Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) is a 638-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13409.
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The mean pLDDT of this model is 72.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 52% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the…
Cytoplasm, cytoskeleton, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Z8I | EM | 3.3 Å | h/o=1-638 |
| 6F1U | EM | 3.4 Å | h=1-638 |
| 6F1Z | EM | 3.4 Å | o/p=1-638 |
| 6F1T | EM | 3.5 Å | g/h/o/p=1-638 |
| 9BLY | EM | 3.5 Å | C/D=1-638 |
| 8PR2 | EM | 3.8 Å | h=1-638 |
| 8PR3 | EM | 3.9 Å | h/o=1-638 |
| 7Z8J | EM | 3.93 Å | h/o=1-638 |
| 9YNC | EM | 3.93 Å | G/H=1-638 |
| 9YNG | EM | 4.07 Å | g/h/o/p=1-638 |
| 8PQW | EM | 4.2 Å | H/I=1-638 |
| 9YND | EM | 4.26 Å | F/G=1-638 |
| 7Z8K | EM | 4.37 Å | h=72-638 |
| 9E28 | EM | 4.4 Å | D/H/g/h=1-638 |
| 9E12 | EM | 4.5 Å | C/D=1-638 |
| 9E13 | EM | 4.5 Å | C/D=1-638 |
| 9E14 | EM | 5.0 Å | C/D=1-638 |
| 8PQZ | EM | 5.5 Å | H/I=1-638 |
| 9YNH | EM | 5.5 Å | C/D/U/V=1-638 |
| 9E23 | EM | 6.2 Å | D/H/g/h=1-638 |
Showing 20 of 29 experimental structures (best resolution first).
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