8BHY: DNA-PK Ku80 mediated dimer
DNA-PK Ku80 mediated dimer bound to PAXX and XLF. Determined by electron microscopy at 5.33 Å resolution. Released 7 Jun 2023.
- Method
- Electron microscopy
- Resolution
- 5.33 Å
- Organism
- Homo sapiens
- Chains
- 20
- Atoms
- 90,193
- Mol. weight
- 1747.96 kDa
- Released
- 7 Jun 2023
Explore 8BHY in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8BHY contains 571 α-helices and 209 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 205 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-22 | 12 | |
| α-helix | 28-45 | 18 | |
| α-helix | 50-71 | 22 | |
| α-helix | 76-94 | 19 | |
| α-helix | 101-116 | 16 | |
| α-helix | 118-120 | 3 | |
| α-helix | 125-140 | 16 | |
| α-helix | 150-160 | 11 | |
| α-helix | 170-173 | 4 | |
| α-helix | 174-178 | 5 | |
| α-helix | 187-208 | 22 | |
| α-helix | 210-212 | 3 | |
| α-helix | 220-232 | 13 | |
| α-helix | 241-251 | 11 | |
| α-helix | 266-277 | 12 | |
| α-helix | 280-282 | 3 | |
| α-helix | 290-302 | 13 | |
| α-helix | 306-328 | 23 | |
| α-helix | 333-340 | 8 | |
| α-helix | 342-348 | 7 | |
| α-helix | 358-375 | 18 | |
| α-helix | 378-396 | 19 | |
| α-helix | 410-423 | 14 | |
| α-helix | 431-444 | 14 | |
| α-helix | 451-468 | 18 | |
| α-helix | 472-492 | 21 | |
| α-helix | 525-527 | 3 | |
| α-helix | 528-535 | 8 | |
| α-helix | 538-546 | 9 | |
| α-helix | 560-578 | 19 | |
| β-strand | 583-584 | 2 | 1 |
| β-strand | 613-614 | 2 | 1 |
| α-helix | 617-633 | 17 | |
| α-helix | 634-636 | 3 | |
| α-helix | 639-642 | 4 | |
| α-helix | 643-659 | 17 | |
| α-helix | 664-680 | 17 | |
| α-helix | 698-718 | 21 | |
| α-helix | 726-734 | 9 | |
| α-helix | 738-741 | 4 | |
| α-helix | 745-761 | 17 | |
| α-helix | 763-779 | 17 | |
| α-helix | 782-785 | 4 | |
| α-helix | 786-788 | 3 | |
| α-helix | 789-792 | 4 | |
| α-helix | 793-797 | 5 | |
| α-helix | 835-838 | 4 | |
| α-helix | 848-862 | 15 | |
| α-helix | 864-867 | 4 | |
| β-strand | 893-895 | 3 | 2 |
| β-strand | 904-906 | 3 | 2 |
| α-helix | 910-919 | 10 | |
| α-helix | 924-947 | 24 | |
| α-helix | 959-973 | 15 | |
| α-helix | 978-994 | 17 | |
| α-helix | 1005-1018 | 14 | |
| α-helix | 1023-1043 | 21 | |
| α-helix | 1046-1051 | 6 | |
| α-helix | 1056-1067 | 12 | |
| α-helix | 1072-1089 | 18 | |
| α-helix | 1093-1098 | 6 | |
| α-helix | 1101-1117 | 17 | |
| α-helix | 1123-1140 | 18 | |
| α-helix | 1143-1146 | 4 | |
| β-strand | 1149 | 1 | 3 |
| α-helix | 1151-1154 | 4 | |
| β-strand | 1163 | 1 | 3 |
| α-helix | 1165-1175 | 11 | |
| α-helix | 1181-1194 | 14 | |
| α-helix | 1206-1213 | 8 | |
| α-helix | 1219-1222 | 4 | |
| α-helix | 1226-1235 | 10 | |
| α-helix | 1250-1272 | 23 | |
| α-helix | 1288-1299 | 12 | |
| α-helix | 1327-1351 | 25 | |
| α-helix | 1354-1356 | 3 | |
| α-helix | 1357-1360 | 4 | |
| α-helix | 1367-1370 | 4 | |
| α-helix | 1372-1377 | 6 | |
| α-helix | 1379-1381 | 3 | |
| α-helix | 1390-1408 | 19 | |
| α-helix | 1412-1422 | 11 | |
| α-helix | 1426-1431 | 6 | |
