G. haemolysans IgA1 protease. Determined by electron microscopy at 3.28 Å resolution. Released 23 Nov 2022.
Explore 7UVK in 3D Show helices and sheets RCSB PDB PDBe
7UVK contains 49 α-helices and 79 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 916-918 | 3 | |
| β-strand | 923-924 | 2 | 1 |
| β-strand | 931-935 | 5 | 2 |
| β-strand | 942-944 | 3 | 2 |
| β-strand | 958-961 | 4 | 2 |
| β-strand | 969-972 | 4 | 2 |
| β-strand | 973-975 | 3 | 3 |
| β-strand | 978-980 | 3 | 3 |
| β-strand | 985-991 | 7 | 3 |
| β-strand | 996-997 | 2 | 1 |
| β-strand | 998-999 | 2 | 4 |
| β-strand | 1004-1005 | 2 | 4 |
| β-strand | 1009-1013 | 5 | 3 |
| α-helix | 1026-1035 | 10 | |
| β-strand | 1040 | 1 | 5 |
| β-strand | 1047-1048 | 2 | 6 |
| β-strand | 1070 | 1 | 5 |
| β-strand | 1072 | 1 | 7 |
| β-strand | 1074 | 1 | 8 |
| β-strand | 1078 | 1 | 8 |
| β-strand | 1081-1082 | 2 | 6 |
| β-strand | 1098 | 1 | 7 |
| β-strand | 1101 | 1 | 9 |
| β-strand | 1102 | 1 | 6 |
| β-strand | 1105-1109 | 5 | 9 |
| β-strand | 1112-1114 | 3 | 10 |
| β-strand | 1117-1120 | 4 | 11 |
| β-strand | 1127 | 1 | 7 |
| β-strand | 1130-1137 | 8 | 9 |
| β-strand | 1140-1142 | 3 | 10 |
| β-strand | 1145-1148 | 4 | 11 |
| β-strand | 1152-1154 | 3 | 7 |
| β-strand | 1157-1164 | 8 | 9 |
| β-strand | 1175 | 1 | 10 |
| β-strand | 1178-1181 | 4 | 11 |
| β-strand | 1187-1189 | 3 | 7 |
| β-strand | 1192-1199 | 8 | 9 |
| β-strand | 1212-1215 | 4 | 11 |
| β-strand | 1220-1222 | 3 | 7 |
| β-strand | 1225-1226 | 2 | 9 |
| β-strand | 1231 | 1 | 9 |
| β-strand | 1243-1245 | 3 | 11 |
| α-helix | 1254-1256 | 3 | |
| β-strand | 1259-1261 | 3 | 7 |
| β-strand | 1263 | 1 | 12 |
| β-strand | 1270 | 1 | 9 |
| β-strand | 1276 | 1 | 11 |
| β-strand | 1288 | 1 | 12 |
| β-strand | 1299-1300 | 2 | 13 |
| β-strand | 1304-1305 | 2 | 13 |
| α-helix | 1319-1322 | 4 | |
| α-helix | 1323-1325 | 3 | |
| α-helix | 1333-1337 | 5 | |
| α-helix | 1360-1362 | 3 | |
| α-helix | 1363-1372 | 10 | |
| α-helix | 1378-1386 | 9 | |
| α-helix | 1393-1395 | 3 | |
| β-strand | 1398 | 1 | 14 |
| β-strand | 1402 | 1 | 15 |
| α-helix | 1413-1416 | 4 | |
| β-strand | 1424-1427 | 4 | 15 |
| β-strand | 1428 | 1 | 14 |
| β-strand | 1433-1436 | 4 | 15 |
| β-strand | 1438-1442 | 5 | 16 |
| β-strand | 1449-1452 | 4 | 16 |
| β-strand | 1458-1459 | 2 | 16 |
