Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region. Determined by electron microscopy at 3.46 Å resolution. Released 20 Nov 2024.
Explore 8V2C in 3D Show helices and sheets RCSB PDB PDBe
8V2C contains 17 α-helices and 37 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 33-46 | 14 | |
| α-helix | 49-59 | 11 | |
| α-helix | 65-73 | 9 | |
| α-helix | 81-86 | 6 | |
| α-helix | 89-114 | 26 | |
| α-helix | 121-143 | 23 | |
| α-helix | 147-149 | 3 | |
| α-helix | 170-200 | 31 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 130-137 | 8 | 1 |
| β-strand | 142-147 | 6 | 1 |
| β-strand | 157-163 | 7 | 2 |
| β-strand | 168 | 1 | 2 |
| β-strand | 172-173 | 2 | 2 |
| β-strand | 180-181 | 2 | 1 |
| α-helix | 185-186 | 2 | |
| β-strand | 192-199 | 8 | 2 |
| β-strand | 204-206 | 3 | 2 |
| β-strand | 210-212 | 3 | 2 |
| α-helix | 214-216 | 3 | |
| β-strand | 218-219 | 2 | 1 |
| α-helix | 220-223 | 4 | |
| β-strand | 224-229 | 6 | 3 |
| β-strand | 238-243 | 6 | 3 |
| α-helix | 246-249 | 4 | |
| β-strand | 253-260 | 8 | 4 |
| β-strand | 268-269 | 2 | 4 |
| α-helix | 270-271 | 2 | |
| α-helix | 272-275 | 4 | |
| β-strand | 281-284 | 4 | 3 |
| β-strand | 292-301 | 10 | 4 |
| α-helix | 308-311 | 4 | |
| β-strand | 315-318 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 148-151 | 4 | 5 |
| β-strand | 155-158 | 4 | 6 |
| β-strand | 163-169 | 7 | 5 |
| β-strand | 176-178 | 3 | 6 |
| β-strand | 179 | 1 | 7 |
| β-strand | 184 | 1 | 7 |
| β-strand | 188 | 1 | 5 |
| β-strand | 194-199 | 6 | 5 |
| β-strand | 210-216 | 7 | 6 |
| β-strand | 223-231 | 9 | 6 |
| α-helix | 233-237 | 5 | |
| β-strand | 238-241 | 4 | 8 |
| β-strand | 244 | 1 | 8 |
| β-strand | 249-255 | 7 | 8 |
| β-strand | 271-274 | 4 | 9 |
| β-strand | 276 | 1 | 10 |
| β-strand | 281 | 1 | 10 |
| β-strand | 284 | 1 | 9 |
| β-strand | 290-294 | 5 | 8 |
| α-helix | 295-296 | 2 | |
| β-strand | 303-310 | 8 | 9 |
| β-strand | 315-322 | 8 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Oncostatin-M | A | protein | 183 | Mus musculus | P53347 (AlphaFold model) |
| Interleukin-6 receptor subunit beta | B | protein | 623 | Mus musculus | Q00560 (AlphaFold model) |
| Oncostatin-M-specific receptor subunit beta | C | protein | 715 | Mus musculus | O70458 (AlphaFold model) |
>8V2C_1 Oncostatin-M (chains A) ANRGCSNSSSQLLSQLQNQANLTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDT LRQLSKPHFLSTVYTTLDRVLYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARL LNHSLEIPEPTQTDSGASRSTTTPDVFNTKIGSCGFLWGYHRFMGSVGRVFREWDDGSTR SRR
>8V2C_2 Interleukin-6 receptor subunit beta (chains B) QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVI NRTTSSVTFTDVVLPSVQLTCNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNM LCQWDPGRETYLETNYTLKSEWATEKFPDCQSKHGTSCMVSYMPTYYVNIEVWVEAENAL GKVSSESINFDPVDKVKPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTK DASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYED RPSRPPSFWYKTNPSHGQEYRSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTG TELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAAYSVVNLKAFPKDNLLWVEWT PPPKPVSKYILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGP GGSESLKAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGK EMVVHVDSSHTEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQKLI SEEDLGGEQKLISEEDLHHHHHH
>8V2C_3 Oncostatin-M-specific receptor subunit beta (chains C) EVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVEN YSTTVKREEAVRWNWTSDIPLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSV EPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVV FLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLT WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFN LTHRVHPKAPQDVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMS ANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGR RIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRI TTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQ DQRCDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPL VNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVL CKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHML
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 3 |
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes. Zhou, Y., Stevis, P.E., Cao, J. et al. Nat Commun (2024) 15:9776-9776. DOI 10.1038/s41467-024-54124-1 · PubMed
Other PDB entries of the same protein (UniProt P53347 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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