| α-helix | 1443-1460 | 18 | |
| α-helix | 1477-1489 | 13 | |
| α-helix | 1505-1519 | 15 | |
| α-helix | 1524-1532 | 9 | |
| β-strand | 1537-1538 | 2 | 4 |
| β-strand | 1553-1554 | 2 | 4 |
| α-helix | 1556-1562 | 7 | |
| α-helix | 1564-1573 | 10 | |
| α-helix | 1577-1584 | 8 | |
| α-helix | 1591-1606 | 16 | |
| α-helix | 1613-1626 | 14 | |
| α-helix | 1639-1655 | 17 | |
| α-helix | 1668-1680 | 13 | |
| α-helix | 1686-1693 | 8 | |
| α-helix | 1696-1698 | 3 | |
| α-helix | 1709-1718 | 10 | |
| α-helix | 1730 | 1 | |
| α-helix | 1734-1753 | 20 | |
| α-helix | 1756-1766 | 11 | |
| α-helix | 1775-1787 | 13 | |
| α-helix | 1791-1803 | 13 | |
| α-helix | 1818-1830 | 13 | |
| α-helix | 1833-1850 | 18 | |
| α-helix | 1864-1880 | 17 | |
| α-helix | 1912-1915 | 4 | |
| α-helix | 1917-1920 | 4 | |
| α-helix | 1935-1954 | 20 | |
| α-helix | 2035-2047 | 13 | |
| α-helix | 2095-2107 | 13 | |
| α-helix | 2126-2134 | 9 | |
| α-helix | 2140-2151 | 12 | |
| α-helix | 2155-2160 | 6 | |
| α-helix | 2161-2172 | 12 | |
| α-helix | 2182-2194 | 13 | |
| α-helix | 2206-2222 | 17 | |
| α-helix | 2230-2245 | 16 | |
| α-helix | 2254-2261 | 8 | |
| α-helix | 2271-2282 | 12 | |
| α-helix | 2301-2308 | 8 | |
| α-helix | 2313-2328 | 16 | |
| α-helix | 2330-2333 | 4 | |
| α-helix | 2339-2350 | 12 | |
| α-helix | 2358-2370 | 13 | |
| α-helix | 2373-2378 | 6 | |
| α-helix | 2379-2385 | 7 | |
| α-helix | 2393-2402 | 10 | |
| α-helix | 2411-2418 | 8 | |
| α-helix | 2420-2425 | 6 | |
| α-helix | 2429-2442 | 14 | |
| α-helix | 2443-2445 | 3 | |
| α-helix | 2448-2455 | 8 | |
| α-helix | 2459-2461 | 3 | |
| α-helix | 2467-2483 | 17 | |
| α-helix | 2493-2508 | 16 | |
| α-helix | 2515-2526 | 12 | |
| α-helix | 2535-2544 | 10 | |
| α-helix | 2554-2564 | 11 | |
| β-strand | 2575 | 1 | 5 |
| β-strand | 2586 | 1 | 6 |
| α-helix | 2724-2730 | 7 | |
| α-helix | 2738-2764 | 27 | |
| α-helix | 2766-2771 | 6 | |
| β-strand | 2778 | 1 | 6 |
| β-strand | 2786 | 1 | 5 |
| α-helix | 2787-2798 | 12 | |
| α-helix | 2802-2820 | 19 | |
| α-helix | 2826-2846 | 21 | |
| α-helix | 2852-2864 | 13 | |
| α-helix | 2873-2882 | 10 | |
| α-helix | 2886-2900 | 15 | |
| α-helix | 2919-2933 | 15 | |
| α-helix | 2937-2942 | 6 | |
| α-helix | 2943-2947 | 5 | |
| α-helix | 2951-2961 | 11 | |
| α-helix | 2966-2977 | 12 | |
| α-helix | 2985-2987 | 3 | |
| α-helix | 2988-3004 | 17 | |
| α-helix | 3008-3015 | 8 | |
| α-helix | 3019-3021 | 3 | |
| α-helix | 3030-3032 | 3 | |
| α-helix | 3035-3054 | 20 | |
| α-helix | 3060-3068 | 9 | |
| α-helix | 3072-3092 | 21 | |
| α-helix | 3096-3116 | 21 | |
| α-helix | 3122-3142 | 21 | |
| α-helix | 3158-3161 | 4 | |
| α-helix | 3163-3167 | 5 | |
| α-helix | 3176-3196 | 21 | |
| α-helix | 3227-3248 | 22 | |
| α-helix | 3256-3266 | 11 | |
| α-helix | 3270-3287 | 18 | |
| α-helix | 3292-3298 | 7 | |
| α-helix | 3305-3310 | 6 | |
| α-helix | 3320-3343 | 24 | |
| α-helix | 3348-3351 | 4 | |
| α-helix | 3355-3363 | 9 | |
