7WOO: Nucleoporin NIC96
Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear pore complex. Determined by electron microscopy at 3.71 Å resolution. Released 13 Apr 2022.
- Method
- Electron microscopy
- Resolution
- 3.71 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 12
- Atoms
- 66,949
- Mol. weight
- 1286.2 kDa
- Released
- 13 Apr 2022
Explore 7WOO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7WOO contains 428 α-helices and 125 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 50 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-30 | 17 | |
| α-helix | 45-55 | 11 | |
| α-helix | 80-91 | 12 | |
| α-helix | 113-139 | 27 | |
| α-helix | 192-194 | 3 | |
| α-helix | 202-204 | 3 | |
| α-helix | 206-227 | 22 | |
| α-helix | 234-242 | 9 | |
| α-helix | 249-262 | 14 | |
| α-helix | 270-293 | 24 | |
| α-helix | 301-308 | 8 | |
| α-helix | 309-313 | 5 | |
| β-strand | 314 | 1 | 1 |
| β-strand | 320 | 1 | 1 |
| β-strand | 327-328 | 2 | 2 |
| β-strand | 331-332 | 2 | 2 |
| α-helix | 333-342 | 10 | |
| α-helix | 346-355 | 10 | |
| α-helix | 362-364 | 3 | |
| α-helix | 365-376 | 12 | |
| α-helix | 384-393 | 10 | |
| α-helix | 394-398 | 5 | |
| α-helix | 406-416 | 11 | |
| α-helix | 432-441 | 10 | |
| α-helix | 453-455 | 3 | |
| α-helix | 459-469 | 11 | |
| α-helix | 478-484 | 7 | |
| α-helix | 488-496 | 9 | |
| α-helix | 500-512 | 13 | |
| α-helix | 534-542 | 9 | |
| α-helix | 550-558 | 9 | |
| α-helix | 559-563 | 5 | |
| α-helix | 566-583 | 18 | |
| α-helix | 586-589 | 4 | |
| β-strand | 593 | 1 | 3 |
| α-helix | 598 | 1 | |
| β-strand | 599 | 1 | 3 |
| α-helix | 600-601 | 2 | |
| α-helix | 603-606 | 4 | |
| α-helix | 609-611 | 3 | |
| α-helix | 616-619 | 4 | |
| α-helix | 620-625 | 6 | |
| α-helix | 626-634 | 9 | |
| α-helix | 637-646 | 10 | |
| α-helix | 650-667 | 18 | |
| α-helix | 685-692 | 8 | |
| α-helix | 693-697 | 5 | |
| α-helix | 700-704 | 5 | |
| α-helix | 708-728 | 21 | |
| α-helix | 732-741 | 10 | |
| α-helix | 750-762 | 13 | |
| α-helix | 765-768 | 4 | |
| α-helix | 771-791 | 21 | |
| α-helix | 797-819 | 23 | |
| α-helix | 821-823 | 3 | |
| α-helix | 826-837 | 12 | |
Chain C: 69 helices, 42 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 69-71 | 3 | |
| α-helix | 90-106 | 17 | |
| α-helix | 108-110 | 3 | |
| α-helix | 114-117 | 4 | |
| β-strand | 122-126 | 5 | 4 |
| α-helix | 133-135 | 3 | |
| β-strand | 138-145 | 8 | 5 |
| α-helix | 146-147 | 2 | |
| α-helix | 148-154 | 7 | |
| β-strand | 161-166 | 6 | 6 |
| β-strand | 171-176 | 6 | 6 |
| β-strand | 179-184 | 6 | 6 |
| β-strand | 191-194 | 4 | 6 |
| β-strand | 201-207 | 7 | 7 |
| α-helix | 208-210 | 3 | |
| β-strand | 220-226 | 7 | 7 |
| β-strand | 229-237 | 9 | 7 |
| α-helix | 243 | 1 | |
| β-strand | 244-254 | 11 | 7 |
| β-strand | 260-266 | 7 | 8 |
| β-strand | 271-276 | 6 | 8 |
| β-strand | 284-288 | 5 | 8 |
| β-strand | 293 | 1 | 9 |
| β-strand | 296 | 1 | 9 |
| β-strand | 299-303 | 5 | 8 |
| α-helix | 324-326 | 3 | |
| α-helix | 337-340 | 4 | |
| β-strand | 342-348 | 7 | 10 |
| β-strand | 353-358 | 6 | 10 |
| β-strand | 363-369 | 7 | 10 |
| β-strand | 372-379 | 8 | 10 |
| α-helix | 381-390 | 10 | |
| α-helix | 397-399 | 3 | |
| β-strand | 406-411 | 6 | 11 |
| β-strand | 420-426 | 7 | 11 |
| β-strand | 431-435 | 5 | 11 |
| β-strand | 438-439 | 2 | 12 |
| β-strand | 442-443 | 2 | 12 |
| α-helix | 444-446 | 3 | |
| β-strand | 447-452 | 6 | 11 |
| α-helix | 453-455 | 3 | |
| α-helix | 457-461 | 5 | |
