7ZSB: DNA-directed RNA polymerase II subunit RPB1

Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C. Determined by electron microscopy at 6.6 Å resolution. Released 16 Nov 2022.

Method
Electron microscopy
Resolution
6.6 Å
Organisms
Saccharomyces cerevisiae, synthetic construct, Xenopus laevis
Chains
38
Atoms
86,808
Mol. weight
1541.85 kDa
Ligands
ZN, SF4, MG
Released
16 Nov 2022

Explore 7ZSB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ZSB contains 479 α-helices and 450 β-strands across 36 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 39 helices, 29 β-strands

ElementResiduesLengthSheet
β-strand2-54116
β-strand8-114116
β-strand171117
α-helix19-3416
β-strand37-415118
α-helix42-432
β-strand451119
α-helix49-6214
β-strand69-735118
α-helix76-9722
β-strand104-1074118
α-helix126-13712
α-helix140-1478
α-helix157-1648
β-strand174-1763118
α-helix178-18811
α-helix192-1987
β-strand205-2095118
α-helix211-2144
α-helix216-2238
β-strand231-2355118
α-helix240-2478
β-strand250-2534120
α-helix254-27724
α-helix280-29011
α-helix295-2984
α-helix313-3153
α-helix328-34619
β-strand352-3543120
α-helix356-36611
α-helix371-3744
α-helix377-38812
α-helix394-3963
α-helix397-41115
β-strand416-4216120
β-strand4231121
β-strand4321121
β-strand434-4396120
α-helix447-4526
β-strand456-4605118
α-helix469-4724
β-strand477-4826118
β-strand492-4976122
β-strand4991123
α-helix5041
β-strand5051123
α-helix5061
α-helix510-5123
α-helix516-53217
β-strand536-5416122
α-helix544-55714
α-helix559-5668
β-strand568-5714122
α-helix576-59116
β-strand596-6016122
α-helix614-6163
β-strand619-6235122
α-helix633-64513
α-helix650-66617
β-strand6711119
β-strand677-6826122
α-helix686-6883
α-helix695-7006
β-strand7081122
α-helix710-72415
α-helix727-7293
β-strand7391117
α-helix741-75111
Chain 1: 33 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand5-84124
β-strand13-186124
β-strand26-316124
β-strand37-415124
β-strand47-504113
β-strand60-634113
β-strand87-882113
β-strand90-912124
α-helix94-12027
α-helix171-1755
α-helix178-18710
α-helix190-1956
α-helix196-2005
α-helix206-2116
α-helix214-22512
α-helix228-2303
α-helix233-2364
β-strand246-2516112
α-helix253-26210
α-helix264-27310
α-helix280-2889
α-helix291-2977
α-helix299-3013
α-helix309-3124
α-helix315-32915
α-helix332-3343
α-helix335-3373
α-helix339-3435
α-helix353-3542
α-helix356-3583
β-strand3621125
β-strand3681125
α-helix371-38717
α-helix414-4196
α-helix426-4283
β-strand4321126
β-strand4341127
α-helix442-4443
α-helix466-48217
α-helix486-4894
α-helix495-51420
α-helix537-5393
α-helix544-56926
α-helix576-60328
α-helix609-6157
α-helix617-63822
Chain 2: 24 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix7-159
α-helix19-257
α-helix29-3810
α-helix41-5111
β-strand57-582128
α-helix59-657
β-strand661129
α-helix68-703
α-helix71-8313
β-strand87-926128
β-strand95-1006128
α-helix102-11312
β-strand1241130
α-helix131-1366
α-helix137-15014
α-helix161-1699
β-strand174-1763131
β-strand181-1833131
α-helix186-1938
α-helix196-21015
α-helix219-23012
β-strand237-2382130
α-helix244-25613
β-strand259-2613130
β-strand268-2714130
α-helix2721
α-helix273-2797
