7EVO: Human 17S U2 snRNP
The cryo-EM structure of the human 17S U2 snRNP. Determined by electron microscopy at 2.5 Å resolution. Released 3 Aug 2022.
- Method
- Electron microscopy
- Resolution
- 2.5 Å
- Organism
- Homo sapiens
- Chains
- 21
- Atoms
- 32,104
- Mol. weight
- 1061.81 kDa
- Ligands
- 9B0, ZN
- Released
- 3 Aug 2022
Explore 7EVO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7EVO contains 176 α-helices and 236 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 60 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 492-498 | 7 | |
| α-helix | 500-505 | 6 | |
| α-helix | 509-526 | 18 | |
| α-helix | 528-539 | 12 | |
| α-helix | 546-562 | 17 | |
| α-helix | 568-570 | 3 | |
| α-helix | 571-578 | 8 | |
| α-helix | 587-603 | 17 | |
| α-helix | 606-613 | 8 | |
| α-helix | 615-617 | 3 | |
| α-helix | 622-639 | 18 | |
| α-helix | 645-651 | 7 | |
| α-helix | 658-675 | 18 | |
| α-helix | 676-682 | 7 | |
| α-helix | 683-690 | 8 | |
| α-helix | 691-695 | 5 | |
| α-helix | 699-716 | 18 | |
| α-helix | 728-737 | 10 | |
| α-helix | 741-753 | 13 | |
| α-helix | 754-756 | 3 | |
| α-helix | 759-776 | 18 | |
| α-helix | 782-795 | 14 | |
| α-helix | 803-805 | 3 | |
| α-helix | 806-810 | 5 | |
| α-helix | 811-817 | 7 | |
| α-helix | 821-825 | 5 | |
| α-helix | 830-844 | 15 | |
| α-helix | 846-854 | 9 | |
| α-helix | 862-878 | 17 | |
| α-helix | 886-901 | 16 | |
| α-helix | 908-921 | 14 | |
| α-helix | 922-924 | 3 | |
| α-helix | 928-941 | 14 | |
| α-helix | 946-964 | 19 | |
| α-helix | 969-980 | 12 | |
| α-helix | 987-1003 | 17 | |
| α-helix | 1013-1020 | 8 | |
| α-helix | 1021-1025 | 5 | |
| α-helix | 1029-1045 | 17 | |
| α-helix | 1047-1049 | 3 | |
| α-helix | 1052-1062 | 11 | |
| α-helix | 1063-1067 | 5 | |
| α-helix | 1071-1088 | 18 | |
| α-helix | 1090-1102 | 13 | |
| α-helix | 1106-1122 | 17 | |
| α-helix | 1125-1127 | 3 | |
| α-helix | 1129-1135 | 7 | |
| α-helix | 1144-1158 | 15 | |
| α-helix | 1159-1164 | 6 | |
| α-helix | 1166-1177 | 12 | |
| α-helix | 1182-1198 | 17 | |
| α-helix | 1205-1215 | 11 | |
| α-helix | 1216-1220 | 5 | |
| α-helix | 1224-1240 | 17 | |
| α-helix | 1243-1250 | 8 | |
| α-helix | 1251-1253 | 3 | |
| α-helix | 1259-1274 | 16 | |
| α-helix | 1279-1282 | 4 | |
| α-helix | 1284-1286 | 3 | |
| α-helix | 1299-1301 | 3 | |
Chain 2: 9 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 462-468 | 7 | |
| α-helix | 472-474 | 3 | |
| α-helix | 477-481 | 5 | |
| α-helix | 485-492 | 8 | |
| α-helix | 526-529 | 4 | |
| α-helix | 569-577 | 9 | |
| β-strand | 608 | 1 | 1 |
| α-helix | 611-617 | 7 | |
| α-helix | 619-622 | 4 | |
| α-helix | 633-639 | 7 | |
| β-strand | 648-649 | 2 | 2 |
| β-strand | 651 | 1 | 3 |
| β-strand | 655 | 1 | 3 |
| β-strand | 683 | 1 | 1 |
| β-strand | 686 | 1 | 1 |
| β-strand | 689-690 | 2 | 2 |
Chain 3: 16 helices, 104 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 4 |
| β-strand | 16-20 | 5 | 5 |
| β-strand | 29-33 | 5 | 5 |
| β-strand | 37-43 | 7 | 5 |
| β-strand | 50-57 | 8 | 5 |
| β-strand | 62-68 | 7 | 6 |
| β-strand | 77-82 | 6 | 6 |
| β-strand | 86-93 | 8 | 6 |
| β-strand | 98-106 | 9 | 6 |
| β-strand | 120-123 | 4 | 7 |
