8FKY: Human nucleolar pre-60S ribosomal subunit
Human nucleolar pre-60S ribosomal subunit (State F). Determined by electron microscopy at 2.67 Å resolution. Released 12 Jul 2023.
- Method
- Electron microscopy
- Resolution
- 2.67 Å
- Organism
- Homo sapiens
- Chains
- 59
- Atoms
- 158,284
- Mol. weight
- 4041.83 kDa
- Ligands
- MG, ZN, ADP, GDP
- Released
- 12 Jul 2023
Explore 8FKY in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8FKY contains 613 α-helices and 526 β-strands across 56 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain BA: 7 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-17 | 7 | 1 |
| α-helix | 25-35 | 11 | |
| α-helix | 39-50 | 12 | |
| β-strand | 58-65 | 8 | 1 |
| β-strand | 68-74 | 7 | 1 |
| α-helix | 77-85 | 9 | |
| α-helix | 87-89 | 3 | |
| β-strand | 103-104 | 2 | 2 |
| α-helix | 106-115 | 10 | |
| α-helix | 125-139 | 15 | |
| β-strand | 142-143 | 2 | 2 |
| β-strand | 146 | 1 | 2 |
| α-helix | 148-157 | 10 | |
Chain BB: 13 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-23 | 17 | |
| α-helix | 30 | 1 | |
| β-strand | 31-38 | 8 | 14 |
| α-helix | 47-49 | 3 | |
| β-strand | 50-54 | 5 | 15 |
| β-strand | 65-68 | 4 | 16 |
| α-helix | 71-80 | 10 | |
| β-strand | 84-85 | 2 | 16 |
| α-helix | 87-94 | 8 | |
| α-helix | 97-106 | 10 | |
| β-strand | 109-113 | 5 | 16 |
| α-helix | 114-117 | 4 | |
| α-helix | 120-131 | 12 | |
| α-helix | 134-135 | 2 | |
| β-strand | 136-138 | 3 | 16 |
| α-helix | 144-153 | 10 | |
| β-strand | 154-158 | 5 | 15 |
| β-strand | 164-171 | 8 | 14 |
| α-helix | 176-193 | 18 | |
| α-helix | 197-200 | 4 | |
| β-strand | 201-207 | 7 | 14 |
| α-helix | 212-213 | 2 | |
| β-strand | 214-215 | 2 | 14 |
Chain BC: 8 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 28 | 1 | 19 |
| α-helix | 32-34 | 3 | |
| β-strand | 35-36 | 2 | 20 |
| β-strand | 41-46 | 6 | 21 |
| β-strand | 52-57 | 6 | 21 |
| β-strand | 62-66 | 5 | 21 |
| β-strand | 70 | 1 | 19 |
| β-strand | 75-80 | 6 | 21 |
| β-strand | 87-92 | 6 | 22 |
| β-strand | 98-103 | 6 | 22 |
| β-strand | 106-112 | 7 | 22 |
| β-strand | 118-123 | 6 | 22 |
| β-strand | 130-134 | 5 | 23 |
| β-strand | 140-145 | 6 | 23 |
| β-strand | 150-154 | 5 | 23 |
| β-strand | 162-164 | 3 | 23 |
| β-strand | 171-176 | 6 | 24 |
| β-strand | 182-187 | 6 | 24 |
| β-strand | 192-196 | 5 | 24 |
| β-strand | 201-205 | 5 | 24 |
| α-helix | 207-209 | 3 | |
| β-strand | 213-219 | 7 | 25 |
| β-strand | 224-229 | 6 | 25 |
| β-strand | 233-238 | 6 | 25 |
| β-strand | 247-250 | 4 | 25 |
| β-strand | 258-261 | 4 | 26 |
| β-strand | 266-270 | 5 | 26 |
| β-strand | 275-280 | 6 | 26 |
| β-strand | 285-292 | 8 | 26 |
| β-strand | 298-303 | 6 | 20 |
| β-strand | 309-314 | 6 | 20 |
| β-strand | 318-323 | 6 | 20 |
| α-helix | 325-328 | 4 | |
| α-helix | 331-333 | 3 | |
| α-helix | 337-339 | 3 | |
| α-helix | 345-346 | 2 | |
| β-strand | 347 | 1 | 26 |
| α-helix | 355-359 | 5 | |
| α-helix | 360-363 | 4 | |
Chain L6: 4 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-24 | 3 | 41 |
| α-helix | 28-45 | 18 | |
| β-strand | 55 | 1 | 42 |
| β-strand | 58-60 | 3 | 43 |
