8B7O: Auranofin-human H-chain ferritin

X-ray structure of Auranofin-human H-chain ferritin. Determined by X-ray diffraction at 1.17 Å resolution. Released 28 Dec 2022.

Method: X-ray diffraction
Resolution: 1.17 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,063
Mol. weight: 22.63 kDa
Ligands: FE, AU, MG
Released: 28 Dec 2022

Explore 8B7O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8B7O contains 8 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	14-41	28
α-helix	49-76	28
α-helix	86-88	3
α-helix	96-123	28
α-helix	127-133	7
α-helix	134-138	5
α-helix	139-158	20
α-helix	164-173	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ferritin heavy chain, N-terminally processed	AAA	protein	183	Homo sapiens	P02794 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>8B7O_1 Ferritin heavy chain, N-terminally processed (chains AAA)
TTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSH
EEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKL
ATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDN
ESG

Ligands and cofactors

ID	Name	Formula	Copies
FE	FE (III) ion	Fe	1
AU	Gold ion	Au	5
MG	Magnesium ion	Mg	8

Water and common crystallization additives (CL) are not listed.

Primary citation

Evaluation of Auranofin Loading within Ferritin Nanocages. Lucignano, R., Pratesi, A., Imbimbo, P. et al. Int J Mol Sci (2022) 23. DOI 10.3390/ijms232214162 · PubMed

Other PDB entries of the same protein (UniProt P02794 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6B8F 1.06 Å, Contracted Human Heavy-Chain Ferritin Crystal-Hydrogel Hybrid
6B8G 1.13 Å, Twice-Contracted Human Heavy-Chain Ferritin Crystal-Hydrogel Hybrid
7A6A 1.15 Å, 1.15 A structure of human apoferritin obtained from Titan Mono- BCOR microscope
6WYF 1.25 Å, Crystal structure of Human H-chain Ferritin variant 157C Delta C-star Modified with a…
6Z6U 1.25 Å, 1.25 A structure of human apoferritin obtained from Titan Mono-BCOR microscope
7RRP 1.27 Å, Apoferritin structure at 1.27 angstrom resolution determined from a 300 kV Titan Krios…
7A6B 1.33 Å, 1.33 A structure of human apoferritin obtained from Titan Mono- BCOR microscope
4Y08 1.34 Å, One minute iron loaded human H ferritin
7K3V 1.34 Å, Apoferritin structure at 1.34 angstrom resolution determined from a 300 kV Titan Krios…
7K3W 1.36 Å, Apoferritin structure at 1.36 angstrom resolution determined from a 300 kV Titan Krios…
9RGH 1.38 Å, X-ray structure of a polyoxidovanadate/human H-ferritin adduct obtained when the protein…
4OYN 1.43 Å, Fifteen minutes iron loaded human H ferritin

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