| β-strand | 129-133 | 5 | 7 |
| β-strand | 139-143 | 5 | 7 |
| β-strand | 144-146 | 3 | 8 |
| β-strand | 152-154 | 3 | 8 |
| β-strand | 158-159 | 2 | 7 |
| β-strand | 165-173 | 9 | 9 |
| β-strand | 181-188 | 8 | 9 |
| α-helix | 191-193 | 3 | |
| β-strand | 207-214 | 8 | 9 |
| β-strand | 219-227 | 9 | 9 |
| β-strand | 232-237 | 6 | 10 |
| α-helix | 238-239 | 2 | |
| β-strand | 248-252 | 5 | 10 |
| β-strand | 255-259 | 5 | 10 |
| α-helix | 264-266 | 3 | |
| β-strand | 267-270 | 4 | 10 |
| α-helix | 271-272 | 2 | |
| β-strand | 273-274 | 2 | 11 |
| β-strand | 287-294 | 8 | 12 |
| β-strand | 299-305 | 7 | 12 |
| β-strand | 309-317 | 9 | 12 |
| β-strand | 322-332 | 11 | 12 |
| β-strand | 336-342 | 7 | 13 |
| β-strand | 346-351 | 6 | 13 |
| β-strand | 356-361 | 6 | 13 |
| β-strand | 373-374 | 2 | 12 |
| β-strand | 386-387 | 2 | 11 |
| β-strand | 395-401 | 7 | 13 |
| α-helix | 405 | 1 | |
| β-strand | 407-413 | 7 | 14 |
| β-strand | 422-427 | 6 | 14 |
| α-helix | 430-432 | 3 | |
| β-strand | 434-440 | 7 | 14 |
| β-strand | 442 | 1 | 15 |
| β-strand | 444-449 | 6 | 16 |
| β-strand | 461-462 | 2 | 17 |
| β-strand | 473-477 | 5 | 17 |
| β-strand | 482-485 | 4 | 17 |
| β-strand | 493 | 1 | 17 |
| β-strand | 507-510 | 4 | 18 |
| β-strand | 516-520 | 5 | 18 |
| β-strand | 523-527 | 5 | 18 |
| β-strand | 533-537 | 5 | 18 |
| β-strand | 546-548 | 3 | 19 |
| β-strand | 555-557 | 3 | 19 |
| β-strand | 563-565 | 3 | 19 |
| β-strand | 566-568 | 3 | 20 |
| β-strand | 574-576 | 3 | 20 |
| β-strand | 581 | 1 | 19 |
| β-strand | 587-592 | 6 | 21 |
| β-strand | 605-609 | 5 | 21 |
| β-strand | 613-617 | 5 | 21 |
| β-strand | 627-632 | 6 | 21 |
| β-strand | 637-643 | 7 | 22 |
| β-strand | 664-669 | 6 | 22 |
| β-strand | 673-678 | 6 | 22 |
| β-strand | 689-690 | 2 | 22 |
| β-strand | 700-706 | 7 | 23 |
| β-strand | 709-715 | 7 | 23 |
| β-strand | 719-723 | 5 | 23 |
| β-strand | 730-733 | 4 | 23 |
| β-strand | 734 | 1 | 15 |
| β-strand | 741 | 1 | 24 |
| β-strand | 744-745 | 2 | 16 |
| β-strand | 753-756 | 4 | 16 |
| β-strand | 757 | 1 | 24 |
| β-strand | 763-767 | 5 | 16 |
| β-strand | 774-780 | 7 | 14 |
| β-strand | 785-790 | 6 | 25 |
| β-strand | 797-804 | 8 | 25 |
| α-helix | 809-824 | 16 | |
| α-helix | 839-842 | 4 | |
| α-helix | 846-848 | 3 | |
| α-helix | 849-852 | 4 | |
| β-strand | 862-869 | 8 | 25 |
| β-strand | 876-881 | 6 | 25 |
| β-strand | 886-894 | 9 | 26 |
| β-strand | 904-911 | 8 | 26 |
| β-strand | 914-915 | 2 | 27 |
| β-strand | 918-919 | 2 | 27 |
| β-strand | 922-928 | 7 | 26 |
| β-strand | 931 | 1 | 28 |
| β-strand | 936 | 1 | 28 |
| β-strand | 939-945 | 7 | 26 |
| β-strand | 949-955 | 7 | 29 |
| β-strand | 958-963 | 6 | 29 |
| β-strand | 966-972 | 7 | 29 |
| β-strand | 977-983 | 7 | 29 |
| β-strand | 990-996 | 7 | 30 |
| β-strand | 999-1004 | 6 | 30 |
| β-strand | 1007 | 1 | 31 |
| β-strand | 1009-1015 | 7 | 30 |
| β-strand | 1020-1026 | 7 | 30 |
| β-strand | 1030 | 1 | 31 |
| β-strand | 1033-1038 | 6 | 32 |
| β-strand | 1043-1048 | 6 | 32 |
| β-strand | 1052-1057 | 6 | 32 |
| β-strand | 1088 | 1 | 30 |
| β-strand | 1090-1096 | 7 | 32 |
| β-strand | 1101-1108 | 8 | 4 |
