8XI3: Mouse SCMC-14-3-3gama complex
Structure of mouse SCMC-14-3-3gama complex. Determined by electron microscopy at 3.0 Å resolution. Released 2 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 3.0 Å
- Organism
- Mus musculus
- Chains
- 5
- Atoms
- 15,162
- Mol. weight
- 258.56 kDa
- Released
- 2 Oct 2024
Explore 8XI3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8XI3 contains 76 α-helices and 68 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 43 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 98-108 | 11 | |
| α-helix | 120-127 | 8 | |
| β-strand | 140-143 | 4 | 1 |
| α-helix | 152-162 | 11 | |
| β-strand | 173 | 1 | 2 |
| β-strand | 176-178 | 3 | 1 |
| α-helix | 190-197 | 8 | |
| α-helix | 204-210 | 7 | |
| β-strand | 215 | 1 | 2 |
| β-strand | 216-220 | 5 | 1 |
| α-helix | 246-254 | 9 | |
| β-strand | 263-267 | 5 | 1 |
| α-helix | 273-276 | 4 | |
| β-strand | 283-289 | 7 | 1 |
| α-helix | 294-302 | 9 | |
| α-helix | 311-318 | 8 | |
| α-helix | 321-326 | 6 | |
| α-helix | 330-345 | 16 | |
| α-helix | 359-367 | 9 | |
| α-helix | 383-399 | 17 | |
| β-strand | 404-405 | 2 | 3 |
| α-helix | 417-423 | 7 | |
| β-strand | 429-431 | 3 | 3 |
| β-strand | 440-442 | 3 | 3 |
| α-helix | 445-457 | 13 | |
| α-helix | 464-467 | 4 | |
| α-helix | 472-475 | 4 | |
| α-helix | 489-497 | 9 | |
| α-helix | 504-511 | 8 | |
| α-helix | 519-531 | 13 | |
| α-helix | 539-551 | 13 | |
| α-helix | 556-561 | 6 | |
| β-strand | 567-572 | 6 | 4 |
| α-helix | 575-585 | 11 | |
| β-strand | 593-598 | 6 | 4 |
| α-helix | 615-617 | 3 | |
| α-helix | 624-638 | 15 | |
| β-strand | 644-646 | 3 | 4 |
| α-helix | 654-664 | 11 | |
| β-strand | 673-675 | 3 | 4 |
| α-helix | 682-684 | 3 | |
| α-helix | 685-692 | 8 | |
| β-strand | 700-702 | 3 | 4 |
| α-helix | 710-721 | 12 | |
| β-strand | 729-731 | 3 | 4 |
| α-helix | 739-750 | 12 | |
| β-strand | 757-759 | 3 | 4 |
| α-helix | 767-778 | 12 | |
| β-strand | 786-788 | 3 | 4 |
| α-helix | 796-806 | 11 | |
| β-strand | 814-816 | 3 | 4 |
| α-helix | 824-835 | 12 | |
| β-strand | 843-845 | 3 | 4 |
| α-helix | 853-864 | 12 | |
| β-strand | 866 | 1 | 5 |
| β-strand | 871-873 | 3 | 4 |
| α-helix | 881-891 | 11 | |
| β-strand | 896 | 1 | 5 |
| β-strand | 900-902 | 3 | 4 |
| α-helix | 910-912 | 3 | |
| α-helix | 913-922 | 10 | |
| β-strand | 928-930 | 3 | 4 |
| α-helix | 937-948 | 12 | |
| β-strand | 957-959 | 3 | 4 |
| α-helix | 970-978 | 9 | |
| β-strand | 985-987 | 3 | 4 |
| α-helix | 995-1005 | 11 | |
| β-strand | 1014-1016 | 3 | 4 |
| α-helix | 1019-1021 | 3 | |
| α-helix | 1024-1036 | 13 | |
| β-strand | 1041-1042 | 2 | 4 |
| α-helix | 1046-1048 | 3 | |
Chain B: 5 helices, 35 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 158-175 | 18 | |
