8BH3: DNA-PK Ku80 mediated dimer

DNA-PK Ku80 mediated dimer bound to PAXX. Determined by electron microscopy at 4.55 Å resolution. Released 7 Jun 2023.

Method: Electron microscopy
Resolution: 4.55 Å
Organism: Homo sapiens
Chains: 18
Atoms: 89,245
Mol. weight: 1682.47 kDa
Released: 7 Jun 2023

Explore 8BH3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8BH3 contains 585 α-helices and 215 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 207 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	11-22	12
α-helix	28-45	18
α-helix	52-71	20
α-helix	76-94	19
α-helix	98-100	3
α-helix	101-116	16
α-helix	118-121	4
α-helix	125-140	16
α-helix	150-160	11
α-helix	169-173	5
α-helix	174-178	5
α-helix	187-208	22
α-helix	210-212	3
α-helix	218-231	14
α-helix	241-251	11
α-helix	263-265	3
α-helix	266-277	12
α-helix	280-282	3
α-helix	290-302	13
α-helix	306-328	23
α-helix	333-340	8
α-helix	342-348	7
α-helix	358-375	18
α-helix	378-396	19
α-helix	410-423	14
α-helix	431-444	14
α-helix	451-468	18
α-helix	472-491	20
α-helix	525-527	3
α-helix	528-535	8
α-helix	538-546	9
α-helix	560-578	19
β-strand	583-584	2	1
β-strand	613-614	2	1
α-helix	617-633	17
α-helix	639-641	3
α-helix	645-659	15
α-helix	664-680	17
α-helix	698-717	20
α-helix	718-720	3
α-helix	726-734	9
α-helix	738-741	4
α-helix	745-761	17
α-helix	763-779	17
α-helix	782-785	4
α-helix	786-788	3
α-helix	789-792	4
α-helix	794-797	4
α-helix	835-838	4
α-helix	848-862	15
α-helix	864-867	4
α-helix	868-870	3
β-strand	894-895	2	2
β-strand	904-905	2	2
α-helix	910-919	10
α-helix	924-947	24
α-helix	959-973	15
α-helix	978-994	17
α-helix	1005-1014	10
α-helix	1023-1043	21
α-helix	1046-1051	6
α-helix	1056-1068	13
α-helix	1072-1089	18
α-helix	1093-1098	6
α-helix	1101-1117	17
α-helix	1123-1140	18
α-helix	1143-1146	4
β-strand	1149-1150	2	3
β-strand	1162-1163	2	3
α-helix	1165-1175	11
α-helix	1181-1194	14
α-helix	1206-1214	9
α-helix	1219-1222	4
α-helix	1232-1236	5
α-helix	1250-1273	24
α-helix	1278-1281	4
α-helix	1288-1300	13
α-helix	1327-1351	25
α-helix	1354-1356	3
α-helix	1357-1360	4
α-helix	1367-1370	4
α-helix	1372-1377	6
α-helix	1379-1381	3
α-helix	1390-1408	19
α-helix	1412-1422	11
α-helix	1427-1431	5
α-helix	1443-1460	18
α-helix	1469-1471	3
α-helix	1477-1489	13
α-helix	1505-1519	15
α-helix	1524-1532	9
β-strand	1537-1538	2	4
β-strand	1553-1554	2	4
α-helix	1556-1562	7
α-helix	1564-1573	10
α-helix	1577-1584	8
α-helix	1591-1606	16
α-helix	1613-1626	14
α-helix	1639-1655	17
α-helix	1668-1680	13
α-helix	1686-1693	8
α-helix	1696-1698	3
α-helix	1708-1718	11
α-helix	1734-1753	20
α-helix	1756-1766	11
α-helix	1775-1786	12
α-helix	1791-1805	15