| α-helix | 3370-3393 | 24 | |
| α-helix | 3408-3427 | 20 | |
| α-helix | 3442-3455 | 14 | |
| α-helix | 3459-3462 | 4 | |
| α-helix | 3465-3474 | 10 | |
| α-helix | 3476-3482 | 7 | |
| α-helix | 3483-3486 | 4 | |
| α-helix | 3496-3501 | 6 | |
| α-helix | 3513-3524 | 12 | |
| α-helix | 3530-3537 | 8 | |
| α-helix | 3548-3560 | 13 | |
| α-helix | 3566-3578 | 13 | |
| α-helix | 3581-3596 | 16 | |
| α-helix | 3605-3616 | 12 | |
| α-helix | 3629-3643 | 15 | |
| α-helix | 3658-3668 | 11 | |
| α-helix | 3685-3688 | 4 | |
| α-helix | 3711-3713 | 3 | |
| β-strand | 3719 | 1 | 7 |
| β-strand | 3726-3728 | 3 | 8 |
| β-strand | 3736-3738 | 3 | 8 |
| β-strand | 3742 | 1 | 7 |
| β-strand | 3750 | 1 | 8 |
| β-strand | 3751-3753 | 3 | 9 |
| α-helix | 3759-3777 | 19 | |
| α-helix | 3779-3784 | 6 | |
| β-strand | 3793-3795 | 3 | 9 |
| β-strand | 3801-3803 | 3 | 9 |
| β-strand | 3810 | 1 | 10 |
| α-helix | 3812-3817 | 6 | |
| α-helix | 3822-3830 | 9 | |
| α-helix | 3835-3838 | 4 | |
| α-helix | 3854-3861 | 8 | |
| α-helix | 3864-3877 | 14 | |
| α-helix | 3882-3890 | 9 | |
| α-helix | 3894-3917 | 24 | |
| α-helix | 3925-3927 | 3 | |
| β-strand | 3928-3931 | 4 | 10 |
| β-strand | 3936-3939 | 4 | 10 |
| β-strand | 3945 | 1 | 11 |
| β-strand | 3948 | 1 | 11 |
| α-helix | 3979-3991 | 13 | |
| α-helix | 3995-4002 | 8 | |
| α-helix | 4040-4051 | 12 | |
| α-helix | 4056-4065 | 10 | |
| α-helix | 4074-4082 | 9 | |
| α-helix | 4086-4089 | 4 | |
| α-helix | 4090-4092 | 3 | |
| α-helix | 4100-4109 | 10 | |
| α-helix | 4113-4118 | 6 | |
| α-helix | 4122-4124 | 3 | |
Chain B: 21 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 35-43 | 9 | 12 |
| α-helix | 46-48 | 3 | |
| α-helix | 57-58 | 2 | |
| α-helix | 59-77 | 19 | |
| β-strand | 82-88 | 7 | 12 |
| β-strand | 102-109 | 8 | 12 |
| α-helix | 113-120 | 8 | |
| α-helix | 124-134 | 11 | |
| α-helix | 143-156 | 14 | |
| β-strand | 161-169 | 9 | 12 |
| α-helix | 174-177 | 4 | |
| α-helix | 180-195 | 16 | |
| β-strand | 199-203 | 5 | 12 |
| β-strand | 213 | 1 | 13 |
| β-strand | 217 | 1 | 13 |
| α-helix | 239-243 | 5 | |
| β-strand | 257 | 1 | 14 |
| α-helix | 259 | 1 | |
| β-strand | 260-262 | 3 | 14 |
| β-strand | 268-274 | 7 | 14 |
| β-strand | 277 | 1 | 15 |
| β-strand | 288-289 | 2 | 16 |
| α-helix | 294 | 1 | |
| β-strand | 295 | 1 | 16 |
| α-helix | 296-297 | 2 | |
| β-strand | 299-304 | 6 | 17 |
| β-strand | 310 | 1 | 17 |
| β-strand | 317-321 | 5 | 18 |
| β-strand | 326-329 | 4 | 18 |
| α-helix | 331-336 | 6 | |
| β-strand | 344-352 | 9 | 14 |
| α-helix | 353-355 | 3 | |
| α-helix | 364-365 | 2 | |
| β-strand | 366-370 | 5 | 14 |
| β-strand | 375 | 1 | 19 |
| α-helix | 378-392 | 15 | |
| β-strand | 394-401 | 8 | 14 |
| β-strand | 409-416 | 8 | 14 |
| β-strand | 419 | 1 | 20 |
| β-strand | 428 | 1 | 20 |
| β-strand | 431-436 | 6 | 14 |
| β-strand | 443 | 1 | 21 |
| α-helix | 456-468 | 13 | |
| β-strand | 470 | 1 | 21 |
| α-helix | 475-477 | 3 | |
| α-helix | 481-495 | 15 | |
