8YIO: COR1 isoform 1
Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in azoxystrobin-bound state. Determined by electron microscopy at 2.35 Å resolution. Released 5 Mar 2025.
- Method
- Electron microscopy
- Resolution
- 2.35 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 20
- Atoms
- 32,370
- Mol. weight
- 460.36 kDa
- Ligands
- 6PH, CN3, CN5, HEM
- Released
- 5 Mar 2025
Explore 8YIO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8YIO contains 235 α-helices and 108 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and L: 24 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 29-33 | 5 | 1 |
| β-strand | 37-42 | 6 | 1 |
| β-strand | 49-55 | 7 | 1 |
| α-helix | 59-61 | 3 | |
| α-helix | 69-77 | 9 | |
| α-helix | 80-89 | 10 | |
| β-strand | 92-97 | 6 | 1 |
| β-strand | 102-108 | 7 | 1 |
| α-helix | 113-121 | 9 | |
| α-helix | 122-126 | 5 | |
| α-helix | 134-154 | 21 | |
| α-helix | 156-168 | 13 | |
| α-helix | 173-175 | 3 | |
| α-helix | 182-185 | 4 | |
| α-helix | 190-200 | 11 | |
| α-helix | 203-205 | 3 | |
| β-strand | 206-212 | 7 | 1 |
| α-helix | 216-224 | 9 | |
| α-helix | 240-242 | 3 | |
| β-strand | 247-253 | 7 | 2 |
| β-strand | 259-266 | 8 | 2 |
| α-helix | 275-285 | 11 | |
| β-strand | 287-289 | 3 | 2 |
| α-helix | 295-297 | 3 | |
| α-helix | 303-309 | 7 | |
| β-strand | 314-321 | 8 | 2 |
| β-strand | 326-334 | 9 | 2 |
| α-helix | 340-351 | 12 | |
| α-helix | 353-356 | 4 | |
| α-helix | 360-378 | 19 | |
| α-helix | 383-397 | 15 | |
| α-helix | 403-411 | 9 | |
| α-helix | 415-425 | 11 | |
| β-strand | 432-437 | 6 | 2 |
| α-helix | 445-449 | 5 | |
| α-helix | 450-452 | 3 | |
Chains B and M: 21 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 18-22 | 5 | 5 |
| β-strand | 28-35 | 8 | 5 |
| α-helix | 39-41 | 3 | |
| α-helix | 47-52 | 6 | |
| β-strand | 59 | 1 | 6 |
| α-helix | 64-74 | 11 | |
| β-strand | 76-82 | 7 | 5 |
| β-strand | 87-94 | 8 | 5 |
| α-helix | 95-97 | 3 | |
| α-helix | 98-111 | 14 | |
| β-strand | 112 | 1 | 6 |
| α-helix | 116-118 | 3 | |
| α-helix | 119-123 | 5 | |
| α-helix | 124-134 | 11 | |
| α-helix | 138-151 | 14 | |
| α-helix | 169-179 | 11 | |
| α-helix | 182-184 | 3 | |
| β-strand | 185-190 | 6 | 5 |
| α-helix | 194-202 | 9 | |
| α-helix | 205-208 | 4 | |
| α-helix | 220-222 | 3 | |
| β-strand | 228-232 | 5 | 7 |
| β-strand | 237-245 | 9 | 7 |
| α-helix | 247-249 | 3 | |
| α-helix | 250-260 | 11 | |
| β-strand | 273-278 | 6 | 7 |
| β-strand | 283-291 | 9 | 7 |
| α-helix | 294-310 | 17 | |
| β-strand | 312-313 | 2 | 8 |
| α-helix | 315-317 | 3 | |
| α-helix | 318-328 | 11 | |
| β-strand | 345-346 | 2 | 8 |
| β-strand | 352-357 | 6 | 7 |
| α-helix | 359-361 | 3 | |
| α-helix | 365-367 | 3 | |
Chains C and N: 23 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-6 | 4 | |
| α-helix | 10-17 | 8 | |
| β-strand | 21-23 | 3 | 3 |
| α-helix | 28-31 | 4 | |
| α-helix | 32-51 | 20 | |
| α-helix | 61-70 | 10 | |
| α-helix | 75-103 | 29 | |
| α-helix | 111-133 | 23 | |
| β-strand | 137 | 1 | 4 |
