7Z8R: CAND1-CUL1-RBX1

CAND1-CUL1-RBX1. Determined by electron microscopy at 2.7 Å resolution. Released 19 Apr 2023.

Method
Electron microscopy
Resolution
2.7 Å
Organism
Homo sapiens
Chains
3
Atoms
15,124
Mol. weight
239.47 kDa
Ligands
ZN
Released
19 Apr 2023

Explore 7Z8R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Z8R contains 116 α-helices and 21 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C: 38 helices, 11 β-strands

ElementResiduesLengthSheet
α-helix19-3113
β-strand3711
α-helix39-5315
α-helix86-10419
α-helix113-13624
α-helix138-15114
α-helix159-1679
α-helix168-1725
α-helix176-19116
α-helix198-21013
α-helix226-2283
α-helix229-2335
α-helix234-25219
α-helix257-27822
α-helix281-2833
α-helix284-29613
α-helix297-2993
α-helix300-31213
α-helix316-32611
α-helix334-35522
α-helix356-3605
α-helix363-38422
α-helix389-40416
α-helix407-4126
α-helix417-43014
α-helix442-45312
α-helix459-47517
α-helix482-49514
α-helix499-52628
β-strand534-54182
α-helix557-5593
α-helix560-57314
β-strand577-592162
β-strand599-60462
α-helix605-6128
α-helix613-6153
β-strand619-62133
α-helix622-6298
α-helix633-64513
β-strand649-65023
β-strand668-67143
β-strand681-68332
α-helix689-72133
β-strand724-72634
α-helix727-73812
α-helix746-75813
β-strand762-76434
α-helix7651
β-strand771-77444
Chain D: 74 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix7-148
α-helix20-3314
α-helix46-5611
α-helix62-7615
α-helix81-9515
α-helix100-11617
α-helix118-1192
α-helix128-14316
α-helix148-16417
α-helix173-1808
α-helix181-1855
α-helix189-20416
α-helix208-22417
α-helix228-24417
α-helix250-2523
α-helix253-26311
α-helix269-28517
α-helix291-2933
α-helix294-30512
α-helix347-36216
α-helix368-3703
α-helix371-3755
α-helix376-3816
α-helix382-3843
α-helix388-40518
α-helix424-44219
α-helix448-46417
α-helix473-48412
α-helix491-50616
α-helix510-5167
α-helix517-52812
α-helix533-55018
α-helix562-57615
α-helix583-60018
α-helix607-61812
α-helix625-63612
α-helix645-65713
α-helix658-6603
α-helix664-68017
α-helix682-6843
α-helix687-6948
α-helix706-72217
α-helix724-7296
α-helix733-74210
α-helix750-76516
α-helix772-78514
α-helix793-80917
α-helix811-8133
α-helix814-82613
α-helix832-84817
α-helix857-8659
α-helix870-88617
α-helix888-90114
α-helix909-91810
α-helix922-9254
α-helix929-93911
α-helix947-96014
α-helix963-97513
α-helix979-98911
α-helix990-9923
α-helix1001-101212
α-helix1013-10153
α-helix1020-103617
α-helix1038-10403
α-helix1042-10443
α-helix1045-105410
β-strand1064-106851
β-strand1071-107551
α-helix1079-109517
α-helix1104-11129
α-helix1117-113014
α-helix1135-11406
α-helix1142-115312
α-helix1163-118422
α-helix1193-120412
α-helix1206-12149
Chain R: 4 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand22-35142
β-strand4115
β-strand4815
α-helix54-574
α-helix601
α-helix63-664
β-strand70-7346
β-strand78-8036
α-helix81-877
β-strand9317
β-strand10017
β-strand103-10536

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cullin-1Cprotein776Homo sapiensQ13616 (AlphaFold model)
Cullin-associated NEDD8-dissociated protein 1Dprotein1238Homo sapiensQ86VP6 (AlphaFold model)
E3 ubiquitin-protein ligase RBX1, N-terminally processedRprotein106Homo sapiensP62877 (AlphaFold model)
Sequence of entity 1 (C), FASTA
>7Z8R_1 Cullin-1 (chains C)
MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN
QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT
QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT
NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT
ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL
EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL
NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE
LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA
SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL
SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT
LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE
VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK
MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Sequence of entity 2 (D), FASTA
>7Z8R_2 Cullin-associated NEDD8-dissociated protein 1 (chains D)
GSPEFPGRMASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKM
ILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKT
VIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNF
HPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTR
TYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYP
HVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRA
AAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWL
CDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQH
IPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPF
YKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISC
MGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGV
PILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMA
ISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGY
MDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTD
SIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYL
PFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVV
ECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFL
KTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFK
HTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLST
LCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKS
PLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
Sequence of entity 3 (R), FASTA
>7Z8R_3 E3 ubiquitin-protein ligase RBX1, N-terminally processed (chains R)
GSMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQAS
ATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn3

Primary citation

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Baek, K., Scott, D.C., Henneberg, L.T. et al. Cell (2023) 186:1895. DOI 10.1016/j.cell.2023.02.035 · PubMed

Other PDB entries of the same protein (UniProt Q13616 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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