7RYP: KIFBP:KIF15

Cryo-EM structure of KIFBP:KIF15. Determined by electron microscopy at 4.8 Å resolution. Released 8 Sept 2021.

Method
Electron microscopy
Resolution
4.8 Å
Organism
Homo sapiens
Chains
2
Atoms
5,694
Mol. weight
112.85 kDa
Released
8 Sept 2021

Explore 7RYP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7RYP contains 33 α-helices and 23 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 22 β-strands

ElementResiduesLengthSheet
β-strand28-3361
α-helix36-383
β-strand58-6032
β-strand69-7132
β-strand74-7631
α-helix82-854
α-helix86-905
α-helix91-999
β-strand10113
β-strand103-10534
β-strand10611
α-helix116-1194
β-strand12315
β-strand12515
α-helix131-1333
α-helix135-15319
β-strand158-16034
β-strand162-17094
β-strand173-17644
β-strand186-18726
β-strand19317
β-strand197-19826
β-strand203-20534
α-helix208-22013
β-strand237-248124
β-strand256-26494
α-helix271-2733
α-helix276-29015
α-helix319-3257
β-strand33314
β-strand335-34061
α-helix344-3463
α-helix347-36014
β-strand36913
β-strand37114
Chain B: 20 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix6-2116
α-helix39-5012
α-helix87-10418
α-helix112-12615
α-helix137-15115
α-helix155-17218
α-helix202-22120
α-helix224-24017
α-helix246-26217
α-helix266-27914
α-helix302-32524
α-helix330-3323
α-helix347-36014
α-helix361-3633
α-helix369-38113
α-helix390-40920
α-helix415-43319
α-helix441-45414
α-helix455-4584
β-strand46017
α-helix465-48521

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Kinesin-like protein KIF15Aprotein375Homo sapiensQ9NS87 (AlphaFold model)
KIF-binding proteinBprotein621Homo sapiensQ96EK5 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>7RYP_1 Kinesin-like protein KIF15 (chains A)
MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR
LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM
GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS
ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF
TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT
ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA
KLIKNKAVVNEDTQG
Sequence of entity 2 (B), FASTA
>7RYP_2 KIF-binding protein (chains B)
MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDER
PEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVK
CLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPP
LDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLE
HNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVP
ELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESIRK
KAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHI
EVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLTVDLNPQYYLLVNRQIQFEIAHA
YYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVL
RPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELS
KEMVSLLPTKMERFRTKMALT

Primary citation

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Solon, A.L., Tan, Z., Schutt, K.L. et al. Sci Adv (2021) 7:eabj9812-eabj9812. DOI 10.1126/sciadv.abj9812 · PubMed

Other PDB entries of the same protein (UniProt Q9NS87 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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