8F2U: Human CCC complex

Human CCC complex. Determined by electron microscopy at 3.53 Å resolution. Released 24 May 2023.

Method: Electron microscopy
Resolution: 3.53 Å
Organism: Homo sapiens
Chains: 12
Atoms: 17,684
Mol. weight: 360.02 kDa
Released: 24 May 2023

Explore 8F2U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8F2U contains 115 α-helices and 42 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	10-23	14
α-helix	33-39	7
α-helix	50-62	13
α-helix	69-80	12
α-helix	85-87	3
α-helix	88-100	13
α-helix	102-111	10
β-strand	117-132	16	1
β-strand	141-150	10	1
α-helix	155-156	2
β-strand	157-163	7	1
α-helix	165-184	20

Chain B: 14 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	7-11	5
α-helix	12-14	3
α-helix	21-36	16
α-helix	42-51	10
α-helix	55-73	19
α-helix	79-86	8
α-helix	87-89	3
α-helix	93-105	13
α-helix	107-114	8
α-helix	115-117	3
α-helix	119-120	2
β-strand	123-137	15	2
β-strand	145-156	12	2
β-strand	159-167	9	2
α-helix	169-182	14
α-helix	185-187	3
α-helix	189-197	9

Chain C: 9 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	5-15	11
α-helix	22-37	16
α-helix	43-46	4
α-helix	49-51	3
α-helix	56-75	20
α-helix	80-89	10
α-helix	96-106	11
α-helix	108-115	8
β-strand	118	1	3
β-strand	124-138	15	2
β-strand	141	1	2
β-strand	146-156	11	2
β-strand	157	1	4
β-strand	160	1	4
β-strand	165-170	6	2
α-helix	172-194	23

Chain D: 10 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
β-strand	9	1	5
α-helix	10-12	3
α-helix	13-23	11
α-helix	27-42	16
α-helix	48-54	7
α-helix	56-58	3
α-helix	62-81	20
α-helix	86-95	10
α-helix	100-110	11
α-helix	114-123	10
β-strand	131-144	14	1
β-strand	152-161	10	1
β-strand	170-176	7	1
α-helix	178-195	18

Chain E: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	31-39	9
α-helix	45-59	15
α-helix	65-75	11
α-helix	79-98	20
α-helix	101-103	3
α-helix	106-112	7
α-helix	123-131	9
α-helix	135-143	9
β-strand	151-165	15	2
β-strand	168	1	2
β-strand	173-182	10	2
β-strand	187-192	6	2
α-helix	194-220	27

Chain F: 1 helix, 3 β-strands

Element	Residues	Length	Sheet
β-strand	18-32	15	1
β-strand	40-50	11	1
β-strand	59-63	5	1
α-helix	65-84	20

Chain G: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	13-16	4
α-helix	17-23	7
α-helix	27-42	16
α-helix	48-61	14
α-helix	65-75	11
α-helix	77-85	9
α-helix	89-99	11
α-helix	103-126	24
β-strand	133-147	15	2
β-strand	156-165	10	2
β-strand	171-177	7	2
α-helix	179-196	18

Chain H: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	8-12	5
α-helix	17-19	3
α-helix	20-32	13
α-helix	35-38	4
α-helix	39-41	3
α-helix	43-45	3
α-helix	48-68	21
α-helix	72-78	7
α-helix	86-96	11
α-helix	98-109	12
β-strand	115-130	16	2
β-strand	138-149	12	2
β-strand	152-160	9	2
α-helix	162-182	21

