Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R). Determined by X-ray diffraction at 1.93 Å resolution. Released 21 Jun 2023.
Explore 8DC0 in 3D Show helices and sheets RCSB PDB PDBe
8DC0 contains 7 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 16-22 | 7 | 1 |
| β-strand | 30 | 1 | 1 |
| α-helix | 31-32 | 2 | |
| β-strand | 35-37 | 3 | 2 |
| β-strand | 42-50 | 9 | 1 |
| β-strand | 56-66 | 11 | 2 |
| β-strand | 77-81 | 5 | 2 |
| β-strand | 85 | 1 | 2 |
| β-strand | 91-93 | 3 | 1 |
| β-strand | 108-115 | 8 | 1 |
| β-strand | 124-135 | 12 | 2 |
| α-helix | 144 | 1 | |
| β-strand | 145 | 1 | 2 |
| α-helix | 146 | 1 | |
| α-helix | 149-154 | 6 | |
| α-helix | 158-164 | 7 | |
| β-strand | 168-177 | 10 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3 | 1 | 3 |
| α-helix | 4-7 | 4 | |
| β-strand | 14 | 1 | 4 |
| β-strand | 16-18 | 3 | 5 |
| β-strand | 21-23 | 3 | 6 |
| α-helix | 24-28 | 5 | |
| β-strand | 35 | 1 | 3 |
| β-strand | 38-40 | 3 | 6 |
| β-strand | 43-45 | 3 | 5 |
| β-strand | 47 | 1 | 4 |
| β-strand | 78-92 | 15 | 3 |
| β-strand | 95-111 | 17 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transforming growth factor beta receptor type 3 | A | protein | 174 | Rattus norvegicus | P26342 (AlphaFold model) |
| Transforming growth factor beta-2 | B | protein | 112 | Homo sapiens | P61812 (AlphaFold model) |
>8DC0_1 Transforming growth factor beta receptor type 3 (chains A) GNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFLSPYSNPD RMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFLFKSVFNTSLLFLHCELT LCSRKKGSLKLPRCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQHHHHHH
>8DC0_2 Transforming growth factor beta-2 (chains B) ALDAAYCFRNVQDNCCLRPLYIDFRKDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSR VLSLYNTINPRASKSPRCRSQDLEPLTIVYYVGRKPKVEQLSNMIVKSCKCS
Structures of TGF-beta with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling. Wieteska, L., Taylor, A.B., Punch, E. et al. Nat Commun (2025) 16:1778-1778. DOI 10.1038/s41467-025-56796-9 · PubMed
Other PDB entries of the same protein (UniProt P26342 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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