| α-helix | 138-148 | 11 | |
| α-helix | 149-153 | 5 | |
| α-helix | 158-166 | 9 | |
| α-helix | 173-204 | 32 | |
| β-strand | 218-220 | 3 | 3 |
| α-helix | 225-246 | 22 | |
| α-helix | 254-257 | 4 | |
| β-strand | 259 | 1 | 4 |
| α-helix | 260 | 1 | |
| α-helix | 273-275 | 3 | |
| α-helix | 276-282 | 7 | |
| α-helix | 288-300 | 13 | |
| α-helix | 301-304 | 4 | |
| α-helix | 305-308 | 4 | |
| α-helix | 320-339 | 20 | |
| α-helix | 348-361 | 14 | |
| α-helix | 362-366 | 5 | |
| α-helix | 367-380 | 14 | |
Chains D and O: 16 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 64-67 | 4 | |
| α-helix | 69-73 | 5 | |
| α-helix | 87-99 | 13 | |
| α-helix | 101-103 | 3 | |
| β-strand | 111 | 1 | 9 |
| α-helix | 112-115 | 4 | |
| β-strand | 116 | 1 | 10 |
| β-strand | 120 | 1 | 10 |
| α-helix | 122-129 | 8 | |
| β-strand | 133-135 | 3 | 11 |
| β-strand | 146-148 | 3 | 11 |
| β-strand | 154 | 1 | 9 |
| α-helix | 155-157 | 3 | |
| α-helix | 162-167 | 6 | |
| α-helix | 174-176 | 3 | |
| α-helix | 188-195 | 8 | |
| α-helix | 202-203 | 2 | |
| α-helix | 208-209 | 2 | |
| β-strand | 213-214 | 2 | 12 |
| β-strand | 222-223 | 2 | 12 |
| α-helix | 244-259 | 16 | |
| α-helix | 263-291 | 29 | |
| α-helix | 293-296 | 4 | |
| β-strand | 299-302 | 4 | 2 |
| α-helix | 304-306 | 3 | |
Chain E: 10 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 36-38 | 3 | |
| β-strand | 43 | 1 | 15 |
| α-helix | 49-79 | 31 | |
| α-helix | 80-82 | 3 | |
| α-helix | 84-85 | 2 | |
| α-helix | 86-89 | 4 | |
| β-strand | 94-96 | 3 | 16 |
| α-helix | 98-100 | 3 | |
| β-strand | 109 | 1 | 17 |
| α-helix | 111-113 | 3 | |
| β-strand | 116 | 1 | 17 |
| α-helix | 125-127 | 3 | |
| α-helix | 134-136 | 3 | |
| α-helix | 143-146 | 4 | |
| β-strand | 156 | 1 | 18 |
| β-strand | 167 | 1 | 19 |
| β-strand | 177-178 | 2 | 19 |
| β-strand | 183-184 | 2 | 19 |
| β-strand | 201 | 1 | 18 |
| β-strand | 205-207 | 3 | 16 |
| β-strand | 212-214 | 3 | 16 |
Chain F: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 77-85 | 9 | |
| α-helix | 89-108 | 20 | |
| α-helix | 124-138 | 15 | |
| α-helix | 139-141 | 3 | |
Chains G and R: 10 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-17 | 13 | |
| α-helix | 21-36 | 16 | |
| α-helix | 38-41 | 4 | |
| α-helix | 45-47 | 3 | |
| α-helix | 54-61 | 8 | |
| α-helix | 65-83 | 19 | |
| α-helix | 90-92 | 3 | |
| α-helix | 94-95 | 2 | |
| α-helix | 96-98 | 3 | |
| α-helix | 104-121 | 18 | |
Chain H: 5 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12 | 1 | 20 |
| β-strand | 15 | 1 | 20 |
| β-strand | 22-29 | 8 | 2 |
| α-helix | 31-33 | 3 | |
| β-strand | 34 | 1 | 15 |
| α-helix | 40-43 | 4 | |
| α-helix | 47-53 | 7 | |
| α-helix | 57-80 | 24 | |
| α-helix | 86-92 | 7 | |
7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| COR1 isoform 1 | A, L | protein | 431 | Saccharomyces cerevisiae | P07256 (AlphaFold model) |
| Cytochrome b | C, N | protein | 385 | Saccharomyces cerevisiae | P00163 (AlphaFold model) |