| α-helix | 483-486 | 4 | |
| β-strand | 495 | 1 | 4 |
| β-strand | 500-502 | 3 | 4 |
| β-strand | 506-513 | 8 | 4 |
| α-helix | 515-517 | 3 | |
| α-helix | 534 | 1 | |
| β-strand | 535-543 | 9 | 4 |
| α-helix | 545-551 | 7 | |
| β-strand | 555-561 | 7 | 4 |
| α-helix | 566 | 1 | |
| β-strand | 567-572 | 6 | 5 |
| α-helix | 589-592 | 4 | |
| α-helix | 597-599 | 3 | |
| β-strand | 600-605 | 6 | 5 |
| β-strand | 608-614 | 7 | 5 |
| α-helix | 617-623 | 7 | |
| α-helix | 629-635 | 7 | |
| α-helix | 637-649 | 13 | |
| α-helix | 655-667 | 13 | |
| β-strand | 669 | 1 | 13 |
| β-strand | 673 | 1 | 13 |
| β-strand | 678-679 | 2 | 14 |
| α-helix | 686-689 | 4 | |
| β-strand | 703-704 | 2 | 14 |
| α-helix | 707-719 | 13 | |
| β-strand | 727 | 1 | 15 |
| β-strand | 729-732 | 4 | 16 |
| α-helix | 733-735 | 3 | |
| β-strand | 742-745 | 4 | 16 |
| α-helix | 749-773 | 25 | |
| α-helix | 785-786 | 2 | |
| α-helix | 787-815 | 29 | |
| α-helix | 819-830 | 12 | |
| α-helix | 838-846 | 9 | |
| β-strand | 848 | 1 | 15 |
| α-helix | 849-853 | 5 | |
| α-helix | 857-876 | 20 | |
| α-helix | 881-891 | 11 | |
| α-helix | 898-916 | 19 | |
| α-helix | 921-937 | 17 | |
| α-helix | 944-956 | 13 | |
| α-helix | 960-974 | 15 | |
| α-helix | 979-985 | 7 | |
| α-helix | 995-1022 | 28 | |
| α-helix | 1035-1048 | 14 | |
| α-helix | 1053-1065 | 13 | |
| α-helix | 1069-1072 | 4 | |
| α-helix | 1080-1088 | 9 | |
| α-helix | 1092-1104 | 13 | |
| α-helix | 1108-1120 | 13 | |
| α-helix | 1127-1141 | 15 | |
| α-helix | 1147-1149 | 3 | |
| α-helix | 1150-1178 | 29 | |
| α-helix | 1185-1195 | 11 | |
| α-helix | 1199-1201 | 3 | |
| α-helix | 1202-1205 | 4 | |
| α-helix | 1206-1210 | 5 | |
| α-helix | 1216-1225 | 10 | |
| α-helix | 1231-1247 | 17 | |
| α-helix | 1257-1276 | 20 | |
| α-helix | 1285-1295 | 11 | |
| α-helix | 1302-1303 | 2 | |
| α-helix | 1306-1313 | 8 | |
| α-helix | 1318-1331 | 14 | |
| α-helix | 1336-1353 | 18 | |
| α-helix | 1355-1360 | 6 | |
| α-helix | 1363-1367 | 5 | |
| α-helix | 1374-1376 | 3 | |
| α-helix | 1380-1387 | 8 | |
Chain D: 62 helices, 40 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 100-116 | 17 | |
| α-helix | 118-120 | 3 | |
| β-strand | 133-139 | 7 | 17 |
| α-helix | 143-145 | 3 | |
| β-strand | 148-155 | 8 | 18 |
| α-helix | 156-157 | 2 | |
| α-helix | 158-163 | 6 | |
| β-strand | 172-176 | 5 | 19 |
| β-strand | 181-185 | 5 | 19 |
| β-strand | 190-194 | 5 | 19 |
| β-strand | 201-204 | 4 | 19 |
| β-strand | 211-217 | 7 | 20 |
| α-helix | 218-220 | 3 | |
| β-strand | 230-236 | 7 | 20 |
| β-strand | 239-247 | 9 | 20 |
| α-helix | 253 | 1 | |
| β-strand | 254-258 | 5 | 20 |
| β-strand | 263-264 | 2 | 20 |
| β-strand | 270-276 | 7 | 21 |
| β-strand | 281-286 | 6 | 21 |
| β-strand | 294-296 | 3 | 21 |
| α-helix | 301-303 | 3 | |
| β-strand | 313-314 | 2 | 21 |
| α-helix | 331-333 | 3 | |
| α-helix | 334-338 | 5 | |
| β-strand | 342-343 | 2 | 22 |
| β-strand | 349-350 | 2 | 22 |
| β-strand | 356-362 | 7 | 23 |
| β-strand | 367-372 | 6 | 23 |
| β-strand | 377-381 | 5 | 23 |
| β-strand | 393 | 1 | 23 |
| α-helix | 395-402 | 8 | |
| β-strand | 420-425 | 6 | 24 |
| β-strand | 434-440 | 7 | 24 |
| β-strand | 445-449 | 5 | 24 |
| β-strand | 452-453 | 2 | 25 |
| β-strand | 456-457 | 2 | 25 |
| β-strand | 461-466 | 6 | 24 |
| α-helix | 473-481 | 9 | |
| α-helix | 496-498 | 3 | |
| β-strand | 524-526 | 3 | 17 |
| β-strand | 530-536 | 7 | 17 |
| β-strand | 560 | 1 | 26 |
| β-strand | 562 | 1 | 26 |
| β-strand | 574-581 | 8 | 17 |
