8PQZ: Cytoplasmic dynein-1 A1/A2 motor domains
Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1. Determined by electron microscopy at 5.5 Å resolution. Released 27 Mar 2024.
- Method
- Electron microscopy
- Resolution
- 5.5 Å
- Organisms
- Homo sapiens, Sus scrofa
- Chains
- 12
- Atoms
- 37,643
- Mol. weight
- 1770.96 kDa
- Ligands
- ATP, MG, ADP
- Released
- 27 Mar 2024
Explore 8PQZ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8PQZ contains 295 α-helices and 269 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 128 helices, 74 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1445-1471 | 27 | |
| β-strand | 1474 | 1 | 1 |
| β-strand | 1476-1480 | 5 | 2 |
| β-strand | 1484-1488 | 5 | 2 |
| α-helix | 1490-1509 | 20 | |
| α-helix | 1513-1515 | 3 | |
| α-helix | 1517-1553 | 37 | |
| α-helix | 1557-1560 | 4 | |
| α-helix | 1562-1583 | 22 | |
| β-strand | 1587 | 1 | 1 |
| α-helix | 1588-1592 | 5 | |
| α-helix | 1597-1612 | 16 | |
| α-helix | 1616-1625 | 10 | |
| α-helix | 1627-1631 | 5 | |
| α-helix | 1634-1642 | 9 | |
| α-helix | 1650-1654 | 5 | |
| β-strand | 1663-1666 | 4 | 3 |
| β-strand | 1673-1677 | 5 | 3 |
| β-strand | 1683-1685 | 3 | 3 |
| α-helix | 1698-1727 | 30 | |
| α-helix | 1735-1744 | 10 | |
| α-helix | 1747-1766 | 20 | |
| α-helix | 1776-1796 | 21 | |
| α-helix | 1802-1827 | 26 | |
| α-helix | 1836-1839 | 4 | |
| β-strand | 1843-1846 | 4 | 4 |
| β-strand | 1857-1861 | 5 | 4 |
| β-strand | 1864-1866 | 3 | 4 |
| α-helix | 1883-1897 | 15 | |
| β-strand | 1901-1905 | 5 | 5 |
| α-helix | 1913-1922 | 10 | |
| β-strand | 1926-1931 | 6 | 5 |
| α-helix | 1938-1951 | 14 | |
| β-strand | 1953-1958 | 6 | 5 |
| α-helix | 1965-1985 | 21 | |
| β-strand | 1998-2000 | 3 | 6 |
| β-strand | 2005-2007 | 3 | 6 |
| β-strand | 2014-2016 | 3 | 5 |
| β-strand | 2018 | 1 | 5 |
| α-helix | 2030-2034 | 5 | |
| β-strand | 2036-2040 | 5 | 5 |
| α-helix | 2046-2057 | 12 | |
| α-helix | 2062-2076 | 15 | |
| α-helix | 2081-2082 | 2 | |
| α-helix | 2090-2112 | 23 | |
| α-helix | 2133-2145 | 13 | |
| α-helix | 2153-2164 | 12 | |
| α-helix | 2176-2188 | 13 | |
| α-helix | 2201-2216 | 16 | |
| β-strand | 2219-2223 | 5 | 7 |
| α-helix | 2230-2245 | 16 | |
| β-strand | 2249-2254 | 6 | 7 |
| α-helix | 2261-2265 | 5 | |
| β-strand | 2268 | 1 | 8 |
| β-strand | 2275 | 1 | 8 |
| α-helix | 2279-2289 | 11 | |
| β-strand | 2298-2303 | 6 | 7 |
| α-helix | 2312-2314 | 3 | |
| β-strand | 2324-2325 | 2 | 9 |
| β-strand | 2333-2334 | 2 | 9 |
| β-strand | 2339-2342 | 4 | 7 |
| α-helix | 2353-2357 | 5 | |
| β-strand | 2360-2363 | 4 | 7 |
| α-helix | 2371-2383 | 13 | |
| α-helix | 2411-2427 | 17 | |
| α-helix | 2433-2440 | 8 | |
| α-helix | 2451-2475 | 25 | |
| α-helix | 2483-2503 | 21 | |
| α-helix | 2508-2521 | 14 | |
| α-helix | 2534-2536 | 3 | |
| β-strand | 2537-2539 | 3 | 10 |
| β-strand | 2545-2547 | 3 | 10 |
| α-helix | 2548-2551 | 4 | |
| α-helix | 2560-2562 | 3 | |
| α-helix | 2572-2585 | 14 | |
| β-strand | 2591-2594 | 4 | 11 |
| α-helix | 2603-2609 | 7 | |
| β-strand | 2615-2620 | 6 | 11 |
| α-helix | 2628-2638 | 11 | |
| β-strand | 2639-2643 | 5 | 12 |
| β-strand | 2648-2652 | 5 | 12 |
| β-strand | 2658-2663 | 6 | 11 |
| α-helix | 2670-2672 | 3 | |
| α-helix | 2678-2688 | 11 | |
| β-strand | 2691-2694 | 4 | 12 |
