7UIF: Mediator-PIC Early

Name: PDB 7UIF: Mediator-PIC Early (Core B)
Published: 2023-02-15
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Mediator-PIC Early (Core B). Determined by electron microscopy at 4.6 Å resolution. Released 15 Feb 2023.

Method: Electron microscopy
Resolution: 4.6 Å
Organism: Saccharomyces cerevisiae S288C
Chains: 33
Atoms: 63,137
Mol. weight: 1466.04 kDa
Released: 15 Feb 2023

Explore 7UIF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7UIF contains 349 α-helices and 337 β-strands across 33 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 12 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	7-21	15
α-helix	28-37	10
β-strand	41-46	6	78
β-strand	51-57	7	78
β-strand	61-68	8	78
β-strand	73-81	9	78
β-strand	91	1	79
β-strand	102	1	79
α-helix	103-109	7
α-helix	115-130	16
α-helix	164-181	18
β-strand	187-190	4	80
β-strand	198-203	6	80
β-strand	209-219	11	80
β-strand	227-229	3	81
β-strand	232-234	3	82
β-strand	239-241	3	82
β-strand	248-250	3	81
β-strand	252-258	7	80
β-strand	272-274	3	83
α-helix	280-282	3
β-strand	283-286	4	80
α-helix	298-304	7
β-strand	312-316	5	84
β-strand	322-324	3	83
β-strand	325-329	5	80
α-helix	332-336	5
α-helix	337-347	11
α-helix	348-352	5
α-helix	353-360	8
β-strand	528-532	5	84
β-strand	536-539	4	84
β-strand	543-546	4	84
α-helix	551-565	15

Chain A: 82 helices, 71 β-strands

Element	Residues	Length	Sheet
α-helix	10	1
β-strand	11	1	1
β-strand	14-18	5	2
α-helix	24-30	7
β-strand	34	1	3
β-strand	41	1	4
β-strand	48	1	4
α-helix	49	1
β-strand	82-91	10	3
α-helix	96-104	9
β-strand	106	1	5
β-strand	113	1	5
α-helix	120-126	7
α-helix	131-142	12
β-strand	147	1	6
β-strand	151-153	3	7
β-strand	161-163	3	7
β-strand	170	1	6
β-strand	173-177	5	8
β-strand	180-185	6	8
α-helix	189-191	3
β-strand	198-201	4	8
α-helix	202-203	2
α-helix	204-212	9
α-helix	216-222	7
α-helix	232-234	3
β-strand	235-241	7	3
α-helix	248-249	2
β-strand	250-253	4	9
β-strand	256-258	3	9
α-helix	261-280	20
α-helix	286-304	19
α-helix	312-314	3
β-strand	315	1	10
α-helix	316	1
α-helix	320	1
β-strand	321	1	10
α-helix	322	1
α-helix	326-329	4
α-helix	335	1
α-helix	336-340	5
β-strand	343-345	3	11
β-strand	348-352	5	12
β-strand	355	1	13
β-strand	363-367	5	12
