Human R-type voltage-gated calcium channel Cav2.3 CH2II-deleted mutant at 3.1 Angstrom resolution. Determined by electron microscopy at 3.1 Å resolution. Released 14 Dec 2022.
Explore 8EPM in 3D Show helices and sheets RCSB PDB PDBe
8EPM contains 89 α-helices and 72 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 91-106 | 16 | |
| β-strand | 112 | 1 | 1 |
| β-strand | 116 | 1 | 1 |
| α-helix | 119-126 | 8 | |
| α-helix | 128-143 | 16 | |
| α-helix | 159-174 | 16 | |
| α-helix | 196-198 | 3 | |
| α-helix | 199-203 | 5 | |
| α-helix | 205-215 | 11 | |
| α-helix | 219-240 | 22 | |
| β-strand | 249-251 | 3 | 2 |
| β-strand | 267 | 1 | 2 |
| β-strand | 279-281 | 3 | 2 |
| α-helix | 295-306 | 12 | |
| α-helix | 311-322 | 12 | |
| α-helix | 327-335 | 9 | |
| α-helix | 336-340 | 5 | |
| α-helix | 341-355 | 15 | |
| α-helix | 476-493 | 18 | |
| α-helix | 502-525 | 24 | |
| α-helix | 543-559 | 17 | |
| α-helix | 569-576 | 8 | |
| α-helix | 586-601 | 16 | |
| α-helix | 604-625 | 22 | |
| α-helix | 643-655 | 13 | |
| α-helix | 659-669 | 11 | |
| α-helix | 677-679 | 3 | |
| α-helix | 680-707 | 28 | |
| α-helix | 1156-1171 | 16 | |
| α-helix | 1181-1207 | 27 | |
| α-helix | 1223-1240 | 18 | |
| α-helix | 1253-1258 | 6 | |
| α-helix | 1259-1267 | 9 | |
| α-helix | 1268-1271 | 4 | |
| α-helix | 1273-1311 | 39 | |
| α-helix | 1312-1315 | 4 | |
| β-strand | 1316-1318 | 3 | 3 |
| β-strand | 1332-1335 | 4 | 4 |
| α-helix | 1337-1339 | 3 | |
| β-strand | 1342-1345 | 4 | 4 |
| β-strand | 1348-1350 | 3 | 3 |
| α-helix | 1358-1370 | 13 | |
| α-helix | 1374-1382 | 9 | |
| α-helix | 1397-1399 | 3 | |
| α-helix | 1400-1409 | 10 | |
| α-helix | 1410-1414 | 5 | |
| α-helix | 1415-1424 | 10 | |
| α-helix | 1478-1495 | 18 | |
| α-helix | 1504-1532 | 29 | |
| α-helix | 1534-1537 | 4 | |
| α-helix | 1541-1561 | 21 | |
| α-helix | 1576-1579 | 4 | |
| α-helix | 1582-1586 | 5 | |
| α-helix | 1592-1595 | 4 | |
| α-helix | 1607-1610 | 4 | |
| α-helix | 1611-1629 | 19 | |
| β-strand | 1632 | 1 | 5 |
| α-helix | 1633-1634 | 2 | |
| α-helix | 1649-1661 | 13 | |
| α-helix | 1665-1671 | 7 | |
| β-strand | 1676 | 1 | 6 |
| β-strand | 1678 | 1 | 5 |
| β-strand | 1694 | 1 | 6 |
| α-helix | 1699-1724 | 26 | |
| α-helix | 1726-1729 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 30-52 | 23 | |
| α-helix | 54-64 | 11 | |
| β-strand | 69-72 | 4 | 7 |
| α-helix | 75-109 | 35 | |
| β-strand | 122-123 | 2 | 8 |
| β-strand | 125-126 | 2 | 9 |
| β-strand | 142-143 | 2 | 8 |
| β-strand | 150-151 | 2 | 10 |
| β-strand | 158-159 | 2 | 10 |
| β-strand | 160 | 1 | 11 |
| β-strand | 165-167 | 3 | 9 |
| α-helix | 173 | 1 | |
| α-helix | 177-186 | 10 | |
| α-helix | 189-199 | 11 | |
| β-strand | 206-210 | 5 | 9 |
| β-strand | 215-218 | 4 | 9 |
| β-strand | 220 | 1 | 11 |
| α-helix | 238-240 | 3 | |
| α-helix | 242-248 | 7 | |
| β-strand | 252 | 1 | 12 |
| β-strand | 255-259 | 5 | 13 |
| α-helix | 262-264 | 3 | |
| α-helix | 267-280 | 14 | |
| β-strand | 289 | 1 | 14 |
| β-strand | 290-294 | 5 | 13 |
| β-strand | 298-300 | 3 | 13 |
| β-strand | 308 | 1 | 14 |
| α-helix | 312-322 | 11 | |
| α-helix | 333-343 | 11 | |
| β-strand | 355 | 1 | 12 |
| β-strand | 357-362 | 6 | 13 |
| α-helix | 370-375 | 6 | |
| β-strand | 383-389 | 7 | 13 |
| α-helix | 397-405 | 9 | |
| β-strand | 409-413 | 5 | 13 |
| α-helix | 417-422 | 6 | |
| α-helix | 426-430 | 5 | |
| α-helix | 432-437 | 6 | |
| α-helix | 439-441 | 3 | |
| β-strand | 445-446 | 2 | 9 |
| β-strand | 450-451 | 2 | 9 |
| β-strand | 458-467 | 10 | 9 |
| β-strand | 484-493 | 10 | 9 |
| α-helix | 494-499 | 6 | |
| β-strand | 511-515 | 5 | 15 |
| β-strand | 520 | 1 | 16 |
| β-strand | 521-523 | 3 | 15 |
| α-helix | 531-533 | 3 | |
| β-strand | 538 | 1 | 17 |
| β-strand | 560 | 1 | 16 |
| α-helix | 561-564 | 4 | |
| α-helix | 569-580 | 12 | |
| β-strand | 584-593 | 10 | 15 |
| β-strand | 599 | 1 | 18 |
| β-strand | 600-611 | 12 | 15 |
| β-strand | 618-624 | 7 | 15 |
| β-strand | 629-632 | 4 | 7 |
| α-helix | 638-645 | 8 | |