| β-strand | 70-72 | 3 | 43 |
| β-strand | 76 | 1 | 44 |
| α-helix | 78-84 | 7 | |
| α-helix | 88-93 | 6 | |
| β-strand | 96 | 1 | 42 |
| β-strand | 98 | 1 | 44 |
| β-strand | 106 | 1 | 45 |
| α-helix | 107-122 | 16 | |
| β-strand | 124-126 | 3 | 46 |
Chain L7: 11 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-10 | 4 | 51 |
| β-strand | 14 | 1 | 52 |
| β-strand | 15 | 1 | 53 |
| α-helix | 16-28 | 13 | |
| β-strand | 33-36 | 4 | 51 |
| α-helix | 38-40 | 3 | |
| β-strand | 42-44 | 3 | 53 |
| α-helix | 47-59 | 13 | |
| α-helix | 76-86 | 11 | |
| α-helix | 93-101 | 9 | |
| β-strand | 102-104 | 3 | 51 |
| α-helix | 112-114 | 3 | |
| β-strand | 118 | 1 | 51 |
| β-strand | 119 | 1 | 54 |
| α-helix | 121-123 | 3 | |
| β-strand | 124 | 1 | 52 |
| α-helix | 125-128 | 4 | |
| β-strand | 135-137 | 3 | 53 |
| α-helix | 138-145 | 8 | |
| α-helix | 150-184 | 35 | |
| α-helix | 190-198 | 9 | |
Chain L8: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 57 |
| β-strand | 11-15 | 5 | 58 |
| β-strand | 24-30 | 7 | 58 |
| β-strand | 35-40 | 6 | 58 |
| β-strand | 45-51 | 7 | 58 |
| β-strand | 55-61 | 7 | 58 |
| α-helix | 70-80 | 11 | |
| α-helix | 82-88 | 7 | |
| α-helix | 90-102 | 13 | |
| α-helix | 106-135 | 30 | |
Chain L9: 10 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-12 | 10 | |
| α-helix | 17-32 | 16 | |
| β-strand | 36-39 | 4 | 64 |
| α-helix | 45-50 | 6 | |
| β-strand | 59-67 | 9 | 64 |
| α-helix | 98-109 | 12 | |
| β-strand | 114-123 | 10 | 64 |
| β-strand | 127-135 | 9 | 64 |
| α-helix | 140-143 | 4 | |
| α-helix | 146-152 | 7 | |
| α-helix | 154-156 | 3 | |
| α-helix | 166-172 | 7 | |
| α-helix | 178-183 | 6 | |
| α-helix | 188-196 | 9 | |
| β-strand | 198-200 | 3 | 41 |
Chain LA: 5 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-22 | 9 | 65 |
| α-helix | 26-36 | 11 | |
| β-strand | 40 | 1 | 65 |
| α-helix | 41-53 | 13 | |
| β-strand | 58 | 1 | 66 |
| α-helix | 67-68 | 2 | |
| β-strand | 69 | 1 | 67 |
| α-helix | 71-76 | 6 | |
| β-strand | 80 | 1 | 67 |
| β-strand | 82 | 1 | 66 |
| α-helix | 85-105 | 21 | |
| β-strand | 112-121 | 10 | 65 |
| β-strand | 144-152 | 9 | 65 |
48 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 60S ribosomal protein L12 | BA | protein | 165 | Homo sapiens | P30050 (AlphaFold model) |
| 60S ribosomal protein L10a | BB | protein | 217 | Homo sapiens | P62906 (AlphaFold model) |
| WD repeat-containing protein 55 | BC | protein | 383 | Homo sapiens | Q9H6Y2 (AlphaFold model) |
| 5.8S rRNA | L1 | RNA | 157 | Homo sapiens | |
| ITS2 rRNA | L2 | RNA | 1167 | Homo sapiens | |
| 28S rRNA | L3 | RNA | 5070 | Homo sapiens | |
| 60S ribosomal protein L13 | L6 | protein | 211 | Homo sapiens | P26373 (AlphaFold model) |
| 60S ribosomal protein L13a | L7 | protein | 203 | Homo sapiens | P40429 |
| 60S ribosomal protein L14 | L8 | protein | 215 | Homo sapiens | P50914 |
| 60S ribosomal protein L15 | L9 | protein | 204 | Homo sapiens | P61313 |
| 60S ribosomal protein L17 | LA | protein | 184 | Homo sapiens | P18621 |
| 60S ribosomal protein L18 | LB | protein | 188 | Homo sapiens | Q07020 |
47 more molecules are not listed.
