7VPX: Human pre-A complex

The cryo-EM structure of the human pre-A complex. Determined by electron microscopy at 3.0 Å resolution. Released 3 May 2023.

Method: Electron microscopy
Resolution: 3.0 Å
Organisms: Homo sapiens, unidentified adenovirus
Chains: 35
Atoms: 43,240
Mol. weight: 1405.82 kDa
Ligands: ZN, SJT
Released: 3 May 2023

Explore 7VPX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7VPX contains 219 α-helices and 279 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 60 helices, 0 β-strands

Element	Residues	Length
α-helix	492-498	7
α-helix	500-505	6
α-helix	509-526	18
α-helix	528-539	12
α-helix	546-562	17
α-helix	568-570	3
α-helix	571-578	8
α-helix	587-603	17
α-helix	606-613	8
α-helix	615-617	3
α-helix	622-639	18
α-helix	645-651	7
α-helix	658-675	18
α-helix	676-682	7
α-helix	683-690	8
α-helix	691-695	5
α-helix	699-716	18
α-helix	721-723	3
α-helix	728-737	10
α-helix	741-753	13
α-helix	754-756	3
α-helix	759-776	18
α-helix	784-795	12
α-helix	803-805	3
α-helix	806-810	5
α-helix	811-817	7
α-helix	821-825	5
α-helix	830-844	15
α-helix	846-854	9
α-helix	862-879	18
α-helix	886-901	16
α-helix	908-921	14
α-helix	922-924	3
α-helix	928-941	14
α-helix	946-963	18
α-helix	969-980	12
α-helix	987-1001	15
α-helix	1013-1020	8
α-helix	1021-1025	5
α-helix	1029-1045	17
α-helix	1053-1062	10
α-helix	1063-1067	5
α-helix	1071-1088	18
α-helix	1090-1102	13
α-helix	1106-1122	17
α-helix	1125-1127	3
α-helix	1129-1135	7
α-helix	1144-1158	15
α-helix	1159-1164	6
α-helix	1166-1177	12
α-helix	1182-1198	17
α-helix	1205-1215	11
α-helix	1216-1220	5
α-helix	1224-1240	17
α-helix	1243-1250	8
α-helix	1251-1253	3
α-helix	1259-1274	16
α-helix	1279-1282	4
α-helix	1284-1286	3
α-helix	1299-1301	3

Chain 2: 10 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	462-468	7
α-helix	472-474	3
α-helix	477-481	5
α-helix	485-492	8
α-helix	523-525	3
α-helix	526-530	5
α-helix	568-577	10
β-strand	608	1	9
α-helix	611-617	7
α-helix	619-622	4
α-helix	633-639	7
β-strand	648-649	2	10
β-strand	651	1	11
β-strand	655	1	11
β-strand	683	1	9
β-strand	686	1	9
β-strand	689-690	2	10

