8X8T: P75NTR juxtamembrane domain

NMR structure of p75NTR juxtamembrane domain in complex with RhoGDI N-terminal domain containing a phosphorylation-mimicking S34D mutation. Determined by solution NMR. Released 3 Apr 2024.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 950
Mol. weight: 13.54 kDa
Released: 3 Apr 2024

Explore 8X8T in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8X8T contains 5 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	8-11	4
α-helix	14-22	9
β-strand	33	1	1
α-helix	37-40	4
α-helix	49-56	8

Chain B: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
α-helix	275-276	2
β-strand	291	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Rho GDP-dissociation inhibitor 1	A	protein	61	Homo sapiens	P52565 (AlphaFold model)
Tumor necrosis factor receptor superfamily member 16	B	protein	62	Homo sapiens	P08138 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8X8T_1 Rho GDP-dissociation inhibitor 1 (chains A)
GSAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKDIQEIQELDKDDESLRKYKEALLGRV
A

Sequence of entity 2 (B), FASTA

>8X8T_2 Tumor necrosis factor receptor superfamily member 16 (chains B)
GSKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALK
GD

Primary citation

RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75 NTR to gate axon growth and neuron survival. Ramanujan, A., Li, Z., Ma, Y. et al. EMBO Rep (2024) 25:1490-1512. DOI 10.1038/s44319-024-00064-2 · PubMed

Other PDB entries of the same protein (UniProt P52565 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1KMT 1.3 Å, Crystal structure of RhoGDI Glu(154,155)Ala mutant
1QVY 1.6 Å, Crystal structure of RhoGDI K(199,200)R double mutant
2JHX 1.6 Å, Crystal structure of rhogdi E155H, E157H mutant
2JHU 1.65 Å, Crystal structure of rhogdi E154A,E155A mutant
2JHT 1.88 Å, Crystal structure of rhogdi K135T,K138T,K141T mutant
2JHY 1.9 Å, Crystal structure of rhogdi E155H, E157H mutant
2JHS 1.95 Å, Crystal structure of rhogdi K135H,K138H,K141H mutant
1FSO 2.0 Å, Crystal structure of truncated human rhogdi quadruple mutant
2JHV 2.07 Å, Crystal structure of rhogdi E154A,E155A mutant
2JI0 2.1 Å, Crystal structure of rhogdi K138Y, K141Y mutant
2JHZ 2.2 Å, Crystal structure of rhogdi E155S, E157S mutant
2BXW 2.4 Å, Crystal structure of rhogdi Lys(135,138,141)Tyr mutant

Browse structure collections

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