β-strand338-3414132
β-strand346-3505132
α-helix354-3607
β-strand365-3706132
β-strand374-3774132
α-helix380-3878
α-helix393-40210
β-strand4041132
α-helix406-42217
α-helix435-44814
β-strand452-460957
α-helix465-47713
β-strand481-485557
β-strand490-494557
α-helix498-5069
Chain 3: 4 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand29-302133
β-strand37-382133
α-helix40-4910
β-strand521134
β-strand631134
β-strand69-702133
α-helix76-8914
α-helix103-12220
α-helix126-13813
Chain 4: 16 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand25-30630
α-helix34-4310
α-helix49-6719
β-strand72-79830
β-strand82-87630
α-helix89-902
α-helix116-13823
α-helix149-16618
β-strand175-181730
α-helix194-20512
β-strand210-215630
α-helix222-2309
β-strand235-238430
α-helix244-2518
β-strand2621129
α-helix268-2703
β-strand275131
β-strand282131
α-helix2831
β-strand286-289432
β-strand295-296232
α-helix299-3002
α-helix301-3033
β-strand304133
α-helix3101
β-strand311133
α-helix312-3132
α-helix314-3207
α-helix322-3243
Chain 5: 3 helices, 3 β-strands
ElementResiduesLengthSheet
β-strand3-11957
α-helix14-2613
β-strand31-34457
β-strand39-42457
α-helix44-463
α-helix47-5913
Chain 6: 19 helices, 22 β-strands
ElementResiduesLengthSheet
α-helix97-11014
β-strand1181127
β-strand120162
β-strand124-132963
α-helix134-1374
α-helix145-16319
β-strand168-175863
β-strand178-186963
α-helix189-20113
α-helix203-2042
α-helix210-22011
β-strand229-235763
α-helix247-25610
β-strand259-265763
α-helix271-28010
β-strand288-290363
α-helix294-30411
α-helix307-3082
β-strand309162
α-helix3101
β-strand3111126
β-strand319-322432
β-strand326-327264
β-strand334-335265
β-strand342-343265
β-strand347-348264
β-strand361-363366
β-strand368-370366
α-helix373-38311
α-helix385-3895
β-strand390-391267
α-helix392-3932
α-helix397-3982
β-strand402168
α-helix4081
β-strand409168
α-helix410-4112
β-strand427-428267
β-strand435-436267
α-helix438-4447
α-helix452-4565
Chain 7: 36 helices, 30 β-strands
ElementResiduesLengthSheet
α-helix105-1073
α-helix110-1123
β-strand117-1182132
α-helix122-1243
β-strand132-134371
β-strand140-144571
α-helix150-16011
β-strand162-165471
β-strand170-174571
α-helix177-1859
α-helix190-20011
β-strand201171
α-helix204-2063
α-helix207-21711
β-strand223-227572
β-strand232-236572
α-helix240-2445
β-strand251173
β-strand314-317472
β-strand318173
α-helix320-3223
α-helix323-33210
β-strand338172
β-strand340-341274
α-helix350-3512
β-strand356175
α-helix364-37310
β-strand379-380274
β-strand382-385476
α-helix392-40312
β-strand407-411576
α-helix414-42714
β-strand428175
β-strand435-438476
β-strand452-456576
α-helix457-4604
α-helix468-47912
α-helix4811
β-strand482-488776
α-helix490-4923
α-helix498-5003
α-helix501-5044
β-strand507-514876
α-helix522-5265
α-helix527-5304
β-strand534-537476
α-helix540-5456
β-strand552-559877
α-helix560-5623
α-helix563-5697
α-helix574-5829
α-helix585-60016
β-strand605-608477
α-helix612-62211
β-strand626-627277
α-helix633-64412
β-strand651-654477
α-helix656-6583
β-strand669-672477
α-helix680-69011
α-helix694-6974
β-strand703-710877
α-helix715-72915
β-strand734-736377
α-helix753-76614
α-helix833-8353