| α-helix | 251-253 | 3 | |
| β-strand | 255 | 1 | 6 |
| β-strand | 259 | 1 | 6 |
| α-helix | 264-266 | 3 | |
| α-helix | 273-277 | 5 | |
| β-strand | 283-291 | 9 | 7 |
| β-strand | 296-300 | 5 | 8 |
| β-strand | 307-312 | 6 | 8 |
| β-strand | 315-320 | 6 | 8 |
| β-strand | 327-328 | 2 | 7 |
| β-strand | 333-336 | 4 | 8 |
| α-helix | 338-340 | 3 | |
| β-strand | 346-351 | 6 | 9 |
| β-strand | 357-362 | 6 | 9 |
| β-strand | 367 | 1 | 10 |
| β-strand | 369-372 | 4 | 9 |
| β-strand | 379-382 | 4 | 9 |
| β-strand | 385 | 1 | 10 |
| β-strand | 394-397 | 4 | 11 |
| β-strand | 401-405 | 5 | 11 |
| β-strand | 411-415 | 5 | 11 |
| β-strand | 421-425 | 5 | 11 |
| β-strand | 434-437 | 4 | 12 |
| β-strand | 441-445 | 5 | 12 |
| β-strand | 450 | 1 | 13 |
| β-strand | 451-455 | 5 | 12 |
| β-strand | 460-461 | 2 | 12 |
| β-strand | 466 | 1 | 13 |
| β-strand | 471-476 | 6 | 14 |
| β-strand | 482-487 | 6 | 14 |
| β-strand | 491-496 | 6 | 14 |
| β-strand | 504-508 | 5 | 14 |
| β-strand | 513-518 | 6 | 15 |
| β-strand | 524-529 | 6 | 15 |
| β-strand | 533-538 | 6 | 15 |
| β-strand | 544-549 | 6 | 15 |
| β-strand | 556-559 | 4 | 7 |
| β-strand | 565-569 | 5 | 7 |
| β-strand | 573-580 | 8 | 7 |
Chain C: 4 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 28-32 | 5 | 1 |
| α-helix | 38-40 | 3 | |
| β-strand | 45-49 | 5 | 16 |
| α-helix | 51-58 | 8 | |
| α-helix | 63-72 | 10 | |
| β-strand | 75-79 | 5 | 16 |
| β-strand | 87-92 | 6 | 16 |
| α-helix | 95-113 | 19 | |
Chain D: 11 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-16 | 15 | |
| α-helix | 20-31 | 12 | |
| α-helix | 39-73 | 35 | |
| α-helix | 76-103 | 28 | |
| α-helix | 104-108 | 5 | |
| α-helix | 118-136 | 19 | |
| α-helix | 141-162 | 22 | |
| α-helix | 170-185 | 16 | |
| α-helix | 190-206 | 17 | |
| α-helix | 216-225 | 10 | |
| α-helix | 228-234 | 7 | |
Chain F: 13 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-17 | 15 | |
| α-helix | 20-33 | 14 | |
| α-helix | 39-70 | 32 | |
| α-helix | 78-103 | 26 | |
| α-helix | 104-109 | 6 | |
| α-helix | 110-111 | 2 | |
| α-helix | 118-135 | 18 | |
| α-helix | 141-164 | 24 | |
| α-helix | 170-182 | 13 | |
| α-helix | 183-187 | 5 | |
| α-helix | 192-206 | 15 | |
| α-helix | 208-211 | 4 | |
| α-helix | 216-235 | 20 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 14-3-3 protein gamma | D, F | protein | 247 | Mus musculus | P61982 (AlphaFold model) |
| NACHT, LRR and PYD domains-containing protein 5 | A | protein | 1059 | Mus musculus | Q9R1M5 (AlphaFold model) |
| Transducin-like enhancer protein 6 | B | protein | 554 | Mus musculus | Q9WVB3 (AlphaFold model) |
| Oocyte-expressed protein homolog | C | protein | 174 | Mus musculus | Q9CWE6 (AlphaFold model) |