| β-strand | 2699-2703 | 5 | 12 |
| β-strand | 2706-2712 | 7 | 11 |
| α-helix | 2722-2724 | 3 | |
| α-helix | 2725-2730 | 6 | |
| β-strand | 2733-2735 | 3 | 11 |
| α-helix | 2741-2755 | 15 | |
| α-helix | 2760-2765 | 6 | |
| α-helix | 2766-2783 | 18 | |
| α-helix | 2796-2809 | 14 | |
| α-helix | 2818-2833 | 16 | |
| α-helix | 2840-2857 | 18 | |
| α-helix | 2863-2866 | 4 | |
| β-strand | 2873-2874 | 2 | 13 |
| β-strand | 2882-2883 | 2 | 13 |
| α-helix | 2887-2900 | 14 | |
| α-helix | 2913-2927 | 15 | |
| β-strand | 2932-2936 | 5 | 14 |
| α-helix | 2943-2953 | 11 | |
| α-helix | 2956 | 1 | |
| β-strand | 2957-2960 | 4 | 14 |
| α-helix | 2969-2986 | 18 | |
| β-strand | 2990-2995 | 6 | 14 |
| α-helix | 3002-3014 | 13 | |
| α-helix | 3024-3040 | 17 | |
| α-helix | 3048-3061 | 14 | |
| β-strand | 3062-3068 | 7 | 14 |
| α-helix | 3074-3081 | 8 | |
| α-helix | 3084-3087 | 4 | |
| β-strand | 3090-3093 | 4 | 14 |
| α-helix | 3097-3098 | 2 | |
| α-helix | 3099-3109 | 11 | |
| α-helix | 3137 | 1 | |
| α-helix | 3139-3164 | 26 | |
| α-helix | 3173-3238 | 66 | |
| α-helix | 3451-3501 | 51 | |
| α-helix | 3503-3516 | 14 | |
| α-helix | 3522-3538 | 17 | |
| α-helix | 3556-3564 | 9 | |
| α-helix | 3571-3581 | 11 | |
| α-helix | 3586 | 1 | |
| β-strand | 3587-3590 | 4 | 15 |
| α-helix | 3595-3603 | 9 | |
| β-strand | 3610-3613 | 4 | 15 |
| α-helix | 3620-3629 | 10 | |
| β-strand | 3633-3636 | 4 | 15 |
| α-helix | 3638-3640 | 3 | |
| α-helix | 3643-3645 | 3 | |
| α-helix | 3646-3650 | 5 | |
| β-strand | 3654-3656 | 3 | 16 |
| β-strand | 3659-3661 | 3 | 16 |
| β-strand | 3662-3664 | 3 | 17 |
| β-strand | 3667-3669 | 3 | 17 |
| β-strand | 3677-3681 | 5 | 15 |
| α-helix | 3690-3693 | 4 | |
| β-strand | 3697-3700 | 4 | 15 |
| α-helix | 3705-3719 | 15 | |
| α-helix | 3722-3754 | 33 | |
| α-helix | 3765-3817 | 53 | |
| α-helix | 3819-3822 | 4 | |
| α-helix | 3829-3840 | 12 | |
| α-helix | 3852-3872 | 21 | |
| α-helix | 3877-3879 | 3 | |
| α-helix | 3881-3894 | 14 | |
| α-helix | 3902-3910 | 9 | |
| α-helix | 3929-3938 | 10 | |
| α-helix | 3947-3953 | 7 | |
| α-helix | 3982-3996 | 15 | |
| α-helix | 3998-4000 | 3 | |
| α-helix | 4001-4012 | 12 | |
| α-helix | 4027-4029 | 3 | |
| α-helix | 4030-4034 | 5 | |
| β-strand | 4041-4045 | 5 | 18 |
| α-helix | 4052-4061 | 10 | |
| β-strand | 4068-4070 | 3 | 18 |
| α-helix | 4074-4089 | 16 | |
| β-strand | 4094-4097 | 4 | 18 |
| α-helix | 4099-4101 | 3 | |
| α-helix | 4103-4114 | 12 | |
| β-strand | 4124-4129 | 6 | 18 |
| α-helix | 4136-4140 | 5 | |
| β-strand | 4143-4147 | 5 | 18 |
| α-helix | 4150 | 1 | |
| α-helix | 4153-4163 | 11 | |
| α-helix | 4166-4169 | 4 | |
| α-helix | 4176-4192 | 17 | |
| α-helix | 4209-4226 | 18 | |
| α-helix | 4240-4246 | 7 | |
| α-helix | 4247-4251 | 5 | |
| α-helix | 4259-4272 | 14 | |
| α-helix | 4275-4278 | 4 | |
| β-strand | 4283-4285 | 3 | 19 |
| β-strand | 4294-4295 | 2 | 19 |
| α-helix | 4296-4297 | 2 | |
| α-helix | 4302-4310 | 9 | |
| α-helix | 4318-4320 | 3 | |
| α-helix | 4329-4349 | 21 | |
| α-helix | 4380-4390 | 11 | |
| α-helix | 4391-4394 | 4 | |
| α-helix | 4408-4438 | 31 | |
| α-helix | 4446-4456 | 11 | |
| β-strand | 4459 | 1 | 20 |
| α-helix | 4460-4461 | 2 | |
| β-strand | 4474 | 1 | 20 |
| α-helix | 4475-4497 | 23 | |
| β-strand | 4509-4510 | 2 | 21 |
