Structural architecture of the acidic region of the B domain of coagulation factor V. Determined by electron microscopy at 3.05 Å resolution. Released 4 Oct 2023.
Explore 8TN9 in 3D Show helices and sheets RCSB PDB PDBe
8TN9 contains 27 α-helices and 117 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 2-3 | 2 | |
| β-strand | 4-12 | 9 | 1 |
| β-strand | 36-40 | 5 | 1 |
| β-strand | 41 | 1 | 2 |
| β-strand | 48 | 1 | 2 |
| α-helix | 49-52 | 4 | |
| β-strand | 64-65 | 2 | 3 |
| β-strand | 69-74 | 6 | 1 |
| β-strand | 82 | 1 | 4 |
| β-strand | 85 | 1 | 5 |
| β-strand | 98 | 1 | 6 |
| α-helix | 106-108 | 3 | |
| β-strand | 114 | 1 | 4 |
| α-helix | 115 | 1 | |
| β-strand | 122-125 | 4 | 1 |
| β-strand | 139-144 | 6 | 3 |
| β-strand | 145 | 1 | 5 |
| β-strand | 147 | 1 | 6 |
| α-helix | 150-155 | 6 | |
| β-strand | 157 | 1 | 1 |
| β-strand | 160-165 | 6 | 3 |
| β-strand | 170 | 1 | 7 |
| β-strand | 176 | 1 | 7 |
| β-strand | 181-189 | 9 | 8 |
| α-helix | 192-194 | 3 | |
| β-strand | 205-206 | 2 | 8 |
| β-strand | 209-210 | 2 | 8 |
| β-strand | 214-219 | 6 | 9 |
| β-strand | 224 | 1 | 10 |
| β-strand | 225-233 | 9 | 8 |
| β-strand | 238-243 | 6 | 9 |
| β-strand | 248-250 | 3 | 11 |
| β-strand | 253-255 | 3 | 11 |
| β-strand | 257-261 | 5 | 9 |
| β-strand | 264-268 | 5 | 8 |
| β-strand | 271 | 1 | 10 |
| β-strand | 276-282 | 7 | 9 |
| α-helix | 285-289 | 5 | |
| β-strand | 294-298 | 5 | 9 |
| α-helix | 302-304 | 3 | |
| β-strand | 323-325 | 3 | 12 |
| β-strand | 328-330 | 3 | 13 |
| β-strand | 333 | 1 | 14 |
| β-strand | 363 | 1 | 14 |
| β-strand | 366-368 | 3 | 13 |
| β-strand | 371 | 1 | 12 |
| α-helix | 392-395 | 4 | |
| β-strand | 396-397 | 2 | 15 |
| β-strand | 402-406 | 5 | 12 |
| β-strand | 415 | 1 | 16 |
| β-strand | 418-419 | 2 | 17 |
| α-helix | 427-429 | 3 | |
| β-strand | 447 | 1 | 16 |
| α-helix | 448 | 1 | |
| β-strand | 454-458 | 5 | 12 |
| β-strand | 472-476 | 5 | 15 |
| β-strand | 477-478 | 2 | 17 |
| α-helix | 483-487 | 5 | |
| β-strand | 494-498 | 5 | 15 |
| β-strand | 512-523 | 12 | 18 |
| α-helix | 525-527 | 3 | |
| α-helix | 531 | 1 | |
| α-helix | 532-536 | 5 | |
| α-helix | 552-555 | 4 | |
| β-strand | 558-561 | 4 | 18 |
| β-strand | 564 | 1 | 18 |
| α-helix | 566-568 | 3 | |
| α-helix | 569-571 | 3 | |
| β-strand | 572 | 1 | 19 |
| β-strand | 575 | 1 | 20 |
| β-strand | 579-586 | 8 | 18 |
| β-strand | 594-598 | 5 | 19 |
| β-strand | 605 | 1 | 21 |
| β-strand | 608 | 1 | 21 |
| β-strand | 612-615 | 4 | 19 |
| β-strand | 617 | 1 | 18 |
| β-strand | 620-626 | 7 | 18 |
| β-strand | 631-637 | 7 | 19 |
| β-strand | 648-653 | 6 | 19 |
| β-strand | 654 | 1 | 20 |
| β-strand | 1513 | 1 | 22 |
| β-strand | 1515 | 1 | 22 |
| α-helix | 1536-1543 | 8 | |
| β-strand | 1551-1562 | 12 | 23 |
| β-strand | 1588-1595 | 8 | 23 |
| β-strand | 1603 | 1 | 23 |
| β-strand | 1620-1623 | 4 | 24 |
| β-strand | 1627-1634 | 8 | 23 |
| β-strand | 1640 | 1 | 25 |
| β-strand | 1643-1644 | 2 | 24 |
| β-strand | 1648-1649 | 2 | 23 |
| β-strand | 1672 | 1 | 25 |
| β-strand | 1676-1683 | 8 | 23 |
| α-helix | 1686-1688 | 3 | |
| β-strand | 1697-1703 | 7 | 24 |
| α-helix | 1708-1711 | 4 | |
| β-strand | 1717-1723 | 7 | 24 |
| β-strand | 1728 | 1 | 26 |
| β-strand | 1735 | 1 | 26 |
| β-strand | 1739-1744 | 6 | 27 |
| β-strand | 1746-1747 | 2 | 28 |
| β-strand | 1778-1779 | 2 | 28 |
| β-strand | 1785 | 1 | 29 |
| β-strand | 1791-1793 | 3 | 29 |
| β-strand | 1797-1803 | 7 | 27 |
| β-strand | 1812-1816 | 5 | 29 |
| β-strand | 1821-1823 | 3 | 27 |
| β-strand | 1829-1831 | 3 | 27 |
| β-strand | 1833-1836 | 4 | 29 |
| β-strand | 1842-1847 | 6 | 27 |
| β-strand | 1852-1858 | 7 | 29 |
| α-helix | 1861-1864 | 4 | |
| β-strand | 1869-1875 | 7 | 29 |