| α-helix | 511-518 | 8 | |
| α-helix | 521-529 | 9 | |
Chain C: 37 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-8 | 2 | |
| β-strand | 9-15 | 7 | 22 |
| α-helix | 18-21 | 4 | |
| α-helix | 23-24 | 2 | |
| α-helix | 30-48 | 19 | |
| β-strand | 53-59 | 7 | 22 |
| β-strand | 65 | 1 | 22 |
| β-strand | 77-84 | 8 | 22 |
| α-helix | 88-96 | 9 | |
| α-helix | 107-122 | 16 | |
| β-strand | 130-131 | 2 | 23 |
| β-strand | 134-135 | 2 | 22 |
| α-helix | 147-157 | 11 | |
| β-strand | 159-160 | 2 | 23 |
| β-strand | 163-165 | 3 | 22 |
| α-helix | 194-196 | 3 | |
| α-helix | 199-215 | 17 | |
| α-helix | 218-222 | 5 | |
| β-strand | 225-226 | 2 | 22 |
| α-helix | 227-231 | 5 | |
| α-helix | 235-237 | 3 | |
| α-helix | 242-246 | 5 | |
| β-strand | 247-253 | 7 | 21 |
| β-strand | 257-267 | 11 | 21 |
| β-strand | 277-279 | 3 | 18 |
| β-strand | 289-294 | 6 | 17 |
| β-strand | 296 | 1 | 24 |
| α-helix | 303 | 1 | |
| β-strand | 304 | 1 | 24 |
| α-helix | 305-306 | 2 | |
| β-strand | 310-311 | 2 | 16 |
| β-strand | 312-316 | 5 | 25 |
| β-strand | 319-323 | 5 | 25 |
| α-helix | 326-331 | 6 | |
| α-helix | 333-334 | 2 | |
| β-strand | 339-347 | 9 | 21 |
| α-helix | 348-350 | 3 | |
| α-helix | 353-355 | 3 | |
| β-strand | 357-366 | 10 | 21 |
| α-helix | 367 | 1 | |
| α-helix | 371-387 | 17 | |
| β-strand | 389-396 | 8 | 21 |
| α-helix | 402-403 | 2 | |
| β-strand | 404-413 | 10 | 21 |
| β-strand | 416-423 | 8 | 21 |
| β-strand | 430 | 1 | 15 |
| α-helix | 442-444 | 3 | |
| α-helix | 445-447 | 3 | |
| α-helix | 448-461 | 14 | |
| β-strand | 462 | 1 | 14 |
| β-strand | 464-467 | 4 | 26 |
| β-strand | 472-475 | 4 | 26 |
| α-helix | 486-499 | 14 | |
| α-helix | 504-509 | 6 | |
| α-helix | 510-516 | 7 | |
| α-helix | 520-536 | 17 | |
| β-strand | 541 | 1 | 19 |
| α-helix | 594-604 | 11 | |
| α-helix | 610-621 | 12 | |
| α-helix | 629-648 | 20 | |
| α-helix | 652-668 | 17 | |
| α-helix | 675-681 | 7 | |
| α-helix | 695-703 | 9 | |
| α-helix | 720-722 | 3 | |
| α-helix | 723-726 | 4 | |
Chain D: 4 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-11 | 4 | 27 |
| α-helix | 17-18 | 2 | |
| β-strand | 20-25 | 6 | 27 |
| β-strand | 38-42 | 5 | 27 |
| β-strand | 47-49 | 3 | 27 |
| α-helix | 54-63 | 10 | |
| α-helix | 73-82 | 10 | |
| β-strand | 85-89 | 5 | 27 |
| β-strand | 93-98 | 6 | 27 |
| β-strand | 105-111 | 7 | 27 |
| α-helix | 114-140 | 27 | |
Chain G: 5 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-9 | 2 | 28 |
| α-helix | 10 | 1 | |
| β-strand | 17-19 | 3 | 28 |
| α-helix | 20 | 1 | |
| β-strand | 34-37 | 4 | 28 |
| β-strand | 42-46 | 5 | 28 |
| α-helix | 54-58 | 5 | |
| α-helix | 65-73 | 9 | |
| β-strand | 84 | 1 | 29 |
| β-strand | 88 | 1 | 30 |
| β-strand | 95 | 1 | 30 |
| β-strand | 97-101 | 5 | 29 |
| β-strand | 104-108 | 5 | 29 |
| β-strand | 112-113 | 2 | 28 |
| α-helix | 119-199 | 81 | |
Chain H: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-9 | 8 | 31 |
| β-strand | 17-24 | 8 | 31 |
