8FL3: Human nuclear pre-60S ribosomal subunit
Human nuclear pre-60S ribosomal subunit (State I2). Determined by electron microscopy at 2.53 Å resolution. Released 12 Jul 2023.
- Method
- Electron microscopy
- Resolution
- 2.53 Å
- Organism
- Homo sapiens
- Chains
- 63
- Atoms
- 185,196
- Mol. weight
- 3753.16 kDa
- Ligands
- GDP, GTP, ZN, MG
- Released
- 12 Jul 2023
Explore 8FL3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8FL3 contains 679 α-helices and 507 β-strands across 60 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain BA: 8 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-18 | 8 | 1 |
| α-helix | 25-35 | 11 | |
| α-helix | 39-49 | 11 | |
| α-helix | 50-52 | 3 | |
| β-strand | 57-65 | 9 | 1 |
| β-strand | 68-74 | 7 | 1 |
| α-helix | 77-85 | 9 | |
| α-helix | 87-89 | 3 | |
| β-strand | 103-104 | 2 | 2 |
| α-helix | 106-116 | 11 | |
| α-helix | 125-139 | 15 | |
| β-strand | 142-143 | 2 | 2 |
| β-strand | 146 | 1 | 2 |
| α-helix | 148-157 | 10 | |
Chain BB: 11 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-18 | 12 | |
| α-helix | 29-30 | 2 | |
| β-strand | 31-38 | 8 | 7 |
| α-helix | 47-49 | 3 | |
| β-strand | 50-54 | 5 | 8 |
| β-strand | 65-68 | 4 | 9 |
| α-helix | 71-80 | 10 | |
| β-strand | 84-85 | 2 | 9 |
| α-helix | 87-92 | 6 | |
| α-helix | 97-106 | 10 | |
| β-strand | 109-113 | 5 | 9 |
| α-helix | 120-123 | 4 | |
| α-helix | 127-130 | 4 | |
| α-helix | 134-135 | 2 | |
| β-strand | 136-138 | 3 | 9 |
| α-helix | 144-152 | 9 | |
| β-strand | 154-158 | 5 | 8 |
| β-strand | 164-171 | 8 | 7 |
| α-helix | 176-193 | 18 | |
| β-strand | 201-207 | 7 | 7 |
| β-strand | 214-215 | 2 | 7 |
Chain BD: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 721-728 | 8 | |
Chain L5: 10 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-13 | 3 | |
| β-strand | 16-25 | 10 | 29 |
| α-helix | 31-44 | 14 | |
| α-helix | 47-48 | 2 | |
| β-strand | 49-52 | 4 | 29 |
| β-strand | 57 | 1 | 30 |
| β-strand | 62 | 1 | 30 |
| β-strand | 67-74 | 8 | 29 |
| α-helix | 77-90 | 14 | |
| β-strand | 93-95 | 3 | 31 |
| α-helix | 96-98 | 3 | |
| β-strand | 99 | 1 | 29 |
| β-strand | 105-109 | 5 | 29 |
| α-helix | 112-115 | 4 | |
| α-helix | 117-119 | 3 | |
| β-strand | 120 | 1 | 32 |
| β-strand | 123 | 1 | 32 |
| β-strand | 128-135 | 8 | 29 |
| α-helix | 139-142 | 4 | |
| α-helix | 153-155 | 3 | |
| α-helix | 159-169 | 11 | |
| β-strand | 173-175 | 3 | 31 |
Chain L6: 10 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-20 | 3 | |
| β-strand | 22-24 | 3 | 41 |
| α-helix | 28-45 | 18 | |
| β-strand | 55 | 1 | 42 |
| β-strand | 58-60 | 3 | 43 |
| β-strand | 70-72 | 3 | 43 |
| β-strand | 76 | 1 | 44 |
| α-helix | 78-84 | 7 | |
| α-helix | 88-94 | 7 | |
| β-strand | 96 | 1 | 42 |
| β-strand | 98 | 1 | 44 |
| β-strand | 106 | 1 | 45 |