| α-helix | 583-587 | 5 | |
| β-strand | 594-598 | 5 | 17 |
| β-strand | 605-610 | 6 | 18 |
| β-strand | 638-643 | 6 | 18 |
| β-strand | 646-652 | 7 | 18 |
| α-helix | 653-654 | 2 | |
| α-helix | 655-661 | 7 | |
| α-helix | 670-687 | 18 | |
| α-helix | 693-704 | 12 | |
| α-helix | 768-780 | 13 | |
| α-helix | 782-785 | 4 | |
| β-strand | 788 | 1 | 27 |
| β-strand | 790 | 1 | 28 |
| β-strand | 832 | 1 | 28 |
| α-helix | 836-855 | 20 | |
| α-helix | 857-859 | 3 | |
| α-helix | 865-867 | 3 | |
| α-helix | 881-883 | 3 | |
| α-helix | 885-914 | 30 | |
| α-helix | 930-933 | 4 | |
| α-helix | 941-944 | 4 | |
| β-strand | 948 | 1 | 27 |
| α-helix | 949-953 | 5 | |
| α-helix | 957-971 | 15 | |
| α-helix | 980-989 | 10 | |
| α-helix | 1001-1016 | 16 | |
| α-helix | 1017-1019 | 3 | |
| α-helix | 1021-1037 | 17 | |
| α-helix | 1039-1041 | 3 | |
| α-helix | 1044-1055 | 12 | |
| α-helix | 1060-1074 | 15 | |
| α-helix | 1079-1085 | 7 | |
| α-helix | 1095-1120 | 26 | |
| α-helix | 1135-1151 | 17 | |
| α-helix | 1155-1167 | 13 | |
| α-helix | 1171-1175 | 5 | |
| α-helix | 1182-1190 | 9 | |
| α-helix | 1194-1206 | 13 | |
| α-helix | 1210-1222 | 13 | |
| α-helix | 1229-1243 | 15 | |
| α-helix | 1249-1251 | 3 | |
| α-helix | 1252-1281 | 30 | |
| α-helix | 1287-1297 | 11 | |
| α-helix | 1304-1306 | 3 | |
| α-helix | 1307-1312 | 6 | |
| α-helix | 1318-1327 | 10 | |
| α-helix | 1333-1350 | 18 | |
| α-helix | 1357-1378 | 22 | |
| α-helix | 1387-1401 | 15 | |
| α-helix | 1407-1408 | 2 | |
| α-helix | 1413-1419 | 7 | |
| α-helix | 1423-1436 | 14 | |
| α-helix | 1442-1458 | 17 | |
| α-helix | 1460-1465 | 6 | |
| α-helix | 1468-1472 | 5 | |
| α-helix | 1479-1481 | 3 | |
| α-helix | 1483-1491 | 9 | |
Chain E: 85 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-24 | 5 | |
| α-helix | 34-46 | 13 | |
| α-helix | 70-77 | 8 | |
| α-helix | 87-91 | 5 | |
| α-helix | 97-118 | 22 | |
| α-helix | 124-130 | 7 | |
| α-helix | 134-150 | 17 | |
| α-helix | 154-161 | 8 | |
| α-helix | 167-198 | 32 | |
| α-helix | 207-215 | 9 | |
| α-helix | 216-220 | 5 | |
| α-helix | 221-228 | 8 | |
| α-helix | 254-272 | 19 | |
| β-strand | 275-276 | 2 | 29 |
| β-strand | 281-282 | 2 | 29 |
| α-helix | 287-289 | 3 | |
| α-helix | 295-307 | 13 | |
| α-helix | 319-335 | 17 | |
| α-helix | 348-355 | 8 | |
| α-helix | 358-368 | 11 | |
| α-helix | 373-386 | 14 | |
| α-helix | 394-404 | 11 | |
| α-helix | 409-413 | 5 | |
| α-helix | 419-425 | 7 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-455 | 6 | |
| β-strand | 460 | 1 | 30 |
| β-strand | 463-466 | 4 | 31 |
| β-strand | 475-476 | 2 | 31 |
| β-strand | 496-501 | 4 | 31 |
| β-strand | 505-507 | 3 | 32 |
| α-helix | 508-509 | 2 | |
| β-strand | 520-522 | 3 | 32 |
| β-strand | 527-531 | 5 | 31 |
| β-strand | 552-555 | 4 | 31 |
| β-strand | 559 | 1 | 30 |
| α-helix | 561-579 | 19 | |
| α-helix | 585-602 | 18 | |
| α-helix | 609-617 | 9 | |
| α-helix | 634-647 | 14 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-678 | 10 | |
| α-helix | 708-722 | 15 | |
| α-helix | 732-750 | 19 | |
| α-helix | 762-769 | 8 | |
| β-strand | 785 | 1 | 33 |
| α-helix | 796-805 | 10 | |
| α-helix | 815-825 | 11 | |
| α-helix | 826-828 | 3 | |
| α-helix | 830-835 | 6 | |
| α-helix | 843-862 | 20 | |
| α-helix | 868-870 | 3 | |
| α-helix | 873-879 | 7 | |
| α-helix | 881-889 | 9 | |
| α-helix | 898-909 | 12 | |
| α-helix | 927-939 | 13 | |
| α-helix | 946-961 | 16 | |
| α-helix | 966-972 | 7 | |