| Cytochrome b-c1 complex subunit 2, mitochondrial | B, M | protein | 352 | Saccharomyces cerevisiae | P07257 (AlphaFold model) |
| Cytochrome c1, heme protein, mitochondrial | D, O | protein | 248 | Saccharomyces cerevisiae | P07143 (AlphaFold model) |
| Cytochrome b-c1 complex subunit Rieske, mitochondrial | E, P | protein | 185 | Saccharomyces cerevisiae | P08067 |
| QCR6 isoform 1 | F, Q | protein | 75 | Saccharomyces cerevisiae | P00127 |
| Cytochrome b-c1 complex subunit 7 | G, R | protein | 126 | Saccharomyces cerevisiae | P00128 |
| Cytochrome b-c1 complex subunit 8 | H, S | protein | 93 | Saccharomyces cerevisiae | P08525 |
| Cytochrome b-c1 complex subunit 9, mitochondrial | I, T | protein | 55 | Saccharomyces cerevisiae | P22289 |
| Cytochrome b-c1 complex subunit 10, mitochondrial | U, V | protein | 52 | Saccharomyces cerevisiae | P37299 |
Sequence of entity 1 (A, L), FASTA
>8YIO_1 COR1 isoform 1 (chains A, L)
AEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENSAVA
AKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLK
QVQDFEENDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNA
VVVGTGNIKHEDLVNSIESKNLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVE
GEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNIQEYQLCDNFNHFSLSYKDSG
LWGFSTATRNVTMIDDLIHFTLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVND
ANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRLWDQDIAIAGTGQIEGLLDYM
RIRSDMSMMRW
Sequence of entity 2 (C, N), FASTA
>8YIO_2 Cytochrome b (chains C, N)
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIEL
AFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVII
FILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFSVSNPTIQRFF
ALHYLVPFIIAAMVIMHLMALHIHGSSNPLGITGNLDRIPMHSYFIFKDLVTVFLFMLIL
ALFVFYSPNTLGHPDNYIPGNPLVTPASIVPEWYLLPFYAILRSIPDKLLGVITMFAAIL
VLLVLPFTDRSVVRGNTFKVLSKFFFFIFVFNFVLLGQIGACHVEVPYVLMGQIATFIYF
AYFLIIVPVISTIENVLFYIGRVNK
Sequence of entity 3 (B, M), FASTA
>8YIO_3 Cytochrome b-c1 complex subunit 2, mitochondrial (chains B, M)
LTVSARDAPTKISTLAVKVHGGSRYATKDGVAHLLNRFNFQNTNTRSALKLVRESELLGG
TFKSTLDREYITLKATFLKDDLPYYVNALADVLYKTAFKPHELTESVLPAARYDYAVAEQ
CPVKSAEDQLYAITFRKGLGNPLLYDGVERVSLQDIKDFADKVYTKENLEVSGENVVEAD
LKRFVDESLLSTLPAGKSLVSKSEPKFFLGEENRVRFIGDSVAAIGIPVNKASLAQYEVL
ANYLTSALSELSGLISSAKLDKFTDGGLFTLFVRDQDSAVVSSNIKKIVADLKKGKDLSP
AINYTKLKNAVQNESVSSPIELNFDAVKDFKLGKFNYVAVGDVSNLPYLDEL
Sequence of entity 4 (D, O), FASTA
>8YIO_4 Cytochrome c1, heme protein, mitochondrial (chains D, O)
MTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSHT
NEEVRNMAEEFEYDDEPDEQGNPKKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLIV
KARHGGCDYIFSLLTGYPDEPPAGVALPPGSNYNPYFPGGSIAMARVLFDDMVEYEDGTP
ATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIILSSLYLLSIWVKKFKWAGIKTRKFV
FNPPKPRK
Sequence of entity 5 (E, P), FASTA
>8YIO_5 Cytochrome b-c1 complex subunit Rieske, mitochondrial (chains E, P)
KSTYRTPNFDDVLKENNDADKGRSYAYFMVGAMGLLSSAGAKSTVETFISSMTATADVLA
MAKVEVNLAAIPLGKNVVVKWQGKPVFIRHRTPHEIQEANSVDMSALKDPQTDADRVKDP
QWLIMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYEFDGD
KVIVG
Sequence of entity 6 (F, Q), FASTA
>8YIO_6 QCR6 isoform 1 (chains F, Q)
EVTDQLEDLREHFKNTEEGKALVHHYEECAERVKIQQQQPGYADLEHKEDCVEEFFHLQH
YLDTATAPRLFDKLK
Sequence of entity 7 (G, R), FASTA
>8YIO_7 Cytochrome b-c1 complex subunit 7 (chains G, R)
PQSFTSIARIGDYILKSPVLSKLCVPVANQFINLAGYKKLGLKFDDLIAEENPIMQTALR
RLPEDESYARAYRIIRAHQTELTHHLLPRNEWIKAQEDVPYLLPYILEAEAAAKEKDELD
NIEVSK
Sequence of entity 8 (H, S), FASTA
>8YIO_8 Cytochrome b-c1 complex subunit 8 (chains H, S)
GPPSGKTYMGWWGHMGGPKQKGITSYAVSPYAQKPLQGIFHNAVFNSFRRFKSQFLYVLI
PAGIYWYWWKNGNEYNEFLYSKAGREELERVNV
Sequence of entity 9 (I, T), FASTA
>8YIO_9 Cytochrome b-c1 complex subunit 9, mitochondrial (chains I, T)
SSLYKTFFKRNAVFVGTIFAGAFVFQTVFDTAITSWYENHNKGKLWKDVKARIAA
Sequence of entity 10 (U, V), FASTA
>8YIO_10 Cytochrome b-c1 complex subunit 10, mitochondrial (chains U, V)
KTGLHFGRLSLRSLTAYAPNLMLWGGASMLGLFVFTEGWPKFQDTLYKKIPL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| 6PH | (1R)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate | C31 H61 O8 P | 2 |
| CN3 | (2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(prop… | C36 H68 O17 P2 | 2 |
| CN5 | (5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-dipho… | C26 H52 O13 P2 | 1 |
| HEM | Protoporphyrin IX containing FE | C34 H32 Fe N4 O4 | 6 |
| 9PE | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]et… | C30 H60 N O8 P | 2 |
| 8PE | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl… | C37 H74 N O8 P | 2 |
| UQ6 | 5-(3,7,11,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3-dimethoxy… | C39 H60 O4 | 2 |
| AZO | Methyl (2Z)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyacryla… | C22 H17 N3 O5 | 2 |
Primary citation
Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in azoxystrobin-bound state. Ye, Y., Li, Z.W., Yang, G.F. To be published.
Other PDB entries of the same protein (UniProt P07256 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3CX5 1.9 Å, Structure of complex III with bound cytochrome c in reduced state and definition of a…
- 1EZV 2.3 Å, Structure of the yeast cytochrome BC1 complex co-crystallized with an antibody fv-fragment
- 1KB9 2.3 Å, Yeast cytochrome BC1 complex
- 2IBZ 2.3 Å, Yeast Cytochrome BC1 Complex with Stigmatellin
- 9ETZ 2.4 Å, III2IV respiratory supercomplex from Saccharomyces cerevisiae
- 8YHQ 2.42 Å, Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in pyraclostrobin-bound state
- 1P84 2.5 Å, HDBT inhibited Yeast Cytochrome bc1 Complex
- 3CXH 2.5 Å, Structure of yeast complex III with isoform-2 cytochrome c bound and definition of a…
- 8ZJC 2.5 Å, Cryo-EM structure of Saccharomyces cerevisiae bc1 complex
- 8ZMT 2.52 Å, Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in Metyltetraprole-bound state
- 9BPB 2.57 Å, Tethered respiratory III2IV2 supercomplex from Saccharomyces cerevisiae
- 8YIL 2.58 Å, Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in YF24228-bound state
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