| α-helix | 646-648 | 3 | |
| α-helix | 650-653 | 4 | |
| β-strand | 658-659 | 2 | 19 |
| β-strand | 667 | 1 | 20 |
| α-helix | 679-689 | 11 | |
| β-strand | 697 | 1 | 20 |
| α-helix | 699-718 | 20 | |
| α-helix | 720-722 | 3 | |
| β-strand | 726 | 1 | 19 |
| β-strand | 729-736 | 8 | 19 |
| β-strand | 741-743 | 3 | 19 |
| α-helix | 746-751 | 6 | |
| α-helix | 758-760 | 3 | |
| α-helix | 762-769 | 8 | |
| β-strand | 774-776 | 3 | 19 |
| β-strand | 792-797 | 6 | 19 |
| β-strand | 800-801 | 2 | 21 |
| β-strand | 806-807 | 2 | 21 |
| β-strand | 810-816 | 7 | 19 |
| α-helix | 818-826 | 9 | |
| β-strand | 848-853 | 6 | 22 |
| β-strand | 858 | 1 | 23 |
| β-strand | 859-861 | 3 | 22 |
| β-strand | 874 | 1 | 23 |
| α-helix | 875-877 | 3 | |
| α-helix | 880-888 | 9 | |
| β-strand | 892-899 | 8 | 18 |
| β-strand | 903-904 | 2 | 24 |
| β-strand | 907 | 1 | 17 |
| β-strand | 972-973 | 2 | 24 |
| β-strand | 976-983 | 8 | 18 |
| β-strand | 989-994 | 6 | 22 |
| β-strand | 1001-1007 | 7 | 22 |
| α-helix | 1008 | 1 | |
| β-strand | 1014-1019 | 6 | 22 |
| α-helix | 1029-1031 | 3 | |
| β-strand | 1036-1037 | 2 | 18 |
| α-helix | 1050-1052 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Voltage-dependent R-type calcium channel subunit alpha-1E | A | protein | 2313 | Homo sapiens | Q15878 (AlphaFold model) |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | C | protein | 1103 | Homo sapiens | P54289 (AlphaFold model) |
>8EPM_1 Voltage-dependent R-type calcium channel subunit alpha-1E (chains A) MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQ NCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPM SRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHF NTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL EFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVL TVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER VENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRT EAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYW IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM KSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWN EVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE EAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQ RTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGL ALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAG GGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDH ELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVV LTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL VDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTN PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVL RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTD SSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQH SVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLE KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYY SAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI YAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED MTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA SDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPY LQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLEPEVSELKSVQPSN HGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSME RSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRC NSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLP PVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNSPHPQQSQ HASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPN GHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC
>8EPM_2 Voltage-dependent calcium channel subunit alpha-2/delta-1 (chains C) MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS LWYIIGIQFLLLWLVSGSTHRLL
Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments. Yao, X., Wang, Y., Wang, Z. et al. Nat Commun (2022) 13:7358-7358. DOI 10.1038/s41467-022-35026-6 · PubMed
Other PDB entries of the same protein (UniProt Q15878 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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