7SGL: DNA-PK complex of DNA end processing

DNA-PK complex of DNA end processing. Determined by electron microscopy at 3.0 Å resolution. Released 12 Jan 2022.

Method
Electron microscopy
Resolution
3.0 Å
Organisms
Homo sapiens, synthetic construct
Chains
6
Atoms
44,704
Mol. weight
737.06 kDa
Ligands
ZN, IHP, ATP, MG
Released
12 Jan 2022

Explore 7SGL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SGL contains 326 α-helices and 103 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 256 helices, 27 β-strands

ElementResiduesLengthSheet
α-helix7-1812
α-helix25-4420
α-helix48-5811
α-helix65-728
α-helix76-783
α-helix79-9517
α-helix104-11714
α-helix121-1233
α-helix125-13713
α-helix142-1454
α-helix149-16012
α-helix165-1673
α-helix168-18417
α-helix186-1894
α-helix193-20816
α-helix217-23014
α-helix242-25615
α-helix266-27712
α-helix290-30112
α-helix307-32923
α-helix334-3385
α-helix339-35012
α-helix356-37318
α-helix378-39215
α-helix393-3975
α-helix407-4093
α-helix410-42112
α-helix429-4313
α-helix432-44413
α-helix446-4483
α-helix451-46818
α-helix473-49119
α-helix494-4952
α-helix500-5012
α-helix509-5102
β-strand513-51421
β-strand515-51622
α-helix521-5222
α-helix524-5263
α-helix528-5358
α-helix539-5457
α-helix560-57617
β-strand583-58423
β-strand613-61423
α-helix617-63317
α-helix636-6394
α-helix646-65914
α-helix664-67916
α-helix698-71720
α-helix718-7203
α-helix723-73513
α-helix738-7414
α-helix749-75810
α-helix763-77917
α-helix782-7854
α-helix786-7883
α-helix789-7924
α-helix793-7964
α-helix797-8004
α-helix815-8217
α-helix848-86114
α-helix867-8704
α-helix873-8797
α-helix880-8834
β-strand88414
β-strand893-89535
β-strand904-90635
α-helix907-9093
α-helix911-92010
α-helix924-94623
α-helix947-9493
α-helix955-9573
α-helix959-97315
α-helix978-99417
α-helix1004-101613
α-helix1024-104219
α-helix1046-10516
α-helix1054-106714
α-helix1072-108918
α-helix1093-111321
α-helix1114-11163
α-helix1123-114018
α-helix1142-11454
β-strand114916
β-strand116316
α-helix1165-117410
α-helix1181-119414
α-helix1195-11973
α-helix1204-12118
α-helix1217-12248
α-helix1231-12333
α-helix1241-12433
α-helix1250-127223
α-helix1278-12825
α-helix1290-12967
α-helix1297-13015
α-helix1306-13105
α-helix1324-135128
α-helix1367-137711
α-helix1379-13813
α-helix1389-13924
α-helix1395-140612
α-helix1412-142211
α-helix1425-14317
α-helix1442-146120
α-helix1464-14674
α-helix1475-148915
α-helix1500-15023
α-helix1505-152117
α-helix1525-15328
α-helix1555-15628
α-helix1564-15718
α-helix1576-15849
α-helix1592-160615
α-helix1612-162312
α-helix1626-16294
α-helix1639-165517
α-helix1668-167912
α-helix1686-16949
α-helix1696-16983
α-helix1705-172117
α-helix1734-175320
α-helix1759-17679
α-helix1775-178814
α-helix1791-180616
α-helix1813-18197
α-helix1820-18245
α-helix1825-18295
α-helix1836-185116
α-helix1863-188119
α-helix1886-18905
α-helix1894-18996
α-helix1911-192313
α-helix1934-195522
α-helix1959-19613
α-helix1962-19676
α-helix1991-19933
α-helix1999-200911
α-helix2010-20145
α-helix2026-20283
α-helix2036-20449
α-helix2094-210613
α-helix2120-21223
α-helix2124-213411
α-helix2140-215213
α-helix2154-21563
α-helix2158-21603
α-helix2161-217313
α-helix2184-219512
α-helix2196-21983
α-helix2206-222116
α-helix2228-224417
α-helix2253-22608
α-helix2269-228214
α-helix2296-23049
α-helix2305-23084
α-helix2313-233220
α-helix2338-235316
α-helix2359-23679
α-helix2372-23743
α-helix2379-23857
α-helix2386-23883
α-helix2392-240312
α-helix2412-24176
α-helix2420-24256
α-helix2429-244214
α-helix2443-24453
α-helix2448-245811
α-helix2459-24635
α-helix2469-248315
α-helix2495-250814
α-helix2509-25113
α-helix2515-252511
α-helix2535-25428
α-helix2543-25453
α-helix2554-256310
α-helix2564-25674
β-strand257517
α-helix2581-25833
α-helix2594-26029
α-helix2606-26116
β-strand2634-263638
α-helix2645-26462
α-helix2769-27713
β-strand2772-277438
β-strand278617
α-helix2787-279812
α-helix2802-281918
α-helix2820-28223
α-helix2826-284520
α-helix2852-286413
α-helix2873-288311
α-helix2886-289914
α-helix2918-293114
α-helix2936-29427
α-helix2943-29475
α-helix2951-296111
α-helix2965-297612
α-helix2985-29873
α-helix2988-300417
α-helix3008-30147
α-helix3027-30315
α-helix3034-30396