| α-helix | 994-1003 | 10 | |
| α-helix | 1010-1025 | 16 | |
| α-helix | 1033-1035 | 3 | |
| α-helix | 1037-1048 | 12 | |
| α-helix | 1051-1054 | 4 | |
| α-helix | 1063-1087 | 25 | |
| α-helix | 1094-1099 | 6 | |
| α-helix | 1106-1113 | 8 | |
| α-helix | 1120-1131 | 12 | |
| α-helix | 1139-1141 | 3 | |
| β-strand | 1143 | 1 | 34 |
| β-strand | 1144 | 1 | 33 |
| α-helix | 1145-1146 | 2 | |
| α-helix | 1149-1151 | 3 | |
| β-strand | 1158 | 1 | 34 |
| α-helix | 1160-1166 | 7 | |
| α-helix | 1171-1174 | 4 | |
| α-helix | 1184-1214 | 31 | |
| α-helix | 1221-1222 | 2 | |
| α-helix | 1224-1238 | 15 | |
| α-helix | 1249-1266 | 18 | |
| α-helix | 1274-1288 | 15 | |
| α-helix | 1305-1307 | 3 | |
| α-helix | 1309-1319 | 11 | |
| α-helix | 1329-1357 | 29 | |
| α-helix | 1383 | 1 | |
| α-helix | 1384-1388 | 5 | |
| α-helix | 1389-1397 | 9 | |
| α-helix | 1402-1415 | 14 | |
| α-helix | 1419-1430 | 12 | |
| β-strand | 1433 | 1 | 35 |
| β-strand | 1436 | 1 | 35 |
| α-helix | 1440-1451 | 12 | |
| α-helix | 1455-1460 | 6 | |
| α-helix | 1466-1470 | 5 | |
| α-helix | 1473-1479 | 7 | |
| α-helix | 1489-1508 | 20 | |
| α-helix | 1515-1537 | 23 | |
| α-helix | 1545-1557 | 13 | |
| α-helix | 1560-1563 | 4 | |
| α-helix | 1592-1606 | 15 | |
| α-helix | 1609-1615 | 7 | |
| α-helix | 1621-1628 | 8 | |
| α-helix | 1633-1654 | 22 | |
Chain F: 81 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-13 | 8 | |
| α-helix | 22-27 | 6 | |
| α-helix | 29-33 | 5 | |
| β-strand | 42 | 1 | 36 |
| α-helix | 46-50 | 5 | |
| α-helix | 51-53 | 3 | |
| β-strand | 55-57 | 3 | 37 |
| β-strand | 63-65 | 3 | 37 |
| α-helix | 68-80 | 13 | |
| β-strand | 83 | 1 | 36 |
| α-helix | 86-93 | 8 | |
| α-helix | 102-121 | 20 | |
| α-helix | 129-134 | 6 | |
| α-helix | 140-168 | 29 | |
| α-helix | 176-199 | 24 | |
| α-helix | 210-219 | 10 | |
| α-helix | 228-231 | 4 | |
| α-helix | 234-240 | 7 | |
| α-helix | 249-258 | 10 | |
| α-helix | 271-286 | 16 | |
| α-helix | 299-305 | 7 | |
| α-helix | 308-316 | 9 | |
| α-helix | 319-326 | 8 | |
| β-strand | 390 | 1 | 38 |
| β-strand | 393 | 1 | 38 |
| α-helix | 425-442 | 18 | |
| α-helix | 449-458 | 10 | |
| α-helix | 478-488 | 11 | |
| α-helix | 494-498 | 5 | |
| α-helix | 499-501 | 3 | |
| α-helix | 506-513 | 8 | |
| α-helix | 520-533 | 14 | |
| α-helix | 537-548 | 12 | |
| α-helix | 563-566 | 4 | |
| α-helix | 567-571 | 5 | |
| α-helix | 579-581 | 3 | |
| α-helix | 603-620 | 18 | |
| α-helix | 626-632 | 7 | |
| α-helix | 635-642 | 8 | |
| α-helix | 652-656 | 5 | |
| α-helix | 666-678 | 13 | |
| α-helix | 688-695 | 8 | |
| α-helix | 704-717 | 14 | |
| α-helix | 751-757 | 7 | |
| α-helix | 772-775 | 4 | |
| α-helix | 786-789 | 4 | |
| α-helix | 836-840 | 5 | |
| α-helix | 850-852 | 3 | |
| α-helix | 861-871 | 11 | |
| α-helix | 872-874 | 3 | |
| α-helix | 894-896 | 3 | |
| α-helix | 912-914 | 3 | |
| β-strand | 920 | 1 | 39 |
| β-strand | 923 | 1 | 39 |
| α-helix | 927-929 | 3 | |
| α-helix | 937-949 | 13 | |
| α-helix | 966-968 | 3 | |
| α-helix | 975-986 | 12 | |
| α-helix | 999-1010 | 12 | |
| α-helix | 1021-1024 | 4 | |
| β-strand | 1028 | 1 | 40 |
| β-strand | 1034 | 1 | 40 |
| α-helix | 1049-1052 | 4 | |
| α-helix | 1070-1087 | 18 | |
| α-helix | 1094-1102 | 9 | |
| α-helix | 1106-1110 | 5 | |
| α-helix | 1138-1140 | 3 | |
| α-helix | 1144-1168 | 25 | |
| α-helix | 1177-1179 | 3 | |
| α-helix | 1213-1216 | 4 | |
| α-helix | 1239-1254 | 16 | |
| α-helix | 1271-1302 | 32 | |
| α-helix | 1310-1313 | 4 | |
