Pleckstrin homology-like domain family B member 2 (PHLDB2) is a 1253-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86SQ0.
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The mean pLDDT of this model is 58.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity)
Interacts with FLNC (PubMed:12376540). Interacts with AMOTL2; interaction may facilitate PHLDB2 localization to the myotube podosome cortex that surrounds the core (PubMed:23525008). Part of a cortical microtubule stabilization complex (CMSC) composed of KANK1, PPFIA1, PPFIBP1, ERC1/ELKS, PHLDB2/LL5beta, CLASPs, KIF21A and possibly additional interactors; within CMSCs KANK1 and PHLDB2/LL5beta…
Cytoplasm, Cytoplasm, cell cortex, Membrane, Cell projection, podosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8WHJ | X-ray | 1.4 Å | A=719-738 |
| 8WHM | X-ray | 2.3 Å | B=413-490 |
| 8WHK | X-ray | 2.4 Å | B=720-770 |
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