| β-strand | 1115-1121 | 7 | 4 |
| β-strand | 1126-1131 | 6 | 4 |
| α-helix | 1135-1151 | 17 | |
| α-helix | 1160-1163 | 4 | |
| β-strand | 1171 | 1 | 32 |
| β-strand | 1173-1175 | 3 | 4 |
| α-helix | 1176-1179 | 4 | |
| α-helix | 1180-1184 | 5 | |
| α-helix | 1187-1194 | 8 | |
| α-helix | 1201-1215 | 15 | |
Chain 4: 7 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-18 | 5 | 33 |
| α-helix | 26-32 | 7 | |
| β-strand | 39-43 | 5 | 33 |
| α-helix | 45 | 1 | |
| β-strand | 46 | 1 | 34 |
| α-helix | 47 | 1 | |
| β-strand | 53 | 1 | 34 |
| β-strand | 56-61 | 6 | 33 |
| α-helix | 64-73 | 10 | |
| β-strand | 77-79 | 3 | 35 |
| β-strand | 82-84 | 3 | 35 |
| β-strand | 85-88 | 4 | 33 |
| β-strand | 102-105 | 4 | 36 |
| α-helix | 113-120 | 8 | |
| β-strand | 126 | 1 | 37 |
| β-strand | 131-132 | 2 | 36 |
| β-strand | 144-147 | 4 | 36 |
| β-strand | 149 | 1 | 37 |
| α-helix | 152-157 | 6 | |
| α-helix | 158-162 | 5 | |
| β-strand | 166 | 1 | 38 |
| β-strand | 171 | 1 | 38 |
| β-strand | 173-176 | 4 | 36 |
Chain 5: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-45 | 18 | |
| α-helix | 47-56 | 10 | |
| α-helix | 61-72 | 12 | |
Chain 6: 5 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-10 | 2 | 39 |
| α-helix | 13-15 | 3 | |
| β-strand | 18-19 | 2 | 40 |
| α-helix | 20 | 1 | |
| β-strand | 21-22 | 2 | 41 |
| β-strand | 30 | 1 | 42 |
| β-strand | 39-42 | 4 | 42 |
| β-strand | 44-45 | 2 | 40 |
| α-helix | 52-54 | 3 | |
| β-strand | 58 | 1 | 41 |
| β-strand | 67-68 | 2 | 41 |
| β-strand | 70-72 | 3 | 42 |
| α-helix | 73-77 | 5 | |
| α-helix | 80-82 | 3 | |
| β-strand | 88-89 | 2 | 39 |
Chain a: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-26 | 7 | |
| α-helix | 29-37 | 9 | |
| β-strand | 41-46 | 6 | 61 |
| β-strand | 51-58 | 8 | 61 |
| β-strand | 65-76 | 12 | 61 |
| β-strand | 90-101 | 12 | 61 |
| β-strand | 106-111 | 6 | 61 |
Chain A: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 161-174 | 14 | |
| α-helix | 186-189 | 4 | |
| α-helix | 205-217 | 13 | |
| α-helix | 221-225 | 5 | |
| α-helix | 236-271 | 36 | |
12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| U2 snRNA | H | RNA | 188 | Homo sapiens | |
| Splicing factor 3B subunit 1 | 1 | protein | 1304 | Homo sapiens | O75533 (AlphaFold model) |
| Splicing factor 3B subunit 2 | 2 | protein | 895 | Homo sapiens | Q13435 (AlphaFold model) |
| Splicing factor 3B subunit 3 | 3 | protein | 1217 | Homo sapiens | Q15393 (AlphaFold model) |
| Splicing factor 3B subunit 4 | 4 | protein | 424 | Homo sapiens | Q15427 (AlphaFold model) |
| Splicing factor 3B subunit 5 | 5 | protein | 86 | Homo sapiens | Q9BWJ5 |
| PHD finger-like domain-containing protein 5A | 6 | protein | 110 | Homo sapiens | Q7RTV0 |
| Splicing factor 3A subunit 1 | A | protein | 793 | Homo sapiens | Q15459 |
| Splicing factor 3A subunit 2 | B | protein | 464 | Homo sapiens | Q15428 |
| Splicing factor 3A subunit 3 | C | protein | 501 | Homo sapiens | Q12874 |
| HIV Tat-specific factor 1 | D | protein | 755 | Homo sapiens | O43719 |
| RNA helicase | E | protein | 1052 | Homo sapiens | Q7L014 |
9 more molecules are not listed.
