Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) is a 476-residue protein from Canis lupus familiaris. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38377.
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The mean pLDDT of this model is 73.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 66% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:10799540, PubMed:1423609). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while…
The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:1423609, PubMed:36261528). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Z3T | EM | 2.69 Å | A=1-476 |
| 8RJB | EM | 2.69 Å | 1=1-476 |
| 8RJD | EM | 2.79 Å | 1=1-476 |
| 8RJC | EM | 2.9 Å | 1=1-476 |
| 7TM3 | EM | 3.25 Å | 1=1-476 |
| 8OJ0 | EM | 3.3 Å | 1=1-476 |
| 8OJ8 | EM | 3.3 Å | 1=1-476 |
| 8BTK | EM | 3.5 Å | SX=1-476 |
| 3JC2 | EM | 3.6 Å | 1=1-476 |
| 7TUT | EM | 3.88 Å | 1=1-476 |
| 6R7Q | EM | 3.9 Å | XX=5-465 |
| 6FTI | EM | 4.2 Å | x=5-465 |
| 6FTJ | EM | 4.7 Å | x=5-465 |
| 2WWB | EM | 6.48 Å | A=1-476 |
| 4CG7 | EM | 6.9 Å | A=1-476 |
| 4CG5 | EM | 7.4 Å | A=1-476 |
| 4CG6 | EM | 7.8 Å | A=1-476 |
| 5A6U | EM | 9.0 Å | A=26-476 |
| 6FTG | EM | 9.1 Å | x=5-465 |
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