8WHM: ELKS2/LL5beta complex

Crystal structure of the ELKS2/LL5beta complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 28 Aug 2024.

Method: X-ray diffraction
Resolution: 2.3 Å
Organisms: Rattus norvegicus, Homo sapiens
Chains: 2
Atoms: 1,079
Mol. weight: 17.41 kDa
Released: 28 Aug 2024

Explore 8WHM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8WHM contains 3 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	262-312	51

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	422-461	40
α-helix	473-486	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ERC protein 2	A	protein	66	Rattus norvegicus	Q8K3M6 (AlphaFold model)
Pleckstrin homology-like domain family B member 2	B	protein	82	Homo sapiens	Q86SQ0 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8WHM_1 ERC protein 2 (chains A)
GPGSEFLTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM
LQSKGL

Sequence of entity 2 (B), FASTA

>8WHM_2 Pleckstrin homology-like domain family B member 2 (chains B)
GPGSKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS
TGTTVEDVQKINKELEKLQLSD

Primary citation

CLASP-mediated competitive binding in protein condensates directs microtubule growth. Jia, X., Lin, L., Guo, S. et al. Nat Commun (2024) 15:6509-6509. DOI 10.1038/s41467-024-50863-3 · PubMed

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