| α-helix | 1469-1480 | 12 | |
| α-helix | 1487-1492 | 6 | |
| α-helix | 1501-1504 | 4 | |
| α-helix | 1507-1515 | 9 | |
| α-helix | 1517-1528 | 12 | |
| β-strand | 1530-1531 | 2 | 2 |
| α-helix | 1538-1549 | 12 | |
| α-helix | 1551-1564 | 14 | |
| β-strand | 1568 | 1 | 17 |
| β-strand | 1573 | 1 | 17 |
| α-helix | 1574-1579 | 6 | |
| β-strand | 1584 | 1 | 18 |
| β-strand | 1586 | 1 | 18 |
| α-helix | 1592-1600 | 9 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1612-1615 | 4 | |
| α-helix | 1616-1620 | 5 | |
| α-helix | 1629-1639 | 11 | |
| α-helix | 1646-1653 | 8 | |
| β-strand | 1657-1660 | 4 | 19 |
| α-helix | 1666-1672 | 7 | |
| α-helix | 1683-1687 | 5 | |
| α-helix | 1695-1697 | 3 | |
| α-helix | 1698-1702 | 5 | |
| β-strand | 1711-1715 | 5 | 19 |
| β-strand | 1718-1721 | 4 | 19 |
| α-helix | 1724-1726 | 3 | |
| α-helix | 1738-1763 | 26 | |
| α-helix | 1769-1771 | 3 | |
| β-strand | 1777-1779 | 3 | 19 |
| β-strand | 1784 | 1 | 20 |
| β-strand | 1793 | 1 | 20 |
| α-helix | 1802-1806 | 5 | |
| β-strand | 1823-1824 | 2 | 19 |
| β-strand | 1828-1830 | 3 | 19 |
| α-helix | 1839-1852 | 14 | |
| α-helix | 1854-1858 | 5 | |
| α-helix | 1870-1873 | 4 | |
| α-helix | 1874-1878 | 5 | |
| α-helix | 1880-1881 | 2 | |
| β-strand | 1888 | 1 | 21 |
| α-helix | 1911-1914 | 4 | |
| α-helix | 1918-1943 | 26 | |
| α-helix | 1948-1954 | 7 | |
| β-strand | 1955-1962 | 8 | 22 |
| β-strand | 1973-1978 | 6 | 22 |
| α-helix | 1982-1987 | 6 | |
| α-helix | 1991-1996 | 6 | |
| β-strand | 1999-2001 | 3 | 22 |
| β-strand | 2010 | 1 | 22 |
| β-strand | 2020 | 1 | 21 |
| β-strand | 2025 | 1 | 22 |
| α-helix | 2040-2051 | 12 | |
| α-helix | 2067-2072 | 6 | |
| β-strand | 2076-2079 | 4 | 23 |
| β-strand | 2082-2085 | 4 | 23 |
| α-helix | 2089-2096 | 8 | |
| α-helix | 2104-2119 | 16 | |
| β-strand | 2127 | 1 | 24 |
| β-strand | 2142 | 1 | 24 |
| α-helix | 2145-2160 | 16 | |
| α-helix | 2174-2189 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| IgA1 Protease | A | protein | 2201 | Gemella haemolysans | C5NYF3 |
