Structural basis of CD4 downregulation by HIV-1 Nef. Released 14 Aug 2020.
Explore 9A0E in 3D Show helices and sheets RCSB PDB PDBe
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Nef | A | protein | 202 | Q90VU7 | |
| CD4mut | B | protein | 26 | P01730 (AlphaFold model) | |
| AP2alpha2 | C | protein | 627 | P18484 (AlphaFold model) | |
| AP2mu2 | D | protein | 135 | Q96CW1 (AlphaFold model) | |
| AP2sigma | E | protein | 142 | P53680 | |
| AP2beta2 | F | protein | 591 | P63010 |
>9A0E_1 Nef (chains A) AGFSMAADGVGAVSRDLEKHGAITSSNTAANNAACAWLEAQEEEEVGFPVTPQVPLRPMT YKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFG WCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHP EYFKNCGVDGSDEASELACPTP
>9A0E_2 CD4mut (chains B) SVRSRHRRRQAERMSQIKRLLSEKKT
>9A0E_3 AP2alpha2 (chains C) MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVC KLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL ASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSP DLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSA STDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKV QHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE FSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYSI REEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAA KTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRAL LLSTYIKFVNLFPEVKATIQDVLRSDSQLKNADVELQQRAVEYLRLSTVASTDILATVLE EMPPFPERESSILAKLKKKKGENLYFQ
>9A0E_4 AP2mu2 (chains D) MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY PQNSETGALKTFITQ
>9A0E_5 AP2sigma (chains E) MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYR RYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLA GEIRETSQTKVLKQLLMLQSLE
>9A0E_6 AP2beta2 (chains F) MTDSKYFTTNKKGEISELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK HPNKYESIIATLCGNLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRK
Structural basis of CD4 downregulation by HIV-1 Nef. Kwon Y, Kaake RM, Echeverria I et al. Nat Struct Mol Biol (2020) 27:822-828. DOI 10.1038/s41594-020-0463-z · PubMed
Other PDB entries of the same protein (UniProt Q90VU7), best resolution first:
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