Structure of y+LAT1 bound with Lys. Determined by electron microscopy at 3.33 Å resolution. Released 22 Jan 2025.
Explore 8XYJ in 3D Show helices and sheets RCSB PDB PDBe
8XYJ contains 24 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 40-50 | 11 | |
| α-helix | 59-62 | 4 | |
| α-helix | 69-97 | 29 | |
| α-helix | 114-122 | 9 | |
| α-helix | 123-127 | 5 | |
| α-helix | 128-144 | 17 | |
| α-helix | 145-147 | 3 | |
| α-helix | 152-154 | 3 | |
| α-helix | 160-175 | 16 | |
| α-helix | 177-207 | 31 | |
| α-helix | 225-238 | 14 | |
| α-helix | 245-247 | 3 | |
| α-helix | 255-284 | 30 | |
| α-helix | 287-290 | 4 | |
| α-helix | 296-304 | 9 | |
| α-helix | 306-308 | 3 | |
| α-helix | 311-340 | 30 | |
| α-helix | 346-349 | 4 | |
| α-helix | 359-371 | 13 | |
| α-helix | 382-406 | 25 | |
| α-helix | 419-437 | 19 | |
| α-helix | 440-456 | 17 | |
| α-helix | 457-461 | 5 | |
| α-helix | 471-483 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Y+L amino acid transporter 1 | A | protein | 529 | Homo sapiens | Q9UM01 (AlphaFold model) |
>8XYJ_1 Y+L amino acid transporter 1 (chains A) DYKDDDDKSGPDEVDASGRVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNG VCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGA SYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLA AACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSS FAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYY TVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREG HLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLY LRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIR VPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
| ID | Name | Formula | Copies |
|---|---|---|---|
| LYS | Lysine | C6 H15 N2 O2 | 1 |
Structural basis for the substrate recognition and transport mechanism of the human y + LAT1-4F2hc transporter complex. Dai, L., Zeng, Q., Zhang, T. et al. Sci Adv (2025) 11:eadq0558-eadq0558. DOI 10.1126/sciadv.adq0558 · PubMed
Other PDB entries of the same protein (UniProt Q9UM01 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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