8U7Y: Human NOX5 Activation

Structural Basis of Human NOX5 Activation. Determined by electron microscopy at 4.06 Å resolution. Released 24 Apr 2024.

Method
Electron microscopy
Resolution
4.06 Å
Organism
Homo sapiens
Chains
2
Atoms
8,803
Mol. weight
170.46 kDa
Ligands
FAD, D12, D10, NAP
Released
24 Apr 2024

Explore 8U7Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8U7Y contains 56 α-helices and 32 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 28 helices, 16 β-strands

ElementResiduesLengthSheet
α-helix10-1910
α-helix27-337
α-helix42-509
α-helix61-688
α-helix76-8712
α-helix98-10811
α-helix118-13215
α-helix141-15010
α-helix183-1908
α-helix196-21318
α-helix221-24121
α-helix246-2516
α-helix254-2585
α-helix264-29330
α-helix321-33717
α-helix341-3455
α-helix349-3557
α-helix356-3583
α-helix359-3679
α-helix373-38917
β-strand399-40131
β-strand402-40872
β-strand412-41872
α-helix419-4202
β-strand430-43343
β-strand444-44743
β-strand44812
β-strand457-46372
α-helix468-47710
β-strand518-52031
β-strand52513
α-helix530-5334
β-strand538-54254
α-helix548-56316
β-strand565-56735
β-strand574-57635
β-strand588-59364
α-helix601-61515
β-strand624-62964
α-helix645-65410
α-helix671-6799
β-strand690-69234
α-helix697-70812
β-strand71514
Chain B: 28 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix10-1910
α-helix27-337
α-helix42-509
α-helix61-688
α-helix76-8712
α-helix98-10811
α-helix118-13215
α-helix141-15010
α-helix183-1908
α-helix196-21318
α-helix221-24121
α-helix246-2516
α-helix254-2585
α-helix264-29330
α-helix321-33717
α-helix341-3455
α-helix349-3557
α-helix356-3583
α-helix359-3679
α-helix373-38917
β-strand399-40136
β-strand402-40877
β-strand412-41877
α-helix419-4202
β-strand430-43348
β-strand444-44748
β-strand44817
β-strand457-46377
α-helix468-47710
β-strand518-52036
β-strand52518
α-helix530-5334
β-strand538-54259
α-helix548-56316
β-strand565-567310
β-strand574-576310
β-strand588-59369
α-helix601-61515
β-strand624-62969
α-helix645-65410
α-helix671-6799
β-strand690-69349
α-helix697-70812
β-strand71519

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
NADPH oxidase 5A, Bprotein719Homo sapiensQ96PH1 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8U7Y_1 NADPH oxidase 5 (chains A, B)
MSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTIT
LQELQEALTLLIHGSPMDKLKFLFQVYDIDGSGSIDPDELRTVLQSCLRESAISLPDEKL
DQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQ
LTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAV
LMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASP
FQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYL
LVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRP
PFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASD
PLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVL
IGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSF
EWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSI
TGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF

Ligands and cofactors

IDNameFormulaCopies
FADFlavin-adenine dinucleotideC27 H33 N9 O15 P22
D12DodecaneC12 H262
D10DecaneC10 H222
NAPNADP nicotinamide-adenine-dinucleotide phosphateC21 H28 N7 O17 P32
HEBHeme b/cC34 H34 Fe N4 O44
ZNZinc ionZn1

Primary citation

Structural basis of human NOX5 activation. Cui, C., Jiang, M., Jain, N. et al. Nat Commun (2024) 15:3994-3994. DOI 10.1038/s41467-024-48467-y · PubMed

Other PDB entries of the same protein (UniProt Q96PH1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 8U7Y directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.