8G7Z: Full length Neuroligin-2 from Mouse

Cryo-EM structure of full length Neuroligin-2 from Mouse bound to two Neurexin-1 Beta conformation one. Determined by electron microscopy at 3.22 Å resolution. Released 14 May 2025.

Method
Electron microscopy
Resolution
3.22 Å
Organism
Mus musculus
Chains
4
Atoms
11,094
Mol. weight
292.73 kDa
Ligands
CA, NAG
Released
14 May 2025

Explore 8G7Z in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8G7Z contains 58 α-helices and 60 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand44-4631
β-strand49-5241
β-strand5412
α-helix56-583
β-strand66-7382
β-strand97-9821
α-helix102-1076
α-helix121-1255
α-helix127-1337
β-strand143-14972
β-strand177-18262
α-helix193-1953
α-helix200-2056
β-strand208-21252
α-helix218-2214
α-helix233-24816
α-helix250-2523
β-strand254-264112
α-helix266-2749
β-strand286-29052
β-strand30113
α-helix304-31512
α-helix322-3309
α-helix334-3385
α-helix343-3453
β-strand35413
α-helix364-3674
β-strand377-38372
α-helix387-3893
α-helix403-41715
α-helix426-4349
α-helix438-4403
α-helix445-45612
α-helix457-4615
α-helix462-47211
β-strand478-48362
α-helix504-5074
α-helix510-5123
α-helix521-5233
α-helix525-54420
β-strand581-58332
α-helix595-5995
α-helix600-6045
α-helix605-6073
Chain B: 25 helices, 14 β-strands
ElementResiduesLengthSheet
β-strand43-4534
β-strand50-5234
β-strand66-6835
β-strand72-7325
β-strand96-9834
α-helix102-1065
α-helix121-1255
α-helix127-1337
β-strand143-14975
β-strand177-18265
α-helix193-1953
α-helix200-2056
β-strand208-21255
α-helix218-2214
α-helix233-24816
α-helix249-2524
β-strand254-264115
α-helix266-27510
β-strand286-29055
α-helix304-31512
α-helix322-33110
α-helix336-3394
α-helix343-3453
α-helix364-3696
β-strand377-38375
α-helix403-41715
α-helix425-43410
α-helix438-4403
α-helix445-45612
α-helix457-4615
α-helix462-47211
β-strand478-48365
α-helix504-5074
α-helix525-54420
β-strand580-58345
β-strand589-59025
α-helix595-5995
α-helix600-6045
α-helix605-6073
Chain C: 2 helices, 16 β-strands
ElementResiduesLengthSheet
β-strand87-8826
β-strand94-9967
β-strand10818
β-strand110-119106
β-strand124-13187
β-strand138-14477
β-strand147-15377
β-strand158-16257
β-strand174-18186
β-strand184-18966
α-helix193-1942
β-strand195-19736
β-strand23718
β-strand240-24567
β-strand256-26386
α-helix268-2725
β-strand279-28357
β-strand286-28726
Chain D: 2 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand86-99149
β-strand108110
β-strand112-11879
β-strand124-13189
β-strand138-14479
β-strand147-15379
β-strand158-16259
β-strand174-18189
β-strand184-18969
α-helix193-1942
β-strand195-19739
β-strand237110
β-strand240-24569
β-strand257-26379
β-strand266-26729
α-helix268-2736
β-strand279-28799

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Neuroligin-2A, Bprotein870Mus musculusQ69ZK9 (AlphaFold model)
Neurexin-1C, Dprotein470Mus musculusE0CZA5 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8G7Z_1 Neuroligin-2 (chains A, B)
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKYPYDVPDYAQRGG
GGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPP
LGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQS
EDCLYLNLYVPTEDDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYR
LGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLI
LSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSR
ELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSA
ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALF
TDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGA
TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNS
KEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPG
PGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAF
AALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVG
ADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPP
PPPTATSHNNTLPHPHSTTRVSNSLEVLFQ
Sequence of entity 2 (C, D), FASTA
>8G7Z_2 Neurexin-1 (chains C, D)
MYQRMLRCGADLGSPGGGSGGGAGGRLALIWIVPLTLGGLLGVAWGASSLGAHHIHHFHG
SSKEFEQKLISEEDLGFEIDKVWHDFPATSPIAIYRSPASLRGGHAGTTYIFSKGGGQIT
YKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTD
DIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG
KEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE
MSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLA
NPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVD
ESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYVSNSLEVLFQ

Ligands and cofactors

IDNameFormulaCopies
CACalcium ionCa2
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O66

Primary citation

Weaker neuroligin 2-neurexin beta 1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering. Boyd, R., Jaqaman, K., Wang, W. Sci Adv (2026) 12:eads9732-eads9732. DOI 10.1126/sciadv.ads9732 · PubMed

Other PDB entries of the same protein (UniProt Q69ZK9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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