8FKV: Human nucleolar pre-60S ribosomal subunit
Human nucleolar pre-60S ribosomal subunit (State D1). Determined by electron microscopy at 2.47 Å resolution. Released 12 Jul 2023.
- Method
- Electron microscopy
- Resolution
- 2.47 Å
- Organism
- Homo sapiens
- Chains
- 56
- Atoms
- 148,975
- Mol. weight
- 4041.9 kDa
- Ligands
- GDP, SF4, ADP, ZN
- Released
- 12 Jul 2023
Explore 8FKV in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8FKV contains 643 α-helices and 474 β-strands across 53 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain BA: 8 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-18 | 8 | 1 |
| α-helix | 22-24 | 3 | |
| α-helix | 25-35 | 11 | |
| α-helix | 39-50 | 12 | |
| β-strand | 57-65 | 9 | 1 |
| β-strand | 68-74 | 7 | 1 |
| α-helix | 77-85 | 9 | |
| α-helix | 87-89 | 3 | |
| β-strand | 103-104 | 2 | 2 |
| α-helix | 106-115 | 10 | |
| α-helix | 125-139 | 15 | |
| β-strand | 142-143 | 2 | 2 |
| β-strand | 146 | 1 | 2 |
| α-helix | 148-157 | 10 | |
Chain BB: 13 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-23 | 17 | |
| β-strand | 31-38 | 8 | 9 |
| α-helix | 47-49 | 3 | |
| β-strand | 50-54 | 5 | 10 |
| β-strand | 65-68 | 4 | 11 |
| α-helix | 71-80 | 10 | |
| β-strand | 84-85 | 2 | 11 |
| α-helix | 87-94 | 8 | |
| α-helix | 97-106 | 10 | |
| β-strand | 109-113 | 5 | 11 |
| α-helix | 114-117 | 4 | |
| α-helix | 120-123 | 4 | |
| α-helix | 125-131 | 7 | |
| α-helix | 134-135 | 2 | |
| β-strand | 136-138 | 3 | 11 |
| α-helix | 144-153 | 10 | |
| β-strand | 154-158 | 5 | 10 |
| β-strand | 164-171 | 8 | 9 |
| α-helix | 176-193 | 18 | |
| α-helix | 197-200 | 4 | |
| β-strand | 201-207 | 7 | 9 |
| α-helix | 212-213 | 2 | |
| β-strand | 214-215 | 2 | 9 |
Chain L6: 4 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-24 | 3 | 29 |
| α-helix | 28-45 | 18 | |
| β-strand | 55 | 1 | 30 |
| β-strand | 58-60 | 3 | 31 |
| β-strand | 70-72 | 3 | 31 |
| β-strand | 76 | 1 | 32 |
| α-helix | 78-84 | 7 | |
| α-helix | 88-94 | 7 | |
| β-strand | 96 | 1 | 30 |
| β-strand | 98 | 1 | 32 |
| β-strand | 106 | 1 | 33 |
| α-helix | 107-122 | 16 | |
| β-strand | 124-126 | 3 | 34 |
Chain L7: 12 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-10 | 4 | 35 |
| β-strand | 14 | 1 | 36 |
| β-strand | 15 | 1 | 37 |
| α-helix | 16-28 | 13 | |
| β-strand | 33-36 | 4 | 35 |
| α-helix | 38-40 | 3 | |
| β-strand | 42-44 | 3 | 37 |
| α-helix | 47-59 | 13 | |
| α-helix | 66-68 | 3 | |
| α-helix | 76-86 | 11 | |
| α-helix | 93-100 | 8 | |
| β-strand | 102-104 | 3 | 35 |
| α-helix | 112-114 | 3 | |
| β-strand | 118 | 1 | 35 |
| β-strand | 119 | 1 | 38 |
| α-helix | 121-123 | 3 | |
| β-strand | 124 | 1 | 36 |
| α-helix | 125-128 | 4 | |
| β-strand | 135-137 | 3 | 37 |
| α-helix | 138-145 | 8 | |
