8PJ4: Eukaryotic translation initiation factor 5B

Structure of human 48S translation initiation complex after eIF5 release (48S-4). Determined by electron microscopy at 3.2 Å resolution. Released 14 Aug 2024.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 53
Atoms: 121,694
Mol. weight: 2351.6 kDa
Ligands: ZN, MG, GTP
Released: 14 Aug 2024

Explore 8PJ4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8PJ4 contains 488 α-helices and 481 β-strands across 50 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 27 helices, 43 β-strands

Element	Residues	Length	Sheet
α-helix	601-622	22
β-strand	625-629	5	1
α-helix	630-632	3
β-strand	633-636	4	2
α-helix	644-652	9
α-helix	656-659	4
α-helix	661-663	3
β-strand	669-674	6	2
α-helix	675-682	8
β-strand	697-702	6	2
α-helix	703-704	2
α-helix	707-709	3
α-helix	710-719	10
β-strand	722-728	7	2
α-helix	735-747	13
β-strand	751-756	6	2
α-helix	758-760	3
α-helix	772-778	7
α-helix	781-801	21
β-strand	805-807	3	2
β-strand	818-823	6	2
β-strand	824	1	3
β-strand	829	1	3
α-helix	831-844	14
α-helix	847-850	4
β-strand	851-852	2	1
β-strand	857-866	10	4
β-strand	870-879	10	4
β-strand	882-883	2	5
β-strand	887-891	5	6
β-strand	896-900	5	6
β-strand	901-906	6	4
α-helix	907-908	2
β-strand	912	1	2
α-helix	919	1
β-strand	920-922	3	4
β-strand	924-925	2	5
β-strand	930-935	6	4
β-strand	946	1	4
β-strand	948-950	3	6
α-helix	955-969	15
β-strand	981-985	5	7
β-strand	987	1	4
α-helix	988-1001	14
β-strand	1005-1010	6	7
β-strand	1013	1	8
α-helix	1015-1022	8
α-helix	1024-1027	4
α-helix	1029-1031	3
β-strand	1033-1037	5	7
β-strand	1041	1	8
α-helix	1043-1052	10
β-strand	1055-1059	5	7
α-helix	1062-1083	22
β-strand	1092-1094	3	9
β-strand	1108	1	10
β-strand	1111	1	11
β-strand	1114-1117	4	9
β-strand	1125-1127	3	9
β-strand	1133-1136	4	9
β-strand	1140-1142	3	11
β-strand	1147	1	11
β-strand	1158-1160	3	11
β-strand	1161	1	10
α-helix	1169-1171	3
β-strand	1172	1	12
β-strand	1176	1	12
β-strand	1182-1183	2	9
α-helix	1188-1195	8
α-helix	1208-1216	9

Chain 1: 16 helices, 50 β-strands

Element	Residues	Length	Sheet
β-strand	181	1	16
β-strand	187-190	4	17
α-helix	199-210	12
α-helix	212-214	3
β-strand	219	1	18
β-strand	225	1	19
β-strand	228	1	19
β-strand	232-235	4	17
β-strand	236	1	18
α-helix	240-242	3
α-helix	243-249	7
β-strand	264	1	17
β-strand	265	1	16
α-helix	285-291	7
α-helix	303-305	3
β-strand	307	1	20
β-strand	309-310	2	21
β-strand	315-319	5	21
β-strand	328-333	6	21
β-strand	338-341	4	22
β-strand	349-352	4	22
β-strand	356-361	6	22
β-strand	366-372	7	22
β-strand	378-381	4	23
β-strand	387-396	10	23
β-strand	402-408	7	23
β-strand	413-417	5	23
β-strand	430-431	2	24
β-strand	437-442	6	24
β-strand	445-450	6	24
β-strand	456	1	24
α-helix	461-463	3
β-strand	469-472	4	25
β-strand	479-482	4	25
α-helix	484-486	3
α-helix	490	1
β-strand	491-496	6	25
β-strand	507-509	3	25
β-strand	517-519	3	26
β-strand	526-531	6	26
β-strand	542-547	6	26
β-strand	556-561	6	26
β-strand	565-570	6	27
α-helix	571	1
β-strand	576-581	6	27
α-helix	584-586	3
β-strand	587-594	8	27
β-strand	600-609	10	27
β-strand	613-616	4	28
β-strand	622-626	5	28
β-strand	638-639	2	28
β-strand	644-645	2	28
β-strand	656-659	4	29
β-strand	665	1	30
β-strand	666-669	4	29
β-strand	676	1	31
β-strand	678	1	31
β-strand	680-683	4	29
β-strand	685	1	30
β-strand	692-695	4	29
β-strand	703	1	20
α-helix	704-706	3
α-helix	714-717	4
α-helix	734-744	11
α-helix	750-754	5
α-helix	757-763	7