| β-strand | 1881-1882 | 2 | 30 |
| α-helix | 1892-1894 | 3 | |
| β-strand | 1895-1897 | 3 | 31 |
| α-helix | 1907-1910 | 4 | |
| β-strand | 1920-1921 | 2 | 32 |
| α-helix | 1932-1934 | 3 | |
| β-strand | 1935-1937 | 3 | 31 |
| β-strand | 1943-1950 | 8 | 30 |
| β-strand | 1951 | 1 | 33 |
| β-strand | 1955 | 1 | 34 |
| β-strand | 1958 | 1 | 34 |
| β-strand | 1961-1970 | 10 | 31 |
| β-strand | 1977-1978 | 2 | 31 |
| β-strand | 1990 | 1 | 31 |
| β-strand | 2000-2010 | 11 | 30 |
| β-strand | 2012-2021 | 10 | 31 |
| β-strand | 2025-2026 | 2 | 32 |
| β-strand | 2027 | 1 | 33 |
| β-strand | 2030-2034 | 5 | 30 |
| β-strand | 2041 | 1 | 35 |
| β-strand | 2055-2056 | 2 | 36 |
| β-strand | 2061-2062 | 2 | 37 |
| β-strand | 2066-2067 | 2 | 37 |
| β-strand | 2095-2110 | 16 | 36 |
| β-strand | 2122-2130 | 9 | 36 |
| β-strand | 2137-2138 | 2 | 36 |
| α-helix | 2139 | 1 | |
| α-helix | 2147-2149 | 3 | |
| β-strand | 2150-2151 | 2 | 36 |
| β-strand | 2160-2180 | 21 | 36 |
| β-strand | 2189-2194 | 6 | 36 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Coagulation factor V | A | protein | 2196 | Homo sapiens | P12259 (AlphaFold model) |
>8TN9_1 Coagulation factor V (chains A) AQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGP TLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREY TYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFD KQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFS IHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKN CPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIG KHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPH GVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSD VDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCE NPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTG HSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDD DEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEE EEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGS PLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGP KVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPP SDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPL ANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTF HPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDT GQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPT DISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQ MPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLD FSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNL SPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQ MTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSE SSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPK EEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEE ISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPII RAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTY VWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMRE FVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRL HLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEV GENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAW SVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFK GNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCST PLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLL KIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHV KNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
Structural architecture of the acidic region of the B domain of coagulation factor V. Mohammed, B.M., Basore, K., Summers, B. et al. J Thromb Haemost (2024) 22:709-714. DOI 10.1016/j.jtha.2023.11.003 · PubMed
Other PDB entries of the same protein (UniProt P12259 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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