α-helix	368-373	6
β-strand	375-379	5	14
α-helix	380	1
α-helix	385-394	10
β-strand	402-406	5	14
β-strand	412-414	3	14
α-helix	424-426	3
β-strand	431-435	5	14
α-helix	436	1
β-strand	441-445	5	12
α-helix	452-454	3
β-strand	455-463	9	12
β-strand	469	1	12
β-strand	470	1	13
β-strand	486-490	5	12
α-helix	495-503	9
β-strand	506	1	12
α-helix	507-509	3
β-strand	512-513	2	15
β-strand	518-519	2	15
α-helix	525-534	10
β-strand	540-541	2	16
α-helix	543-552	10
α-helix	559-563	5
β-strand	565-567	3	17
β-strand	571	1	17
β-strand	572-573	2	16
α-helix	574-578	5
β-strand	588-590	3	18
β-strand	605-608	4	18
β-strand	611-614	4	18
α-helix	619-622	4
α-helix	629-636	8
α-helix	639-660	22
α-helix	666-668	3
α-helix	673-697	25
α-helix	702-704	3
α-helix	710-736	27
α-helix	742-749	8
α-helix	755-758	4
α-helix	759-763	5
β-strand	766-767	2	19
β-strand	770	1	20
β-strand	773	1	20
α-helix	794-796	3
β-strand	799-800	2	19
α-helix	810-845	36
β-strand	849-850	2	21
β-strand	856-857	2	21
β-strand	863-865	3	21
α-helix	868-870	3
β-strand	873	1	22
β-strand	878-882	5	23
α-helix	890-897	8
α-helix	904-906	3
α-helix	907-909	3
β-strand	913	1	24
α-helix	916-919	4
α-helix	924-946	23
β-strand	953-957	5	23
α-helix	960-970	11
β-strand	979	1	24
α-helix	983-995	13
α-helix	1005-1025	21
α-helix	1028-1029	2
α-helix	1030-1035	6
α-helix	1039-1054	16
β-strand	1057	1	22
α-helix	1058-1059	2
α-helix	1064-1078	15
α-helix	1083-1088	6
α-helix	1090-1092	3
α-helix	1098-1106	9
β-strand	1116-1119	4	25
β-strand	1120	1	26
α-helix	1128-1138	11
β-strand	1141-1142	2	27
α-helix	1143-1145	3
β-strand	1147-1154	8	28
α-helix	1164-1174	11
α-helix	1179-1184	6
α-helix	1185-1187	3
β-strand	1191-1197	7	28
α-helix	1199-1204	6
α-helix	1209-1210	2
α-helix	1211-1215	5
α-helix	1216-1221	6
β-strand	1224-1228	5	28
β-strand	1236-1242	7	28
α-helix	1250-1254	5
α-helix	1256-1269	14
β-strand	1272-1274	3	27
β-strand	1281-1292	12	25
β-strand	1298-1309	12	25
α-helix	1313-1316	4
β-strand	1322	1	26
β-strand	1328-1329	2	25
α-helix	1332-1338	7
α-helix	1341-1357	17
α-helix	1365-1375	11
α-helix	1386-1389	4
α-helix	1396-1400	5
α-helix	1405-1415	11
β-strand	1418-1419	2	2
α-helix	1424-1429	6
β-strand	1437	1	29
β-strand	1441-1445	5	30
α-helix	1447-1452	6