Sequence of entity 1 (D, F), FASTA
>8XI3_1 14-3-3 protein gamma (chains D, F)
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSW
RVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESK
VFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYS
VFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDD
DGGEGNN
Sequence of entity 2 (A), FASTA
>8XI3_2 NACHT, LRR and PYD domains-containing protein 5 (chains A)
MGPPEKDSKAILKARGLEEEQKSESTMSPSENVSRAILKDSGSEEVEQASERKMTSPEND
SKSIQKDQGPEQEQTSETLQSKEEDEVTEADKDNGGDLQDYKAHVIAKFDTSVDLHYDSP
EMKLLSDAFKPYQKTFQPHTIILHGRPGVGKSALARSIVLGWAQGKLFQKMSFVIFFSVR
EIKWTEKSSLAQLIAKECPDSWDLVTKIMSQPERLLFVIDGLDDMDSVLQHDDMTLSRDW
KDEQPIYILMYSLLRKALLPQSFLIITTRNTGLEKLKSMVVSPLYILVEGLSASRRSQLV
LENISNESDRIQVFHSLIENHQLFDQCQAPSVCSLVCEALQLQKKLGKRCTLPCQTLTGL
YATLVFHQLTLKRPSQSALSQEEQITLVGLCMMAAEGVWTMRSVFYDDDLKNYSLKESEI
LALFHMNILLQVGHNSEQCYVFSHLSLQDFFAALYYVLEGLEEWNQHFCFIENQRSIMEV
KRTDDTRLLGMKRFLFGLMNKDILKTLEVLFEYPVIPTVEQKLQHWVSLIAQQVNGTSPM
DTLDAFYCLFESQDEEFVGGALKRFQEVWLLINQKMDLKVSSYCLKHCQNLKAIRVDIRD
LLSVDNTLELCPVVTVQETQCKPLLMEWWGNFCSVLGSLRNLKELDLGDSILSQRAMKIL
CLELRNQSCRIQKLTFKSAEVVSGLKHLWKLLFSNQNLKYLNLGNTPMKDDDMKLACEAL
KHPKCSVETLRLDSCELTIIGYEMISTLLISTTRLKCLSLAKNRVGVKSMISLGNALSSS
MCLLQKLILDNCGLTPASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECA
LQRLILNHCNIVDDAYGFLAMRLANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQE
LELVDCQLTQNCCEDLACMITTTKHLKSLDLGNNALGDKGVITLCEGLKQSSSSLRRLGL
GACKLTSNCCEALSLAISCNPHLNSLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGLWKQ
EYYARVRRQLEEVEFVKPHVVIDGDWYASDEDDRNWWKN
Sequence of entity 3 (B), FASTA
>8XI3_3 Transducin-like enhancer protein 6 (chains B)
MWSHPQFEKSGDEVDAGSGHIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPC
HVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDP
QPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHR
NSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQ
PSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAE
DRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCE
GLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGL
DACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVD
TKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLII
TGSRDCASVYHIKY
Sequence of entity 4 (C), FASTA
>8XI3_4 Oocyte-expressed protein homolog (chains C)
MASHTADADAKPDSDSQKLLNVLPVSLRLRTRPWWFPIQEVSNPLVLYMEAWVAERVIGT
DQAEISEIEWMCQALLTVDSVNSGNLAEITIFGQPSAQTRMKNILLNMAAWHKENELQRA
VKVKEVEEFLKIRASSILSKLSKKGLKLAGFPLPLEGRETQMESLEWSHPQFEK
Primary citation
The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Han, Z., Wang, R., Chi, P. et al. Nat Commun (2024) 15:8887-8887. DOI 10.1038/s41467-024-53277-3 · PubMed
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