8PJ5: Eukaryotic translation initiation factor 5B
Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5). Determined by electron microscopy at 2.9 Å resolution. Released 14 Aug 2024.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 51
- Atoms
- 113,033
- Mol. weight
- 2256.47 kDa
- Ligands
- MG, GTP, ZN
- Released
- 14 Aug 2024
Explore 8PJ5 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8PJ5 contains 448 α-helices and 436 β-strands across 48 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 27 helices, 39 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 601-622 | 22 | |
| β-strand | 624-629 | 6 | 1 |
| α-helix | 630-632 | 3 | |
| β-strand | 633-638 | 6 | 2 |
| α-helix | 644-652 | 9 | |
| α-helix | 656-659 | 4 | |
| α-helix | 661-663 | 3 | |
| β-strand | 669-674 | 6 | 2 |
| α-helix | 675-681 | 7 | |
| β-strand | 697-702 | 6 | 2 |
| α-helix | 703-704 | 2 | |
| α-helix | 707-709 | 3 | |
| α-helix | 710-719 | 10 | |
| β-strand | 722-728 | 7 | 2 |
| α-helix | 735-747 | 13 | |
| β-strand | 751 | 1 | 2 |
| β-strand | 753-756 | 4 | 2 |
| α-helix | 758-760 | 3 | |
| α-helix | 772-778 | 7 | |
| α-helix | 781-801 | 21 | |
| β-strand | 805-807 | 3 | 2 |
| β-strand | 818-822 | 5 | 2 |
| α-helix | 831-844 | 14 | |
| α-helix | 847-850 | 4 | |
| β-strand | 851-853 | 3 | 1 |
| β-strand | 857-866 | 10 | 3 |
| β-strand | 870-879 | 10 | 3 |
| β-strand | 881-883 | 3 | 4 |
| β-strand | 887-891 | 5 | 5 |
| β-strand | 896-900 | 5 | 5 |
| β-strand | 901-906 | 6 | 3 |
| α-helix | 907-908 | 2 | |
| β-strand | 912 | 1 | 2 |
| α-helix | 919 | 1 | |
| β-strand | 920-922 | 3 | 3 |
| β-strand | 924-926 | 3 | 4 |
| β-strand | 929-935 | 7 | 3 |
| β-strand | 946-947 | 2 | 3 |
| β-strand | 948-950 | 3 | 5 |
| α-helix | 955-969 | 15 | |
| β-strand | 982-985 | 4 | 6 |
| β-strand | 987 | 1 | 3 |
| α-helix | 988-1000 | 13 | |
| β-strand | 1008-1010 | 3 | 6 |
| β-strand | 1013 | 1 | 7 |
| α-helix | 1015-1022 | 8 | |
| α-helix | 1024-1027 | 4 | |
| α-helix | 1029-1031 | 3 | |
| β-strand | 1033-1037 | 5 | 6 |
| β-strand | 1041 | 1 | 7 |
| α-helix | 1043-1052 | 10 | |
| β-strand | 1055-1059 | 5 | 6 |
| α-helix | 1062-1083 | 22 | |
| β-strand | 1092-1097 | 6 | 8 |
| β-strand | 1111-1117 | 7 | 8 |
| β-strand | 1125-1128 | 4 | 8 |
| β-strand | 1132-1136 | 5 | 8 |
| β-strand | 1140-1142 | 3 | 8 |
| β-strand | 1147 | 1 | 8 |
| β-strand | 1157-1160 | 4 | 8 |
| α-helix | 1169-1171 | 3 | |
| β-strand | 1172 | 1 | 9 |
| β-strand | 1176 | 1 | 9 |
| β-strand | 1181-1184 | 4 | 8 |
| α-helix | 1188-1195 | 8 | |
| α-helix | 1208-1214 | 7 | |
Chain 1: 13 helices, 48 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 187-190 | 4 | 12 |
| α-helix | 199-210 | 12 | |
| β-strand | 219 | 1 | 13 |
| β-strand | 225 | 1 | 14 |
| β-strand | 228 | 1 | 14 |
| β-strand | 232-235 | 4 | 12 |
| β-strand | 236 | 1 | 13 |
| α-helix | 240-242 | 3 | |
| α-helix | 243-249 | 7 | |
| β-strand | 264-265 | 2 | 12 |
| α-helix | 281-284 | 4 | |
| α-helix | 287-291 | 5 | |
| α-helix | 303-305 | 3 | |
| β-strand | 306 | 1 | 15 |
| β-strand | 308-310 | 3 | 16 |
| β-strand | 315-319 | 5 | 16 |
| β-strand | 328-333 | 6 | 16 |
| β-strand | 338-342 | 5 | 17 |
| β-strand | 349-352 | 4 | 17 |
| β-strand | 356-361 | 6 | 17 |
| β-strand | 366-372 | 7 | 17 |
| β-strand | 378-381 | 4 | 18 |
| β-strand | 387-396 | 10 | 18 |
| β-strand | 402-408 | 7 | 18 |
