8WOG: SUCR1

Cryo-EM structure of SUCR1 in complex with succinate and Gi protein. Determined by electron microscopy at 2.97 Å resolution. Released 11 Sept 2024.

Method: Electron microscopy
Resolution: 2.97 Å
Organism: Homo sapiens
Chains: 4
Atoms: 7,382
Mol. weight: 119.78 kDa
Ligands: SIN
Released: 11 Sept 2024

Explore 8WOG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8WOG contains 35 α-helices and 40 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	11-20	10
α-helix	21-25	5
α-helix	26-45	20
α-helix	57-73	17
α-helix	76-85	10
α-helix	92-125	34
α-helix	132-134	3
α-helix	138-154	17
α-helix	155-157	3
β-strand	164-166	3	1
β-strand	169-171	3	1
α-helix	181-192	12
α-helix	193-197	5
α-helix	198-216	19
α-helix	229-258	30
α-helix	268-285	18
α-helix	287-291	5
α-helix	292-297	6
α-helix	300-311	12

Chain C: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	8-30	23
β-strand	33-40	8	2
α-helix	46-52	7
β-strand	184-190	7	2
β-strand	195-201	7	2
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	2
β-strand	233	1	3
β-strand	241	1	3
α-helix	242-254	13
β-strand	256	1	4
β-strand	259	1	4
β-strand	263-269	7	2
α-helix	271-278	8
α-helix	283-285	3
α-helix	300-308	9
β-strand	319-323	5	2
α-helix	331-351	21

Chain D: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
α-helix	11-24	14
α-helix	30-34	5
β-strand	47-51	5	5
β-strand	58-62	5	6
β-strand	69-74	6	6
β-strand	78-83	6	6
β-strand	89-94	6	6
α-helix	95	1
β-strand	100-105	6	7
β-strand	111-116	6	7
β-strand	121-125	5	7
β-strand	134-139	6	7
β-strand	146-153	8	8
β-strand	156-161	6	8
β-strand	165-170	6	8
β-strand	175-180	6	8
β-strand	187-192	6	9
β-strand	198-203	6	9
β-strand	207-212	6	9
β-strand	217-223	7	9
β-strand	229-234	6	10
β-strand	240-245	6	10
β-strand	250-254	5	10
β-strand	259-264	6	10
β-strand	273-278	6	11
β-strand	284-289	6	11
β-strand	293-298	6	11
β-strand	303-309	7	11
β-strand	315-320	6	5
β-strand	327-331	5	5
β-strand	336-339	4	5

Chain E: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	9-21	13
α-helix	30-43	14
α-helix	45-47	3
α-helix	53-55	3
α-helix	56-58	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Succinate receptor 1	A	protein	311	Homo sapiens	Q9BXA5 (AlphaFold model)
Guanine nucleotide-binding protein G(i) subunit alpha-1	C	protein	353	Homo sapiens	P63096 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	D	protein	338	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	E	protein	56	Homo sapiens	P59768 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8WOG_1 Succinate receptor 1 (chains A)
NATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSV
SDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYP
FREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIY
SMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTP
YHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLM
NQLRHNFKSLT

Sequence of entity 2 (C), FASTA

>8WOG_2 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains C)
GCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGY
SEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTA
ELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKT
TGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMN
RMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAA
YIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

Sequence of entity 3 (D), FASTA

>8WOG_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains D)
ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH
WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS
IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG
HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA
TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA
DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (E), FASTA

>8WOG_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains E)
SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFRE

Ligands and cofactors

ID	Name	Formula	Copies
SIN	Succinic acid	C4 H6 O4	1

Primary citation

Structural insights into ligand recognition and activation of the succinate receptor SUCNR1. Liu, A., Liu, Y., Zhang, W. et al. Cell Rep (2024) 43:114381-114381. DOI 10.1016/j.celrep.2024.114381 · PubMed

Other PDB entries of the same protein (UniProt Q9BXA5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8YKV 2.48 Å, Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
8YKX 2.69 Å, Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
8YKW 2.75 Å, Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
8JPN 2.9 Å, Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
8WP1 3.15 Å, Cryo-EM structure of SUCR1 in complex with cis-epoxysuccinic acid and Gi proteins
8JPP 3.2 Å, Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq

Browse structure collections

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