| α-helix | 107-122 | 16 | |
| β-strand | 124-126 | 3 | 46 |
| α-helix | 127-128 | 2 | |
| α-helix | 141-145 | 5 | |
| β-strand | 167-168 | 2 | 47 |
| α-helix | 169-170 | 2 | |
| α-helix | 171-175 | 5 | |
| α-helix | 178-210 | 33 | |
Chain L7: 12 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-10 | 5 | 54 |
| β-strand | 14 | 1 | 55 |
| β-strand | 15 | 1 | 56 |
| α-helix | 16-28 | 13 | |
| β-strand | 32-36 | 5 | 54 |
| α-helix | 38-40 | 3 | |
| β-strand | 42-44 | 3 | 56 |
| α-helix | 47-59 | 13 | |
| α-helix | 66-68 | 3 | |
| α-helix | 76-85 | 10 | |
| α-helix | 93-100 | 8 | |
| β-strand | 102-104 | 3 | 54 |
| α-helix | 112-114 | 3 | |
| β-strand | 118 | 1 | 54 |
| β-strand | 119 | 1 | 57 |
| α-helix | 121-123 | 3 | |
| β-strand | 124 | 1 | 55 |
| α-helix | 125-128 | 4 | |
| β-strand | 135-137 | 3 | 56 |
| α-helix | 138-144 | 7 | |
| α-helix | 150-184 | 35 | |
| α-helix | 186-198 | 13 | |
Chain L8: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-8 | 2 | 63 |
| β-strand | 11-15 | 5 | 64 |
| β-strand | 24-30 | 7 | 64 |
| β-strand | 35-40 | 6 | 64 |
| α-helix | 41-43 | 3 | |
| β-strand | 45-51 | 7 | 64 |
| β-strand | 55-61 | 7 | 64 |
| α-helix | 70-80 | 11 | |
| α-helix | 82-88 | 7 | |
| α-helix | 90-102 | 13 | |
| α-helix | 106-135 | 30 | |
Chain L9: 11 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-10 | 8 | |
| α-helix | 17-32 | 16 | |
| β-strand | 36-39 | 4 | 67 |
| α-helix | 45-50 | 6 | |
| β-strand | 59-67 | 9 | 67 |
| α-helix | 89-91 | 3 | |
| α-helix | 98-109 | 12 | |
| β-strand | 114-123 | 10 | 67 |
| β-strand | 127-135 | 9 | 67 |
| α-helix | 140-143 | 4 | |
| α-helix | 146-152 | 7 | |
| α-helix | 154-156 | 3 | |
| α-helix | 166-170 | 5 | |
| α-helix | 178-183 | 6 | |
| α-helix | 188-196 | 9 | |
| β-strand | 198-200 | 3 | 41 |
52 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 60S ribosomal protein L12 | BA | protein | 165 | Homo sapiens | P30050 (AlphaFold model) |
| 60S ribosomal protein L10a | BB | protein | 217 | Homo sapiens | P62906 (AlphaFold model) |
| Ribosomal biogenesis protein LAS1L | BD | protein | 734 | Homo sapiens | Q9Y4W2 (AlphaFold model) |
| 5.8S rRNA | L1 | RNA | 157 | Homo sapiens | |
| 28S rRNA | L3 | RNA | 5070 | Homo sapiens | |
| 5S rRNA | L4 | RNA | 121 | Homo sapiens | |
| 60S ribosomal protein L11 | L5 | protein | 178 | Homo sapiens | P62913 (AlphaFold model) |
| 60S ribosomal protein L13 | L6 | protein | 211 | Homo sapiens | P26373 |
| 60S ribosomal protein L13a | L7 | protein | 203 | Homo sapiens | P40429 |
| 60S ribosomal protein L14 | L8 | protein | 215 | Homo sapiens | P50914 |
| 60S ribosomal protein L15 | L9 | protein | 204 | Homo sapiens | P61313 |
| 60S ribosomal protein L17 | LA | protein | 184 | Homo sapiens | P18621 |
49 more molecules are not listed.