| β-strand | 33-37 | 5 | 32 |
| β-strand | 42-46 | 5 | 32 |
| α-helix | 63-72 | 10 | |
| α-helix | 119-199 | 81 | |
Chain I: 10 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 657-659 | 3 | |
| β-strand | 663-665 | 3 | 33 |
| α-helix | 675-684 | 10 | |
| β-strand | 688-690 | 3 | 33 |
| β-strand | 697-701 | 5 | 33 |
| α-helix | 707-714 | 8 | |
| β-strand | 720-721 | 2 | 33 |
| α-helix | 723-732 | 10 | |
| α-helix | 735-737 | 3 | |
| α-helix | 748-757 | 10 | |
| α-helix | 771-779 | 9 | |
| α-helix | 789-802 | 14 | |
| α-helix | 838-844 | 7 | |
| α-helix | 872-880 | 9 | |
Chain L: 29 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-15 | 8 | 34 |
| β-strand | 17 | 1 | 35 |
| α-helix | 18-21 | 4 | |
| α-helix | 23-24 | 2 | |
| α-helix | 30-47 | 18 | |
| β-strand | 53-59 | 7 | 34 |
| β-strand | 77-84 | 8 | 34 |
| α-helix | 88-95 | 8 | |
| β-strand | 101 | 1 | 35 |
| α-helix | 107-121 | 15 | |
| β-strand | 129-135 | 7 | 34 |
| α-helix | 147-157 | 11 | |
| β-strand | 160 | 1 | 34 |
| β-strand | 163-165 | 3 | 34 |
| α-helix | 199-215 | 17 | |
| α-helix | 218-220 | 3 | |
| β-strand | 225-226 | 2 | 34 |
| α-helix | 227-230 | 4 | |
| α-helix | 235-237 | 3 | |
| α-helix | 243-246 | 4 | |
| β-strand | 247-253 | 7 | 36 |
| β-strand | 257-263 | 7 | 36 |
| β-strand | 265 | 1 | 36 |
| β-strand | 267 | 1 | 37 |
| β-strand | 277-280 | 4 | 38 |
| β-strand | 289-297 | 9 | 39 |
| β-strand | 304 | 1 | 39 |
| β-strand | 310-316 | 7 | 40 |
| β-strand | 319-322 | 4 | 40 |
| α-helix | 325-329 | 5 | |
| β-strand | 339-347 | 9 | 36 |
| α-helix | 348-350 | 3 | |
| α-helix | 353-355 | 3 | |
| β-strand | 357-364 | 8 | 36 |
| β-strand | 366 | 1 | 36 |
| α-helix | 371-387 | 17 | |
| β-strand | 389-396 | 8 | 36 |
| β-strand | 404-412 | 9 | 36 |
| β-strand | 417-424 | 8 | 36 |
| β-strand | 430 | 1 | 41 |
| α-helix | 445-447 | 3 | |
| α-helix | 448-461 | 14 | |
| β-strand | 462 | 1 | 42 |
| β-strand | 464-466 | 3 | 43 |
| β-strand | 473-475 | 3 | 43 |
| α-helix | 485-499 | 15 | |
| α-helix | 504-506 | 3 | |
| α-helix | 510-516 | 7 | |
| α-helix | 520-536 | 17 | |
| α-helix | 594-602 | 9 | |
| α-helix | 610-621 | 12 | |
| α-helix | 629-648 | 20 | |
| α-helix | 652-668 | 17 | |
| α-helix | 675-681 | 7 | |
| α-helix | 694-703 | 10 | |
| α-helix | 723-725 | 3 | |
| α-helix | 726-730 | 5 | |
6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA-dependent protein kinase catalytic subunit | A, S | protein | 4128 | Homo sapiens | P78527 |
| X-ray repair cross-complementing protein 6 | B, T | protein | 609 | Homo sapiens | P12956 (AlphaFold model) |
| X-ray repair cross-complementing protein 5 | C, L | protein | 732 | Homo sapiens | P13010 (AlphaFold model) |
| Protein PAXX | D, M | protein | 204 | Homo sapiens | Q9BUH6 (AlphaFold model) |
| DNA repair protein XRCC4 | G, H, P, Q | protein | 336 | Homo sapiens | Q13426 |
| DNA ligase 4 | I, R | protein | 911 | Homo sapiens | P49917 |
| DNA (25-mer) | d | DNA | 25 | Homo sapiens | |