Chain 3: 17 helices, 104 β-strands

Element	Residues	Length	Sheet
β-strand	3-9	7	12
β-strand	16-20	5	13
β-strand	29-33	5	13
β-strand	37-43	7	13
β-strand	50-57	8	13
β-strand	62-68	7	14
β-strand	77-82	6	14
β-strand	86-93	8	14
β-strand	98-106	9	14
β-strand	120-123	4	15
β-strand	129-133	5	15
β-strand	139-143	5	15
β-strand	144-146	3	16
β-strand	152-154	3	16
β-strand	158-159	2	15
β-strand	165-173	9	17
β-strand	181-188	8	17
α-helix	191-193	3
β-strand	207-214	8	17
β-strand	219-227	9	17
β-strand	232-237	6	18
α-helix	238-239	2
β-strand	248-252	5	18
β-strand	255-259	5	18
α-helix	264-266	3
β-strand	267-270	4	18
α-helix	271-272	2
β-strand	273-274	2	19
β-strand	287-294	8	20
β-strand	299-305	7	20
β-strand	309-317	9	20
β-strand	322-332	11	20
β-strand	336-342	7	21
β-strand	346-351	6	21
β-strand	356-361	6	21
β-strand	373-374	2	20
β-strand	386-387	2	19
β-strand	395-401	7	21
α-helix	405	1
β-strand	407-413	7	22
β-strand	422-427	6	22
α-helix	430-432	3
β-strand	434-440	7	22
β-strand	442	1	23
β-strand	444-449	6	24
β-strand	461-462	2	25
β-strand	473-477	5	25
β-strand	482-485	4	25
β-strand	493	1	25
β-strand	507-510	4	26
β-strand	516-520	5	26
β-strand	523-527	5	26
β-strand	533-537	5	26
β-strand	546-548	3	27
β-strand	555-557	3	27
β-strand	563-565	3	27
β-strand	566-568	3	28
β-strand	574-576	3	28
β-strand	581	1	27
β-strand	587-592	6	29
β-strand	605-609	5	29
β-strand	613-617	5	29
β-strand	627-632	6	29
β-strand	637-643	7	30
β-strand	664-669	6	30
β-strand	673-678	6	30
β-strand	689-690	2	30
β-strand	700-706	7	31
β-strand	709-715	7	31
β-strand	719-723	5	31
β-strand	730-733	4	31
β-strand	734	1	23
β-strand	741	1	32
β-strand	744-745	2	24
β-strand	753-756	4	24
β-strand	757	1	32
β-strand	763-767	5	24
β-strand	774-780	7	22
β-strand	785-790	6	33
β-strand	797-804	8	33
α-helix	809-824	16
α-helix	839-842	4
α-helix	846-848	3
α-helix	849-852	4
β-strand	862-869	8	33
β-strand	876-881	6	33
β-strand	886-894	9	34
β-strand	904-911	8	34
β-strand	914-915	2	35
β-strand	918-919	2	35
β-strand	922-928	7	34
β-strand	931	1	36
β-strand	936	1	36
β-strand	939-945	7	34
β-strand	949-955	7	37
β-strand	958-963	6	37
β-strand	966-972	7	37
β-strand	977-983	7	37
β-strand	990-996	7	38
β-strand	999-1004	6	38
β-strand	1007	1	39
β-strand	1009-1015	7	38
β-strand	1020-1026	7	38
β-strand	1030	1	39
β-strand	1033-1038	6	40
β-strand	1043-1048	6	40
β-strand	1052-1057	6	40
α-helix	1058-1059	2
β-strand	1088	1	38
β-strand	1090-1096	7	40
β-strand	1101-1108	8	12
β-strand	1115-1121	7	12
β-strand	1126-1131	6	12
α-helix	1135-1151	17
α-helix	1160-1163	4
β-strand	1171	1	40
β-strand	1173-1175	3	12
α-helix	1176-1179	4
α-helix	1180-1184	5
α-helix	1187-1194	8
α-helix	1201-1215	15

Chain 4: 7 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	14-18	5	42
α-helix	26-32	7
β-strand	39-43	5	42
α-helix	45	1
β-strand	46	1	43
α-helix	47	1
β-strand	53	1	43
β-strand	56-61	6	42
α-helix	64-73	10
β-strand	77-79	3	44
β-strand	82-84	3	44
β-strand	85-88	4	42
β-strand	102-105	4	45
α-helix	113-120	8
β-strand	126	1	46
β-strand	131-132	2	45
β-strand	144-147	4	45
β-strand	149	1	46
α-helix	152-157	6
α-helix	158-162	5
β-strand	166	1	47
β-strand	171	1	47
β-strand	173-176	4	45

Chain 5: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	28-45	18
α-helix	47-56	10
α-helix	61-72	12

Chain 6: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	10	1	48
β-strand	18-19	2	49
α-helix	20	1
β-strand	21-22	2	50
β-strand	39-42	4	51
β-strand	44-45	2	49
α-helix	48-50	3
α-helix	52-54	3
β-strand	57	1	52
β-strand	58	1	50
β-strand	64	1	52
β-strand	67-68	2	50
β-strand	70-72	3	51
α-helix	73-77	5
β-strand	88	1	48

Chain a: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	20-26	7
α-helix	29-37	9
β-strand	41-46	6	63
β-strand	51-58	8	63
β-strand	65-76	12	63
β-strand	90-101	12	63
β-strand	106-111	6	63

Chain A: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	161-174	14
α-helix	186-189	4
α-helix	205-217	13
α-helix	221-225	5
α-helix	236-271	36

23 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Splicing factor 3A subunit 2	B	protein	464	Homo sapiens	Q15428 (AlphaFold model)
Splicing factor 1	D	protein	639	Homo sapiens	Q15637 (AlphaFold model)
DnaJ homolog subfamily C member 8	J	protein	253	Homo sapiens	O75937 (AlphaFold model)
U2 snRNA	H	RNA	188	Homo sapiens
Splicing factor 3B subunit 1	1	protein	1304	Homo sapiens	O75533 (AlphaFold model)
Splicing factor 3B subunit 2	2	protein	895	Homo sapiens	Q13435
Splicing factor 3B subunit 3	3	protein	1217	Homo sapiens	Q15393
Splicing factor 3B subunit 4	4	protein	424	Homo sapiens	Q15427
Splicing factor 3B subunit 5	5	protein	86	Homo sapiens	Q9BWJ5
Splicing factor 3A subunit 1	A	protein	793	Homo sapiens	Q15459
Splicing factor 3A subunit 3	C	protein	501	Homo sapiens	Q12874
Probable ATP-dependent RNA helicase DDX46	E	protein	1031	Homo sapiens	Q7L014

16 more molecules are not listed.