Chain 2: 4 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	4-6	3	36
β-strand	13-18	6	37
β-strand	25-29	5	37
β-strand	34-37	4	38
β-strand	44-48	5	38
β-strand	57-60	4	39
β-strand	67-70	4	39
β-strand	75	1	40
β-strand	76-78	3	39
α-helix	79-80	2
β-strand	91	1	40
β-strand	99-101	3	41
β-strand	107-111	5	41
β-strand	122-126	5	41
α-helix	129-131	3
β-strand	140-142	3	41
β-strand	149-154	6	42
α-helix	156-158	3
β-strand	161-165	5	42
β-strand	169	1	43
β-strand	170-171	2	42
β-strand	173-174	2	44
β-strand	179-180	2	44
β-strand	185	1	43
β-strand	205-207	3	45
β-strand	211-215	5	45
β-strand	222-226	5	45
α-helix	237-238	2
β-strand	243-246	4	46
β-strand	265-267	3	47
β-strand	268-271	4	46
β-strand	277	1	46
β-strand	281-284	4	47
β-strand	290-293	4	36
β-strand	300-303	4	36
β-strand	309-311	3	36

Chain 3: 14 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	3-16	14
α-helix	27-38	12
α-helix	44-56	13
α-helix	63-75	13
α-helix	81-87	7
α-helix	91-95	5
α-helix	97-110	14
α-helix	115-120	6
α-helix	126-130	5
α-helix	134-149	16
β-strand	153	1	52
α-helix	155-161	7
α-helix	167-177	11
β-strand	181	1	52
β-strand	187	1	52
α-helix	192-195	4
α-helix	211-215	5

Chain 4: 8 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	91-94	4	54
α-helix	96-108	13
α-helix	109-111	3
β-strand	118-125	8	55
β-strand	128-135	8	55
β-strand	139	1	56
β-strand	148	1	56
α-helix	150-163	14
β-strand	168-174	7	55
α-helix	181-193	13
β-strand	199-202	4	55
β-strand	213-216	4	55
β-strand	217	1	57
β-strand	233	1	57
β-strand	236-239	4	54
α-helix	245-257	13
α-helix	266-293	28
α-helix	302-312	11
α-helix	320-355	36

Chain 5: 28 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	50-76	27
α-helix	81-93	13
α-helix	94-99	6
α-helix	100-106	7
α-helix	111-114	4
α-helix	119-122	4
α-helix	126-143	18
α-helix	150-168	19
α-helix	180-202	23
α-helix	204-206	3
α-helix	209-217	9
α-helix	224-238	15
α-helix	240-248	9
α-helix	253-256	4
α-helix	259-262	4
α-helix	264-284	21
α-helix	287-292	6
α-helix	304-307	4
α-helix	309-325	17
α-helix	329-350	22
α-helix	354-377	24
α-helix	384-402	19
α-helix	406-416	11
α-helix	425-426	2
α-helix	438-464	27
β-strand	469-471	3	60
α-helix	472-478	7
α-helix	483-497	15
β-strand	499-501	3	61
β-strand	512-514	3	61
β-strand	520-524	5	60
β-strand	527-531	5	60
α-helix	538-559	22

Chain 6: 21 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	16-40	25
α-helix	44-53	10
α-helix	60-74	15
α-helix	81-92	12
α-helix	97-110	14
α-helix	116-129	14
α-helix	134-144	11
α-helix	156-171	16
α-helix	175-191	17
α-helix	192-194	3
α-helix	196-199	4
α-helix	201-212	12
α-helix	222-226	5
α-helix	238-244	7
α-helix	250-254	5
α-helix	255-259	5
α-helix	270-287	18
β-strand	293	1	63
α-helix	294-300	7
α-helix	305-307	3
α-helix	308-317	10
β-strand	322-325	4	64
β-strand	331	1	63
β-strand	332-335	4	64
α-helix	343-368	26

Chain 8: 11 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	32	1	69
β-strand	36	1	69
α-helix	43-54	12
β-strand	65-68	4	70
β-strand	72	1	71
β-strand	75	1	71
β-strand	80-82	3	70
α-helix	84-86	3
α-helix	93-106	14
β-strand	119-122	4	70
α-helix	131-143	13
β-strand	150-152	3	70
β-strand	164-166	3	70
β-strand	168-169	2	72
α-helix	171-177	7
β-strand	198-199	2	72
α-helix	212-224	13
α-helix	229-235	7
α-helix	236-240	5
α-helix	248-286	39
α-helix	295-303	9
α-helix	309-349	41

42 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eukaryotic translation initiation factor 5B	0	protein	1220	Homo sapiens	O60841 (AlphaFold model)
Eukaryotic translation initiation factor 3 subunit B	1	protein	814	Homo sapiens	P55884 (AlphaFold model)
Eukaryotic translation initiation factor 3 subunit I	2	protein	325	Homo sapiens	Q13347 (AlphaFold model)
Eukaryotic translation initiation factor 3 subunit K	3	protein	218	Homo sapiens	Q9UBQ5 (AlphaFold model)
Eukaryotic translation initiation factor 3 subunit F	4	protein	357	Homo sapiens	O00303
Eukaryotic translation initiation factor 3 subunit L	5	protein	564	Homo sapiens	Q9Y262
Eukaryotic translation initiation factor 3 subunit M	6	protein	374	Homo sapiens	Q7L2H7
mRNA	7	RNA	255	Homo sapiens
Eukaryotic translation initiation factor 3 subunit H	8	protein	352	Homo sapiens	O15372
60S ribosomal protein L41	9	protein	25	Homo sapiens	P62945
18S rRNA	A	RNA	1869	Homo sapiens
40S ribosomal protein S11	B	protein	158	Homo sapiens	P62280

41 more molecules are not listed.

