8G81: Full length Neuroligin-2 from Mouse

Cryo-EM structure of full length Neuroligin-2 from Mouse bound to two Neurexin-1 Beta conformation three. Determined by electron microscopy at 3.22 Å resolution. Released 14 May 2025.

Method
Electron microscopy
Resolution
3.22 Å
Organism
Mus musculus
Chains
4
Atoms
11,148
Mol. weight
292.73 kDa
Ligands
CA, NAG
Released
14 May 2025

Explore 8G81 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8G81 contains 54 α-helices and 61 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 14 β-strands

ElementResiduesLengthSheet
β-strand43-4641
β-strand49-5241
β-strand5412
α-helix56-583
β-strand66-7382
β-strand96-9831
α-helix102-1076
α-helix121-1255
α-helix127-1304
β-strand143-14972
β-strand177-18372
α-helix200-2056
β-strand208-21252
α-helix218-2214
α-helix233-25220
β-strand254-264112
α-helix266-2749
β-strand286-29052
α-helix304-31512
α-helix322-3309
α-helix334-3385
α-helix343-3453
α-helix364-3696
β-strand377-38372
α-helix406-41712
α-helix427-4348
α-helix445-45612
α-helix457-4615
α-helix462-47211
β-strand478-48362
α-helix504-5074
α-helix510-5123
α-helix525-54420
β-strand580-58342
β-strand589-59022
α-helix595-5995
α-helix600-6045
α-helix605-6073
Chain B: 26 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand43-4533
β-strand50-5233
α-helix64-652
β-strand66-7384
β-strand96-9833
α-helix102-1076
α-helix121-1255
α-helix127-1337
β-strand143-14974
β-strand177-18264
α-helix193-1953
α-helix200-2056
β-strand208-21254
α-helix218-2214
α-helix233-24816
β-strand254-264114
α-helix266-2738
β-strand286-29054
β-strand30115
α-helix304-31512
α-helix322-33110
α-helix343-3453
β-strand35415
α-helix364-3696
β-strand377-38374
α-helix387-3893
α-helix403-41715
α-helix427-4348
α-helix438-4403
α-helix445-4473
α-helix448-4569
α-helix457-4615
α-helix462-47211
β-strand478-48364
α-helix504-5074
α-helix525-54319
β-strand580-58344
β-strand589-59024
α-helix595-5995
α-helix600-6045
α-helix605-6073
Chain C: 2 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand86-99146
β-strand10817
β-strand110-11896
β-strand123-13196
β-strand138-14476
β-strand147-15376
β-strand158-16366
β-strand174-18186
β-strand184-18966
α-helix193-1942
β-strand195-19736
β-strand23717
β-strand240-24566
β-strand257-26376
β-strand266-26726
α-helix268-2725
β-strand279-28796
Chain D: 2 helices, 17 β-strands
ElementResiduesLengthSheet
β-strand87-8828
β-strand94-9969
β-strand108110
β-strand110-11898
β-strand124-13189
β-strand138-14479
β-strand147-15379
β-strand158-16259
β-strand174-18188
β-strand184-18968
α-helix193-1942
β-strand195-19738
β-strand237110
β-strand240-24569
β-strand257-26378
β-strand26718
α-helix268-2736
β-strand279-28359
β-strand286-28728

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Neuroligin-2A, Bprotein870Mus musculusQ69ZK9 (AlphaFold model)
Neurexin-1C, Dprotein470Mus musculusE0CZA5 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8G81_1 Neuroligin-2 (chains A, B)
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKYPYDVPDYAQRGG
GGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPP
LGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQS
EDCLYLNLYVPTEDDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYR
LGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLI
LSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSR
ELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSA
ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALF
TDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGA
TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNS
KEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPG
PGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAF
AALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVG
ADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPP
PPPTATSHNNTLPHPHSTTRVSNSLEVLFQ
Sequence of entity 2 (C, D), FASTA
>8G81_2 Neurexin-1 (chains C, D)
MYQRMLRCGADLGSPGGGSGGGAGGRLALIWIVPLTLGGLLGVAWGASSLGAHHIHHFHG
SSKEFEQKLISEEDLGFEIDKVWHDFPATSPIAIYRSPASLRGGHAGTTYIFSKGGGQIT
YKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTD
DIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG
KEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE
MSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLA
NPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVD
ESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYVSNSLEVLFQ

Ligands and cofactors

IDNameFormulaCopies
CACalcium ionCa2
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O66

Primary citation

Weaker neuroligin 2-neurexin beta 1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering. Boyd, R., Jaqaman, K., Wang, W. Sci Adv (2026) 12:eads9732-eads9732. DOI 10.1126/sciadv.ads9732 · PubMed

Other PDB entries of the same protein (UniProt Q69ZK9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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