α-helix	1816-1830	15
α-helix	1833-1850	18
α-helix	1863-1881	19
α-helix	1911-1920	10
α-helix	1935-1954	20
α-helix	2035-2047	13
α-helix	2095-2107	13
α-helix	2126-2134	9
α-helix	2140-2151	12
α-helix	2158-2160	3
α-helix	2161-2172	12
α-helix	2182-2194	13
α-helix	2206-2222	17
α-helix	2229-2245	17
α-helix	2254-2261	8
α-helix	2271-2282	12
α-helix	2301-2308	8
α-helix	2313-2328	16
α-helix	2330-2333	4
α-helix	2339-2350	12
α-helix	2358-2370	13
α-helix	2372-2377	6
α-helix	2379-2385	7
α-helix	2393-2402	10
α-helix	2412-2417	6
α-helix	2420-2425	6
α-helix	2429-2442	14
α-helix	2443-2445	3
α-helix	2448-2458	11
α-helix	2459-2461	3
α-helix	2467-2484	18
α-helix	2493-2508	16
α-helix	2515-2525	11
α-helix	2535-2544	10
α-helix	2551-2564	14
β-strand	2575	1	5
β-strand	2586-2588	3	6
α-helix	2724-2730	7
α-helix	2738-2764	27
α-helix	2766-2769	4
β-strand	2776-2778	3	6
β-strand	2786	1	5
α-helix	2787-2798	12
α-helix	2802-2820	19
α-helix	2826-2846	21
α-helix	2852-2864	13
α-helix	2873-2883	11
α-helix	2886-2899	14
α-helix	2920-2932	13
α-helix	2937-2943	7
α-helix	2951-2961	11
α-helix	2966-2977	12
α-helix	2988-3004	17
α-helix	3008-3015	8
α-helix	3019-3021	3
α-helix	3035-3054	20
α-helix	3060-3069	10
α-helix	3072-3092	21
α-helix	3096-3116	21
α-helix	3122-3142	21
α-helix	3156-3161	6
α-helix	3163-3167	5
α-helix	3176-3196	21
α-helix	3227-3248	22
α-helix	3256-3266	11
α-helix	3270-3287	18
α-helix	3292-3298	7
α-helix	3305-3307	3
α-helix	3313-3316	4
α-helix	3320-3343	24
α-helix	3348-3351	4
α-helix	3355-3363	9
α-helix	3370-3393	24
α-helix	3408-3427	20
α-helix	3442-3454	13
α-helix	3459-3462	4
α-helix	3465-3474	10
α-helix	3476-3482	7
α-helix	3483-3485	3
α-helix	3496-3498	3
α-helix	3499-3503	5
α-helix	3512-3524	13
α-helix	3530-3536	7
α-helix	3548-3561	14
α-helix	3565-3578	14
α-helix	3581-3596	16
α-helix	3605-3613	9
α-helix	3614-3618	5
α-helix	3629-3643	15
α-helix	3658-3668	11
α-helix	3685-3688	4
β-strand	3700	1	7
β-strand	3718	1	7
β-strand	3719	1	8
β-strand	3726-3728	3	9
β-strand	3736-3741	6	9
β-strand	3742	1	8
β-strand	3747-3753	7	9
α-helix	3759-3777	19
α-helix	3779-3784	6
β-strand	3793-3794	2	9
β-strand	3801-3804	4	9
β-strand	3809-3811	3	10
α-helix	3812-3817	6
α-helix	3822-3830	9
α-helix	3835-3838	4
α-helix	3854-3860	7
α-helix	3864-3877	14
α-helix	3882-3889	8
α-helix	3894-3917	24
α-helix	3925-3927	3
β-strand	3928-3931	4	10
β-strand	3936-3939	4	10
β-strand	3945	1	11
β-strand	3948	1	11
α-helix	3965-3969	5
α-helix	3979-3991	13
α-helix	3995-4002	8
α-helix	4040-4051	12
α-helix	4056-4068	13
α-helix	4074-4082	9
α-helix	4086-4089	4
α-helix	4090-4092	3
α-helix	4100-4110	11
α-helix	4113-4118	6
α-helix	4122-4124	3

