Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode. Determined by X-ray diffraction at 2.4 Å resolution. Released 15 Oct 1989.
Explore 8ADH in 3D Show helices and sheets RCSB PDB PDBe
8ADH contains 19 α-helices and 23 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 7-13 | 7 | 1 |
| β-strand | 14 | 1 | 2 |
| β-strand | 22-28 | 7 | 1 |
| α-helix | 29-31 | 3 | |
| β-strand | 35-44 | 10 | 3 |
| α-helix | 47-54 | 8 | |
| β-strand | 63 | 1 | 2 |
| β-strand | 69-76 | 8 | 3 |
| β-strand | 88-91 | 4 | 3 |
| α-helix | 101-104 | 4 | |
| β-strand | 130-132 | 3 | 1 |
| β-strand | 135-136 | 2 | 1 |
| β-strand | 138 | 1 | 2 |
| β-strand | 147 | 1 | 1 |
| β-strand | 149-153 | 5 | 3 |
| α-helix | 154-156 | 3 | |
| β-strand | 157-159 | 3 | 3 |
| α-helix | 169-173 | 5 | |
| α-helix | 175-181 | 7 | |
| α-helix | 182-187 | 6 | |
| β-strand | 194-198 | 5 | 4 |
| α-helix | 202-213 | 12 | |
| β-strand | 218-222 | 5 | 4 |
| α-helix | 226-228 | 3 | |
| α-helix | 229-235 | 7 | |
| β-strand | 239-241 | 3 | 4 |
| α-helix | 243-245 | 3 | |
| α-helix | 250-257 | 8 | |
| β-strand | 262 | 1 | 5 |
| β-strand | 264-267 | 4 | 4 |
| α-helix | 272-280 | 9 | |
| β-strand | 282 | 1 | 5 |
| β-strand | 288-291 | 4 | 4 |
| α-helix | 306-309 | 4 | |
| β-strand | 313-316 | 4 | 4 |
| α-helix | 319-321 | 3 | |
| α-helix | 324-336 | 13 | |
| α-helix | 343-345 | 3 | |
| β-strand | 346-351 | 6 | 3 |
| α-helix | 352-354 | 3 | |
| α-helix | 355-363 | 9 | |
| β-strand | 369-373 | 5 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Apo-liver alcohol dehydrogenase | A | protein | 374 | Equus caballus | P00327 (AlphaFold model) |
>8ADH_1 APO-LIVER ALCOHOL DEHYDROGENASE (chains A) STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTP LPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPR GTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGY GSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN LSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFD LLRSGESIRTILTF
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode. Colonna-Cesari, F., Perahia, D., Karplus, M. et al. J Biol Chem (1986) 261:15273-15280. PubMed
Other PDB entries of the same protein (UniProt P00327 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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