Sequence of entity 1 (BA), FASTA
>8FKY_1 60S ribosomal protein L12 (chains BA)
MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITV
KLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRS
LARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS
Sequence of entity 2 (BB), FASTA
>8FKY_2 60S ribosomal protein L10a (chains BB)
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPR
PKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQI
PRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELV
YNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY
Sequence of entity 3 (BC), FASTA
>8FKY_3 WD repeat-containing protein 55 (chains BC)
MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDG
DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLER
RVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAK
KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN
GFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEE
LALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFA
GLREEGEDSMAQEEKEETGDDSD
Sequence of entity 4 (L1), FASTA
>8FKY_4 5.8S rRNA (chains L1)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 5 (L2), FASTA
>8FKY_5 ITS2 rRNA (chains L2)
GCCGAUCAAUCGCCCCCGGGGGUGCCUCCGGGCUCCUCGGGGUGCGCGGCUGGGGGUUCC
CUCGCAGGGCCCGCCGGGGGCCCUCCGUCCCCCUAAGCGCAGACCCGGCGGCGUCCGCCC
UCCUCUUGCCGCCGCGCCCGCCCCUUCCCCCUCCCCCCGCGGGCCCUGCGUGGUCACGCG
UCGGGUGGCGGGGGGGAGAGGGGGGCGCGCCCGGCUGAGAGAGACGGGGAGGGCGGCGCC
GCCGCCGCCCGCGAAGACGGAGAGGGAAAGAGAGAGCCGGCUCGGGCCGAGUUCCCGUGG
CCGCCGCCUGCGGUCCGGGUUCCUCCCUCGGGGGGCUCCCUCGCGCCGCGCGCGGCUCGG
GGUUCGGGGUUCGUCGGCCCCGGCCGGGUGGAAGGUCCCGUGCCCGUCGUCGUCGUCGUC
GUCGCGCGUCGUCGGCGGUGGGGGCGUGUUGCGUGCGGUGUGGUGGUGGGGGAGGAGGAA
GGCGGGUCCGGAAGGGGAAGGGUGCCGGCGGGGAGAGAGGGUCGGGGGAGCGCGUCCCGG
UCGCCGCGGUUCGCCGCCCGCCCCCGGUGGCGGCCCGGCGUCCGGCCGACCGCCGCUCCC
GCGCCCCUCCUCCUCCCCGCCGCCCCUCCUCCGAGGCCCCGCCCGUCCUCCUCGCCCUCC
CCGCGCGUACGCGCGCCCGCCCGCCCGGCUCGCCUCGCGGCGCGUCGGCCGGGGCCGGGA
GCCCGCCCCGCGGCCCGCCCGGCCGCGCCCGUGGCCGCGGCGCCGGGGUUCGCGUGUCCC
CGGCGGCGACCCGCGGGACGCCGCGGUGUCGUCCGCCGUCGCGCGCCCGCCUCCGGCUCG
CGGCCGCGCCGCGCCGCGCCGGGGCCCCGUCCCGAGCUUCCGCGUCGGGGCGGGGCGGCU
CCGCCGCCGCGUCCUCGGACCCGUCCCCCCGACCUCCGCGGGGGAGACGGGUCGGGGCGU
GCGGCGCCCGUCCCGCCCCCGGCCCGUGCCCCUCCCUCCGGUCGUCCCGCUCCGGCGGGG
CGGCGCGGGGGUGCCGCCGGCCGCGCGCUCUCUCUCCCGUCGCCUCUCCCCCUCGCCGGG
CCCGUCUCCCGACGGAGCGUCGGGCGGGCGGUCGGGCCGGCGCGAUUCCGUCCGUCCGUC
CGCCGAGCGGCCCGUCCCCCUCCGAGA
Sequence of entity 6 (L3), FASTA
>8FKY_6 28S rRNA (chains L3)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCGCCGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG
Sequence of entity 7 (L6), FASTA
>8FKY_7 60S ribosomal protein L13 (chains L6)
MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR
CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEY
RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFA
SLRMARANARLFGIRAKRAKEAAEQDVEKKK
Sequence of entity 8 (L7), FASTA
>8FKY_8 60S ribosomal protein L13a (chains L7)
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRK
RMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVV
PAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQ
AEKNVEKKIDKYTEVLKTHGLLV
Sequence of entity 9 (L8), FASTA
>8FKY_9 60S ribosomal protein L14 (chains L8)
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA
Sequence of entity 10 (L9), FASTA
>8FKY_10 60S ribosomal protein L15 (chains L9)
MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYV
IYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYW
VGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKF
HHTIGGSRRAAWRRRNTLQLHRYR
Sequence of entity 11 (LA), FASTA
>8FKY_11 60S ribosomal protein L17 (chains LA)
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE
Sequence of entity 12 (LB), FASTA
>8FKY_12 60S ribosomal protein L18 (chains LB)
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 70 |
| ZN | Zinc ion | Zn | 3 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 1 |
Water and common crystallization additives (K) are not listed.
Primary citation
Principles of human pre-60 S biogenesis. Vanden Broeck, A., Klinge, S. Science (2023) 381:eadh3892-eadh3892. DOI 10.1126/science.adh3892 · PubMed
Other PDB entries of the same protein (UniProt P30050 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 8YOP 2.2 Å, Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline
- 9S3D 2.32 Å, NAC bound human RNC with 58 amino acid ARF1-linker
- 9S3B 2.38 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 1
- 8K2C 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline
- 8XSX 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2
- 9PKD 2.42 Å, In situ CHX and HHT treated 80S consensus ribosome
- 9S3C 2.42 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 2
- 8FKV 2.47 Å, Human nucleolar pre-60S ribosomal subunit (State D1)
- 9QLO 2.47 Å, NMT1-NAC bound human RNC with full length ARF1 - State 1
Browse structure collections
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