7SU3: DNA-PK complex VII

CryoEM structure of DNA-PK complex VII. Determined by electron microscopy at 3.3 Å resolution. Released 12 Jan 2022.

Method: Electron microscopy
Resolution: 3.3 Å
Organisms: Homo sapiens, Escherichia coli
Chains: 7
Atoms: 41,242
Mol. weight: 648.13 kDa
Ligands: IHP, ATP
Released: 12 Jan 2022

Explore 7SU3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SU3 contains 273 α-helices and 83 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 224 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	10-17	8
α-helix	27-43	17
α-helix	48-58	11
α-helix	65-71	7
α-helix	79-95	17
α-helix	101-103	3
α-helix	104-117	14
α-helix	121-137	17
α-helix	149-161	13
α-helix	171-183	13
α-helix	187-189	3
α-helix	193-208	16
α-helix	217-230	14
α-helix	242-255	14
α-helix	267-278	12
α-helix	284-288	5
α-helix	290-300	11
α-helix	306-327	22
α-helix	335-350	16
α-helix	357-368	12
α-helix	371-376	6
α-helix	387-396	10
α-helix	407-409	3
α-helix	410-422	13
α-helix	432-444	13
α-helix	450	1
α-helix	454-468	15
α-helix	472-475	4
α-helix	477-490	14
α-helix	494-495	2
α-helix	520-522	3
α-helix	524-526	3
α-helix	528-536	9
α-helix	539-542	4
α-helix	561-576	16
β-strand	583-585	3	1
β-strand	612-614	3	1
α-helix	619-630	12
α-helix	643-645	3
α-helix	646-659	14
α-helix	666-679	14
α-helix	698-717	20
α-helix	718-720	3
α-helix	724-734	11
α-helix	738-741	4
α-helix	745-758	14
α-helix	763-779	17
α-helix	786-788	3
α-helix	789-792	4
α-helix	793-796	4
α-helix	819-822	4
α-helix	828-837	10
α-helix	848-862	15
α-helix	867-869	3
α-helix	876-880	5
β-strand	884	1	2
β-strand	893-895	3	3
β-strand	904-906	3	3
α-helix	907-909	3
α-helix	911-919	9
α-helix	924-945	22
α-helix	959-972	14
β-strand	977	1	4
α-helix	978-995	18
α-helix	1005-1016	12
α-helix	1023-1040	18
α-helix	1049-1051	3
α-helix	1056-1067	12
α-helix	1072-1090	19
α-helix	1093-1113	21
α-helix	1123-1140	18
β-strand	1149	1	5
α-helix	1151-1154	4
α-helix	1158-1159	2
β-strand	1163	1	5
α-helix	1166-1174	9
α-helix	1181-1194	14
α-helix	1204-1213	10
α-helix	1217-1225	9
β-strand	1226	1	6
β-strand	1234	1	6
α-helix	1250-1272	23
α-helix	1279-1282	4
α-helix	1284-1286	3
α-helix	1290-1300	11
α-helix	1325-1351	27
α-helix	1366-1377	12
α-helix	1390-1405	16
α-helix	1412-1422	11
α-helix	1425-1433	9
α-helix	1446-1461	16
α-helix	1464-1467	4
α-helix	1480-1489	10
α-helix	1502-1504	3
α-helix	1505-1520	16
α-helix	1525-1532	8
β-strand	1537	1	7
β-strand	1554	1	7
α-helix	1555-1562	8
α-helix	1566-1573	8
α-helix	1575-1583	9
α-helix	1590-1606	17
α-helix	1612-1624	13
α-helix	1626-1629	4
α-helix	1639-1655	17
α-helix	1668-1679	12
α-helix	1686-1689	4
α-helix	1690-1692	3
α-helix	1696-1698	3
α-helix	1706-1721	16
α-helix	1734-1752	19
α-helix	1756-1766	11
α-helix	1775-1786	12
α-helix	1793-1806	14
α-helix	1813-1818	6
α-helix	1819-1824	6
α-helix	1825-1828	4
α-helix	1835-1851	17
α-helix	1860-1882	23