Chain B: 18 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	36-43	8	12
α-helix	47-49	3
α-helix	57-58	2
α-helix	59-78	20
β-strand	82-88	7	12
β-strand	102-109	8	12
α-helix	113-120	8
α-helix	127-134	8
α-helix	143-156	14
β-strand	163-170	8	12
α-helix	174-176	3
α-helix	180-195	16
β-strand	199-204	6	12
α-helix	239-243	5
β-strand	260-262	3	13
β-strand	268-274	7	13
β-strand	277	1	14
α-helix	282-285	4
β-strand	288-289	2	15
β-strand	299-304	6	16
β-strand	317-322	6	17
β-strand	325-329	5	17
α-helix	331-336	6
β-strand	345-352	8	13
α-helix	353-355	3
β-strand	366-370	5	13
β-strand	376	1	18
α-helix	378-392	15
β-strand	394-400	7	13
β-strand	409-416	8	13
β-strand	419	1	19
β-strand	428	1	19
β-strand	431-436	6	13
β-strand	443	1	20
α-helix	456-468	13
β-strand	470	1	20
α-helix	475-477	3
α-helix	481-495	15
α-helix	511-518	8
α-helix	521-529	9

Chain C: 34 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	21
α-helix	18-21	4
β-strand	24	1	22
β-strand	27	1	22
α-helix	30-48	19
β-strand	53-59	7	21
β-strand	65	1	21
β-strand	77-84	8	21
α-helix	88-92	5
α-helix	93-97	5
α-helix	107-122	16
β-strand	129-135	7	21
α-helix	147-157	11
β-strand	160-165	6	21
α-helix	191-192	2
α-helix	194-196	3
α-helix	199-215	17
α-helix	218-223	6
β-strand	224-226	3	21
α-helix	227-231	5
α-helix	235-237	3
α-helix	243-246	4
β-strand	247-253	7	20
β-strand	257-268	12	20
β-strand	277-279	3	17
β-strand	289-294	6	16
β-strand	296	1	23
β-strand	304	1	23
β-strand	310-311	2	15
β-strand	312-316	5	24
β-strand	319-323	5	24
α-helix	326-331	6
β-strand	339-347	9	20
α-helix	348-350	3
α-helix	353-355	3
β-strand	357-366	10	20
α-helix	367	1
α-helix	371-387	17
β-strand	389-396	8	20
β-strand	404-412	9	20
β-strand	417-424	8	20
β-strand	430	1	14
α-helix	442-444	3
α-helix	445-447	3
α-helix	448-460	13
β-strand	462	1	13
β-strand	464-466	3	25
β-strand	473-475	3	25
α-helix	485-499	15
α-helix	504-506	3
α-helix	510-516	7
α-helix	518-519	2
α-helix	520-536	17
β-strand	540	1	18
α-helix	594-605	12
α-helix	610-621	12
α-helix	629-648	20
α-helix	652-668	17
α-helix	675-681	7
α-helix	694-703	10
α-helix	720-722	3
α-helix	723-728	6

Chain D: 5 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	8-11	4	26
α-helix	17-18	2
β-strand	20-25	6	26
β-strand	38-42	5	26
β-strand	47-49	3	26
α-helix	54-63	10
α-helix	72-82	11
β-strand	85-90	6	26
β-strand	93-98	6	26
β-strand	105-111	7	26
α-helix	112-113	2
α-helix	114-140	27

Chain G: 4 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	27
β-strand	17-21	5	27
β-strand	33-37	5	27
β-strand	42	1	27
β-strand	43-45	3	28
α-helix	53-56	4
α-helix	61-62	2
α-helix	65-74	10
β-strand	89	1	29
β-strand	94	1	29
β-strand	98-101	4	30
β-strand	104-107	4	30
β-strand	113-115	3	28
α-helix	119-199	81

Chain H: 4 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	2-8	7	31
β-strand	18-24	7	31
α-helix	28-30	3
β-strand	35-37	3	32
β-strand	42-44	3	32
α-helix	49-51	3
α-helix	64-72	9
β-strand	101	1	33
β-strand	104	1	33
α-helix	119-200	82

Chain I: 11 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	663-666	4	34
α-helix	675-684	10
β-strand	688-690	3	34
β-strand	697-701	5	34
α-helix	707-714	8
β-strand	720-721	2	34
α-helix	723-732	10
α-helix	735-737	3
β-strand	743	1	34
α-helix	748-757	10
β-strand	758	1	35
β-strand	764	1	35
α-helix	771-780	10
α-helix	782-783	2
α-helix	789-802	14
α-helix	838-844	7
α-helix	869-871	3
α-helix	872-879	8

Chain L: 37 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	36
α-helix	19-21	3
α-helix	30-47	18
β-strand	54-59	6	36
β-strand	65	1	36
β-strand	77-84	8	36
α-helix	88-92	5
α-helix	93-97	5
α-helix	107-122	16
β-strand	129-135	7	36
α-helix	147-157	11
β-strand	159-165	7	36
α-helix	194-196	3
α-helix	199-216	18
α-helix	219-222	4
β-strand	224-226	3	36
α-helix	227-230	4
β-strand	243	1	37
α-helix	244-246	3
β-strand	247-253	7	38
β-strand	257-263	7	38
β-strand	265-268	4	38
β-strand	277-280	4	39
β-strand	291-294	4	40
β-strand	296	1	41
α-helix	303	1
β-strand	304	1	41
α-helix	305-306	2
α-helix	307-309	3
β-strand	310-316	7	42
β-strand	319-322	4	42
α-helix	325-331	7
β-strand	339-347	9	38
α-helix	348-350	3
α-helix	353-355	3
β-strand	360-364	5	38
β-strand	366	1	38
α-helix	371-386	16
β-strand	389-396	8	38
α-helix	402-403	2
β-strand	404-412	9	38
β-strand	417-424	8	38
β-strand	430	1	43
α-helix	438-440	3
α-helix	442-444	3
α-helix	445-447	3
α-helix	448-461	14
β-strand	462	1	44
β-strand	464-466	3	45
α-helix	467	1
β-strand	473-475	3	45
α-helix	479-481	3
α-helix	486-499	14
α-helix	504-506	3
α-helix	510-516	7
α-helix	518-519	2
α-helix	520-536	17
β-strand	540	1	46
α-helix	594-605	12
α-helix	610-621	12
α-helix	629-648	20
α-helix	652-667	16
α-helix	675-681	7
α-helix	694-702	9
α-helix	723-730	8