| α-helix | 4517-4532 | 16 | |
| β-strand | 4540-4544 | 5 | 21 |
| β-strand | 4558-4561 | 4 | 21 |
| β-strand | 4563-4564 | 2 | 22 |
| β-strand | 4568-4571 | 4 | 22 |
| β-strand | 4574-4577 | 4 | 22 |
| β-strand | 4584-4585 | 2 | 22 |
| β-strand | 4588-4593 | 6 | 21 |
| β-strand | 4604-4610 | 7 | 22 |
| β-strand | 4618-4626 | 9 | 22 |
| α-helix | 4632-4637 | 6 | |
| β-strand | 4642-4643 | 2 | 22 |
Chain B: 3 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 91-93 | 3 | |
| β-strand | 96 | 1 | 23 |
| β-strand | 102-105 | 4 | 24 |
| β-strand | 111-116 | 6 | 25 |
| β-strand | 123-127 | 5 | 25 |
| β-strand | 132-136 | 5 | 25 |
| β-strand | 141-146 | 6 | 25 |
| β-strand | 153-158 | 6 | 26 |
| β-strand | 164-169 | 6 | 26 |
| β-strand | 174-178 | 5 | 26 |
| β-strand | 183-188 | 6 | 26 |
| β-strand | 197-199 | 3 | 27 |
| β-strand | 206-210 | 5 | 27 |
| β-strand | 215-220 | 6 | 27 |
| β-strand | 226-231 | 6 | 27 |
| β-strand | 237-242 | 6 | 28 |
| β-strand | 248-253 | 6 | 28 |
| β-strand | 258-262 | 5 | 28 |
| β-strand | 268-272 | 5 | 28 |
| β-strand | 279-284 | 6 | 29 |
| α-helix | 285-286 | 2 | |
| α-helix | 287-292 | 6 | |
| β-strand | 310-315 | 6 | 29 |
| β-strand | 319-324 | 6 | 29 |
| β-strand | 329-335 | 7 | 29 |
| β-strand | 341-346 | 6 | 30 |
| β-strand | 352-357 | 6 | 30 |
| β-strand | 362-366 | 5 | 30 |
| β-strand | 371-376 | 6 | 30 |
| β-strand | 383-388 | 6 | 24 |
| β-strand | 394-399 | 6 | 24 |
| β-strand | 403-408 | 6 | 24 |
| β-strand | 409 | 1 | 23 |
Chain C: 5 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 91-93 | 3 | |
| β-strand | 96 | 1 | 31 |
| α-helix | 100 | 1 | |
| β-strand | 102-105 | 4 | 32 |
| β-strand | 111-116 | 6 | 33 |
| β-strand | 123-127 | 5 | 33 |
| β-strand | 132-136 | 5 | 33 |
| β-strand | 141-146 | 6 | 33 |
| β-strand | 153-158 | 6 | 34 |
| β-strand | 164-169 | 6 | 34 |
| β-strand | 174-178 | 5 | 34 |
| β-strand | 184-188 | 5 | 34 |
| β-strand | 195-200 | 6 | 35 |
| β-strand | 206-211 | 6 | 35 |
| β-strand | 215-220 | 6 | 35 |
| β-strand | 225-231 | 7 | 35 |
| β-strand | 237-242 | 6 | 36 |
| β-strand | 248-253 | 6 | 36 |
| β-strand | 258-262 | 5 | 36 |
| β-strand | 268-272 | 5 | 36 |
| β-strand | 279-284 | 6 | 37 |
| α-helix | 285-286 | 2 | |
| α-helix | 287-289 | 3 | |
| α-helix | 290-296 | 7 | |
| β-strand | 310-315 | 6 | 37 |
| β-strand | 319-324 | 6 | 37 |
| β-strand | 330-335 | 6 | 37 |
| β-strand | 341-346 | 6 | 38 |
| β-strand | 353-357 | 5 | 38 |
| β-strand | 361-366 | 6 | 38 |
| β-strand | 371-377 | 7 | 38 |
| β-strand | 383-388 | 6 | 32 |
| β-strand | 394-399 | 6 | 32 |
| β-strand | 403-408 | 6 | 32 |
| β-strand | 409 | 1 | 31 |
Chain D: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| α-helix | 25-34 | 10 | |
| α-helix | 42-46 | 5 | |
| α-helix | 50-74 | 25 | |
Chain E: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-21 | 17 | |
| α-helix | 25-34 | 10 | |
| α-helix | 44-47 | 4 | |
| α-helix | 50-55 | 6 | |
| α-helix | 58-74 | 17 | |
Chain F: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 397-435 | 39 | |
| α-helix | 440-467 | 28 | |
| α-helix | 469-540 | 72 | |
Chain G: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 397-434 | 38 | |
| α-helix | 437-542 | 106 | |