| β-strand | 414-418 | 5 | 18 |
| β-strand | 430-431 | 2 | 19 |
| β-strand | 437-442 | 6 | 19 |
| β-strand | 445-450 | 6 | 19 |
| β-strand | 456 | 1 | 19 |
| β-strand | 469-472 | 4 | 20 |
| β-strand | 479-482 | 4 | 20 |
| α-helix | 484-486 | 3 | |
| α-helix | 490 | 1 | |
| β-strand | 491-496 | 6 | 20 |
| β-strand | 503-509 | 7 | 20 |
| β-strand | 517-519 | 3 | 21 |
| β-strand | 525-531 | 7 | 21 |
| β-strand | 542-548 | 7 | 21 |
| β-strand | 556-561 | 6 | 21 |
| β-strand | 565-570 | 6 | 22 |
| α-helix | 571 | 1 | |
| β-strand | 576-581 | 6 | 22 |
| β-strand | 587-594 | 8 | 22 |
| β-strand | 600-609 | 10 | 22 |
| β-strand | 613-616 | 4 | 23 |
| β-strand | 622-626 | 5 | 23 |
| β-strand | 638-639 | 2 | 23 |
| β-strand | 644-645 | 2 | 23 |
| β-strand | 656-659 | 4 | 24 |
| β-strand | 665 | 1 | 25 |
| β-strand | 666-669 | 4 | 24 |
| β-strand | 676 | 1 | 26 |
| β-strand | 678 | 1 | 26 |
| β-strand | 680-684 | 5 | 24 |
| β-strand | 685 | 1 | 25 |
| β-strand | 690-695 | 6 | 24 |
| β-strand | 704 | 1 | 15 |
| α-helix | 705-706 | 2 | |
| α-helix | 714-717 | 4 | |
| α-helix | 736-744 | 9 | |
| α-helix | 751-763 | 13 | |
Chain 2: 3 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-6 | 3 | 30 |
| β-strand | 13-18 | 6 | 31 |
| β-strand | 25-29 | 5 | 31 |
| β-strand | 34-37 | 4 | 32 |
| β-strand | 44-48 | 5 | 32 |
| β-strand | 58-60 | 3 | 33 |
| β-strand | 67-69 | 3 | 33 |
| β-strand | 75 | 1 | 34 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 33 |
| α-helix | 80 | 1 | |
| β-strand | 91 | 1 | 34 |
| β-strand | 99-101 | 3 | 35 |
| β-strand | 107-111 | 5 | 35 |
| β-strand | 122-126 | 5 | 35 |
| β-strand | 128 | 1 | 36 |
| β-strand | 133 | 1 | 36 |
| β-strand | 140-142 | 3 | 35 |
| β-strand | 151-154 | 4 | 37 |
| α-helix | 156-158 | 3 | |
| β-strand | 161-164 | 4 | 37 |
| β-strand | 169-174 | 6 | 37 |
| β-strand | 179-185 | 7 | 37 |
| β-strand | 205-206 | 2 | 38 |
| β-strand | 211-215 | 5 | 38 |
| β-strand | 222-227 | 6 | 38 |
| β-strand | 246 | 1 | 39 |
| β-strand | 265-267 | 3 | 40 |
| β-strand | 268 | 1 | 39 |
| β-strand | 270 | 1 | 41 |
| β-strand | 277 | 1 | 41 |
| β-strand | 281-284 | 4 | 40 |
| β-strand | 291-293 | 3 | 30 |
| β-strand | 300-303 | 4 | 30 |
| β-strand | 309-311 | 3 | 30 |
Chain 3: 17 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-14 | 12 | |
| α-helix | 23-25 | 3 | |
| α-helix | 26-39 | 14 | |
| α-helix | 44-56 | 13 | |
| α-helix | 58-60 | 3 | |
| α-helix | 63-73 | 11 | |
| α-helix | 81-87 | 7 | |
| α-helix | 91-94 | 4 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-120 | 7 | |
| α-helix | 126-130 | 5 | |
| α-helix | 137-149 | 13 | |
| β-strand | 150 | 1 | 46 |
| β-strand | 152-153 | 2 | 47 |
| α-helix | 155-162 | 8 | |
| α-helix | 167-177 | 11 | |
| β-strand | 180 | 1 | 47 |
| β-strand | 187-188 | 2 | 47 |
| α-helix | 192-195 | 4 | |
| α-helix | 197-198 | 2 | |
| α-helix | 207-215 | 9 | |
Chain 4: 8 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 91-94 | 4 | 49 |
| α-helix | 96-108 | 13 | |
| β-strand | 118-125 | 8 | 49 |
| β-strand | 128-135 | 8 | 49 |
| β-strand | 139 | 1 | 50 |
| β-strand | 148 | 1 | 50 |
| α-helix | 150-163 | 14 | |
| β-strand | 169-174 | 6 | 49 |
| α-helix | 181-193 | 13 | |
| β-strand | 198-202 | 5 | 49 |
| β-strand | 213-217 | 5 | 49 |
| β-strand | 235-239 | 5 | 49 |
| α-helix | 245-257 | 13 | |
| α-helix | 266-293 | 28 | |
