-strand	501	1	106
β-strand	507-510	4	105
β-strand	523-525	3	105
β-strand	530-533	4	105
β-strand	538-541	4	105
β-strand	544	1	106
β-strand	549-553	5	105
β-strand	563-566	4	105
β-strand	577	1	104
α-helix	578-579	2
β-strand	588-594	7	107
α-helix	597-599	3
α-helix	600-613	14
β-strand	618-621	4	107
β-strand	627-631	5	107
α-helix	634-646	13
β-strand	653-655	3	107
α-helix	656-658	3
β-strand	659-660	2	107
β-strand	663-665	3	108
β-strand	675-677	3	109
β-strand	684-691	8	109
α-helix	696-701	6
α-helix	711-722	12
α-helix	726-729	4
β-strand	732-735	4	109
β-strand	743-747	5	109
α-helix	756-776	21
β-strand	783-784	2	108
β-strand	787-795	9	109
α-helix	796-797	2
α-helix	808-821	14
β-strand	826-839	14	108
α-helix	840-842	3
α-helix	843-852	10
β-strand	856-862	7	108
α-helix	863	1
β-strand	868-876	9	108
α-helix	883-890	8
β-strand	896-906	11	108
α-helix	923-924	2
α-helix	926-928	3
α-helix	929-940	12

Chain B: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	12-15	4
α-helix	28-45	18
α-helix	47-54	8
α-helix	61-73	13
α-helix	74-76	3

Chain C: 55 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	491-506	16
α-helix	509-521	13
α-helix	523-526	4
α-helix	528-539	12
α-helix	546-563	18
α-helix	564-567	4
α-helix	571-581	11
α-helix	587-603	17
α-helix	606-617	12
α-helix	622-639	18
α-helix	641-652	12
α-helix	658-675	18
α-helix	677-679	3
α-helix	683-694	12
α-helix	699-715	17
α-helix	725-727	3
α-helix	728-734	7
α-helix	741-753	13
α-helix	754-756	3
α-helix	759-776	18
α-helix	782-797	16
α-helix	804-809	6
α-helix	811-817	7
α-helix	821-825	5
α-helix	828-844	17
α-helix	846-852	7
α-helix	855-858	4
α-helix	862-878	17
α-helix	886-901	16
α-helix	908-921	14
α-helix	922-925	4
α-helix	929-939	11
β-strand	942	1	32
α-helix	945-964	20
α-helix	968-980	13
α-helix	981-983	3
α-helix	987-1004	18
α-helix	1013-1020	8
α-helix	1022-1025	4
α-helix	1029-1045	17
α-helix	1047-1049	3
α-helix	1052-1065	14
α-helix	1071-1088	18
α-helix	1092-1103	12
α-helix	1110-1122	13
α-helix	1129-1134	6
α-helix	1135-1137	3
α-helix	1143-1158	16
α-helix	1159-1164	6
α-helix	1166-1177	12
α-helix	1182-1198	17
α-helix	1205-1215	11
α-helix	1216-1220	5
α-helix	1224-1240	17
α-helix	1243-1251	9
α-helix	1259-1275	17

Chain D: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	19	1	33
β-strand	22	1	34
α-helix	24-26	3
β-strand	39-42	4	35
β-strand	44	1	33
β-strand	57	1	36
α-helix	63	1
β-strand	64	1	36
α-helix	65	1
β-strand	67	1	34
β-strand	70-72	3	35
α-helix	80-83	4

Chain E: 13 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	462-468	7
α-helix	472-474	3
α-helix	479-481	3
α-helix	485-492	8
α-helix	499-501	3
α-helix	502-504	3
α-helix	509	1
α-helix	526-531	6
α-helix	533-545	13
α-helix	549-557	9
α-helix	569-575	7
α-helix	611-616	6
α-helix	633-638	6
β-strand	683	1	38
β-strand	686	1	38

Chain F: 2 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	14-18	5	39
α-helix	26-35	10
β-strand	39-43	5	39
β-strand	57-61	5	39
α-helix	64-72	9
β-strand	78-79	2	40
β-strand	82-83	2	40
β-strand	85-88	4	39

25 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Splicing factor 3B subunit 3	A	protein	1217	Homo sapiens	Q15393 (AlphaFold model)
Splicing factor 3B subunit 5	B	protein	86	Homo sapiens	Q9BWJ5 (AlphaFold model)
Splicing factor 3B subunit 1	C	protein	1304	Homo sapiens	O75533 (AlphaFold model)
PHD finger-like domain-containing protein 5A	D	protein	110	Homo sapiens	Q7RTV0 (AlphaFold model)
Splicing factor 3B subunit 2	E	protein	895	Homo sapiens	Q13435
Splicing factor 3B subunit 4	F	protein	424	Homo sapiens	Q15427
G-patch domain and KOW motifs-containing protein	G	protein	476	Homo sapiens	Q92917
Splicing factor 3A subunit 2	I	protein	464	Homo sapiens	Q15428
Splicing factor 3A subunit 3	J	protein	501	Homo sapiens	Q12874
BUD13 homolog	L	protein	619	Homo sapiens	Q9BRD0
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	N	protein	1041	Homo sapiens	O60231
Pleiotropic regulator 1	O	protein	514	Homo sapiens	O43660