Sequence of entity 1 (BA), FASTA
>8FL3_1 60S ribosomal protein L12 (chains BA)
MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITV
KLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRS
LARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS
Sequence of entity 2 (BB), FASTA
>8FL3_2 60S ribosomal protein L10a (chains BB)
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPR
PKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQI
PRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELV
YNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY
Sequence of entity 3 (BD), FASTA
>8FL3_3 Ribosomal biogenesis protein LAS1L (chains BD)
MSWESGAGPGLGSQGMDLVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFC
DDHKLQRYALNRITVWRSRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALV
RFVNLISERKTKFAKVPLKCLAQEVNIPDWIVDLRHELTHKKMPHINDCRRGCYFVLDWL
QKTYWCRQLENSLRETWELEEFREGIEEEDQEEDKNIVVDDITEQKPEPQDDGKSTESDV
KADGDSKGSEEVDSHCKKALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNP
SPRVECVLAELKGVTCENREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTD
PKSHKNVDLNDVLVPKPFSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYIL
RWTVELIVANTKTGRNARRFSAGQWEARRGWRLFNCSASLDWPRMVESCLGSPCWASPQL
LRIIFKAMGQGLPDEEQEKLLRICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVK
PASSSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDD
EEEDRMEVGPFSTGQESPTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTE
DPAELMLENYDTMYLLDQPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWS
QGQLHGLKTGLQLF
Sequence of entity 4 (L1), FASTA
>8FL3_4 5.8S rRNA (chains L1)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 5 (L3), FASTA
>8FL3_5 28S rRNA (chains L3)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG
Sequence of entity 6 (L4), FASTA
>8FL3_6 5S rRNA (chains L4)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U
Sequence of entity 7 (L5), FASTA
>8FL3_7 60S ribosomal protein L11 (chains L5)
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSF
GIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYD
PSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Sequence of entity 8 (L6), FASTA
>8FL3_8 60S ribosomal protein L13 (chains L6)
MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR
CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEY
RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFA
SLRMARANARLFGIRAKRAKEAAEQDVEKKK
Sequence of entity 9 (L7), FASTA
>8FL3_9 60S ribosomal protein L13a (chains L7)
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRK
RMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVV
PAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQ
AEKNVEKKIDKYTEVLKTHGLLV
Sequence of entity 10 (L8), FASTA
>8FL3_10 60S ribosomal protein L14 (chains L8)
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA
Sequence of entity 11 (L9), FASTA
>8FL3_11 60S ribosomal protein L15 (chains L9)
MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYV
IYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYW
VGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKF
HHTIGGSRRAAWRRRNTLQLHRYR
Sequence of entity 12 (LA), FASTA
>8FL3_12 60S ribosomal protein L17 (chains LA)
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| ZN | Zinc ion | Zn | 5 |
| MG | Magnesium ion | Mg | 100 |
Water and common crystallization additives (K) are not listed.
Primary citation
Principles of human pre-60 S biogenesis. Vanden Broeck, A., Klinge, S. Science (2023) 381:eadh3892-eadh3892. DOI 10.1126/science.adh3892 · PubMed
Other PDB entries of the same protein (UniProt P30050 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 8YOP 2.2 Å, Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline
- 9S3D 2.32 Å, NAC bound human RNC with 58 amino acid ARF1-linker
- 9S3B 2.38 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 1
- 8K2C 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline
- 8XSX 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2
- 9PKD 2.42 Å, In situ CHX and HHT treated 80S consensus ribosome
- 9S3C 2.42 Å, NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 2
- 8FKV 2.47 Å, Human nucleolar pre-60S ribosomal subunit (State D1)
- 9QLO 2.47 Å, NMT1-NAC bound human RNC with full length ARF1 - State 1
Browse structure collections
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