8F2R: Human CCC complex

Human CCC complex. Determined by electron microscopy at 3.12 Å resolution. Released 24 May 2023.

Method: Electron microscopy
Resolution: 3.12 Å
Organism: Homo sapiens
Chains: 10
Atoms: 14,504
Mol. weight: 206.84 kDa
Released: 24 May 2023

Explore 8F2R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8F2R contains 91 α-helices and 36 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	2-5	4
α-helix	9-20	12
α-helix	21-25	5
α-helix	32-39	8
α-helix	45-63	19
α-helix	69-81	13
α-helix	85-87	3
α-helix	88-112	25
α-helix	117	1
β-strand	118-132	15	1
β-strand	141-150	10	1
α-helix	155-156	2
β-strand	157-163	7	1
α-helix	165-186	22

Chain B: 13 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	4-6	3
α-helix	7-13	7
α-helix	16-18	3
α-helix	21-37	17
α-helix	41-51	11
α-helix	55-75	21
α-helix	79-89	11
α-helix	93-104	12
α-helix	107-114	8
α-helix	115-117	3
α-helix	119-120	2
β-strand	123-137	15	1
β-strand	145-155	11	1
β-strand	161-167	7	1
α-helix	169-187	19
α-helix	189-197	9

Chain C: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	5-14	10
α-helix	22-37	16
α-helix	43-46	4
α-helix	49-52	4
α-helix	56-75	20
α-helix	80-89	10
α-helix	94-116	23
α-helix	122-123	2
β-strand	124-138	15	1
β-strand	146-156	11	1
β-strand	165-170	6	1
α-helix	172-194	23

Chain D: 11 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	2
α-helix	4-6	3
β-strand	9	1	2
α-helix	10-12	3
α-helix	13-23	11
α-helix	27-41	15
α-helix	48-53	6
α-helix	56-58	3
α-helix	62-82	21
α-helix	86-96	11
α-helix	100-123	24
β-strand	130-144	15	1
β-strand	152-162	11	1
α-helix	168-169	2
β-strand	170-177	8	1
α-helix	178-198	21

Chain E: 11 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	31-39	9
α-helix	40-42	3
α-helix	45-59	15
α-helix	65-75	11
α-helix	79-98	20
α-helix	106-115	10
α-helix	120-131	12
α-helix	134-142	9
α-helix	143-146	4
α-helix	150	1
β-strand	151-161	11	1
β-strand	165	1	1
β-strand	168	1	1
β-strand	174-182	9	1
β-strand	187-192	6	1
α-helix	194-221	28

Chain F: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	12-15	4
β-strand	18-32	15	1
β-strand	35	1	1
β-strand	41-50	10	1
β-strand	57-64	8	1
α-helix	65-84	20

Chain G: 8 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	13-24	12
α-helix	27-42	16
α-helix	47-61	15
α-helix	65-85	21
α-helix	89-99	11
α-helix	103-114	12
α-helix	117-125	9
β-strand	133-147	15	1
β-strand	156-166	11	1
β-strand	169-178	10	1
α-helix	179-197	19

Chain H: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	8-14	7
α-helix	17-19	3
α-helix	20-31	12
α-helix	35-38	4
α-helix	39-41	3
α-helix	48-67	20
α-helix	72-77	6
α-helix	84-95	12
α-helix	98-110	13
β-strand	116-130	15	1
β-strand	138-149	12	1
β-strand	152-160	9	1
α-helix	162-182	21

2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
COMM domain-containing protein 1	A	protein	187	Homo sapiens	Q8N668 (AlphaFold model)
COMM domain-containing protein 2	B	protein	199	Homo sapiens	Q86X83 (AlphaFold model)
COMM domain-containing protein 3	C	protein	195	Homo sapiens	Q9UBI1 (AlphaFold model)
COMM domain-containing protein 4	D	protein	199	Homo sapiens	Q9H0A8 (AlphaFold model)
COMM domain-containing protein 5	E	protein	205	Homo sapiens	Q9GZQ3
COMM domain-containing protein 6	F	protein	77	Homo sapiens	Q7Z4G1
COMM domain-containing protein 7	G	protein	200	Homo sapiens	Q86VX2
COMM domain-containing protein 8	H	protein	179	Homo sapiens	Q9NX08
COMM domain-containing protein 9	I	protein	198	Homo sapiens	Q9P000
COMM domain-containing protein 10	J	protein	198	Homo sapiens	Q9Y6G5

Sequence of entity 1 (A), FASTA

>8F2R_1 COMM domain-containing protein 1 (chains A)
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILK
SIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLR
GLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEE
SISTLIS

Sequence of entity 2 (B), FASTA

>8F2R_2 COMM domain-containing protein 2 (chains B)
MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQH
GVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPS
LPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLE
QALEEMKTNHCRRVVRNIK

Sequence of entity 3 (C), FASTA

>8F2R_3 COMM domain-containing protein 3 (chains C)
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK
HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR
SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG
KLKDASKSLERATQL

Sequence of entity 4 (D), FASTA

>8F2R_4 COMM domain-containing protein 4 (chains D)
MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKF
ESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKH
LRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADK
FQVLLAELKQAQTLMSSLG

Sequence of entity 5 (E), FASTA

>8F2R_5 COMM domain-containing protein 5 (chains E)
GRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPE
EQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLD
SVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQE
LRYSVALVLKEMADLEKRCERRLQD

Sequence of entity 6 (F), FASTA

>8F2R_6 COMM domain-containing protein 6 (chains F)
LDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQF
QNFYRQFKEIAAVIETV

Sequence of entity 7 (G), FASTA

>8F2R_7 COMM domain-containing protein 7 (chains G)
MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATT
NQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTL
ARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLP
QFYSFLHEMERVRTSMECFC

Sequence of entity 8 (H), FASTA

>8F2R_8 COMM domain-containing protein 8 (chains H)
EGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKA
IVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQV
KLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Sequence of entity 9 (I), FASTA

>8F2R_9 COMM domain-containing protein 9 (chains I)
MAALTAEHFAALQSLLKASSKDVVRQLCQESFSSSALGLKKLLDVTCSSLSVTQEEAEEL
LQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISL
PRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETLDT
MLDGLGRIRDQLSAVASK

Sequence of entity 10 (J), FASTA

>8F2R_10 COMM domain-containing protein 10 (chains J)
AALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLE
KQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKF
RQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKEL
FDFYNKLETIQAQLDSLT

Primary citation

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Healy, M.D., McNally, K.E., Butkovic, R. et al. Cell (2023) 186:2219-2237.e29. DOI 10.1016/j.cell.2023.04.003 · PubMed

Other PDB entries of the same protein (UniProt Q8N668 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8P0W 2.9 Å, Structure of the human Commander complex COMMD ring
8F2U 3.53 Å, Human CCC complex
2H2M Solution Structure of the N-terminal domain of COMMD1 (Murr1)

Browse structure collections

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