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
COMM domain-containing protein 1	A	protein	190	Homo sapiens	Q8N668 (AlphaFold model)
COMM domain-containing protein 2	B	protein	199	Homo sapiens	Q86X83 (AlphaFold model)
COMM domain-containing protein 3	C	protein	195	Homo sapiens	Q9UBI1 (AlphaFold model)
COMM domain-containing protein 4	D	protein	199	Homo sapiens	Q9H0A8 (AlphaFold model)
COMM domain-containing protein 5	E	protein	260	Homo sapiens	Q9GZQ3
COMM domain-containing protein 6	F	protein	85	Homo sapiens	Q7Z4G1
COMM domain-containing protein 7	G	protein	200	Homo sapiens	Q86VX2
COMM domain-containing protein 8	H	protein	183	Homo sapiens	Q9NX08
COMM domain-containing protein 9	I	protein	198	Homo sapiens	Q9P000
COMM domain-containing protein 10	J	protein	212	Homo sapiens	Q9Y6G5
Coiled-coil domain-containing protein 93	N	protein	631	Homo sapiens	Q567U6
Coiled-coil domain-containing protein 22	T	protein	627	Homo sapiens	O60826

Sequence of entity 1 (A), FASTA

>8F2U_1 COMM domain-containing protein 1 (chains A)
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILK
SIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLR
GLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEE
SISTLISQPN

Sequence of entity 2 (B), FASTA

>8F2U_2 COMM domain-containing protein 2 (chains B)
MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQH
GVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPS
LPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLE
QALEEMKTNHCRRVVRNIK

Sequence of entity 3 (C), FASTA

>8F2U_3 COMM domain-containing protein 3 (chains C)
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK
HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR
SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG
KLKDASKSLERATQL

Sequence of entity 4 (D), FASTA

>8F2U_4 COMM domain-containing protein 4 (chains D)
MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKF
ESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKH
LRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADK
FQVLLAELKQAQTLMSSLG

Sequence of entity 5 (E), FASTA

>8F2U_5 COMM domain-containing protein 5 (chains E)
MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQ
GEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQ
DLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQL
KLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQDGSLFQGPWSHPQFEKG
GGSGGGSGGSSAWSHPQFEK

Sequence of entity 6 (F), FASTA

>8F2U_6 COMM domain-containing protein 6 (chains F)
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKC
FEMTIPQFQNFYRQFKEIAAVIETV

Sequence of entity 7 (G), FASTA

>8F2U_7 COMM domain-containing protein 7 (chains G)
MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATT
NQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTL
ARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLP
QFYSFLHEMERVRTSMECFC

Sequence of entity 8 (H), FASTA

>8F2U_8 COMM domain-containing protein 8 (chains H)
MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK
FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF
DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL
QLK

Sequence of entity 9 (I), FASTA

>8F2U_9 COMM domain-containing protein 9 (chains I)
MAALTAEHFAALQSLLKASSKDVVRQLCQESFSSSALGLKKLLDVTCSSLSVTQEEAEEL
LQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISL
PRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETLDT
MLDGLGRIRDQLSAVASK

Sequence of entity 10 (J), FASTA

>8F2U_10 COMM domain-containing protein 10 (chains J)
MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAA
FSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQET
VEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFS
HKELFDFYNKLETIQAQLDSLTHHHHHHHHHH

Sequence of entity 11 (N), FASTA

>8F2U_11 Coiled-coil domain-containing protein 93 (chains N)
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWC
ITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVV
QWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRR
KYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAH
EEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSEL
SAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTY
SEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIEN
LKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAI
LHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLN
SIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLE
KQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS

Sequence of entity 12 (T), FASTA

>8F2U_12 Coiled-coil domain-containing protein 22 (chains T)
MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLA
MSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPA
GDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEP
REFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQED
TRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFT
FHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGV
SFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQ
WEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSE
LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD
ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL
SNLEKIREDYRALRQENAGLLGRVREA

Primary citation

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Healy, M.D., McNally, K.E., Butkovic, R. et al. Cell (2023) 186:2219-2237.e29. DOI 10.1016/j.cell.2023.04.003 · PubMed

Other PDB entries of the same protein (UniProt Q8N668 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8P0W 2.9 Å, Structure of the human Commander complex COMMD ring
8F2R 3.12 Å, Human CCC complex
2H2M Solution Structure of the N-terminal domain of COMMD1 (Murr1)

Browse structure collections

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