Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1) - R312H mutant. Determined by electron microscopy at 6.0 Å resolution. Released 4 Dec 2024.
Explore 8QQL in 3D Show helices and sheets RCSB PDB PDBe
8QQL contains 24 α-helices and 24 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 86-109 | 24 | |
| β-strand | 123 | 1 | 10 |
| α-helix | 129-140 | 12 | |
| β-strand | 150 | 1 | 10 |
| α-helix | 155-176 | 22 | |
| α-helix | 204-206 | 3 | |
| β-strand | 226 | 1 | 11 |
| β-strand | 255 | 1 | 12 |
| β-strand | 269 | 1 | 12 |
| α-helix | 285-289 | 5 | |
| β-strand | 299 | 1 | 11 |
| α-helix | 317-319 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Inward rectifier potassium channel 2 | A, B, C, D | protein | 317 | Homo sapiens | P63252 (AlphaFold model) |
>8QQL_1 Inward rectifier potassium channel 2 (chains A, B, C, D) RFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWL IALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQS IVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEA HVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQ DIDNADFEIVVILEGMVEATAMTTQCHSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFH KTYEVPNTPLCSARDLA
Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome. Zuniga, D., Zoumpoulakis, A., Veloso, R.F. et al. FASEB J (2024) 38:e70146-e70146. DOI 10.1096/fj.202401567R · PubMed
Other PDB entries of the same protein (UniProt P63252 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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