α-helix3041-305313
α-helix3060-306910
α-helix3072-308110
α-helix3083-309210
α-helix3096-311419
α-helix3122-31298
α-helix3132-314615
α-helix3155-316410
α-helix3176-319722
α-helix3227-324822
α-helix3252-326615
α-helix3271-328717
α-helix3293-330715
α-helix3313-33164
α-helix3320-334324
α-helix3345-33484
α-helix3353-336311
α-helix3370-339223
α-helix3405-342925
α-helix3442-345514
α-helix3459-34624
α-helix3465-347410
α-helix3476-348611
α-helix3487-34893
α-helix3492-34987
α-helix3499-35024
α-helix3509-35113
α-helix3512-352413
α-helix3526-35283
α-helix3530-35378
α-helix3546-356217
α-helix3567-357610
α-helix3581-359717
α-helix3601-36022
α-helix3603-361715
α-helix3627-363610
α-helix3639-36424
α-helix3649-36524
α-helix3656-367116
β-strand367919
α-helix3680-36823
α-helix3685-36884
α-helix3697-36993
β-strand3700110
α-helix3713-37153
β-strand3718110
β-strand3719-3722411
β-strand372519
β-strand3727-3728211
α-helix37291
β-strand3736-3742711
β-strand3747-3754811
α-helix3759-377719
α-helix3779-37824
β-strand3793-3797511
β-strand3800-3804511
α-helix3805-38062
β-strand3809-3811312
α-helix3812-38176
α-helix3822-38309
α-helix3835-384713
α-helix3853-38619
α-helix3864-387512
α-helix3882-38898
β-strand389114
α-helix3894-391825
α-helix3925-39273
β-strand3928-3931412
β-strand3937-3939312
α-helix3948-39514
α-helix3965-39706
α-helix3979-399315
α-helix3996-400611
α-helix4013-40219
α-helix4040-405213
α-helix4056-406712
α-helix4074-40829
α-helix4100-411112
α-helix4114-41174
α-helix4122-41243
Chain B: 18 helices, 27 β-strands
ElementResiduesLengthSheet
β-strand35-43913
α-helix46-494
α-helix59-7719
β-strand82-88713
β-strand94113
β-strand102-109813
α-helix113-1208
α-helix125-13410
α-helix143-15412
β-strand161-1701013
α-helix181-19616
β-strand199-204613
β-strand211114
α-helix217-2193
β-strand232114
α-helix239-2424
β-strand257-262615
β-strand268-274715
β-strand277116
α-helix282-2854
β-strand286-289417
β-strand295117
β-strand297-304818
β-strand310118
α-helix313-3153
β-strand316-322719
β-strand325-329519
α-helix333-3364
β-strand344-352915
α-helix353-3553
β-strand366-370515
β-strand375-376220
α-helix378-39114
β-strand394-401815
β-strand409-416815
β-strand419-421321
β-strand425-428421
β-strand431-436615
β-strand443122
α-helix444-4485
α-helix456-46914
β-strand470122
α-helix481-49414
α-helix511-5188
α-helix521-5299
Chain C: 32 helices, 24 β-strands
ElementResiduesLengthSheet
β-strand7-15923
α-helix19-213
α-helix30-4718
β-strand53-59723
β-strand65123
β-strand77-84823
α-helix88-958
α-helix107-12115
β-strand127-135923
α-helix147-15711
β-strand160-165623
α-helix1931
α-helix199-21618
α-helix218-2236
β-strand224-226323
α-helix229-2313
α-helix241-2466
β-strand247-252622
β-strand258-2681122
β-strand277-280419
α-helix286-2883
β-strand289-296818
β-strand304-305218
β-strand310-315617
β-strand320-322317
α-helix325-3306
β-strand339-347922
α-helix348-3503
α-helix353-3553
β-strand360-366722
α-helix372-38615
β-strand389-396822
α-helix402-4032
β-strand404-412922
β-strand417-423722
α-helix424-4252
α-helix427-4293
β-strand430116
α-helix445-4473
α-helix448-46013
β-strand462115
β-strand464-467424
β-strand472-475424
α-helix479-4813
α-helix483-4842
α-helix485-49915
α-helix504-5096
α-helix510-5156
α-helix520-53617
β-strand540-541220
α-helix550-5534
α-helix609-62517
α-helix629-64416
α-helix645-6473
α-helix652-66817
α-helix726-7305
Chain D: 20 helices, 25 β-strands
ElementResiduesLengthSheet
β-strand14-16325
β-strand18126
α-helix23-253
β-strand28-30325
α-helix36-383
β-strand40126
α-helix45-517
β-strand59-61325
α-helix63-719
α-helix73-786
β-strand82-84325
β-strand91-94427
β-strand105-112827
β-strand120-126727
β-strand129-133527
α-helix144-1463
α-helix148-1503
β-strand151-152228
β-strand155-156228
β-strand161-164427
β-strand173-17532
α-helix176-1783
α-helix179-19416
β-strand200-204529
α-helix213-22311
β-strand227-228229
α-helix233-2353
α-helix239-2424
β-strand245-246229
β-strand253-254229
α-helix261-2666
β-strand276-277230
β-strand280-281230
α-helix2821
β-strand283-290829
α-helix294-2963
β-strand301-30221
β-strand304-308529
β-strand311-315529
α-helix322-33211
β-strand338-339227
α-helix348-3558
α-helix356-3583
α-helix366-3683
α-helix394-4007

