Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole. Determined by electron microscopy at 2.86 Å resolution. Released 10 Jan 2024.
Explore 8TF4 in 3D Show helices and sheets RCSB PDB PDBe
8TF4 contains 164 α-helices and 48 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 29-46 | 18 | |
| α-helix | 48-55 | 8 | |
| α-helix | 58-66 | 9 | |
| β-strand | 75 | 1 | 1 |
| β-strand | 81 | 1 | 1 |
| α-helix | 82-88 | 7 | |
| α-helix | 92-101 | 10 | |
| α-helix | 103-107 | 5 | |
| α-helix | 108 | 1 | |
| β-strand | 109 | 1 | 2 |
| α-helix | 110 | 1 | |
| β-strand | 119 | 1 | 2 |
| α-helix | 120-126 | 7 | |
| α-helix | 130-137 | 8 | |
| α-helix | 166-173 | 8 | |
| α-helix | 176-184 | 9 | |
| α-helix | 199-204 | 6 | |
| α-helix | 209-223 | 15 | |
| α-helix | 232-234 | 3 | |
| α-helix | 243-249 | 7 | |
| α-helix | 253-260 | 8 | |
| β-strand | 264-270 | 7 | 3 |
| β-strand | 273-279 | 7 | 3 |
| α-helix | 281-284 | 4 | |
| α-helix | 292-297 | 6 | |
| α-helix | 304-309 | 6 | |
| α-helix | 311-320 | 10 | |
| α-helix | 321-325 | 5 | |
| α-helix | 326-348 | 23 | |
| β-strand | 352-354 | 3 | 4 |
| β-strand | 366 | 1 | 5 |
| β-strand | 368-370 | 3 | 4 |
| α-helix | 371-372 | 2 | |
| α-helix | 373-376 | 4 | |
| α-helix | 380-410 | 31 | |
| α-helix | 412-415 | 4 | |
| α-helix | 423-444 | 22 | |
| α-helix | 451-463 | 13 | |
| α-helix | 464-471 | 8 | |
| α-helix | 476-485 | 10 | |
| α-helix | 486-490 | 5 | |
| α-helix | 491-512 | 22 | |
| β-strand | 515 | 1 | 6 |
| α-helix | 526-537 | 12 | |
| α-helix | 542-544 | 3 | |
| α-helix | 553-562 | 10 | |
| α-helix | 563-570 | 8 | |
| α-helix | 571-607 | 37 | |
| α-helix | 610-612 | 3 | |
| α-helix | 614-616 | 3 | |
| β-strand | 618-619 | 2 | 3 |
| α-helix | 621-623 | 3 | |
| β-strand | 629-636 | 8 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 5 | A, B, C, D | protein | 739 | Oryctolagus cuniculus | Q9XSM3 (AlphaFold model) |
>8TF4_1 Transient receptor potential cation channel subfamily V member 5 (chains A, B, C, D) MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG EGDGEEVYHFTETSQVAPA
| ID | Name | Formula | Copies |
|---|---|---|---|
| ECN | 1-[(2S)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole | C18 H15 Cl3 N2 O | 4 |
| CPL | 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine | C42 H80 N O8 P | 8 |
| ERG | Ergosterol | C28 H44 O | 8 |
Structural mechanism of TRPV5 inhibition by econazole. De Jesus-Perez, J.J., Gabrielle, M., Raheem, S. et al. Structure (2024) 32:148-156.e5. DOI 10.1016/j.str.2023.11.012 · PubMed
Other PDB entries of the same protein (UniProt Q9XSM3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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