8TJ5: Inner spoke ring of the yeast NPC
Inner spoke ring of the yeast NPC. Determined by electron microscopy at 6.6 Å resolution. Released 11 Oct 2023.
- Method
- Electron microscopy
- Resolution
- 6.6 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 46
- Atoms
- 138,272
- Mol. weight
- 2852.49 kDa
- Released
- 11 Oct 2023
Explore 8TJ5 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8TJ5 contains 883 α-helices and 233 β-strands across 42 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains 0 and Y: 54 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 100-115 | 16 | |
| α-helix | 124-126 | 3 | |
| β-strand | 134-135 | 2 | 21 |
| β-strand | 148-155 | 8 | 22 |
| α-helix | 158-165 | 8 | |
| β-strand | 171-176 | 6 | 23 |
| β-strand | 181-186 | 6 | 23 |
| β-strand | 189-194 | 6 | 23 |
| β-strand | 201-204 | 4 | 23 |
| α-helix | 210 | 1 | |
| β-strand | 211-217 | 7 | 24 |
| β-strand | 230-236 | 7 | 24 |
| β-strand | 239-248 | 10 | 24 |
| β-strand | 253-264 | 12 | 24 |
| β-strand | 270-276 | 7 | 25 |
| β-strand | 281-286 | 6 | 25 |
| β-strand | 292-296 | 5 | 25 |
| β-strand | 311-313 | 3 | 25 |
| β-strand | 358-362 | 5 | 26 |
| β-strand | 367-371 | 5 | 26 |
| β-strand | 377-382 | 6 | 26 |
| β-strand | 387-393 | 7 | 26 |
| α-helix | 396-402 | 7 | |
| α-helix | 411-413 | 3 | |
| β-strand | 420-425 | 6 | 27 |
| β-strand | 434-440 | 7 | 27 |
| β-strand | 445-452 | 8 | 27 |
| β-strand | 457-466 | 10 | 27 |
| α-helix | 474-490 | 17 | |
| α-helix | 505-511 | 7 | |
| β-strand | 519-526 | 8 | 21 |
| β-strand | 530-535 | 6 | 21 |
| α-helix | 574-575 | 2 | |
| β-strand | 576-581 | 6 | 21 |
| α-helix | 583-589 | 7 | |
| β-strand | 594-599 | 6 | 21 |
| α-helix | 600 | 1 | |
| β-strand | 607-610 | 4 | 22 |
| α-helix | 627-630 | 4 | |
| α-helix | 635-637 | 3 | |
| β-strand | 638-642 | 5 | 22 |
| β-strand | 646-652 | 7 | 22 |
| α-helix | 655-661 | 7 | |
| α-helix | 667-673 | 7 | |
| α-helix | 675-687 | 13 | |
| α-helix | 693-703 | 11 | |
| α-helix | 768-781 | 14 | |
| α-helix | 782-784 | 3 | |
| β-strand | 788 | 1 | 28 |
| β-strand | 790-791 | 2 | 29 |
| β-strand | 831-832 | 2 | 29 |
| α-helix | 836-861 | 26 | |
| α-helix | 875-877 | 3 | |
| α-helix | 880-917 | 38 | |
| α-helix | 927-935 | 9 | |
| α-helix | 938-945 | 8 | |
| β-strand | 948 | 1 | 28 |
| α-helix | 949-953 | 5 | |
| α-helix | 957-977 | 21 | |
| α-helix | 981-991 | 11 | |
| α-helix | 998-1016 | 19 | |
| α-helix | 1017-1019 | 3 | |
| α-helix | 1021-1036 | 16 | |
| α-helix | 1044-1055 | 12 | |
| α-helix | 1060-1073 | 14 | |
| α-helix | 1079-1085 | 7 | |
| α-helix | 1094-1120 | 27 | |
| α-helix | 1137-1151 | 15 | |
| α-helix | 1155-1167 | 13 | |
| α-helix | 1171-1175 | 5 | |
| α-helix | 1182-1190 | 9 | |
| α-helix | 1194-1206 | 13 | |
| α-helix | 1210-1221 | 12 | |
| α-helix | 1229-1243 | 15 | |
| α-helix | 1252-1281 | 30 | |
| α-helix | 1292-1297 | 6 | |
| α-helix | 1304-1309 | 6 | |
| α-helix | 1318-1328 | 11 | |
| α-helix | 1333-1349 | 17 | |
| α-helix | 1357-1378 | 22 | |
| α-helix | 1387-1401 | 15 | |
| α-helix | 1413-1420 | 8 | |
| α-helix | 1423-1436 | 14 | |
| α-helix | 1441-1458 | 18 | |
| α-helix | 1460-1462 | 3 | |
| α-helix | 1468-1472 | 5 | |
| α-helix | 1483-1488 | 6 | |
Chain 1: 49 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 80-83 | 4 | |
| α-helix | 90-106 | 17 | |
| β-strand | 121-123 | 3 | 30 |
| α-helix | 133-135 | 3 | |
| β-strand | 138-139 | 2 | 31 |
| α-helix | 148-154 | 7 | |
| β-strand | 161-166 | 6 | 32 |
| β-strand | 171-176 | 6 | 32 |
| β-strand | 179-184 | 6 | 32 |
