HIF prolyl hydroxylase 2 (PHD2) T387S variant bound to acetate (ACT) and hydroxylated Hypoxia-inducible Factor 2alpha (HIF2alpha). Determined by X-ray diffraction at 1.39 Å resolution. Released 12 Feb 2025.
Explore 8RV1 in 3D Show helices and sheets RCSB PDB PDBe
8RV1 contains 11 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 190-193 | 4 | |
| α-helix | 194-198 | 5 | |
| α-helix | 199-205 | 7 | |
| β-strand | 207-210 | 4 | 1 |
| α-helix | 216-231 | 16 | |
| β-strand | 236-237 | 2 | 1 |
| β-strand | 240 | 1 | 2 |
| α-helix | 248-250 | 3 | |
| β-strand | 252 | 1 | 3 |
| β-strand | 255-259 | 5 | 1 |
| α-helix | 267-282 | 16 | |
| β-strand | 292-295 | 4 | 1 |
| α-helix | 296-297 | 2 | |
| β-strand | 298-304 | 7 | 1 |
| β-strand | 308-313 | 6 | 3 |
| β-strand | 322-329 | 8 | 1 |
| β-strand | 331 | 1 | 4 |
| α-helix | 336-339 | 4 | |
| β-strand | 340 | 1 | 3 |
| β-strand | 343-345 | 3 | 3 |
| β-strand | 354-356 | 3 | 3 |
| β-strand | 359 | 1 | 4 |
| β-strand | 362-367 | 6 | 1 |
| β-strand | 374-379 | 6 | 3 |
| β-strand | 382-392 | 11 | 1 |
| α-helix | 393-405 | 13 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 526-529 | 4 | |
| β-strand | 531 | 1 | 2 |
| α-helix | 532 | 1 | |
| β-strand | 540-541 | 2 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Egl nine homolog 1 | A | protein | 227 | Homo sapiens | Q9GZT9 (AlphaFold model) |
| Endothelial PAS domain-containing protein 1 | B | protein | 20 | Homo sapiens | Q99814 (AlphaFold model) |
>8RV1_1 Egl nine homolog 1 (chains A) PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF DRLLFFWSDRRNPHEVQPAYATRYAISVWYFDADERARAKVKYLTGE
>8RV1_2 Endothelial PAS domain-containing protein 1 (chains B) ELDLETLAPYIPMDGEDFQL
investigating gatekeeper residues in prolyl hydroxyalse 2. Fiorini, G., Schofield, C.J. To be published.
Other PDB entries of the same protein (UniProt Q9GZT9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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