Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current. Determined by X-ray diffraction at 1.01 Å resolution. Released 28 Feb 2024.
Explore 8KDX in 3D Show helices and sheets RCSB PDB PDBe
8KDX contains 3 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 87-89 | 3 | 1 |
| β-strand | 93 | 1 | 2 |
| β-strand | 100 | 1 | 1 |
| α-helix | 101-102 | 2 | |
| β-strand | 103 | 1 | 2 |
| β-strand | 108-113 | 6 | 1 |
| β-strand | 119-124 | 6 | 1 |
| β-strand | 130-134 | 5 | 1 |
| α-helix | 135-137 | 3 | |
| β-strand | 138-140 | 3 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 216-218 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Fyn | A | protein | 61 | Homo sapiens | P06241 (AlphaFold model) |
| Microtubule-associated protein tau | B | protein | 15 | Homo sapiens | P10636 (AlphaFold model) |
>8KDX_1 Tyrosine-protein kinase Fyn (chains A) SGTTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV D
>8KDX_2 Microtubule-associated protein tau (chains B) GSRSRTPSLPTPPTR
Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current. Jos, S., Poulose, R., Kambaru, A. et al. J Mol Biol (2024) 436:168445-168445. DOI 10.1016/j.jmb.2024.168445 · PubMed
Other PDB entries of the same protein (UniProt P06241 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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