| β-strand | 191-194 | 4 | 32 |
| β-strand | 203-207 | 5 | 33 |
| α-helix | 208-210 | 3 | |
| β-strand | 220-225 | 6 | 33 |
| β-strand | 229-237 | 9 | 33 |
| β-strand | 244-254 | 11 | 33 |
| β-strand | 260-265 | 6 | 34 |
| β-strand | 272-276 | 5 | 34 |
| β-strand | 283-288 | 6 | 34 |
| β-strand | 299-302 | 4 | 34 |
| β-strand | 344-348 | 5 | 35 |
| β-strand | 353-357 | 5 | 35 |
| β-strand | 363-369 | 7 | 35 |
| β-strand | 372-379 | 8 | 35 |
| α-helix | 381-390 | 10 | |
| α-helix | 397-399 | 3 | |
| β-strand | 406-411 | 6 | 36 |
| β-strand | 420-426 | 7 | 36 |
| β-strand | 431-438 | 8 | 36 |
| β-strand | 443-451 | 9 | 36 |
| β-strand | 494 | 1 | 30 |
| β-strand | 500-502 | 3 | 30 |
| β-strand | 506-512 | 7 | 30 |
| β-strand | 536-543 | 8 | 30 |
| α-helix | 545-551 | 7 | |
| β-strand | 554-561 | 8 | 30 |
| β-strand | 567-572 | 6 | 31 |
| β-strand | 600-605 | 6 | 31 |
| β-strand | 609-614 | 6 | 31 |
| α-helix | 617-623 | 7 | |
| α-helix | 629-635 | 7 | |
| α-helix | 637-649 | 13 | |
| α-helix | 655-665 | 11 | |
| α-helix | 708-719 | 12 | |
| β-strand | 727 | 1 | 37 |
| β-strand | 730-732 | 3 | 38 |
| β-strand | 742-744 | 3 | 38 |
| α-helix | 749-768 | 20 | |
| α-helix | 770-772 | 3 | |
| α-helix | 788-814 | 27 | |
| α-helix | 819-830 | 12 | |
| α-helix | 838-845 | 8 | |
| β-strand | 848 | 1 | 37 |
| α-helix | 849-853 | 5 | |
| α-helix | 857-876 | 20 | |
| α-helix | 881-891 | 11 | |
| α-helix | 898-915 | 18 | |
| α-helix | 922-937 | 16 | |
| α-helix | 939-941 | 3 | |
| α-helix | 944-956 | 13 | |
| α-helix | 960-974 | 15 | |
| α-helix | 979-985 | 7 | |
| α-helix | 995-1022 | 28 | |
| α-helix | 1035-1049 | 15 | |
| α-helix | 1053-1065 | 13 | |
| α-helix | 1069-1072 | 4 | |
| α-helix | 1080-1089 | 10 | |
| α-helix | 1092-1104 | 13 | |
| α-helix | 1108-1119 | 12 | |
| α-helix | 1127-1141 | 15 | |
| α-helix | 1150-1178 | 29 | |
| α-helix | 1185-1195 | 11 | |
| α-helix | 1202-1205 | 4 | |
| α-helix | 1206-1210 | 5 | |
| α-helix | 1216-1225 | 10 | |
| α-helix | 1231-1246 | 16 | |
| α-helix | 1256-1273 | 18 | |
| α-helix | 1285-1295 | 11 | |
| α-helix | 1308-1314 | 7 | |
| α-helix | 1318-1331 | 14 | |
| α-helix | 1336-1353 | 18 | |
| α-helix | 1355-1358 | 4 | |
| α-helix | 1363-1367 | 5 | |
| α-helix | 1380-1386 | 7 | |
Chains 3 and 4: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-16 | 14 | |
Chains 7 and 8: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 69-82 | 14 | |
Chains A and G: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 638-690 | 53 | |
| α-helix | 694-704 | 11 | |
| α-helix | 707-724 | 18 | |
| α-helix | 745-749 | 5 | |
| α-helix | 757-774 | 18 | |
| α-helix | 790-815 | 26 | |
Chain b: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 239-270 | 32 | |
Chains B and H: 6 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 310-314 | 5 | 80 |
| α-helix | 333-340 | 8 | |
| β-strand | 348-352 | 5 | 80 |
| α-helix | 356-388 | 33 | |
| β-strand | 391 | 1 | 81 |
| β-strand | 393 | 1 | 81 |
| α-helix | 395-418 | 24 | |
| α-helix | 436-446 | 11 | |
| α-helix | 450-472 | 23 | |
| α-helix | 508-534 | 27 | |
Chain c: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 313-317 | 5 | |
| α-helix | 319-324 | 6 | |
22 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Spoke connector | 3, 4, 7, 8, a, b, c, d, e, f, g, h, i, j, k, l, m, n | protein | 37 | Saccharomyces cerevisiae | |
| Nucleoporin NUP170 | 0, Y | protein | 1502 | Saccharomyces cerevisiae | P38181 (AlphaFold model) |
| Nucleoporin NUP157 | 1, Z | protein | 1391 | Saccharomyces cerevisiae | P40064 (AlphaFold model) |