| α-helix | 299-301 | 3 | |
| α-helix | 308-314 | 7 | |
| α-helix | 320-355 | 36 | |
Chain 5: 18 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 184-205 | 22 | |
| α-helix | 209-217 | 9 | |
| α-helix | 224-246 | 23 | |
| α-helix | 253-256 | 4 | |
| α-helix | 257-261 | 5 | |
| α-helix | 262-267 | 6 | |
| α-helix | 275-289 | 15 | |
| α-helix | 298-302 | 5 | |
| α-helix | 312-325 | 14 | |
| α-helix | 329-341 | 13 | |
| α-helix | 358-374 | 17 | |
| α-helix | 388-401 | 14 | |
| α-helix | 406-416 | 11 | |
| α-helix | 439-461 | 23 | |
| β-strand | 469-470 | 2 | 46 |
| α-helix | 472-480 | 9 | |
| α-helix | 491-496 | 6 | |
| α-helix | 497-499 | 3 | |
| β-strand | 505-506 | 2 | 46 |
| β-strand | 513-514 | 2 | 46 |
| α-helix | 525-550 | 26 | |
Chain 6: 19 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-25 | 8 | |
| α-helix | 31-34 | 4 | |
| α-helix | 46-53 | 8 | |
| α-helix | 60-64 | 5 | |
| α-helix | 65-74 | 10 | |
| α-helix | 86-92 | 7 | |
| α-helix | 97-105 | 9 | |
| α-helix | 117-129 | 13 | |
| α-helix | 155-169 | 15 | |
| α-helix | 175-192 | 18 | |
| α-helix | 200-213 | 14 | |
| α-helix | 252-256 | 5 | |
| α-helix | 263-266 | 4 | |
| α-helix | 269-278 | 10 | |
| α-helix | 281-285 | 5 | |
| α-helix | 297-301 | 5 | |
| α-helix | 305-317 | 13 | |
| β-strand | 322 | 1 | 55 |
| β-strand | 332 | 1 | 55 |
| α-helix | 342-346 | 5 | |
| α-helix | 348-355 | 8 | |
Chain 8: 14 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 32 | 1 | 60 |
| β-strand | 36 | 1 | 60 |
| β-strand | 39 | 1 | 61 |
| α-helix | 43-53 | 11 | |
| β-strand | 65-67 | 3 | 62 |
| β-strand | 70-72 | 3 | 61 |
| β-strand | 75-77 | 3 | 61 |
| β-strand | 88 | 1 | 63 |
| β-strand | 92 | 1 | 63 |
| α-helix | 98-106 | 9 | |
| β-strand | 118-121 | 4 | 62 |
| α-helix | 131-143 | 13 | |
| β-strand | 149-151 | 3 | 62 |
| β-strand | 165-166 | 2 | 62 |
| β-strand | 167-168 | 2 | 64 |
| α-helix | 171-177 | 7 | |
| α-helix | 187-190 | 4 | |
| β-strand | 199-200 | 2 | 64 |
| α-helix | 212-224 | 13 | |
| α-helix | 229-235 | 7 | |
| α-helix | 236-240 | 5 | |
| α-helix | 248-274 | 27 | |
| α-helix | 275-279 | 5 | |
| α-helix | 280-281 | 2 | |
| α-helix | 282-287 | 6 | |
| α-helix | 306-308 | 3 | |
| α-helix | 316-350 | 35 | |
40 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Eukaryotic translation initiation factor 5B | 0 | protein | 1220 | Homo sapiens | O60841 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit B | 1 | protein | 814 | Homo sapiens | P55884 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit I | 2 | protein | 325 | Homo sapiens | Q13347 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit K | 3 | protein | 218 | Homo sapiens | Q9UBQ5 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit F | 4 | protein | 357 | Homo sapiens | O00303 |
| Eukaryotic translation initiation factor 3 subunit L | 5 | protein | 564 | Homo sapiens | Q9Y262 |
| Eukaryotic translation initiation factor 3 subunit M | 6 | protein | 374 | Homo sapiens | Q7L2H7 |
| mRNA | 7 | RNA | 255 | Homo sapiens | |
| Eukaryotic translation initiation factor 3 subunit H | 8 | protein | 352 | Homo sapiens | O15372 |
| 60S ribosomal protein L41 | 9 | protein | 25 | Homo sapiens | P62945 |
| 18S rRNA | A | RNA | 1869 | Homo sapiens | |
| 40S ribosomal protein S11 | B | protein | 158 | Homo sapiens | P62280 |
39 more molecules are not listed.