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-dependent protein kinase catalytic subunitAprotein4128Homo sapiensP78527
X-ray repair cross-complementing protein 6Bprotein612Homo sapiensP12956 (AlphaFold model)
X-ray repair cross-complementing protein 5Cprotein732Homo sapiensP13010 (AlphaFold model)
Protein artemisDprotein701Homo sapiensQ96SD1 (AlphaFold model)
Hairpin_1E, FDNA54synthetic construct
Sequence of entity 1 (A), FASTA
>7SGL_1 DNA-dependent protein kinase catalytic subunit (chains A)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Sequence of entity 2 (B), FASTA
>7SGL_2 X-ray repair cross-complementing protein 6 (chains B)
GPVMSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDEL
TPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRIL
ELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHG
NDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESS
KLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVK
TKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLK
KHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQE
EELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDS
FENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPE
GKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQ
ELLEALTKHFQD
Sequence of entity 3 (C), FASTA
>7SGL_3 X-ray repair cross-complementing protein 5 (chains C)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI
Sequence of entity 4 (D), FASTA
>7SGL_4 Protein artemis (chains D)
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLY
CSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSV
MFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSRE
ECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPE
ILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRK
TNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCR
SSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTA
VSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQ
KADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQS
THITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKD
TYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAE
LPKREHLQYLYEKLATGESIAVKKRKCSLLDTAAALEVLFQ
Sequence of entity 5 (E, F), FASTA
>7SGL_5 Hairpin_1 (chains E, F)
TCAGAAGCAGTAGAGCATGCATATATGCATGCTCTACTGCTTCTGACGATATCG

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn1
IHPInositol hexakisphosphateC6 H18 O24 P61
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P31
MGMagnesium ionMg3

Primary citation

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Liu, L., Chen, X., Li, J. et al. Mol Cell (2022) 82:177. DOI 10.1016/j.molcel.2021.11.025 · PubMed

Other PDB entries of the same protein (UniProt P78527), best resolution first:

Browse structure collections

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