| α-helix | 150-184 | 35 | |
| α-helix | 190-198 | 9 | |
Chain L8: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 47 |
| β-strand | 11-15 | 5 | 48 |
| β-strand | 24-30 | 7 | 48 |
| β-strand | 35-40 | 6 | 48 |
| β-strand | 45-51 | 7 | 48 |
| β-strand | 55-61 | 7 | 48 |
| α-helix | 70-80 | 11 | |
| α-helix | 82-88 | 7 | |
| α-helix | 90-102 | 13 | |
| α-helix | 106-135 | 30 | |
Chain L9: 12 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-12 | 10 | |
| α-helix | 17-32 | 16 | |
| β-strand | 36-39 | 4 | 51 |
| α-helix | 45-50 | 6 | |
| β-strand | 59-67 | 9 | 51 |
| α-helix | 98-109 | 12 | |
| β-strand | 114-123 | 10 | 51 |
| β-strand | 127-135 | 9 | 51 |
| α-helix | 140-143 | 4 | |
| α-helix | 146-148 | 3 | |
| α-helix | 150-152 | 3 | |
| α-helix | 154-156 | 3 | |
| α-helix | 160-162 | 3 | |
| α-helix | 166-172 | 7 | |
| α-helix | 178-183 | 6 | |
| α-helix | 188-196 | 9 | |
| β-strand | 198-200 | 3 | 29 |
Chain LA: 7 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-13 | 3 | |
| β-strand | 14-22 | 9 | 55 |
| α-helix | 26-36 | 11 | |
| β-strand | 40 | 1 | 55 |
| α-helix | 41-53 | 13 | |
| β-strand | 58-59 | 2 | 56 |
| β-strand | 69 | 1 | 57 |
| α-helix | 71-76 | 6 | |
| β-strand | 80 | 1 | 57 |
| β-strand | 81-82 | 2 | 56 |
| α-helix | 85-105 | 21 | |
| β-strand | 112-121 | 10 | 55 |
| β-strand | 144-152 | 9 | 55 |
| α-helix | 153-156 | 4 | |
| α-helix | 160-175 | 16 | |
Chain LB: 6 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-38 | 16 | |
| α-helix | 42-51 | 10 | |
| β-strand | 61-62 | 2 | 60 |
| α-helix | 63-71 | 9 | |
| β-strand | 79-87 | 9 | 60 |
| β-strand | 99-105 | 7 | 60 |
| α-helix | 107-115 | 9 | |
| β-strand | 119-121 | 3 | 60 |
| α-helix | 123-129 | 7 | |
| β-strand | 136-139 | 4 | 60 |
| α-helix | 148-151 | 4 | |
45 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 60S ribosomal protein L12 | BA | protein | 165 | Homo sapiens | P30050 (AlphaFold model) |
| 60S ribosomal protein L10a | BB | protein | 217 | Homo sapiens | P62906 (AlphaFold model) |
| 5.8S rRNA | L1 | RNA | 157 | Homo sapiens | |
| ITS2 rRNA | L2 | RNA | 1167 | Homo sapiens | |
| 28S rRNA | L3 | RNA | 5070 | Homo sapiens | |
| 60S ribosomal protein L13 | L6 | protein | 211 | Homo sapiens | P26373 (AlphaFold model) |
| 60S ribosomal protein L13a | L7 | protein | 203 | Homo sapiens | P40429 (AlphaFold model) |
| 60S ribosomal protein L14 | L8 | protein | 215 | Homo sapiens | P50914 |
| 60S ribosomal protein L15 | L9 | protein | 204 | Homo sapiens | P61313 |
| 60S ribosomal protein L17 | LA | protein | 184 | Homo sapiens | P18621 |
| 60S ribosomal protein L18 | LB | protein | 188 | Homo sapiens | Q07020 |
| 60S ribosomal protein L18a | LC | protein | 176 | Homo sapiens | Q02543 |
44 more molecules are not listed.