Sequence of entity 1 (0), FASTA
>8PJ5_1 Eukaryotic translation initiation factor 5B (chains 0)
MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK
ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD
SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI
NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER
KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE
TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR
EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE
ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV
PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE
EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT
KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE
AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC
DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK
KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE
LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK
DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK
ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK
QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS
IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
EMQKSDWQLIVELKKVFEII
Sequence of entity 2 (1), FASTA
>8PJ5_2 Eukaryotic translation initiation factor 3 subunit B (chains 1)
MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEA
GPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSR
AQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEA
DGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASP
AHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEA
ECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALW
GGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHC
ESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA
FWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGV
VTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKI
ELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWD
PTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQI
KKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRG
GVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE
Sequence of entity 3 (2), FASTA
>8PJ5_3 Eukaryotic translation initiation factor 3 subunit I (chains 2)
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA
Sequence of entity 4 (3), FASTA
>8PJ5_4 Eukaryotic translation initiation factor 3 subunit K (chains 3)
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAF
FQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQA
LDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWS
ADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
Sequence of entity 5 (4), FASTA
>8PJ5_5 Eukaryotic translation initiation factor 3 subunit F (chains 4)
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Sequence of entity 6 (5), FASTA
>8PJ5_6 Eukaryotic translation initiation factor 3 subunit L (chains 5)
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP
Sequence of entity 7 (6), FASTA
>8PJ5_7 Eukaryotic translation initiation factor 3 subunit M (chains 6)
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE
LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN
LNKVKNSLLSLSDT
Sequence of entity 8 (7), FASTA
>8PJ5_8 mRNA (chains 7)
GGGCAACAACAACAAGCUAGCCACAACAACAACAACAACAACAACAAGUCGACCAACAAC
AACAACAACAACAACAACAACUCGAGCAACAACAACAACAACAACAACAACAAGGAUCCA
AAACAGACCACCAUGGUACGUUUCAAGGCUUGAGCCCUCGUCACUGCCCUGUGGGGCAAG
GUGACUCUGGAAGAAGUUGGUGGUGAGGCCCUGGGCAGGCUGCAGAGUGUGAGGGAAGGU
CUGGUUGUCUACCAA
Sequence of entity 9 (8), FASTA
>8PJ5_9 Eukaryotic translation initiation factor 3 subunit H (chains 8)
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
Sequence of entity 10 (9), FASTA
>8PJ5_10 60S ribosomal protein L41 (chains 9)
MRAKWRKKRMRRLKRKRRKMRQRSK
Sequence of entity 11 (A), FASTA
>8PJ5_11 18S rRNA (chains A)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUG
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCG
ACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCG
GUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAU
AACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUA
UCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGG
GUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCG
CGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCU
UUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAG
GGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGC
UGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGA
GCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGU
CCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCC
GCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUC
GGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGU
GAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCA
UUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCA
UAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCG
GGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAA
UUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACXCAACACGGGAAA
CCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUG
GGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAAC
GAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAAC
UUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUG
CCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCU
ACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAA
UUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAG
UCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCC
UCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGA
ACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAA
GGAUCAUUA
Sequence of entity 12 (B), FASTA
>8PJ5_12 40S ribosomal protein S11 (chains B)
MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKC
PFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDV
QIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 91 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
Structural basis for translational control by the human 48S initiation complex. Petrychenko, V., Yi, S.H., Liedtke, D. et al. Nat Struct Mol Biol (2024). DOI 10.1038/s41594-024-01378-4 · PubMed
Other PDB entries of the same protein (UniProt O60841 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7TQL 3.2 Å, CryoEM structure of the human 40S small ribosomal subunit in complex with translation…
- 8PJ4 3.2 Å, Structure of human 48S translation initiation complex after eIF5 release (48S-4)
- 9KRP 3.2 Å, Structure of the HCV IRES-dependent 48S translation initiation complex with eIF5B and eIF3
- 9KN6 3.3 Å, Structure of the HCV IRES-dependent pre-48S translation initiation complex with eIF1A,…
- 8PJ3 3.7 Å, Structure of human 48S translation initiation complex upon transfer of initiator tRNA to…
Browse structure collections
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