α-helix	1887-1890	4
α-helix	1894-1897	4
α-helix	1912-1923	12
α-helix	1934-1955	22
α-helix	1963-1966	4
β-strand	1970	1	8
β-strand	1975	1	8
α-helix	1978-1981	4
α-helix	1986-1988	3
β-strand	1993-1994	2	9
α-helix	2083-2085	3
α-helix	2094-2105	12
α-helix	2124-2133	10
α-helix	2140-2152	13
α-helix	2166-2172	7
α-helix	2184-2195	12
α-helix	2206-2221	16
α-helix	2228-2244	17
α-helix	2253-2260	8
α-helix	2268-2270	3
α-helix	2271-2283	13
α-helix	2285-2286	2
α-helix	2297-2304	8
α-helix	2305-2308	4
α-helix	2313-2332	20
α-helix	2338-2355	18
α-helix	2357-2367	11
α-helix	2372-2374	3
α-helix	2379-2385	7
α-helix	2392-2403	12
α-helix	2412-2417	6
α-helix	2420-2424	5
α-helix	2429-2442	14
α-helix	2443-2445	3
α-helix	2448-2458	11
α-helix	2459-2463	5
α-helix	2467-2483	17
α-helix	2493-2508	16
α-helix	2509-2511	3
α-helix	2517-2525	9
α-helix	2535-2541	7
α-helix	2542-2544	3
α-helix	2554-2563	10
α-helix	2565-2568	4
β-strand	2575	1	10
β-strand	2599	1	4
β-strand	2732-2733	2	9
α-helix	2736-2763	28
β-strand	2786	1	10
α-helix	2788-2798	11
α-helix	2802-2818	17
α-helix	2829-2846	18
α-helix	2852-2860	9
α-helix	2866-2868	3
α-helix	2873-2882	10
α-helix	2886-2897	12
α-helix	2920-2932	13
α-helix	2936-2940	5
α-helix	2952-2961	10
α-helix	2965-2975	11
α-helix	2985-2987	3
α-helix	2988-3004	17
α-helix	3008-3016	9
α-helix	3027-3031	5
α-helix	3035-3039	5
α-helix	3041-3053	13
α-helix	3061-3068	8
α-helix	3074-3081	8
α-helix	3084-3092	9
α-helix	3096-3114	19
α-helix	3124-3129	6
α-helix	3132-3146	15
α-helix	3155-3164	10
α-helix	3169-3170	2
α-helix	3176-3196	21
α-helix	3227-3248	22
α-helix	3252-3260	9
α-helix	3263-3266	4
α-helix	3270-3287	18
α-helix	3296-3301	6
α-helix	3320-3343	24
α-helix	3353-3363	11
α-helix	3373-3392	20
α-helix	3409-3425	17
α-helix	3426-3429	4
α-helix	3434-3439	6
α-helix	3442-3454	13
α-helix	3459-3462	4
α-helix	3465-3471	7
α-helix	3481-3487	7
α-helix	3499-3505	7
α-helix	3515-3524	10
α-helix	3530-3536	7
α-helix	3548-3561	14
α-helix	3567-3575	9
α-helix	3581-3596	16
α-helix	3607-3617	11
α-helix	3629-3636	8
α-helix	3637-3639	3
α-helix	3656-3670	15
α-helix	3680-3683	4
β-strand	3700	1	11
α-helix	3701	1
β-strand	3718	1	11
β-strand	3719-3722	4	12
β-strand	3727-3728	2	12
β-strand	3736-3742	7	12
β-strand	3747-3753	7	12
α-helix	3759-3774	16
α-helix	3779-3784	6
β-strand	3793-3797	5	12
β-strand	3800-3804	5	12
β-strand	3809-3811	3	13
α-helix	3812-3819	8
α-helix	3822-3829	8
α-helix	3835-3847	13
α-helix	3853-3859	7
α-helix	3865-3875	11
α-helix	3883-3890	8
β-strand	3891	1	2
α-helix	3894-3917	24
α-helix	3925-3927	3
β-strand	3928-3931	4	13
β-strand	3937-3939	3	13
α-helix	3965-3968	4
α-helix	3979-3991	13
α-helix	3996-4001	6
α-helix	4003-4007	5
α-helix	4011-4023	13
α-helix	4027-4029	3
α-helix	4039-4050	12
β-strand	4054	1	14
α-helix	4056-4067	12
α-helix	4074-4081	8
β-strand	4096	1	14
α-helix	4100-4111	12
α-helix	4114-4117	4
α-helix	4122-4124	3