Chain B: 52 helices, 72 β-strands

Element	Residues	Length	Sheet
α-helix	27-40	14
α-helix	45-53	9
α-helix	54-58	5
α-helix	59-65	7
β-strand	69-73	5	33
α-helix	80-82	3
β-strand	84-97	14	33
α-helix	98-100	3
β-strand	101-103	3	34
β-strand	109-111	3	34
α-helix	114-120	7
β-strand	125-140	16	33
β-strand	150-156	7	33
α-helix	161-163	3
β-strand	164-171	8	33
β-strand	173	1	35
α-helix	180-183	4
α-helix	186-191	6
β-strand	203-205	3	35
β-strand	208-212	5	35
β-strand	214-218	5	36
β-strand	224-227	4	37
β-strand	234-241	8	37
β-strand	253-259	7	37
β-strand	268-272	5	37
β-strand	280-281	2	37
α-helix	282-289	8
α-helix	294-301	8
α-helix	309-321	13
α-helix	327-336	10
α-helix	345-359	15
α-helix	371-389	19
α-helix	395-397	3
α-helix	401-403	3
β-strand	404-407	4	36
α-helix	409-437	29
α-helix	441-443	3
α-helix	444-447	4
α-helix	451-463	13
β-strand	466	1	38
β-strand	476	1	38
β-strand	480-482	3	35
α-helix	483-484	2
α-helix	488-494	7
β-strand	497-499	3	36
α-helix	516-518	3
β-strand	522	1	39
β-strand	536-538	3	36
β-strand	539	1	39
β-strand	544-545	2	40
α-helix	552-560	9
α-helix	563	1
β-strand	564-565	2	41
α-helix	566-568	3
α-helix	577	1
β-strand	578-582	5	41
β-strand	585-590	6	41
α-helix	593-605	13
β-strand	614-618	5	41
β-strand	623-627	5	41
β-strand	633-638	6	40
β-strand	640-643	4	42
β-strand	648-651	4	42
α-helix	655-667	13
α-helix	681-686	6
β-strand	690-694	5	40
α-helix	697-700	4
β-strand	703-704	2	43
α-helix	707-710	4
β-strand	740-741	2	43
α-helix	745-748	4
α-helix	759-761	3
α-helix	764-773	10
β-strand	792-796	5	44
β-strand	800	1	45
β-strand	804-805	2	46
α-helix	809-812	4
β-strand	821-827	7	47
β-strand	838-842	5	47
α-helix	843-847	5
β-strand	853-862	10	44
β-strand	873-874	2	48
β-strand	882-883	2	48
α-helix	890-892	3
β-strand	898	1	49
β-strand	904-905	2	44
β-strand	910	1	50
β-strand	912	1	49
β-strand	914-917	4	48
β-strand	934-936	3	48
β-strand	940	1	50
α-helix	941-942	2
β-strand	947-956	10	44
β-strand	962-972	11	44
β-strand	980-982	3	47
β-strand	987-994	8	47
β-strand	1001-1002	2	51
β-strand	1010-1012	3	47
α-helix	1014-1016	3
α-helix	1023-1038	16
α-helix	1041	1
β-strand	1042-1043	2	46
α-helix	1052-1060	9
β-strand	1069-1070	2	47
β-strand	1072-1073	2	51
β-strand	1080	1	51
β-strand	1085-1094	10	47
α-helix	1099-1101	3
β-strand	1104-1106	3	12
α-helix	1118-1119	2
β-strand	1128-1130	3	11
α-helix	1132-1141	10
β-strand	1143	1	29
α-helix	1144-1148	5
α-helix	1149-1153	5
β-strand	1158-1163	6	1
β-strand	1172-1174	3	52
β-strand	1179-1181	3	52
β-strand	1182	1	53
β-strand	1187	1	53
β-strand	1191-1196	6	1
α-helix	1198-1208	11
β-strand	1215-1218	4	2
α-helix	1219-1222	4

Chain C: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	7-13	7	54
β-strand	17-23	7	54
α-helix	27-39	13
β-strand	43-54	12	55
α-helix	60-67	8
β-strand	72	1	56
α-helix	77-79	3
β-strand	97-104	8	55
β-strand	111-114	4	57
β-strand	119-120	2	55
α-helix	131	1
β-strand	132	1	56
α-helix	133	1
β-strand	143-147	5	57
β-strand	152-162	11	55
α-helix	168-170	3
β-strand	173-179	7	54
α-helix	197-200	4
α-helix	202-204	3
α-helix	205-209	5
α-helix	211-214	4
α-helix	218-219	2
β-strand	228-234	7	54
α-helix	240-270	31

Chain d: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	32-39	8
α-helix	41-61	21
α-helix	67-88	22
α-helix	92-127	36
α-helix	132-147	16
α-helix	150-164	15
α-helix	185-190	6
α-helix	192-198	7

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	36-38	3	58
β-strand	44-46	3	58
β-strand	49	1	59
α-helix	52-77	26
α-helix	111-114	4
α-helix	119-133	15
α-helix	139-150	12
α-helix	157-168	12
α-helix	174-182	9
α-helix	188-194	7
α-helix	196-198	3
α-helix	204-217	14
α-helix	219-220	2

Chain E: 13 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	3-25	23
β-strand	28	1	60
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	61
β-strand	53	1	61
α-helix	55-58	4
β-strand	60-62	3	62
β-strand	64	1	60
α-helix	66-71	6
β-strand	78-82	5	62
β-strand	87-88	2	63
α-helix	90-103	14
β-strand	107-112	6	62
β-strand	115-116	2	63
α-helix	118-121	4
α-helix	124-126	3
β-strand	131-136	6	62
α-helix	137-139	3
α-helix	144-146	3
β-strand	152-155	4	64
α-helix	158-168	11
α-helix	172-174	3
β-strand	177-178	2	64
α-helix	183-188	6
β-strand	195-202	8	64
β-strand	206-214	9	64