28 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-directed RNA polymerase II subunit RPB1Aprotein1733Saccharomyces cerevisiaeP04050 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2Bprotein1224Saccharomyces cerevisiaeP08518 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3Cprotein347Saccharomyces cerevisiaeP16370 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4Dprotein221Saccharomyces cerevisiaeP20433 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1Eprotein215Saccharomyces cerevisiaeP20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2Fprotein155Saccharomyces cerevisiaeP20435
DNA-directed RNA polymerase II subunit RPB7Gprotein177Saccharomyces cerevisiaeP34087
DNA-directed RNA polymerases I, II, and III subunit RPABC3Hprotein146Saccharomyces cerevisiaeP20436
DNA-directed RNA polymerase II subunit RPB9Iprotein122Saccharomyces cerevisiaeP27999
DNA-directed RNA polymerases I, II, and III subunit RPABC5Jprotein70Saccharomyces cerevisiaeP22139
DNA-directed RNA polymerase II subunit RPB11Kprotein120Saccharomyces cerevisiaeP38902
DNA-directed RNA polymerases I, II, and III subunit RPABC4Lprotein70Saccharomyces cerevisiaeP40422

22 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>7ZSB_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGS
IDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNE
LMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLK
LVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLP
VPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLE
LDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNA
DFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSP
KDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVR
FLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRR
LVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNI
RRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMT
LNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEH
TTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRA
AMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHML
KKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVP
GIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGG
LTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGA
FDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGS
NDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTS
PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS
PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR
Sequence of entity 2 (B), FASTA
>7ZSB_2 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQ
DIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLR
NLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCY
LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEI
RSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH
ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVS
QVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLS
LMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETL
RTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAK
LMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEEND
LDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIA
PGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDG
LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKK
LMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAA
KLLFQELMAMNITPRLYTDRSRDF
Sequence of entity 3 (C), FASTA
>7ZSB_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MGSHHHHHHSNSGLNDIFEAQKIEWHEDTGSSEGPQVKIREASKDNVDFILSNVDLAMAN
SLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLIPLQSMDIEQLEYSRDCFCEDH
CDKCSVVLTLQAFGESESTTNVYSKDLVIVSNLMGRNIGHPIIQDKEGNGVLICKLRKGQ
ELKLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEWPQSKNCEYED
PPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQKKVASILLALTQMDQDKVN
FASGDNNTASNMLGSNEDVMMTGAEQDPYSNASQMGNTGSGGYDNAW
Sequence of entity 4 (D), FASTA
>7ZSB_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIK
EALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLDEDDVNADDDDFMHSETRE
KELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQL
GSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
Sequence of entity 5 (E), FASTA
>7ZSB_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
Sequence of entity 6 (F), FASTA
>7ZSB_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
Sequence of entity 7 (G), FASTA
>7ZSB_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTGKFGYILCVLDYDNIDIQRGR
ILPTDGSAEFNVKYRAVVFKPFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLT
FNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAIGSIKEDYLGAIHHHHHH
Sequence of entity 8 (H), FASTA
>7ZSB_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR
Sequence of entity 9 (I), FASTA
>7ZSB_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQ
DIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQ
FS
Sequence of entity 10 (J), FASTA
>7ZSB_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD
Sequence of entity 11 (K), FASTA
>7ZSB_11 DNA-directed RNA polymerase II subunit RPB11 (chains K)
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAA
YKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF
Sequence of entity 12 (L), FASTA
>7ZSB_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn17
SF4Iron/sulfur clusterFe4 S41
MGMagnesium ionMg1

Primary citation

Structures of transcription preinitiation complex engaged with the +1 nucleosome. Wang, H., Schilbach, S., Ninov, M. et al. Nat Struct Mol Biol (2023) 30:226-232. DOI 10.1038/s41594-022-00865-w · PubMed

Other PDB entries of the same protein (UniProt P04050 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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