Chain B: 17 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	34	1
β-strand	35-43	9	15
α-helix	59-77	19
β-strand	82-88	7	15
β-strand	102-104	3	15
β-strand	109	1	15
α-helix	114-119	6
α-helix	120-122	3
α-helix	124-132	9
α-helix	143-155	13
β-strand	161-170	10	15
α-helix	181-195	15
β-strand	198-204	7	15
α-helix	239-242	4
β-strand	260-262	3	16
β-strand	268-274	7	16
β-strand	277	1	17
α-helix	282-285	4
β-strand	286-289	4	18
β-strand	295	1	18
β-strand	298-304	7	19
β-strand	310	1	19
β-strand	316-322	7	20
β-strand	325-329	5	20
β-strand	344-352	9	16
α-helix	353-355	3
β-strand	366-370	5	16
β-strand	375-376	2	21
α-helix	378-389	12
β-strand	394-401	8	16
β-strand	409-416	8	16
β-strand	419-420	2	22
β-strand	426-428	3	22
β-strand	431-436	6	16
β-strand	443	1	23
α-helix	445-448	4
α-helix	456-468	13
α-helix	481-494	14
α-helix	500-505	6
α-helix	511-517	7
α-helix	522-529	8

Chain C: 32 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	24
α-helix	30-47	18
β-strand	52-59	8	24
β-strand	65	1	24
β-strand	77-79	3	24
α-helix	88-93	6
α-helix	108-114	7
α-helix	117-120	4
β-strand	130-135	6	24
α-helix	147-156	10
β-strand	160-165	6	24
α-helix	199-215	17
α-helix	220-222	3
β-strand	224-226	3	24
α-helix	227-231	5
α-helix	235-237	3
α-helix	243-246	4
β-strand	247-251	5	23
β-strand	259-268	10	23
β-strand	277-280	4	20
β-strand	289-295	7	19
β-strand	305	1	19
β-strand	310-315	6	18
β-strand	320-322	3	18
α-helix	325-330	6
β-strand	339-344	6	23
β-strand	348	1	25
β-strand	351	1	25
α-helix	353-355	3
β-strand	360-365	6	23
α-helix	371-386	16
β-strand	391-396	6	23
α-helix	402-403	2
β-strand	404-412	9	23
β-strand	417-423	7	23
β-strand	430	1	17
α-helix	445-447	3
α-helix	448-460	13
β-strand	462	1	16
β-strand	464	1	26
β-strand	475	1	26
α-helix	483-484	2
α-helix	485-499	15
α-helix	510-516	7
α-helix	518-519	2
α-helix	520-523	4
α-helix	527-536	10
β-strand	540-541	2	21
α-helix	550-553	4
α-helix	578-580	3
α-helix	596-603	8
α-helix	611-625	15
α-helix	629-647	19
α-helix	652-668	17
α-helix	672-677	6
α-helix	678-682	5
α-helix	699-704	6
α-helix	725-728	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-dependent protein kinase catalytic subunit	A	protein	4128	Homo sapiens	P78527
X-ray repair cross-complementing protein 6	B	protein	609	Homo sapiens	P12956 (AlphaFold model)
X-ray repair cross-complementing protein 5	C	protein	732	Homo sapiens	P13010 (AlphaFold model)
DNA (5'-d(gpcpaptpgpcptpcptpapcptpgpcptptpcpgpaptpaptpcpg)-3')	D, F	DNA	24	Escherichia coli
DNA (5'-d(apapgpcpapgptpapgpap*g)-3')	E, G	DNA	16	Escherichia coli

Sequence of entity 1 (A), FASTA

>7SU3_1 DNA-dependent protein kinase catalytic subunit (chains A)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM

Sequence of entity 2 (B), FASTA

>7SU3_2 X-ray repair cross-complementing protein 6 (chains B)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD

Sequence of entity 3 (C), FASTA

>7SU3_3 X-ray repair cross-complementing protein 5 (chains C)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI

Sequence of entity 4 (D, F), FASTA

>7SU3_4 DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3') (chains D, F)
GCATGCTCTACTGCTTCGATATCG

Sequence of entity 5 (E, G), FASTA

>7SU3_5 DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3') (chains E, G)
AAGCAGTAGAGCATGC

Ligands and cofactors

ID	Name	Formula	Copies
IHP	Inositol hexakisphosphate	C6 H18 O24 P6	1
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1

Primary citation

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Liu, L., Chen, X., Li, J. et al. Mol Cell (2022) 82:177. DOI 10.1016/j.molcel.2021.11.025 · PubMed

Other PDB entries of the same protein (UniProt P78527), best resolution first:

7Z87 2.91 Å, DNA-PK in the active state
7OTY 2.96 Å, DNA-PKcs in complex with M3814
7OTW 2.99 Å, DNA-PKcs in complex with AZD7648
7SGL 3.0 Å, DNA-PK complex of DNA end processing
7K11 3.21 Å, CryoEM structure of inactivated-form FATKIN domain of DNA-PK
6ZFP 3.24 Å, Cryo-EM structure of DNA-PKcs (State 2)
7OTV 3.24 Å, DNA-PKcs in complex with wortmannin
7K10 3.3 Å, CryoEM structure of activated-form FATKIN domain of DNA-PK
7OTM 3.33 Å, Cryo-EM structure of DNA-PKcs in complex with NU7441
7TYR 3.33 Å, Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14)
7Z88 3.33 Å, DNA-PK in the intermediate state
7OTP 3.4 Å, DNA-PKcs in complex with ATPgammaS-Mg

Browse structure collections

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