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-dependent protein kinase catalytic subunit	A, S	protein	4128	Homo sapiens	P78527
X-ray repair cross-complementing protein 6	B, T	protein	609	Homo sapiens	P12956 (AlphaFold model)
X-ray repair cross-complementing protein 5	C, L	protein	732	Homo sapiens	P13010 (AlphaFold model)
Protein PAXX	D, M	protein	204	Homo sapiens	Q9BUH6 (AlphaFold model)
DNA repair protein XRCC4	G, H, P, Q	protein	336	Homo sapiens	Q13426
DNA ligase 4	I, R	protein	911	Homo sapiens	P49917
DNA (25-mer)	j	DNA	25	Homo sapiens
DNA (27-mer)	i	DNA	27	Homo sapiens
DNA (26-mer)	d	DNA	26	Homo sapiens
DNA (28-mer)	e	DNA	28	Homo sapiens

Sequence of entity 1 (A, S), FASTA

>8BH3_1 DNA-dependent protein kinase catalytic subunit (chains A, S)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM

Sequence of entity 2 (B, T), FASTA

>8BH3_2 X-ray repair cross-complementing protein 6 (chains B, T)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD

Sequence of entity 3 (C, L), FASTA

>8BH3_3 X-ray repair cross-complementing protein 5 (chains C, L)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI

Sequence of entity 4 (D, M), FASTA

>8BH3_4 Protein PAXX (chains D, M)
MDPLSPPLCTLPPGPEPPRFVCYCEGEESGEGDRGGFNLYVTDAAELWSTCFTPDSLAAL
KARFGLSAAEDITPRFRAACEQQAVALTLQEDRASLTLSGGPSALAFDLSKVPGPEAAPR
LRALTLGLAKRVWSLERRLAAAEETAVSPRKSPRPAGPQLFLPDPDPQRGGPGPGVRRRC
PGESLINPGFKSKKPAGGVDFDET

Sequence of entity 5 (G, H, P, Q), FASTA

>8BH3_5 DNA repair protein XRCC4 (chains G, H, P, Q)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI

Sequence of entity 6 (I, R), FASTA

>8BH3_6 DNA ligase 4 (chains I, R)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

Sequence of entity 7 (j), FASTA

>8BH3_7 DNA (25-MER) (chains j)
TAATAATAGTTTTTAGTTTATTGGG

Sequence of entity 8 (i), FASTA

>8BH3_8 DNA (27-MER) (chains i)
GCTAATAAACTAAAAACTATTATTATG

Sequence of entity 9 (d), FASTA

>8BH3_9 DNA (26-MER) (chains d)
TAATAATAGTTTTTAGTTTATTGGGC

Sequence of entity 10 (e), FASTA

>8BH3_10 DNA (28-MER) (chains e)
AGCTAATAAACTAAAAACTATTATTATG

Primary citation

PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Seif-El-Dahan, M., Kefala-Stavridi, A., Frit, P. et al. Sci Adv (2023) 9:eadg2834-eadg2834. DOI 10.1126/sciadv.adg2834 · PubMed

Other PDB entries of the same protein (UniProt P78527), best resolution first:

7Z87 2.91 Å, DNA-PK in the active state
7OTY 2.96 Å, DNA-PKcs in complex with M3814
7OTW 2.99 Å, DNA-PKcs in complex with AZD7648
7SGL 3.0 Å, DNA-PK complex of DNA end processing
7K11 3.21 Å, CryoEM structure of inactivated-form FATKIN domain of DNA-PK
6ZFP 3.24 Å, Cryo-EM structure of DNA-PKcs (State 2)
7OTV 3.24 Å, DNA-PKcs in complex with wortmannin
7K10 3.3 Å, CryoEM structure of activated-form FATKIN domain of DNA-PK
7SU3 3.3 Å, CryoEM structure of DNA-PK complex VII
7OTM 3.33 Å, Cryo-EM structure of DNA-PKcs in complex with NU7441
7TYR 3.33 Å, Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14)
7Z88 3.33 Å, DNA-PK in the intermediate state

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