25 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7QTT_1 Splicing factor 3B subunit 3 (chains A)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF

Sequence of entity 2 (B), FASTA

>7QTT_2 Splicing factor 3B subunit 5 (chains B)
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN

Sequence of entity 3 (C), FASTA

>7QTT_3 Splicing factor 3B subunit 1 (chains C)
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAA
TELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYK
KHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGE
LKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAK
GSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTE
RDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPI
GTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAG
YVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLV
DVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLM
SPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNL
AKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQA
RHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYG
IESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP
DEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVEL
ANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAF
QEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAV
VMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRL
TPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNT
FGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPE
LNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVY
GFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARK
VRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL

Sequence of entity 4 (D), FASTA

>7QTT_4 PHD finger-like domain-containing protein 5A (chains D)
MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVI
CGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR

Sequence of entity 5 (E), FASTA

>7QTT_5 Splicing factor 3B subunit 2 (chains E)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF

Sequence of entity 6 (F), FASTA

>7QTT_6 Splicing factor 3B subunit 4 (chains F)
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVE
FLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTF
SAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKK
DSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPP
GSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGG
MPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGS
PMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRG
PLPQ

Sequence of entity 7 (G), FASTA

>7QTT_7 G-patch domain and KOW motifs-containing protein (chains G)
MADSKEGVLPLTAASTAPISFGFTRTSARRRLADSGDGAGPSPEEKDFLKTVEGRELQSV
KPQEAPKELVIPLIQNGHRRQPPARPPGPSTDTGALADGVVSQAVKELIAESKKSLEERE
NAGVDPTLAIPMIQKGCTPSGEGADSEPRAETVPEEANYEAVPVEAYGLAMLRGMGWKPG
EGIGRTFNQVVKPRVNSLRPKGLGLGANLTEAQALTPTGPSRMPRPDEEQEKDKEDQPQG
LVPGGAVVVLSGPHRGLYGKVEGLDPDNVRAMVRLAVGSRVVTVSEYYLRPVSQQEFDKN
TLDLRQQNGTASSRKTLWNQELYIQQDNSERKRKHLPDRQDGPAAKSEKAAPRSQHWLHR
DLRVRFVDNMYKGGQYYNTKMIIEDVLSPDTCVCRTDEGRVLEGLREDMLETLVPKAEGD
RVMVVLGPQTGRVGHLLSRDRARSRALVQLPRENQVVELHYDAICQYMGPSDTDDD

Sequence of entity 8 (I), FASTA

>7QTT_8 Splicing factor 3A subunit 2 (chains I)
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN

Sequence of entity 9 (J), FASTA

>7QTT_9 Splicing factor 3A subunit 3 (chains J)
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDL
YDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENP
SEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNA
EYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHA
GAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSL
FAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEE
EEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPK
AFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYE
DSSGNVVNKKTYEDLKRQGLL

Sequence of entity 10 (L), FASTA

>7QTT_10 BUD13 homolog (chains L)
MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA
ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR
HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI
RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS
PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP
HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR
HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA
HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ
RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER
EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR
LASKKAVEELAYKWSVEDM

Sequence of entity 11 (N), FASTA

>7QTT_11 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (chains N)
MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDTDTLDLSGPAR
DFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLEDSEESSEETVSRAGSSLQK
KRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDA
FAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKRER
EKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHM
PKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEE
ETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLII
EGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYS
IRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVA
RFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVL
QIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIF
QPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASAN
QRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDF
LDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEI
LTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYE
NFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYR
TVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKE
LEDPHAKKMPKKIGKTREELG

Sequence of entity 12 (O), FASTA

>7QTT_12 Pleiotropic regulator 1 (chains O)
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	12
IHP	Inositol hexakisphosphate	C6 H18 O24 P6	1
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1
MG	Magnesium ion	Mg	7

Primary citation

Structural basis of catalytic activation in human splicing. Schmitzova, J., Cretu, C., Dienemann, C. et al. Nature (2023) 617:842-850. DOI 10.1038/s41586-023-06049-w · PubMed

Other PDB entries of the same protein (UniProt Q15393 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Q4O 2.1 Å, Substrate-bound A-like U2 snRNP
7Q4P 2.15 Å, U2 snRNP after ATP-dependent remodelling
7Q3L 2.21 Å, Human 17S U2 snRNP 5' domain
7B9C 2.4 Å, Structure of a minimal SF3B core in complex with spliceostatin A (form I)
9RDK 2.41 Å, Cryo-EM structure of the human SAGA co-activator complex
7EVO 2.5 Å, The cryo-EM structure of the human 17S U2 snRNP
7EVN 2.6 Å, The cryo-EM structure of the DDX42-SF3b complex
8H6L 2.6 Å, Cryo-EM structure of human exon-defined spliceosome in the early B state.
8H6K 2.7 Å, Cryo-EM structure of human exon-defined spliceosome in the mature B state.
8HK1 2.7 Å, The cryo-EM structure of human pre-17S U2 snRNP
7DVQ 2.89 Å, Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
7B0I 3.0 Å, Structure of a minimal SF3B core in complex with spliceostatin A (form II)

Browse structure collections

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