| α-helix | 1347-1363 | 17 | |
| α-helix | 1381-1385 | 5 | |
| α-helix | 1386-1388 | 3 | |
| α-helix | 1401-1413 | 13 | |
| α-helix | 1422-1430 | 9 | |
| α-helix | 1435-1442 | 8 | |
| α-helix | 1453-1470 | 18 | |
| α-helix | 1475-1479 | 5 | |
| α-helix | 1485-1493 | 9 | |
| α-helix | 1510-1526 | 17 | |
| α-helix | 1534-1539 | 6 | |
| α-helix | 1544-1549 | 6 | |
| α-helix | 1551-1553 | 3 | |
| α-helix | 1595-1610 | 16 | |
| α-helix | 1621-1632 | 12 | |
| α-helix | 1634-1636 | 3 | |
| α-helix | 1638-1643 | 6 | |
| α-helix | 1657-1674 | 18 | |
Chain G: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 272-358 | 87 | |
| α-helix | 362-364 | 3 | |
| α-helix | 366-407 | 42 | |
| α-helix | 438-469 | 32 | |
Chain H: 9 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 289-298 | 10 | |
| β-strand | 312 | 1 | 41 |
| α-helix | 332-339 | 8 | |
| α-helix | 348-349 | 2 | |
| β-strand | 350 | 1 | 41 |
| α-helix | 355-389 | 35 | |
| α-helix | 390-394 | 5 | |
| α-helix | 395-422 | 28 | |
| α-helix | 431-447 | 17 | |
| α-helix | 450-475 | 26 | |
| α-helix | 511-535 | 25 | |
Chain I: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 639-725 | 87 | |
| α-helix | 742-775 | 34 | |
| α-helix | 794-819 | 26 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Nucleoporin NIC96 | A, Z | protein | 839 | Saccharomyces cerevisiae | P34077 (AlphaFold model) |
| Nucleoporin NUP157 | C | protein | 1391 | Saccharomyces cerevisiae | P40064 (AlphaFold model) |
| Nucleoporin NUP170 | D | protein | 1502 | Saccharomyces cerevisiae | P38181 (AlphaFold model) |
| Nucleoporin NUP188 | E | protein | 1655 | Saccharomyces cerevisiae | P52593 (AlphaFold model) |
| Nucleoporin NUP192 | F | protein | 1683 | Saccharomyces cerevisiae | P47054 |
| Nucleoporin NUP49/NSP49 | G, J | protein | 472 | Saccharomyces cerevisiae | Q02199 |
| Nucleoporin NUP57 | H, K | protein | 541 | Saccharomyces cerevisiae | P48837 |
| Nucleoporin NSP1 | I, L | protein | 823 | Saccharomyces cerevisiae | P14907 |
Sequence of entity 1 (A, Z), FASTA
>7WOO_1 Nucleoporin NIC96 (chains A, Z)
MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKN
KASKDYTKAHYLLANSGLSFEDVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEEN
ILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFGILIQDKKTVDHKKSISSLDP
KLPSWGNKGNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFIS
ILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLAT
NVNKIKSFIDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANI
KKVEQSFLTYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDL
SRKNIPAVTLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQ
TLLLSGLYGLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILAN
YTKSFRYSDPRVAVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARI
PGVIEERQPLLHVRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSL
LSDTLSASDLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNI
SSIRELYFNKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLS
CISNMIHILNESKYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL
Sequence of entity 2 (C), FASTA
>7WOO_2 Nucleoporin NUP157 (chains C)
MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSSRSFLSERKTRKDVLN
KYGEAGNTIESELRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKG
LDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKL
ILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTISFNDR
THELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVWELQYNCSENLFNSKSN
KICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAGTEEETISQLEVDQSRGVLHTLSTK
SIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLLSNRAFKIAKIVSISMCENNDL
FLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNKSFIIGHHPLNTHDT
GPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYV
SAPDYGILKNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLK
VAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSYGLSEACSTALYLACKFNKSEHIKSS
ALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYGSALLITRLF
SQIWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPK
GSNAITASDAESIAMNALILLINSIKDALSLINVFYEDIDAFKSLLNTLMGAGGVYDSKT
REYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTSADYIVNVLKERFGSFCHSAD
ILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQ
PKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTS
IEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFV
LPYLKERAEKSLEISNLLWFYLFKEEHFLEAADVLYALASSDFDLKLSERIECLARANGL
CDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVL
PLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQES
FLSSISNTLIRIGKTTRDTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLK
LYYILSRIIENSEGNVELAKKEMVWLIKDWYQSDSDLRGSIAPEQIKKLEKYDPNTDPVQ
DYVKDRHHGLK
Sequence of entity 3 (D), FASTA
>7WOO_3 Nucleoporin NUP170 (chains D)
MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPI
TGSNPLMRASAMGATSGSINPNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPV
LDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEILHEFSTSQTKTDMGIFPELN
RCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMEL
FMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSG
SDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLT
IDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRIIGTTTARAAPILGPKYLKI
VKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQE
LLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQ
QTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLE
TAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFE
DLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRY
SVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRL
LRDIWGRHVFMTFTDNRVTSHAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIE
YYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDKTEEVANQAESIAINAMIKMV
QSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTK
SLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRN
YDSLNYHLKNATALLEQIVDDLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLA
CQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEKKQSSKTQNQISISNDDEVK
LRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNIL
WVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLAS
RIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEI
ALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQD
SEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSD
NSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFY
KE
Sequence of entity 4 (E), FASTA
>7WOO_4 Nucleoporin NUP188 (chains E)
MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFLKANKTNLIESLNTIRQ
NVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAVEFFMSERSSRLHIVYSLLVNP
DIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSLAHDYNNDQDMFTIVSLVQLK
KFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQNQFVEFCRNINSTDKSIDTSSLQ
LYKFQNFQDLSYLSETLISRISSLFTITTILILGLNTSIAQFDIQSPLYMDTETFDTVNS
ALENDVATNIVNEDPIFHPMIHYSWSFILYYRRALQSSESFDDSDITKFALFAESHDVLQ
KLNTLSEILSFDPVYTTVITVFLEFSLNFIPITASTSRVFAKIISKAPEQFIENFLTNDT
FEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICSFAVTKSSLNDLDYDLIAD
TITNSSSSSDIIVPDLIELKSDLLVAPPLENENSNCLLSIPKSTKGKILTIKQQQQQQQQ
QNGQQPPTTSNLIIFLYKFNGWSLVGRILQNLLHSYMEKGTQLDDLQHELMISIIKLVTN
VVDPKTSIEKSSEILSYLSNSLDTSASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEF
MTMLTPNYLHLVSSYLNKSDLLDKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIR
ESLSLKNIHISKRSKIDIINKLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLH
DVFTINPHQKDQLIISSSANKLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKIL
GNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLEKLLFINSSKLVDVYTLPSYVHFKVQI
IELLSYLVEAPWNDDYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLL
ESKQDGLSILFLTGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETI
TYVLNTWTNSKIFIKDPKFVNSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVE
IFALCIYNSTDSNSEILNFLNQEDLFELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQ
SFQKIPLSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYE
ISTAKAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFY
ILYSFKLSGKLLKEEKIIELMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLE
LVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHTTQIVNLED
NTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDEPILG
QITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNIWSNGLL
SIVLLLLSQFGIKVLPETCLFVSYFGKQIKSTIYNWGDNKLAVSSSLIKETNQLVLLQKM
LNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSAALSKFLTHPKYLNSRIIPTT
LEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV
Sequence of entity 5 (F), FASTA
>7WOO_5 Nucleoporin NUP192 (chains F)
MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQLEKGEIELSD
GSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTANNGKVQYFLRRQYILQIVSFI
VNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQQINKAQILENYNALFQQNIK
FRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHL
FASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTM
DFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQDKSMELFYDIRSLLERHIPRLIPKQL
LDDEKIFSQTTNSTYNPASATDNMSGRGLWNPSYPGMMSTTGTARLNSMPNNVNEYSYTT
IVLSDQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLER
FFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENA
LNVYHYFGENSSISWKNIAQCLSDYTKKISNFNSSLHKRQQFSESTHNDIDSTAVALEEG
LNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNL
VPKLESSRTKFWSFLDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIH
SRENNSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPI
LKIIYTGLCSFDYSVILNSIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSI
FNVVDVGVDQLSIELEGGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFL
PKNYSLHGLRSFYDAIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLS
KRNKLLTIFDSVDESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTIS
HLLLGFQVSNVISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAAL
EIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNGSPFDNSTEEKCKNFIE
SESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDP
LNYGNICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSN
SFSLTVSKEQFLKDADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLE
PSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDKGTVDGR
LYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKKLVEI
IWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKNTDALLN
STTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSFLKVDPDLG
LDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMGSSNK
AVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLCTLTGYQ
NND
Sequence of entity 6 (G, J), FASTA
>7WOO_6 Nucleoporin NUP49/NSP49 (chains G, J)
MFGLNKASSTPAGGLFGQASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTGG
LGASFGQQQQQSQTNAFGGSATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNA
QTSRGLFGNNNTNNINNSSSGMNNASAGLFGSKPAGGTSLFGNTSTSSAPAQNQGMFGAK
PAGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQ
QLQQQPQMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHLKADTID
HDELIDSIPRDVAYLLKSESATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTP
GSKISSNDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNGIDTDLFGAPNNPNSTAITAD
LGSSEAENLLQLKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASLSI
Sequence of entity 7 (H, K), FASTA
>7WOO_7 Nucleoporin NUP57 (chains H, K)
MFGFSGSNNGFGNKPAGSTGFSFGQNNNNTNTQPSASGFGFGGSQPNSGTATTGGFGANQ
ATNTFGSNQQSSTGGGLFGNKPALGSLGSSSTTASGTTATGTGLFGQQTAQPQQSTIGGG
LFGNKPTTTTGGLFGNSAQNNSTTSGGLFGNKVGSTGSLMGGNSTQNTSNMNAGGLFGAK
PQNTTATTGGLFGSKPQGSTTNGGLFGSGTQNNNTLGGGGLFGQSQQPQTNTAPGLGNTV
STQPSFAWSKPSTGSNLQQQQQQQIQVPLQQTQAIAQQQQLSNYPQQIQEQVLKCKESWD
PNTTKTKLRAFVYNKVNETEAILYTKPGHVLQEEWDQAMEKKPSPQTIPIQIYGFEGLNQ
RNQVQTENVAQARIILNHILEKSTQLQQKHELDTASRILKAQSRNVEIEKRILKLGTQLA
TLKNRGLPLGIAEEKMWSQFQTLLQRSEDPAGLGKTNELWARLAILKERAKNISSQLDSK
LMVFNDDTKNQDSMSKGTGEESNDRINKIVEILTNQQRGITYLNEVLEKDAAIVKKYKNK
T
Sequence of entity 8 (I, L), FASTA
>7WOO_8 Nucleoporin NSP1 (chains I, L)
MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFGFNNSAPNNTNNANSSI
TPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQTKSNGTAGG
NTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGNANTSNNLFGATANANKPAFS
FGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFG
SGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNKTTNTTPSFSFGAKSDENKAGATSK
PAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAF
SFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSFGAKPEEKKDDNSSKPAFSFG
AKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKS
DEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAFSFGAKANEK
KESDESKSAFSFGSKPTGKEEGDGAKAAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKT
EESSTGKSTADVKSSDSLKLNSKPVELKPVSLDNKTLDDLVTKWTNQLTESASHFEQYTK
KINSWDQVLVKGGEQISQLYSDAVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEA
LLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTT
NIDINNEDENIQLIKILNSHFDALRSLDDNSTSLEKQINSIKK
Primary citation
Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Li, Z., Chen, S., Zhao, L. et al. Cell Res (2022) 32:437-450. DOI 10.1038/s41422-022-00632-y · PubMed
Other PDB entries of the same protein (UniProt P34077 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6X07 2.1 Å, Nic96 from S. cerevisiae bound by VHH-SAN12
- 2QX5 2.5 Å, Structure of nucleoporin Nic96
- 2RFO 2.6 Å, Crystral Structure of the nucleoporin Nic96
- 7WOT 3.73 Å, Cryo-EM structure of the inner ring monomer of the Saccharomyces cerevisiae nuclear pore…
- 8TJ5 6.6 Å, Inner spoke ring of the yeast NPC
- 7N85 7.6 Å, Inner ring spoke from the isolated yeast NPC
- 7N9F 37.0 Å, Structure of the in situ yeast NPC
- 8ZZA Integrative structure and functional anatomy of a single spoke of a nuclear pore complex
- 8ZZB Integrative structure and functional anatomy of three spokes of a nuclear pore complex
- 8ZZC Integrative structure and functional anatomy of eight spokes of a nuclear pore complex
- 9A0F Integrative model of the wild type yeast nuclear pore complex
- 9A0G Integrative model of Nup116 knockout (at 25C) yeast nuclear pore complex
Browse structure collections
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