Sequence of entity 1 (H), FASTA
>7EVO_1 U2 snRNA (chains H)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC
Sequence of entity 2 (1), FASTA
>7EVO_2 Splicing factor 3B subunit 1 (chains 1)
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAA
TELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYK
KHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGE
LKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAK
GSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTE
RDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPI
GTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAG
YVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLV
DVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLM
SPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNL
AKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQA
RHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYG
IESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP
DEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVEL
ANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAF
QEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAV
VMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRL
TPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNT
FGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPE
LNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVY
GFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARK
VRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Sequence of entity 3 (2), FASTA
>7EVO_3 Splicing factor 3B subunit 2 (chains 2)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Sequence of entity 4 (3), FASTA
>7EVO_4 Splicing factor 3B subunit 3 (chains 3)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF
Sequence of entity 5 (4), FASTA
>7EVO_5 Splicing factor 3B subunit 4 (chains 4)
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVE
FLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTF
SAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKK
DSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPP
GSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGG
MPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGS
PMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRG
PLPQ
Sequence of entity 6 (5), FASTA
>7EVO_6 Splicing factor 3B subunit 5 (chains 5)
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN
Sequence of entity 7 (6), FASTA
>7EVO_7 PHD finger-like domain-containing protein 5A (chains 6)
MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVI
CGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR
Sequence of entity 8 (A), FASTA
>7EVO_8 Splicing factor 3A subunit 1 (chains A)
MPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFV
ARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQ
QQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQ
FLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVL
DQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTT
PEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSD
DEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKI
PASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVE
ETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDD
TKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRP
PMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAP
VPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEW
KLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAV
IHLALKERGGRKK
Sequence of entity 9 (B), FASTA
>7EVO_9 Splicing factor 3A subunit 2 (chains B)
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
Sequence of entity 10 (C), FASTA
>7EVO_10 Splicing factor 3A subunit 3 (chains C)
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDL
YDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENP
SEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNA
EYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHA
GAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSL
FAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEE
EEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPK
AFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYE
DSSGNVVNKKTYEDLKRQGLL
Sequence of entity 11 (D), FASTA
>7EVO_11 HIV Tat-specific factor 1 (chains D)
MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF
PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA
ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL
KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL
SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ
IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR
EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM
AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC
SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE
EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS
EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD
KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD
SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI
Sequence of entity 12 (E), FASTA
>7EVO_12 RNA helicase (chains E)
MASDYKDDDDKASDEVDAGTMGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRS
RSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGR
RSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEM
RKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEM
EGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKK
KGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVP
ELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQT
QAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQ
ITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNL
RRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIE
VQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLM
RASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHY
EDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQ
KAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESM
FNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNA
ILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEIN
DFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ
KAKAEITRLIKEELIRLQNSYQPTNKGRYKVL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| 9B0 | [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-m… | C40 H66 N2 O9 | 1 |
| ZN | Zinc ion | Zn | 4 |
Primary citation
Structural insights into branch site proofreading by human spliceosome. Zhang, X., Zhan, X., Bian, T. et al. Nat Struct Mol Biol (2024). DOI 10.1038/s41594-023-01188-0 · PubMed
Other PDB entries of the same protein (UniProt O75533 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4OZ1 1.74 Å, Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5
- 7SN6 1.8 Å, U2AF65 uhm bound to SF3B155 ULM5
- 6N3E 1.89 Å, Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
- 6N3F 2.1 Å, Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
- 7Q4O 2.1 Å, Substrate-bound A-like U2 snRNP
- 2PEH 2.11 Å, Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5
- 7Q4P 2.15 Å, U2 snRNP after ATP-dependent remodelling
- 7Q3L 2.21 Å, Human 17S U2 snRNP 5' domain
- 3LQV 2.38 Å, Branch Recognition by SF3b14
- 7B9C 2.4 Å, Structure of a minimal SF3B core in complex with spliceostatin A (form I)
- 2F9D 2.5 Å, 2.5 angstrom resolution structure of the spliceosomal protein p14 bound to region of…
- 7EVN 2.6 Å, The cryo-EM structure of the DDX42-SF3b complex
Browse structure collections
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