Sequence of entity 1 (0), FASTA

>8PJ4_1 Eukaryotic translation initiation factor 5B (chains 0)
MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK
ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD
SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI
NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER
KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE
TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR
EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE
ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV
PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE
EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT
KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE
AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC
DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK
KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE
LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK
DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK
ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK
QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS
IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
EMQKSDWQLIVELKKVFEII

Sequence of entity 2 (1), FASTA

>8PJ4_2 Eukaryotic translation initiation factor 3 subunit B (chains 1)
MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEA
GPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSR
AQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEA
DGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASP
AHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEA
ECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALW
GGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHC
ESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA
FWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGV
VTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKI
ELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWD
PTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQI
KKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRG
GVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE

Sequence of entity 3 (2), FASTA

>8PJ4_3 Eukaryotic translation initiation factor 3 subunit I (chains 2)
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA

Sequence of entity 4 (3), FASTA

>8PJ4_4 Eukaryotic translation initiation factor 3 subunit K (chains 3)
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAF
FQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQA
LDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWS
ADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ

Sequence of entity 5 (4), FASTA

>8PJ4_5 Eukaryotic translation initiation factor 3 subunit F (chains 4)
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL

Sequence of entity 6 (5), FASTA

>8PJ4_6 Eukaryotic translation initiation factor 3 subunit L (chains 5)
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP

Sequence of entity 7 (6), FASTA

>8PJ4_7 Eukaryotic translation initiation factor 3 subunit M (chains 6)
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE
LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN
LNKVKNSLLSLSDT

Sequence of entity 8 (7), FASTA

>8PJ4_8 mRNA (chains 7)
GGGCAACAACAACAAGCUAGCCACAACAACAACAACAACAACAACAAGUCGACCAACAAC
AACAACAACAACAACAACAACUCGAGCAACAACAACAACAACAACAACAACAAGGAUCCA
AAACAGACCACCAUGGUACGUUUCAAGGCUUGAGCCCUCGUCACUGCCCUGUGGGGCAAG
GUGACUCUGGAAGAAGUUGGUGGUGAGGCCCUGGGCAGGCUGCAGAGUGUGAGGGAAGGU
CUGGUUGUCUACCAA

Sequence of entity 9 (8), FASTA

>8PJ4_9 Eukaryotic translation initiation factor 3 subunit H (chains 8)
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN

Sequence of entity 10 (9), FASTA

>8PJ4_10 60S ribosomal protein L41 (chains 9)
MRAKWRKKRMRRLKRKRRKMRQRSK

Sequence of entity 11 (A), FASTA

>8PJ4_11 18S rRNA (chains A)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUG
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCG
ACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCG
GUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAU
AACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUA
UCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGG
GUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCG
CGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCU
UUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAG
GGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGC
UGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGA
GCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGU
CCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCC
GCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUC
GGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGU
GAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCA
UUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCA
UAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCG
GGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAA
UUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACXCAACACGGGAAA
CCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUG
GGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAAC
GAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAAC
UUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUG
CCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCU
ACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAA
UUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAG
UCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCC
UCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGA
ACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAA
GGAUCAUUA

Sequence of entity 12 (B), FASTA

>8PJ4_12 40S ribosomal protein S11 (chains B)
MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKC
PFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDV
QIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	2
MG	Magnesium ion	Mg	89
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1

Water and common crystallization additives (NA) are not listed.

Primary citation

Structural basis for translational control by the human 48S initiation complex. Petrychenko, V., Yi, S.H., Liedtke, D. et al. Nat Struct Mol Biol (2025) 32:62-72. DOI 10.1038/s41594-024-01378-4 · PubMed

Other PDB entries of the same protein (UniProt O60841 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8PJ5 2.9 Å, Structure of human 48S translation initiation complex after eIF2 release prior 60S…
7TQL 3.2 Å, CryoEM structure of the human 40S small ribosomal subunit in complex with translation…
9KRP 3.2 Å, Structure of the HCV IRES-dependent 48S translation initiation complex with eIF5B and eIF3
9KN6 3.3 Å, Structure of the HCV IRES-dependent pre-48S translation initiation complex with eIF1A,…
8PJ3 3.7 Å, Structure of human 48S translation initiation complex upon transfer of initiator tRNA to…

Browse structure collections

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