| Nucleoporin NSP1 | A, D, G, J | protein | 823 | Saccharomyces cerevisiae | P14907 (AlphaFold model) |
| Nucleoporin NUP57 | B, E, H, K | protein | 541 | Saccharomyces cerevisiae | P48837 (AlphaFold model) |
| Nucleoporin NUP49/NSP49 | C, F, I, L | protein | 472 | Saccharomyces cerevisiae | Q02199 |
| Nucleoporin NUP192 | M, O | protein | 1683 | Saccharomyces cerevisiae | P47054 |
| Nucleoporin NUP188 | N, P | protein | 1655 | Saccharomyces cerevisiae | P52593 |
| Nucleoporin NIC96 | Q, R, S, T | protein | 839 | Saccharomyces cerevisiae | P34077 |
| Nucleoporin NUP53 | U, W | protein | 475 | Saccharomyces cerevisiae | Q03790 |
| Nucleoporin 59 | V, X | protein | 528 | Saccharomyces cerevisiae | Q05166 |
Sequence of entity 1 (3, 4, 7, 8, a, b, c, d, e, f, g, h, i, j, k, l, m, n), FASTA
>8TJ5_1 Spoke connector (chains 3, 4, 7, 8, a, b, c, d, e, f, g, h, i, j, k, l, m, n)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 2 (0, Y), FASTA
>8TJ5_2 Nucleoporin NUP170 (chains 0, Y)
MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPI
TGSNPLMRASAMGATSGSINPNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPV
LDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEILHEFSTSQTKTDMGIFPELN
RCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMEL
FMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSG
SDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLT
IDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRIIGTTTARAAPILGPKYLKI
VKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQE
LLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQ
QTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLE
TAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFE
DLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRY
SVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRL
LRDIWGRHVFMTFTDNRVTSHAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIE
YYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDKTEEVANQAESIAINAMIKMV
QSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTK
SLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRN
YDSLNYHLKNATALLEQIVDDLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLA
CQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEKKQSSKTQNQISISNDDEVK
LRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNIL
WVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLAS
RIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEI
ALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQD
SEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSD
NSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFY
KE
Sequence of entity 3 (1, Z), FASTA
>8TJ5_3 Nucleoporin NUP157 (chains 1, Z)
MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSSRSFLSERKTRKDVLN
KYGEAGNTIESELRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKG
LDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKL
ILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTISFNDR
THELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVWELQYNCSENLFNSKSN
KICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAGTEEETISQLEVDQSRGVLHTLSTK
SIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLLSNRAFKIAKIVSISMCENNDL
FLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNKSFIIGHHPLNTHDT
GPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYV
SAPDYGILKNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLK
VAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSYGLSEACSTALYLACKFNKSEHIKSS
ALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYGSALLITRLF
SQIWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPK
GSNAITASDAESIAMNALILLINSIKDALSLINVFYEDIDAFKSLLNTLMGAGGVYDSKT
REYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTSADYIVNVLKERFGSFCHSAD
ILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQ
PKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTS
IEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFV
LPYLKERAEKSLEISNLLWFYLFKEEHFLEAADVLYALASSDFDLKLSERIECLARANGL
CDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVL
PLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQES
FLSSISNTLIRIGKTTRDTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLK
LYYILSRIIENSEGNVELAKKEMVWLIKDWYQSDSDLRGSIAPEQIKKLEKYDPNTDPVQ
DYVKDRHHGLK
Sequence of entity 4 (A, D, G, J), FASTA
>8TJ5_4 Nucleoporin NSP1 (chains A, D, G, J)
MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFGFNNSAPNNTNNANSSI
TPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQTKSNGTAGG
NTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGNANTSNNLFGATANANKPAFS
FGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFG
SGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNKTTNTTPSFSFGAKSDENKAGATSK
PAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAF
SFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSFGAKPEEKKDDNSSKPAFSFG
AKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKS
DEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAFSFGAKANEK
KESDESKSAFSFGSKPTGKEEGDGAKAAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKT
EESSTGKSTADVKSSDSLKLNSKPVELKPVSLDNKTLDDLVTKWTNQLTESASHFEQYTK
KINSWDQVLVKGGEQISQLYSDAVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEA
LLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTT
NIDINNEDENIQLIKILNSHFDALRSLDDNSTSLEKQINSIKK
Sequence of entity 5 (B, E, H, K), FASTA
>8TJ5_5 Nucleoporin NUP57 (chains B, E, H, K)
MFGFSGSNNGFGNKPAGSTGFSFGQNNNNTNTQPSASGFGFGGSQPNSGTATTGGFGANQ
ATNTFGSNQQSSTGGGLFGNKPALGSLGSSSTTASGTTATGTGLFGQQTAQPQQSTIGGG
LFGNKPTTTTGGLFGNSAQNNSTTSGGLFGNKVGSTGSLMGGNSTQNTSNMNAGGLFGAK
PQNTTATTGGLFGSKPQGSTTNGGLFGSGTQNNNTLGGGGLFGQSQQPQTNTAPGLGNTV
STQPSFAWSKPSTGSNLQQQQQQQIQVPLQQTQAIAQQQQLSNYPQQIQEQVLKCKESWD
PNTTKTKLRAFVYNKVNETEAILYTKPGHVLQEEWDQAMEKKPSPQTIPIQIYGFEGLNQ
RNQVQTENVAQARIILNHILEKSTQLQQKHELDTASRILKAQSRNVEIEKRILKLGTQLA
TLKNRGLPLGIAEEKMWSQFQTLLQRSEDPAGLGKTNELWARLAILKERAKNISSQLDSK
LMVFNDDTKNQDSMSKGTGEESNDRINKIVEILTNQQRGITYLNEVLEKDAAIVKKYKNK
T
Sequence of entity 6 (C, F, I, L), FASTA
>8TJ5_6 Nucleoporin NUP49/NSP49 (chains C, F, I, L)
MFGLNKASSTPAGGLFGQASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTGG
LGASFGQQQQQSQTNAFGGSATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNA
QTSRGLFGNNNTNNINNSSSGMNNASAGLFGSKPAGGTSLFGNTSTSSAPAQNQGMFGAK
PAGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQ
QLQQQPQMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHLKADTID
HDELIDSIPRDVAYLLKSESATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTP
GSKISSNDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNGIDTDLFGAPNNPNSTAITAD
LGSSEAENLLQLKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASLSI
Sequence of entity 7 (M, O), FASTA
>8TJ5_7 Nucleoporin NUP192 (chains M, O)
MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQLEKGEIELSD
GSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTANNGKVQYFLRRQYILQIVSFI
VNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQQINKAQILENYNALFQQNIK
FRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHL
FASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTM
DFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQDKSMELFYDIRSLLERHIPRLIPKQL