| DNA (27-mer) | e | DNA | 27 | Homo sapiens | |
| DNA (26-mer) | i | DNA | 26 | Homo sapiens | |
| DNA (5'-d(p*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*gp*gp*g)-3') | j | DNA | 24 | Homo sapiens | |
| Non-homologous end-joining factor 1 | f, m | protein | 299 | Homo sapiens | Q9H9Q4 |
Sequence of entity 1 (A, S), FASTA
>8BHY_1 DNA-dependent protein kinase catalytic subunit (chains A, S)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Sequence of entity 2 (B, T), FASTA
>8BHY_2 X-ray repair cross-complementing protein 6 (chains B, T)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD
Sequence of entity 3 (C, L), FASTA
>8BHY_3 X-ray repair cross-complementing protein 5 (chains C, L)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI
Sequence of entity 4 (D, M), FASTA
>8BHY_4 Protein PAXX (chains D, M)
MDPLSPPLCTLPPGPEPPRFVCYCEGEESGEGDRGGFNLYVTDAAELWSTCFTPDSLAAL
KARFGLSAAEDITPRFRAACEQQAVALTLQEDRASLTLSGGPSALAFDLSKVPGPEAAPR
LRALTLGLAKRVWSLERRLAAAEETAVSPRKSPRPAGPQLFLPDPDPQRGGPGPGVRRRC
PGESLINPGFKSKKPAGGVDFDET
Sequence of entity 5 (G, H, P, Q), FASTA
>8BHY_5 DNA repair protein XRCC4 (chains G, H, P, Q)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Sequence of entity 6 (I, R), FASTA
>8BHY_6 DNA ligase 4 (chains I, R)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
Sequence of entity 7 (d), FASTA
>8BHY_7 DNA (25-MER) (chains d)
AATAATAGTTTTTAGTTTATTGGGC
Sequence of entity 8 (e), FASTA
>8BHY_8 DNA (27-MER) (chains e)
GCTAATAAACTAAAAACTATTATTATG
Sequence of entity 9 (i), FASTA
>8BHY_9 DNA (26-MER) (chains i)
CTAATAAACTAAAAACTATTATTATG
Sequence of entity 10 (j), FASTA
>8BHY_10 DNA (5'-D(P*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*G)-3') (chains j)
AATAATAGTTTTTAGTTTATTGGG
Sequence of entity 11 (f, m), FASTA
>8BHY_11 Non-homologous end-joining factor 1 (chains f, m)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS
Primary citation
PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Seif-El-Dahan, M., Kefala-Stavridi, A., Frit, P. et al. Sci Adv (2023) 9:eadg2834-eadg2834. DOI 10.1126/sciadv.adg2834 · PubMed
Other PDB entries of the same protein (UniProt P78527), best resolution first:
- 7Z87 2.91 Å, DNA-PK in the active state
- 7OTY 2.96 Å, DNA-PKcs in complex with M3814
- 7OTW 2.99 Å, DNA-PKcs in complex with AZD7648
- 7SGL 3.0 Å, DNA-PK complex of DNA end processing
- 7K11 3.21 Å, CryoEM structure of inactivated-form FATKIN domain of DNA-PK
- 6ZFP 3.24 Å, Cryo-EM structure of DNA-PKcs (State 2)
- 7OTV 3.24 Å, DNA-PKcs in complex with wortmannin
- 7K10 3.3 Å, CryoEM structure of activated-form FATKIN domain of DNA-PK
- 7SU3 3.3 Å, CryoEM structure of DNA-PK complex VII
- 7OTM 3.33 Å, Cryo-EM structure of DNA-PKcs in complex with NU7441
- 7TYR 3.33 Å, Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14)
- 7Z88 3.33 Å, DNA-PK in the intermediate state
Browse structure collections
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