7T6O: TRPV5 in nanodiscs at pH6 state 3

Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 3. Determined by electron microscopy at 2.6 Å resolution. Released 4 May 2022.

Method

Electron microscopy

Resolution

2.6 Å

Organism

Oryctolagus cuniculus

Chains

4

Atoms

19,412

Mol. weight

335.14 kDa

Released

4 May 2022

Explore 7T6O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7T6O contains 164 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C and D: 41 helices, 8 β-strands

Molecules and chains

>7T6O_1 Transient receptor potential cation channel subfamily V member 5 (chains A, B, C, D)
MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL
LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA
LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK
KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT
DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI
LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI
IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ
EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG
EGDGEEVYHFTETSQVAPA

Primary citation

Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Fluck, E.C., Yazici, A.T., Rohacs, T. et al. Cell Rep (2022) 39:110737-110737. DOI 10.1016/j.celrep.2022.110737 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9XSM3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 8TF2 2.57 Å, Wildtype rabbit TRPV5 into nanodiscs in Apo state
• 8FFQ 2.65 Å, Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red
• 6O1U 2.8 Å, Cryo-EM structure of TRPV5 W583A in nanodisc
• 7T6M 2.8 Å, Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1
• 7T6P 2.8 Å, Cryo-EM structure of TRPV5 T709D in nanodiscs
• 8TF4 2.86 Å, Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole
• 6O1N 2.9 Å, Cryo-EM structure of TRPV5 (1-660) in nanodisc
• 7T6N 2.9 Å, Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 2
• 8TF3 2.94 Å, Wildtype rabbit TRPV5 into nanodiscs in complex with econazole
• 8FFN 2.96 Å, RR-bound wildtype rabbit TRPV5 in nanodiscs
• 6O1P 3.0 Å, Cryo-EM structure of full length TRPV5 in nanodisc
• 7T6K 3.0 Å, Cryo-EM structure of TRPV5 at pH6 in nanodiscs

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