>7UVK_1 IgA1 Protease (chains A) MRKYLEEKYNKFSLRKLTVGVCSMTIGSFFLVSTVQPEDYVVKAADNAIVHYKYVGEDNL TDKEKELIKKEVPSVVSSKEETYYLVFKPTKTTQLNKLPNTGLNYGVGSMLLGGMLGLVV VVVAKGKNKSRKILSILLVTSLGATTLELPARAMEDLQLSVYNMDYNLKVGDKLPEISSI PGYSFVGFIKNEAETKKENEEVKEQITSQQHNKKQPELKENTDENVIENKQENKTTLKIS DKKEDKKVIENINKKDEKKVQGVNTVNPQDEVLAGKLTKPELLYSDKIIETPLKYNQIIE SNDQLPEGTTRIKQQGKEGKKTEVIRMFTVEGKEVSRELISTKTEEPVSEIIEKGTKKAV SNVITKGQKLVKPAVEVKPEYTGVQAGAIVEPVKAEVPKEYTGVQAGAIVEPAKVETPKE YTGVQAGAIVEPAKAEVSKEYTGVQAGTIVEPAKAEVPKEYTGVQAGAIVEPEKVEPQYG GVTSGALVKPEKIEAPKEYTGVQAGAVVEPAKAEAPKEYRGVQAGAIVEPEKIESPKEYT GVQAGAVVEPAKAEVPKEYRGVQAGAIVEPEKIESPKEYTGEQSGAIVEPEKVETTKEYT GIQAGALVEPEKVEAPKEYTGVQAGAIVEPEKVEPPKEYTGVQAGAIVEPEKVEAPKEYT GKIEPLKTENPKPTVENNNTAEINNVPKNASALLRMNFVKGNQVLSGTGSATFIAPNVLL TVAHNFINNSADNSTGEFIGDKSKNTYEWQTPDGQKGSFTSEDIHFYNKKDYPKGFIYDL AVITLPQSTRRQHANLVENYSKVNVNDKLNVYGYPRGEYAHLKDTTVEIEQKYANNTYGV QYQGGKAGMSGGGIFNSKGEVIGLHQNGAENRSGGLILSPTQLDWIRSIIKGKEITPNYD ALERHKDEKKDDIKEEKQVDKKLELRNISNVELYTLENNKYRHVSSLSSVPTNPEAYFMK VKSENFKDVMLPVKSIESARKDNQDVYKIVGQANDLIQHENNITLENYTYYLPKTVNSEN GVYTSFKNLVDAMNINPYGTFRLGATMDAREVELSDGQESYINKEFSGKLIGENKGKYYA IYNLKKPLFKALSHATIQDLSIKEANVSSKEDAATIAKEAKNDTTIANVHSSGVIAGERS IGGLISQVTDSTISNSSFTGRITNTYDTTATYQIGGLVGKLSGVGALIEKSISSIDMATN ANTGDQVVGGVAGVVDKKATIRNSYVEGNLNNVKPFGKVGGVVGNLWDRETSEVSNSGNL TNVLSDVNVTNGNAIAGYDFNGIKATNTYSNKNNKVVKVVQVDDEVLSKDSEEQRGTVLE NNIVLEKKIELVPKKNTKIEDFNFSSRYETDYKNLKDADVSRLRVYKNIEKLLPFYNRET IVKYGNLVDANNTLYTKDLVSVVPMKDKEVISDINKNKTSINKLLLHYSDNTSQTLDIKY LQDFSKVAEYEIANTKLIYTPNTLLHSYNNIVKAVLNDLKSVQYDSDAVRKVLDISSNIK LTELYLDEQFTKTKANIEDSLSKLLSADAVIAENSNSIIDNYVIEKIKNNKEALLLGLTY LERWYNFKYDNTSAKDLVLYHLDFFGKSNSSALDNVIELGKSGFNNLLAKNNVITYNVLL SKNYGTEGLFKALEGYRKVFLPNVSNNDWFKTQSKAYIVEEKSTIPEVSSKQSKQGTEHS IGVYDRLTSPSWKYQSMVLPLLTLPEEKMIFMIANISTIGFGAYDRYRSSEYPKGDKLNR FVEENAQAAAKRFRDHYDYWYKILDKENKEKLFRSVLVYDAFRFGNDTNKETQEANFETN NPVIKNFFGPAGNNVVHNKHGAYATGDAFYYMAYRMLDKSGAVTYTHEMTHNSDREIYLG GYGRRSGLGPEFYAKGLLQAPDHSYDPTITINSVLKYDDSENSTRLQIADPTQRFTNVED LHNYMHNMFDLIYTLEILEGRAVAKLDYNEKNDLLRKIENIYKKDPDGNSVYATNAVRRL TSDEIKNLTSFDKLIENDVITRRGYIDQGEYERNGYHTINLFSPIYSALSSKIGTPGDLM GRRMAFELLAAKGYKEGMVPYISNQYEKEAKDRGSKIRSYGKEIGLVTDDLVLEKVFNKK YGSWVEFKKDMYKERVEQFSKLNRVSFFDPNGPWGRQKNVTVNNISVLEKMIETAVREDA EDFTAQVYPDTNSRVLKLKKAIFKAYLDQTKDFRTSIFGGK
A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Redzic, J.S., Rahkola, J., Tran, N. et al. Commun Biol (2022) 5:1190-1190. DOI 10.1038/s42003-022-04173-3 · PubMed
Other PDB entries of the same protein (UniProt C5NYF3), best resolution first:
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