Chain f: 6 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	14-19	6
α-helix	27-32	6
α-helix	42-55	14
α-helix	89-96	8
α-helix	98-107	10
β-strand	113-121	9	85
β-strand	125-134	10	85
β-strand	146-156	11	85
β-strand	159-161	3	85
α-helix	166-191	26
β-strand	193-195	3	86
β-strand	199-201	3	86

25 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A, z	protein	1733	Saccharomyces cerevisiae S288C	P04050 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1224	Saccharomyces cerevisiae S288C	P08518 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	318	Saccharomyces cerevisiae S288C	P16370 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	221	Saccharomyces cerevisiae S288C	P20433 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae S288C	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae S288C	P20435
DNA-directed RNA polymerase II subunit RPB7	G	protein	171	Saccharomyces cerevisiae S288C	P34087
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae S288C	P20436
DNA-directed RNA polymerase II subunit RPB9	I	protein	122	Saccharomyces cerevisiae S288C	P27999
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae S288C	P22139
DNA-directed RNA polymerase II subunit RPB11	K	protein	120	Saccharomyces cerevisiae S288C	P38902
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae S288C	P40422

20 more molecules are not listed.

Sequence of entity 1 (A, z), FASTA

>7UIF_1 DNA-directed RNA polymerase II subunit RPB1 (chains A, z)
MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGS
IDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNE
LMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLK
LVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLP
VPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLE
LDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNA
DFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSP
KDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVR
FLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRR
LVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNI
RRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMT
LNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEH
TTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRA
AMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHML
KKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVP
GIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGG
LTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGA
FDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGS
NDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTS
PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS
PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR

Sequence of entity 2 (B), FASTA

>7UIF_2 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQ
DIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLR
NLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCY
LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEI
RSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH
ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVS
QVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLS
LMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETL
RTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAK
LMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEEND
LDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIA
PGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDG
LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKK
LMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAA
KLLFQELMAMNITPRLYTDRSRDF

Sequence of entity 3 (C), FASTA

>7UIF_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLAD
EFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVI
VSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEY
DPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPV
DQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPY
SNASQMGNTGSGGYDNAW

Sequence of entity 4 (D), FASTA

>7UIF_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIK
EALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLDEDDVNADDDDFMHSETRE
KELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQL
GSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY

Sequence of entity 5 (E), FASTA

>7UIF_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>7UIF_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>7UIF_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTGKFGYILCVLDYDNIDIQRGR
ILPTDGSAEFNVKYRAVVFKPFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLT
FNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAIGSIKEDYLGAI

Sequence of entity 8 (H), FASTA

>7UIF_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>7UIF_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQ
DIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQ
FS

Sequence of entity 10 (J), FASTA

>7UIF_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>7UIF_11 DNA-directed RNA polymerase II subunit RPB11 (chains K)
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAA
YKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF

Sequence of entity 12 (L), FASTA

>7UIF_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Primary citation

Structural basis of a transcription pre-initiation complex on a divergent promoter. Gorbea Colon, J.J., Palao 3rd, L., Chen, S.F. et al. Mol Cell (2023) 83:574. DOI 10.1016/j.molcel.2023.01.011 · PubMed

Other PDB entries of the same protein (UniProt P04050 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5VKO 1.8 Å, SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493
9SV6 1.96 Å, CryoEM structure of transcribing RNA polymerase II elongation complex with ATP and Elf1
5VKL 2.2 Å, SPT6 tSH2-RPB1 1476-1500 pS1493
9W8V 2.23 Å, Structure of post-translocation state of yeast Pol II complexed with a cisplatin-induced…
9QEB 2.26 Å, CryoEM structure of transcribing RNA polymerase II elongation complex
1TWF 2.3 Å, RNA polymerase II complexed with UTP at 2.3 A resolution
9RYB 2.33 Å, CryoEM structure of transcribing RNA polymerase II elongation complex in post-catalysis…
9KD8 2.46 Å, The structure of RNA polymerase II elongation complex paused at N-2 state by actinomycin…
6NPW 2.49 Å, SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide
9K7F 2.5 Å, RNA polymerase II elongation complex apo structure.
30ES 2.54 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…
30EP 2.55 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…

Browse structure collections

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