Sequence of entity 1 (B), FASTA

>7VPX_1 Splicing factor 3A subunit 2 (chains B)
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN

Sequence of entity 2 (D), FASTA

>7VPX_2 Splicing factor 1 (chains D)
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIED
LTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALN
PDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLR
KMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDP
QSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGP
PPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP
PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGS
IPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPP
PPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN

Sequence of entity 3 (J), FASTA

>7VPX_3 DnaJ homolog subfamily C member 8 (chains J)
MAASGESGTSGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFE
VLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRAL
DVIQAGKEYVEHTVKERKKQLKKEGKPTIVEEDDPELFKQAVYKQTMKLFAELEIKRKER
EAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRNFQANTKGKKEKKNRT
FLRPPKVKMEQRE

Sequence of entity 4 (H), FASTA

>7VPX_4 U2 snRNA (chains H)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC

Sequence of entity 5 (1), FASTA

>7VPX_5 Splicing factor 3B subunit 1 (chains 1)
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAA
TELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYK
KHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGE
LKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAK
GSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTE
RDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPI
GTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAG
YVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLV
DVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLM
SPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNL
AKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQA
RHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYG
IESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP
DEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVEL
ANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAF
QEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAV
VMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRL
TPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNT
FGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPE
LNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVY
GFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARK
VRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL

Sequence of entity 6 (2), FASTA

>7VPX_6 Splicing factor 3B subunit 2 (chains 2)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF

Sequence of entity 7 (3), FASTA

>7VPX_7 Splicing factor 3B subunit 3 (chains 3)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF

Sequence of entity 8 (4), FASTA

>7VPX_8 Splicing factor 3B subunit 4 (chains 4)
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVE
FLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTF
SAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKK
DSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPP
GSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGG
MPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGS
PMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRG
PLPQ

Sequence of entity 9 (5), FASTA

>7VPX_9 Splicing factor 3B subunit 5 (chains 5)
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN

Sequence of entity 10 (A), FASTA

>7VPX_10 Splicing factor 3A subunit 1 (chains A)
MPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFV
ARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQ
QQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQ
FLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVL
DQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTT
PEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSD
DEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKI
PASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVE
ETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDD
TKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRP
PMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAP
VPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEW
KLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAV
IHLALKERGGRKK

Sequence of entity 11 (C), FASTA

>7VPX_11 Splicing factor 3A subunit 3 (chains C)
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDL
YDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENP
SEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNA
EYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHA
GAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSL
FAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEE
EEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPK
AFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYE
DSSGNVVNKKTYEDLKRQGLL

Sequence of entity 12 (E), FASTA

>7VPX_12 Probable ATP-dependent RNA helicase DDX46 (chains E)
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRS
RSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRS
KEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAME
NIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVK
KFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEE
VDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGI
TVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGS
GKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVY
GGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFE
PQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVI
EEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDS
IINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAY
TFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKF
DETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPA
PTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQL
AEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISE
YSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSY
QPTNKGRYKVL

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6
SJT	spliceostatin A (form II)	C28 H45 N O8	1

Primary citation

Structural insights into branch site proofreading by human spliceosome. Zhang, X., Zhan, X., Bian, T. et al. Nat Struct Mol Biol (2024). DOI 10.1038/s41594-023-01188-0 · PubMed

Other PDB entries of the same protein (UniProt Q15428 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Q4O 2.1 Å, Substrate-bound A-like U2 snRNP
7Q4P 2.15 Å, U2 snRNP after ATP-dependent remodelling
7EVO 2.5 Å, The cryo-EM structure of the human 17S U2 snRNP
8H6L 2.6 Å, Cryo-EM structure of human exon-defined spliceosome in the early B state.
8H6K 2.7 Å, Cryo-EM structure of human exon-defined spliceosome in the mature B state.
8HK1 2.7 Å, The cryo-EM structure of human pre-17S U2 snRNP
8I0R 3.0 Å, The cryo-EM structure of human Bact-I complex
8I0T 3.0 Å, The cryo-EM structure of human Bact-III complex
7ONB 3.1 Å, Structure of the U2 5' module of the A3'-SSA complex
7QTT 3.1 Å, Structural organization of a late activated human spliceosome (Baqr, core region)
8H6E 3.2 Å, Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.
8H6J 3.25 Å, Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.

Browse structure collections

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