Sequence of entity 1 (BA), FASTA
>8FKV_1 60S ribosomal protein L12 (chains BA)
MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITV
KLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRS
LARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS
Sequence of entity 2 (BB), FASTA
>8FKV_2 60S ribosomal protein L10a (chains BB)
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPR
PKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQI
PRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELV
YNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY
Sequence of entity 3 (L1), FASTA
>8FKV_3 5.8S rRNA (chains L1)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 4 (L2), FASTA
>8FKV_4 ITS2 rRNA (chains L2)
GCCGAUCAAUCGCCCCCGGGGGUGCCUCCGGGCUCCUCGGGGUGCGCGGCUGGGGGUUCC
CUCGCAGGGCCCGCCGGGGGCCCUCCGUCCCCCUAAGCGCAGACCCGGCGGCGUCCGCCC
UCCUCUUGCCGCCGCGCCCGCCCCUUCCCCCUCCCCCCGCGGGCCCUGCGUGGUCACGCG
UCGGGUGGCGGGGGGGAGAGGGGGGCGCGCCCGGCUGAGAGAGACGGGGAGGGCGGCGCC
GCCGCCGCCCGCGAAGACGGAGAGGGAAAGAGAGAGCCGGCUCGGGCCGAGUUCCCGUGG
CCGCCGCCUGCGGUCCGGGUUCCUCCCUCGGGGGGCUCCCUCGCGCCGCGCGCGGCUCGG
GGUUCGGGGUUCGUCGGCCCCGGCCGGGUGGAAGGUCCCGUGCCCGUCGUCGUCGUCGUC
GUCGCGCGUCGUCGGCGGUGGGGGCGUGUUGCGUGCGGUGUGGUGGUGGGGGAGGAGGAA
GGCGGGUCCGGAAGGGGAAGGGUGCCGGCGGGGAGAGAGGGUCGGGGGAGCGCGUCCCGG
UCGCCGCGGUUCGCCGCCCGCCCCCGGUGGCGGCCCGGCGUCCGGCCGACCGCCGCUCCC
GCGCCCCUCCUCCUCCCCGCCGCCCCUCCUCCGAGGCCCCGCCCGUCCUCCUCGCCCUCC
CCGCGCGUACGCGCGCCCGCCCGCCCGGCUCGCCUCGCGGCGCGUCGGCCGGGGCCGGGA
GCCCGCCCCGCGGCCCGCCCGGCCGCGCCCGUGGCCGCGGCGCCGGGGUUCGCGUGUCCC
CGGCGGCGACCCGCGGGACGCCGCGGUGUCGUCCGCCGUCGCGCGCCCGCCUCCGGCUCG
CGGCCGCGCCGCGCCGCGCCGGGGCCCCGUCCCGAGCUUCCGCGUCGGGGCGGGGCGGCU
CCGCCGCCGCGUCCUCGGACCCGUCCCCCCGACCUCCGCGGGGGAGACGGGUCGGGGCGU
GCGGCGCCCGUCCCGCCCCCGGCCCGUGCCCCUCCCUCCGGUCGUCCCGCUCCGGCGGGG
CGGCGCGGGGGUGCCGCCGGCCGCGCGCUCUCUCUCCCGUCGCCUCUCCCCCUCGCCGGG
CCCGUCUCCCGACGGAGCGUCGGGCGGGCGGUCGGGCCGGCGCGAUUCCGUCCGUCCGUC
CGCCGAGCGGCCCGUCCCCCUCCGAGA
Sequence of entity 5 (L3), FASTA
>8FKV_5 28S rRNA (chains L3)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG
Sequence of entity 6 (L6), FASTA
>8FKV_6 60S ribosomal protein L13 (chains L6)
MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR
CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEY
RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFA
SLRMARANARLFGIRAKRAKEAAEQDVEKKK
Sequence of entity 7 (L7), FASTA
>8FKV_7 60S ribosomal protein L13a (chains L7)
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRK
RMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVV
PAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQ
AEKNVEKKIDKYTEVLKTHGLLV
Sequence of entity 8 (L8), FASTA
>8FKV_8 60S ribosomal protein L14 (chains L8)
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA
Sequence of entity 9 (L9), FASTA
>8FKV_9 60S ribosomal protein L15 (chains L9)
MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYV
IYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYW
VGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKF
HHTIGGSRRAAWRRRNTLQLHRYR
Sequence of entity 10 (LA), FASTA
>8FKV_10 60S ribosomal protein L17 (chains LA)
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE
Sequence of entity 11 (LB), FASTA
>8FKV_11 60S ribosomal protein L18 (chains LB)
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN
Sequence of entity 12 (LC), FASTA
>8FKV_12 60S ribosomal protein L18a (chains LC)
MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGE
IVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRAR
AHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 1 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
| ZN | Zinc ion | Zn | 2 |
| MG | Magnesium ion | Mg | 65 |
Water and common crystallization additives (K) are not listed.
Primary citation
Principles of human pre-60 S biogenesis. Vanden Broeck, A., Klinge, S. Science (2023) 381:eadh3892-eadh3892. DOI 10.1126/science.adh3892 · PubMed
Other PDB entries of the same protein (UniProt P30050 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 8YOP 2.2 Å, Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline
- 9S3D 2.32 Å, NAC bound human RNC with 58 amino acid ARF1-linker
- 9S3B 2.38 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 1
- 8K2C 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline
- 8XSX 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2
- 9PKD 2.42 Å, In situ CHX and HHT treated 80S consensus ribosome
- 9S3C 2.42 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 2
- 9QLO 2.47 Å, NMT1-NAC bound human RNC with full length ARF1 - State 1
- 9P8B 2.48 Å, In situ human eEF1A-A/T-P-E state 80S ribosome
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