LDDEKIFSQTTNSTYNPASATDNMSGRGLWNPSYPGMMSTTGTARLNSMPNNVNEYSYTT
IVLSDQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLER
FFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENA
LNVYHYFGENSSISWKNIAQCLSDYTKKISNFNSSLHKRQQFSESTHNDIDSTAVALEEG
LNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNL
VPKLESSRTKFWSFLDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIH
SRENNSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPI
LKIIYTGLCSFDYSVILNSIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSI
FNVVDVGVDQLSIELEGGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFL
PKNYSLHGLRSFYDAIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLS
KRNKLLTIFDSVDESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTIS
HLLLGFQVSNVISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAAL
EIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNGSPFDNSTEEKCKNFIE
SESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDP
LNYGNICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSN
SFSLTVSKEQFLKDADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLE
PSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDKGTVDGR
LYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKKLVEI
IWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKNTDALLN
STTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSFLKVDPDLG
LDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMGSSNK
AVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLCTLTGYQ
NND
Sequence of entity 8 (N, P), FASTA
>8TJ5_8 Nucleoporin NUP188 (chains N, P)
MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFLKANKTNLIESLNTIRQ
NVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAVEFFMSERSSRLHIVYSLLVNP
DIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSLAHDYNNDQDMFTIVSLVQLK
KFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQNQFVEFCRNINSTDKSIDTSSLQ
LYKFQNFQDLSYLSETLISRISSLFTITTILILGLNTSIAQFDIQSPLYMDTETFDTVNS
ALENDVATNIVNEDPIFHPMIHYSWSFILYYRRALQSSESFDDSDITKFALFAESHDVLQ
KLNTLSEILSFDPVYTTVITVFLEFSLNFIPITASTSRVFAKIISKAPEQFIENFLTNDT
FEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICSFAVTKSSLNDLDYDLIAD
TITNSSSSSDIIVPDLIELKSDLLVAPPLENENSNCLLSIPKSTKGKILTIKQQQQQQQQ
QNGQQPPTTSNLIIFLYKFNGWSLVGRILQNLLHSYMEKGTQLDDLQHELMISIIKLVTN
VVDPKTSIEKSSEILSYLSNSLDTSASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEF
MTMLTPNYLHLVSSYLNKSDLLDKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIR
ESLSLKNIHISKRSKIDIINKLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLH
DVFTINPHQKDQLIISSSANKLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKIL
GNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLEKLLFINSSKLVDVYTLPSYVHFKVQI
IELLSYLVEAPWNDDYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLL
ESKQDGLSILFLTGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETI
TYVLNTWTNSKIFIKDPKFVNSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVE
IFALCIYNSTDSNSEILNFLNQEDLFELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQ
SFQKIPLSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYE
ISTAKAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFY
ILYSFKLSGKLLKEEKIIELMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLE
LVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHTTQIVNLED
NTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDEPILG
QITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNIWSNGLL
SIVLLLLSQFGIKVLPETCLFVSYFGKQIKSTIYNWGDNKLAVSSSLIKETNQLVLLQKM
LNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSAALSKFLTHPKYLNSRIIPTT
LEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV
Sequence of entity 9 (Q, R, S, T), FASTA
>8TJ5_9 Nucleoporin NIC96 (chains Q, R, S, T)
MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKN
KASKDYTKAHYLLANSGLSFEDVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEEN
ILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFGILIQDKKTVDHKKSISSLDP
KLPSWGNKGNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFIS
ILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLAT
NVNKIKSFIDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANI
KKVEQSFLTYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDL
SRKNIPAVTLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQ
TLLLSGLYGLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILAN
YTKSFRYSDPRVAVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARI
PGVIEERQPLLHVRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSL
LSDTLSASDLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNI
SSIRELYFNKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLS
CISNMIHILNESKYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL
Sequence of entity 10 (U, W), FASTA
>8TJ5_10 Nucleoporin NUP53 (chains U, W)
MADLQKQENSSRFTNVSVIAPESQGQHEQQKQQEQLEQQKQPTGLLKGLNGFPSAPQPLF
MEDPPSTVSGELNDNPAWFNNPRKRAIPNSIIKRSNGQSLSPVRSDSADVPAFSNSNGFN
NVTFGSKKDPRILKNVSPNDNNSANNNAHSSDLGTVVFDSNEAPPKTSLADWQKEDGIFS
SKTDNIEDPNLSSNITFDGKPTATPSPFRPLEKTSRILNFFDKNTKTTPNTASSEASAGS
KEGASTNWDDHAIIIFGYPETIANSIILHFANFGEILEDFRVIKDFKKLNSKNMSKSPSL
TAQKYPIYTGDGWVKLTYKSELSKSRALQENGIIMNGTLIGCVSYSPAALKQLASLKKSE
EIINNKTSSQTSLSSKDLSNYRKTEGIFEKAKAKAVTSKVRNAEFKVSKNSTSFKNPRRL
EIKDGRSLFLRNRGKIHSGVLSSIESDLKKREQASKSKKSWLNRLNNWLFGWNDL
Sequence of entity 11 (V, X), FASTA
>8TJ5_11 Nucleoporin 59 (chains V, X)
MFGIRSGNNNGGFTNLTSQAPQTTQMFQSQSQLQPQPQPQPQQQQQHLQFNGSSDASSLR
FGNSLSNTVNANNYSSNIGNNSINNNNIKNGTNNISQHGQGNNPSWVNNPKKRFTPHTVI
RRKTTKQNSSSDINQNDDSSSMNATMRNFSKQNQDSKHNERNKSAANNDINSLLSNFNDI
PPSVTLQDWQREDEFGSIPSLTTQFVTDKYTAKKTNRSAYDSKNTPNVFDKDSYVRIANI
EQNHLDNNYNTAETNNKVHETSSKSSSLSAIIVFGYPESISNELIEHFSHFGHIMEDFQV
LRLGRGINPNTFRIFHNHDTGCDENDSTVNKSITLKGRNNESNNKKYPIFTGESWVKLTY
NSPSSALRALQENGTIFRGSLIGCIPYSKNAVEQLAGCKIDNVDDIGEFNVSMYQNSSTS
STSNTPSPPNVIITDGTLLREDDNTPAGHAGNPTNISSPIVANSPNKRLDVIDGKLPFMQ
NAGPNSNIPNLLRNLESKMRQQEAKYRNNEPAGFTHKLSNWLFGWNDL
Primary citation
Implications of a multiscale structure of the yeast nuclear pore complex. Akey, C.W., Echeverria, I., Ouch, C. et al. Mol Cell (2023) 83:3283-3302.e5. DOI 10.1016/j.molcel.2023.08.025 · PubMed
Other PDB entries of the same protein (UniProt P38181 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3I5Q 2.2 Å, Nup170(aa1253-1502) at 2.2 A, S.cerevisiae
- 3I5P 3.2 Å, Nup170(aa979-1502), S.cerevisiae
- 7WOO 3.71 Å, Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear…
- 7WOT 3.73 Å, Cryo-EM structure of the inner ring monomer of the Saccharomyces cerevisiae nuclear pore…
- 7N85 7.6 Å, Inner ring spoke from the isolated yeast NPC
- 7N9F 37.0 Å, Structure of the in situ yeast NPC
- 8ZZA Integrative structure and functional anatomy of a single spoke of a nuclear pore complex
- 8ZZB Integrative structure and functional anatomy of three spokes of a nuclear pore complex
- 8ZZC Integrative structure and functional anatomy of eight spokes of a nuclear pore complex
- 9A0F Integrative model of the wild type yeast nuclear pore complex
- 9A0G Integrative model of Nup116 knockout (at 25C) yeast nuclear pore complex
- 9A1P Comprehensive structure and functional adaptations of the yeast nuclear pore complex
Browse structure collections
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