Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) is a 1103-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54289.
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The mean pLDDT of this model is 86.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). Plays an important role in excitation-contraction coupling (By similarity)
Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity)
Membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7VFS | EM | 2.8 Å | B=1-1103 |
| 8WE6 | EM | 2.9 Å | D=1-1103 |
| 8WE8 | EM | 2.9 Å | D=1-1103 |
| 8X93 | EM | 2.92 Å | B=1-1103 |
| 8X90 | EM | 2.95 Å | B=1-1103 |
| 7MIX | EM | 3.0 Å | D=1-1103 |
| 7UHG | EM | 3.0 Å | D=1-1103 |
| 7VFU | EM | 3.0 Å | B=1-1103 |
| 7VFV | EM | 3.0 Å | B=1-1103 |
| 7YG5 | EM | 3.0 Å | D=1-1103 |
| 8WE9 | EM | 3.0 Å | D=1-1103 |
| 9VLG | EM | 3.01 Å | A=25-1076 |
| 7MIY | EM | 3.1 Å | D=1-1103 |
| 7UHF | EM | 3.1 Å | D=1-1103 |
| 7XLQ | EM | 3.1 Å | D=27-1103 |
| 8E59 | EM | 3.1 Å | D=1-1103 |
| 8EPL | EM | 3.1 Å | C=1-1103 |
| 8EPM | EM | 3.1 Å | C=1-1103 |
| 8X91 | EM | 3.11 Å | B=1-1103 |
| 8IF3 | EM | 3.2 Å | A=1-1103 |
Showing 20 of 30 experimental structures (best resolution first).
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