8RQ6: Amyloid beta precursor like protein 2 TMD

Solution NMR structure of Amyloid beta precursor like protein 2 TMD. Determined by solution NMR. Released 26 Jun 2024.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 224
Mol. weight: 3.21 kDa
Released: 26 Jun 2024

Explore 8RQ6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8RQ6 contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	695-717	23

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Amyloid beta precursor like protein 2	A	protein	31	Homo sapiens	Q06481 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8RQ6_1 Amyloid beta precursor like protein 2 (chains A)
SLSSSALIGLLVIAVAIATVIVISLVMLRKR

Primary citation

Substrate Selection Criteria in Regulated Intramembrane Proteolysis. Moser, C., Guschtschin-Schmidt, N., Silber, M. et al. ACS Chem Neurosci (2024) 15:1321-1334. DOI 10.1021/acschemneuro.4c00068 · PubMed

Other PDB entries of the same protein (UniProt Q06481 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5JBT 1.4 Å, Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2)
5TPT 2.42 Å, The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain

Browse structure collections

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