human KCNQ2-CaM-Ebio1 complex in the presence of PIP2. Determined by electron microscopy at 3.4 Å resolution. Released 17 Jan 2024.
Explore 8IJK in 3D Show helices and sheets RCSB PDB PDBe
8IJK contains 92 α-helices and 16 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 71-85 | 15 | |
| α-helix | 91-114 | 24 | |
| α-helix | 119-148 | 30 | |
| α-helix | 156-164 | 9 | |
| α-helix | 167-183 | 17 | |
| α-helix | 196-210 | 15 | |
| α-helix | 216-227 | 12 | |
| α-helix | 229-253 | 25 | |
| α-helix | 259-261 | 3 | |
| α-helix | 264-275 | 12 | |
| α-helix | 288-348 | 61 | |
| α-helix | 536-558 | 23 | |
| α-helix | 564-599 | 36 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-20 | 14 | |
| β-strand | 27-28 | 2 | 1 |
| α-helix | 30-40 | 11 | |
| α-helix | 46-56 | 11 | |
| β-strand | 64-65 | 2 | 1 |
| α-helix | 66-74 | 9 | |
| α-helix | 77-80 | 4 | |
| α-helix | 83-93 | 11 | |
| β-strand | 102 | 1 | 2 |
| α-helix | 103-112 | 10 | |
| α-helix | 116-118 | 3 | |
| α-helix | 119-129 | 11 | |
| β-strand | 136 | 1 | 2 |
| α-helix | 139-147 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-20 | 14 | |
| β-strand | 27-28 | 2 | 5 |
| α-helix | 30-40 | 11 | |
| α-helix | 46-56 | 11 | |
| β-strand | 64-65 | 2 | 5 |
| α-helix | 66-73 | 8 | |
| α-helix | 77-80 | 4 | |
| α-helix | 83-93 | 11 | |
| β-strand | 102 | 1 | 6 |
| α-helix | 103-112 | 10 | |
| α-helix | 116-118 | 3 | |
| α-helix | 119-129 | 11 | |
| β-strand | 136 | 1 | 6 |
| α-helix | 139-147 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | A, B, C, D | protein | 656 | Homo sapiens | O43526 (AlphaFold model) |
| Calmodulin-1 | E, F, G, H | protein | 149 | Homo sapiens | P0DP23 (AlphaFold model) |
>8IJK_1 Potassium voltage-gated channel subfamily KQT member 2 (chains A, B, C, D) MAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSS EGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAV LAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLC LILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGV SFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQY YERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSPCR GPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPK SWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRA VCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDK DRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAK EPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSVEGGSSGGWSHPQFEK
>8IJK_2 Calmodulin-1 (chains E, F, G, H) MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
| ID | Name | Formula | Copies |
|---|---|---|---|
| 7PN | N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide | C19 H14 F N O | 4 |
A small-molecule activation mechanism that directly opens the KCNQ2 channel. Zhang, S., Ma, D., Wang, K. et al. Nat Chem Biol (2024) 20:847-856. DOI 10.1038/s41589-023-01515-y · PubMed
Other PDB entries of the same protein (UniProt O43526 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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