Chain H: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-34 | 31 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Cytoplasmic dynein 1 heavy chain 1 | A, J | protein | 4646 | Homo sapiens | Q14204 |
| Platelet-activating factor acetylhydrolase IB subunit beta | B, C, D, E, K, L | protein | 410 | Homo sapiens | P43034 (AlphaFold model) |
| Dynactin subunit 1 | F, G | protein | 1281 | Sus scrofa | A0A287B8J2 (AlphaFold model) |
| Cytoplasmic dynein 1 intermediate chain 2 | H, I | protein | 612 | Homo sapiens | Q13409 (AlphaFold model) |
Sequence of entity 1 (A, J), FASTA
>8PQZ_1 Cytoplasmic dynein 1 heavy chain 1 (chains A, J)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQEFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGEIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE
Sequence of entity 2 (B, C, D, E, K, L), FASTA
>8PQZ_2 Platelet-activating factor acetylhydrolase IB subunit beta (chains B, C, D, E, K, L)
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
Sequence of entity 3 (F, G), FASTA
>8PQZ_3 Dynactin subunit 1 (chains F, G)
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRRE
GTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGAQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGIRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGI
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSVLKGAQMKASLAALPPLHVAKLSLPPHE
GPGSELAAGALYRKTNQLLETLNQLSTHTHVVDITRSSPAAKSPSAQLLEQVTQLKSLSD
TIEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLG
QRHRLVLTQEQLHQLHDRLIS
Sequence of entity 4 (H, I), FASTA
>8PQZ_4 Cytoplasmic dynein 1 intermediate chain 2 (chains H, I)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQV
DFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPH
ELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLS
LNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPE
YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYC
VNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNN
FVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV
KLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS
VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRA
DAEEEAATRIPA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
| MG | Magnesium ion | Mg | 4 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 6 |
Primary citation
Molecular mechanism of dynein-dynactin complex assembly by LIS1. Singh, K., Lau, C.K., Manigrasso, G. et al. Science (2024) 383:eadk8544-eadk8544. DOI 10.1126/science.adk8544 · PubMed
Other PDB entries of the same protein (UniProt Q14204), best resolution first:
- 5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
- 9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
- 9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
- 9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
- 9E0X 2.7 Å, Cryo-EM structure of Phi dynein
- 9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
- 9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
- 9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
- 9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
- 9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
- 9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
- 9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi
Browse structure collections
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